Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness

ABSTRACT

The present invention relates to methods, systems and kits for the diagnosis, prognosis and the determination of cancer progression of prostate cancer in a subject. The invention also provides clinically useful genomic classifiers for predicting prostate cancer metastasis and identifying tumor aggressiveness. The methods, systems and kits can provide expression-based analysis of biomarkers for purposes of predicting metastatic disease and lethal prostate cancer in a subject. Further disclosed herein, in certain instances, are probe sets for use in predicting prostate cancer metastasis in a subject. Classifiers for predicting prostate cancer metastasis are provided. Methods of treating cancer based on tumor aggressiveness are also provided. The methods and classifiers of the present invention are also useful for predicting early prostate cancer metastasis.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No.15/977,249, filed May 11, 2018, entitled “GENETIC SIGNATURES TO PREDICTPROSTATE CANCER METASTASIS AND IDENTIFY TUMOR AGGRESSIVENESS”, whichclaims priority to the U.S. Provisional Patent Application Ser. No.62/505,665, filed on May 12, 2017, which is hereby incorporated byreference herein in its entirety.

INCORPORATION OF SEQUENCE LISTING

The material in the accompanying sequence listing is hereby incorporatedby reference into this application. The accompanying sequence listingtext file, name GENDX_001C1.txt, was created on Jul. 30, 2021, and is531 kb. The file can be assessed using Microsoft Word on a computer thatuses Windows OS.

FIELD OF THE INVENTION

The present invention relates to methods, systems and kits for thediagnosis, prognosis and the determination of cancer progression ofprostate cancer in a subject. The invention also provides clinicallyuseful genomic classifiers for predicting prostate cancer metastasis andidentifying tumor aggressiveness. The methods, systems and kits canprovide expression-based analysis of biomarkers for purposes ofpredicting metastatic disease and lethal prostate cancer in a subject.Further disclosed herein, in certain instances, are probe sets for usein predicting prostate cancer metastasis in a subject. Classifiers forpredicting prostate cancer metastasis are provided. Methods of treatingcancer based on tumor aggressiveness are also provided. The methods andclassifiers of the present invention are also useful for predictingearly prostate cancer metastasis.

BACKGROUND OF THE INVENTION

Cancer is the uncontrolled growth of abnormal cells anywhere in a body.The abnormal cells are termed cancer cells, malignant cells, or tumorcells. Many cancers and the abnormal cells that compose the cancertissue are further identified by the name of the tissue that theabnormal cells originated from (for example, prostate cancer). Cancercells can proliferate uncontrollably and form a mass of cancer cells.Cancer cells can break away from this original mass of cells, travelthrough the blood and lymph systems, and lodge in other organs wherethey can again repeat the uncontrolled growth cycle. This process ofcancer cells leaving an area and growing in another body area is oftentermed metastatic spread or metastatic disease. For example, if prostatecancer cells spread to a bone (or anywhere else), it can mean that theindividual has metastatic prostate cancer.

Standard clinical parameters such as tumor size, grade, lymph nodeinvolvement and tumor-node-metastasis (TNM) staging (American JointCommittee on Cancer http://www.cancerstaging.org) may correlate withoutcome and serve to stratify patients with respect to (neo)adjuvantchemotherapy, immunotherapy, antibody therapy and/or radiotherapyregimens. Incorporation of molecular markers in clinical practice maydefine tumor subtypes that are more likely to respond to targetedtherapy. However, stage-matched tumors grouped by histological ormolecular subtypes may respond differently to the same treatmentregimen. Additional key genetic and epigenetic alterations may existwith important etiological contributions. A more detailed understandingof the molecular mechanisms and regulatory pathways at work in cancercells and the tumor microenvironment (TME) could dramatically improvethe design of novel anti-tumor drugs and inform the selection of optimaltherapeutic strategies. For example, methods that enable theidentification of aggressive tumors would ensure that those patients areadequately treated for their cancer, while patients with low risk tumorscould avoid unnecessary cancer treatment. The development andimplementation of diagnostic, prognostic and therapeutic biomarkers tocharacterize the biology of each tumor may assist clinicians in makingimportant decisions with regard to individual patient care andtreatment. Thus, provided herein are methods, systems and kits for thediagnosis, prognosis and the determination of cancer progression ofcancer in a subject. The invention also provides biomarkers thatidentify aggressive prostate cancer, clinically useful classifiers forpredicting prostate cancer metastasis, bioinformatic methods fordetermining clinically useful classifiers, and methods of use of each ofthe foregoing. The methods, systems and kits can provideexpression-based analysis of biomarkers for purposes of predictingprostate cancer metastasis in a subject. Further disclosed herein, incertain instances, are probe sets for use in predicting prostate cancermetastasis in a subject. Classifiers for predicting prostate cancermetastasis are provided. Methods of treating cancer based on tumoraggressiveness are also provided. The methods and classifiers of thepresent invention are also useful for predicting early prostate cancermetastasis.

This background information is provided for the purpose of making knowninformation believed by the applicant to be of possible relevance to thepresent invention. No admission is necessarily intended, nor should beconstrued, that any of the preceding information constitutes prior artagainst the present invention.

SUMMARY OF THE INVENTION

The present invention relates to methods, systems and kits for thediagnosis, prognosis and the determination of cancer progression ofcancer in a subject. The invention also provides biomarkers that definesubgroups of prostate cancer, clinically useful classifiers forpredicting prostate cancer aggressiveness and metastasis, bioinformaticmethods for determining clinically useful classifiers, and methods ofuse of each of the foregoing. The methods, systems and kits can provideexpression-based analysis of biomarkers for purposes of prognosing anddiagnosing prostate cancer in a subject. Further disclosed herein, incertain instances, are probe sets for use in prognosing and diagnosingprostate cancer in a subject. Classifiers for prognosing and diagnosinga prostate cancer are provided. Methods of treating cancer based onprognosis and/or diagnosis according to the present invention are alsoprovided.

In one embodiment, the present invention provides a method comprising:obtaining a biological sample from a subject; and detecting the presenceor assaying an expression level in the sample from the subject for aplurality of target sequences, wherein the plurality of target sequencesis selected from Table 1 or SEQ ID NOs: 1-1815. In some embodiments, theplurality of target sequences comprises a coding and/or non-codingtarget. In other embodiments, the coding target is an exonic sequence.In yet other embodiments, non-coding target comprises an intronicsequence, partially overlaps an intronic sequence, a sequence within theUTR or partially overlaps with a UTR sequence. In other embodiments, theplurality of target sequences comprises a nucleic acid sequence. Instill other embodiments, the nucleic acid sequence is a DNA sequence oran RNA sequence. In some embodiments, the plurality of target sequencescomprises at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 or 60target sequences selected from Table 1 or SEQ ID NOs: 1-1815. In someembodiments, the subject has cancer. In other embodiments, the cancer isselected from the group consisting of skin cancer, lung cancer, coloncancer, pancreatic cancer, prostate cancer, liver cancer, thyroidcancer, ovarian cancer, uterine cancer, breast cancer, cervical cancer,kidney cancer, epithelial carcinoma, squamous carcinoma, basal cellcarcinoma, melanoma, papilloma, and adenomas. In yet other embodiments,the cancer is prostate cancer. In still other embodiments, the methodsfurther comprise administering a treatment to the subject. In someembodiments, the treatment is selected from the group consisting ofsurgery, chemotherapy, radiation therapy, immunotherapy/biologicaltherapy, and photodynamic therapy. In other embodiments, the biologicalsample is a biopsy. In yet other embodiments, the biological sample is aurine sample, a blood sample or a prostate tumor sample. In certainembodiments, the blood sample is plasma, serum, or whole blood. In otherembodiments, the subject is a human.

In another embodiment, the present invention provides methods ofdiagnosing, prognosing and determining cancer progression of cancer in asubject comprising obtaining a biological sample from a subject; anddetecting the presence or assaying an expression level in the samplefrom the subject for a plurality of target sequences, wherein theplurality of target sequences is selected from Table 1 or SEQ ID NOs:1-1815, thereby diagnosing, prognosing and determining cancerprogression of cancer in the subject. In some embodiments, the pluralityof target sequences comprises a coding and/or non-coding target. Inother embodiments, the coding target is an exonic sequence. In yet otherembodiments, non-coding target comprises an intronic sequence, partiallyoverlaps an intronic sequence, a sequence within the UTR or partiallyoverlaps with a UTR sequence. In other embodiments, the plurality oftarget sequences comprises a nucleic acid sequence. In still otherembodiments, the nucleic acid sequence is a DNA sequence or an RNAsequence. In some embodiments, the plurality of target sequencescomprises at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 or 60target sequences selected from Table 1 or SEQ ID NOs: 1-1815. In someembodiments, the subject has cancer. In other embodiments, the cancer isselected from the group consisting of skin cancer, lung cancer, coloncancer, pancreatic cancer, prostate cancer, liver cancer, thyroidcancer, ovarian cancer, uterine cancer, breast cancer, cervical cancer,kidney cancer, epithelial carcinoma, squamous carcinoma, basal cellcarcinoma, melanoma, papilloma, and adenomas. In yet other embodiments,the cancer is prostate cancer. In still other embodiments, the methodsfurther comprise administering a treatment to the subject. In someembodiments, the treatment is selected from the group consisting ofsurgery, chemotherapy, radiation therapy, immunotherapy/biologicaltherapy, and photodynamic therapy. In other embodiments, the biologicalsample is a biopsy. In yet other embodiments, the biological sample is aurine sample, a blood sample or a prostate tumor sample. In certainembodiments, the blood sample is plasma, serum, or whole blood. In otherembodiments, the subject is a human.

In other embodiments, the present invention provides methods ofdetermining a treatment regimen for a subject having cancer comprising:obtaining a biological sample from a subject having cancer; assaying anexpression level in a sample from the subject for a plurality of targetsequences, wherein the plurality of target sequences is selected fromTable 1 or SEQ ID NOs: 1-1815; and determining the treatment regimen forthe subject. In other embodiments, the expression level is increased orreduced compared to a control. In still other embodiments, the assayingan expression level comprises performing in situ hybridization, aPCR-based method, an array-based method, an immunohistochemical method,an RNA assay method, or an immunoassay method. In other embodiments, theassaying an expression level comprises using a reagent selected from thegroup consisting of a nucleic acid probe, one or more nucleic acidprimers, and an antibody. In yet other embodiments, the assaying anexpression level comprises assaying the level of an RNA transcript. Inother embodiments, the method further comprises administering at leastone cancer treatment selected from the group consisting of surgery,radiation therapy, immunotherapy, biological therapy, neoadjuvantchemotherapy, and photodynamic therapy after androgen deprivationtherapy.

In other embodiments, the present invention provides kits for predictingcancer aggressiveness or risk of metastasis, the kit comprising agentsfor assaying an expression level of a plurality of genes, wherein saidplurality of genes comprises one or more genes selected from Table 1 orSEQ ID NOs: 1-1815. In certain embodiments, the kit comprises agents forassaying an expression level of the genes listed in Table 1. In certainaspects, the agents comprise reagents for performing in situhybridization, a PCR-based method, an array-based method, animmunohistochemical method, an RNA assay method, or an immunoassaymethod. In other aspects, the agents comprise one or more of amicroarray, a nucleic acid probe, a nucleic acid primer, or an antibody.In certain embodiments, the kit comprises at least one set of PCRprimers capable of amplifying a nucleic acid comprising a sequence of agene selected from Table 1 or its complement. In other embodiments, thekit comprises at least one probe capable of hybridizing to a nucleicacid comprising a sequence of a gene selected from Table 1 or itscomplement. In yet other embodiments, the kits further comprise one ormore control reference samples.

In one embodiment, the present invention provides a probe set forprognosing or diagnosing cancer in a subject, the probe set comprising aplurality of probes for detecting a plurality of target nucleic acids,wherein the plurality of target nucleic acids comprises one or more genesequences, or complements thereof, of genes selected from Table 1. Inone aspect, at least one probe is detectably labeled.

In other embodiments, the present invention provides methods fortreating a subject with cancer, the method comprising: a) obtaining abiological sample from a subject having cancer; b) detecting thepresence or assaying the expression level in the biological sample for aplurality of targets selected from Table 1 or SEQ ID NOs: 1-1815; and c)administering a treatment to the subject. In some embodiments, thetreatment is selected from the group consisting of surgery,chemotherapy, radiation therapy, immunotherapy, biological therapy,hormonal therapy, and photodynamic therapy. In other embodiments, thecancer is prostate cancer.

In one embodiment, the present invention provides a method comprising:a) obtaining a biological sample from a subject; and b) detecting thepresence or assaying the expression level in the biological sample for aplurality of targets selected from the group consisting of AC020571.3,ANO7, ARL6IP1P2, ASPN, AZGP1, AZGP1P1, DEGS1, ERO1LB, FBXL8, FMOS,FTH1P2, FTH1P8, GLB1L2, GLB1L3, GLYATL1P3, GMNN, HIF3A, INHBA, KIAA1210,KRT15, LIPH, LPAR3, LPGAT1, MIR4435-1HG, MKI67, MLLT11, MYBPC1, NADK2,NR4A1, NUSAP1, OR51A6P, PABPC1, PART1, PCAT14, PGM5P4-AS1, PICK1, PTTG1,R3HDM1, RNA5SP121, RP11-121G22.3 RP11-159H20.3, RP11-755011.2,RP11-770G2.5, RP11-923111.3, RP13-753N3.3, RPL31P57, SCIN, SESN3,SETP14, SLC22A3, SMC4, TIPARP, TMEM100, TNFRSF19, TOP2A, TPX2, TRIQK,VBP1, WFDC2, and XPO6. In one aspect, the plurality of target sequencescomprises a coding and/or non-coding target. In some embodiments, theplurality of target sequences comprises a coding and/or non-codingtarget. In other embodiments, the coding target is an exonic sequence.In yet other embodiments, non-coding target comprises an intronicsequence, partially overlaps an intronic sequence, a sequence within theUTR or partially overlaps with a UTR sequence. In other embodiments, theplurality of target sequences comprises a nucleic acid sequence. Instill other embodiments, the nucleic acid sequence is a DNA sequence oran RNA sequence. In some embodiments, the plurality of target sequencescomprises at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 or 60target sequences selected from Table 1 or SEQ ID NOs: 1-1815. In someembodiments, the subject has cancer. In other embodiments, the cancer isselected from the group consisting of skin cancer, lung cancer, coloncancer, pancreatic cancer, prostate cancer, liver cancer, thyroidcancer, ovarian cancer, uterine cancer, breast cancer, cervical cancer,kidney cancer, epithelial carcinoma, squamous carcinoma, basal cellcarcinoma, melanoma, papilloma, and adenomas. In yet other embodiments,the cancer is prostate cancer. In still other embodiments, the methodsfurther comprise administering a treatment to the subject. In someembodiments, the treatment is selected from the group consisting ofsurgery, chemotherapy, radiation therapy, immunotherapy/biologicaltherapy, and photodynamic therapy. In other embodiments, the biologicalsample is a biopsy. In yet other embodiments, the biological sample is aurine sample, a blood sample or a prostate tumor sample. In certainembodiments, the blood sample is plasma, serum, or whole blood. In otherembodiments, the subject is a human.

The plurality of targets may comprise one or more targets selected fromACO20571.3, ANO7, ARL6IP1P2, ASPN, AZGP1, AZGP1P1, DEGS1, ERO1LB, FBXL8,FMOS, FTH1P2, FTH1P8, GLB1L2, GLB1L3, GLYATL1P3, GMNN, HIF3A, INHBA,KIAA1210, KRT15, LIPH, LPAR3, LPGAT1, MIR4435-1HG, MKI67, MLLT11,MYBPC1, NADK2, NR4A1, NUSAP1, OR51A6P, PABPC1, PART1, PCAT14,PGMSP4-AS1, PICK1, PTTG1, R3HDM1, RNA5SP121, RP11-121G22.3RP11-159H20.3, RP11-755011.2, RP11-770G2.5, RP11-923111.3, RP13-753N3.3,RPL31P57, SCIN, SESN3, SETP14, SLC22A3, SMC4, TIPARP, TMEM100, TNFRSF19,TOP2A, TPX2, TRIQK, VBP1, WFDC2, and XPO6; TIPARP and TMEM100; SETP14,MLLT11, and INHBA; ANO7, NR4A1, PART1, PCAT-14, SLC22A3, and TIPARP;FBXL8, MKI67, NUSAP1, PTTG1, TOP2A, and TPX2; ASPN, AZGP1, KRT15,MYBPC1, PICK1, TRIQK, and WFDC2; DEGS1, ERO1LB, FMOS, GLB1L2, GLB1L3,GLYATL1P3, LIPH, LPGAT1, NADK2, and XPO6; GMNN, SESN3, SMC4, and VBP1;HIF3A; INHBA, R3HDM1, and TNFRSF19; LPAR3 and SCIN; LOC101927482,ARL6IP1P2, AZGP1P1, FTH1P2, FTH1P8, KIAA1210, MIR4435-1HG, OR51A6P,PGMSP4-AS1, RNA5SP121, RP11-121G22.3, RP11-159H20.3, RP11-755011.2,RP11-77062.5, RP11-923111.3, and RP13-753N3.3; ANO7, NR4A1, and PART1;PCAT-14, SLC22A3, and TIPARP; FBXL8, MKI67, and NUSAP1; PTTG1, TOP2A,and TPX2; ASPN, AZGP1, and KRT15; MYBPC1, PICK1, TRIQK, and WFDC2;DEGS1, ERO1LB, and FMOS; GLB1L2, GLB1L3, and GLYATL1P3; LIPH, LPGAT1,NADK2, and XPO6; GMNN and SESN3; SMC4 and VBP1; INHBA and R3HDM1; INHBAand TNFRSF19; LPAR3 and SCIN; LOC101927482 and ARL6IP1P2; AZGP1P1 andFTH1P2; FTH1P8 and KIAA1210; MIR4435-1HG and OR51A6P; PGMSP4-AS1 andRNA5SP121; RP11-121G22.3 and RP11-159H20.3; RP11-755011.2 andRP11-77062.5; RP11-923111.3 and RP13-753N3.3; ACO20571.3 and ANO7;ARL6IP1P2 and ASPN; AZGP1 and AZGP1P1; DEGS1 and ERO1LB; FBXL8 and FMOS;FTH1P2 and FTH1P8; GLB1L2 and GLB1L3; GLYATL1P3 and GMNN; HIF3A andINHBA; KIAA1210 and KRT15; LIPH and LPAR3; LPGAT1 and MIR4435-1HG; MKI67and MLLT11; MYBPC1 and NADK2; NR4A1 and NUSAP1; OR51A6P and PABPC1;PART1 and PCAT14; PGM5P4-AS1 and PICK1; PTTG1 and R3HDM1; RNA5SP121 andRP11-121G22.3; RP11-159H20.3 and RP11-755011.2; RP11-770G2.5 andRP11-923111.3; RP13-753N3.3 and RPL31P57; SCIN and SESN3; SETP14 andSLC22A3; SMC4 and TIPARP; TMEM100 and TNFRSF19; TOP2A and TPX2; TRIQKand VBP1; WFDC2 and XPO6; TIPARP and TMEM100.

In one embodiment, the present invention provides a method comprising:a) obtaining a biological sample from a subject having prostate cancerand b) detecting the presence or expression level in the biologicalsample for a plurality of targets selected from Table 1 or SEQ ID NOs:1-1815. In some embodiments, the method further comprises treating theprostate cancer in the subject according to a genomic classifier scorebased on the presence or expression levels of the plurality of targets.

In some embodiments, the present invention also provides a method ofdiagnosing, prognosing, assessing the risk of recurrence or predictingbenefit from therapy in a subject with prostate cancer, comprising:providing a biological sample comprising prostate cancer cells from thesubject; assaying an expression level in the biological sample from thesubject for a plurality of targets using at least one reagent thatspecifically binds to said targets, wherein the plurality of targetscomprises one or more targets selected from Table 1 or SEQ ID NOs:1-1815; and diagnosing, prognosing, assessing the risk of recurrence orpredicting benefit from therapy in the subject based on the expressionlevels of the plurality of targets. In some embodiments, the expressionlevel of the target is reduced expression of the target. In otherembodiments, the expression level of said target is increased expressionof said target. In yet other embodiments, the level of expression ofsaid target is determined by using a method selected from the groupconsisting of in situ hybridization, a PCR-based method, an array-basedmethod, an immunohistochemical method, an RNA assay method and animmunoassay method. In other embodiments, the reagent is selected fromthe group consisting of a nucleic acid probe, one or more nucleic acidprimers, and an antibody. In other embodiments, the target comprises anucleic acid sequence.

In some embodiments, the present invention provides a system foranalyzing a cancer, comprising, a probe set comprising a plurality oftarget sequences, wherein the plurality of target sequences hybridizesto one or more targets selected from Table 1 or SEQ ID NOs: 1-1815; orthe plurality of target sequences comprises one or more targets selectedfrom Table 1 or SEQ ID NOs: 1-1815; and a computer model or algorithmfor analyzing an expression level and/or expression profile of thetarget hybridized to the probe in a sample from a subject suffering fromprostate cancer. In some embodiments, the method further comprises alabel that specifically binds to the target, the probe, or a combinationthereof.

In some embodiments, the present invention provides a method comprising:(a) providing a biological sample from a subject with prostate cancer;(b) detecting the presence or expression level in the biological samplefor a plurality of targets, wherein the plurality of targets comprisesone or more targets selected from Table 1 or SEQ ID NOs: 1-1815; (c)generating a genomic classifier score based on the presence orexpression levels of the plurality of targets; and (d) administering atreatment to the subject, wherein the treatment is selected from thegroup consisting of surgery, chemotherapy, radiation therapy,immunotherapy/biological therapy, hormonal therapy, and photodynamictherapy. In some embodiments, the present invention provides a method oftreating a subject with prostate cancer, comprising: providing abiological sample comprising prostate cancer cells from the subject;determining the level of expression or amplification of at least one ormore targets selected from Table 1 or SEQ ID NOs: 1-1815 using at leastone reagent that specifically binds to said targets; generating agenomic classifier score based on the level of expression oramplification of the at least one or more targets; and prescribing atreatment regimen based on the genomic classifier score.

In some embodiments, the present invention provides a kit for analyzinga prostate cancer, comprising, a probe set comprising a plurality oftarget sequences, wherein the plurality of target sequences comprises atleast one target sequence listed in Table 1 or SEQ ID NOs: 1-1815; and acomputer model or algorithm for analyzing an expression level and/orexpression profile of the target sequences in a sample. In someembodiments, the method further comprises a computer model or algorithmfor correlating the expression level or expression profile with diseasestate or outcome. In other embodiments, the method further comprises acomputer model or algorithm for designating a treatment modality for theindividual. In yet other embodiments, the method further comprises acomputer model or algorithm for normalizing expression level orexpression profile of the target sequences. In some embodiments, themethod further comprises sequencing the plurality of targets. In someembodiments, the method further comprises hybridizing the plurality oftargets to a solid support. In some embodiments, the solid support is abead or array. In some embodiments, assaying the expression level of aplurality of targets may comprise the use of a probe set. In someembodiments, assaying the expression level may comprise the use of aclassifier. The classifier may comprise a probe selection region (PSR).In some embodiments, the classifier may comprise the use of analgorithm. The algorithm may comprise a machine learning algorithm. Insome embodiments, assaying the expression level may also comprisesequencing the plurality of targets.

Further disclosed herein methods for using genomic classifiers forprognosing and/or diagnosing prostate cancer, wherein the genomicclassifier has an AUC value of at least about 0.40 to predict patientoutcomes. In some embodiments, patient outcomes are selected from thegroup consisting of biochemical recurrence (BCR), metastasis (MET) andprostate cancer death (PCSM) after radical prostatectomy. The AUC of thegenomic classifier may be at least about 0.40, 0.45, 0.50, 0.55, 0.60,0.61, 0.62, 0.63, 0.64, 0.65, 0.66, 0.67, 0.68, 0.69, 0.70 or more.

Further disclosed herein is a method for using genomic classifiers forprognosing and/or diagnosing prostate cancer, comprising determining thelevel of expression or amplification of at least one or more targets ofthe present invention, wherein the significance of the expression levelof the one or more targets is based on one or more metrics selected fromthe group comprising T-test, P-value, KS (Kolmogorov Smirnov) P-value,accuracy, accuracy P-value, positive predictive value (PPV), negativepredictive value (NPV), sensitivity, specificity, AUC, AUC P-value(Auc.pvalue), Wilcoxon Test P-value, Median Fold Difference (MFD),Kaplan Meier (KM) curves, survival AUC (survAUC), Kaplan Meier P-value(KM P-value), Univariable Analysis Odds Ratio P-value (uvaORPval),multivariable analysis Odds Ratio P-value (mvaORPval), UnivariableAnalysis Hazard Ratio P-value (uvaHRPval) and Multivariable AnalysisHazard Ratio P-value (mvaHRPval). The significance of the expressionlevel of the one or more targets may be based on two or more metricsselected from the group comprising AUC, AUC P-value (Auc.pvalue),Wilcoxon Test P-value, Median Fold Difference (MFD), Kaplan Meier (KM)curves, survival AUC (survAUC), Univariable Analysis Odds Ratio P-value(uvaORPval), multivariable analysis Odds Ratio P-value (mvaORPval),Kaplan Meier P-value (KM P-value), Univariable Analysis Hazard RatioP-value (uvaHRPval) and Multivariable Analysis Hazard Ratio P-value(mvaHRPval). The molecular subtypes of the present invention are usefulfor predicting clinical characteristics of subjects with prostatecancer. In some embodiments, the clinical characteristics are selectedfrom the group consisting of seminal vesical invasion (SVI), lymph nodeinvasion (LNI), prostate-specific antigen (PSA), and gleason score (GS).

INCORPORATION BY REFERENCE

All publications, patents, and patent applications mentioned in thisspecification are herein incorporated by reference in their entiretiesto the same extent as if each individual publication, patent, or patentapplication was specifically and individually indicated to beincorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1A-B set forth data showing correlation of genomic classifierswith biopsy Grade Groups and NCCN risk categories.

FIGS. 2A-C set forth data showing correlation of genomic classifierswith diagnostic PSA, clinical stage and percentage of positive cores.

FIGS. 3A-B set forth data showing correlation of genomic classifier withpathological tumor grade and stage.

FIG. 4 sets forth data showing genomic classifier correlation withprospective RP and biopsy tumor specimens across tumor Grade Groups.

FIG. 5 sets forth data showing the distribution of genomic classifierscores among cases where tumor grading changed.

FIGS. 6A-C set forth data showing correlation of genomic classifierswith Gleason scores after pathological re-review in 1,694 biopsysamples.

FIGS. 7A-B set forth data showing genomic classifier scores forcomposite endpoint: High Stage Disease (LNI or pT3b) for biopsy samples.

FIG. 8 sets forth data showing AUC for predicting LNI for variousgenomic classifiers.

DETAILED DESCRIPTION OF THE INVENTION

The present invention discloses systems and methods for diagnosing,predicting, and/or monitoring the status or outcome of a prostate cancerin a subject using expression-based analysis of a plurality of targets.Generally, the method comprises (a) optionally obtaining a sample from asubject; (b) assaying the expression level for a plurality of targets inthe sample; and (c) diagnosing, predicting and/or monitoring the statusor outcome of a prostate cancer based on the expression level of theplurality of targets.

Assaying the expression level for a plurality of targets in the samplemay comprise applying the sample to a microarray. In some instances,assaying the expression level may comprise the use of an algorithm. Thealgorithm may be used to produce a classifier and subsequently aclassifier score. Alternatively, the classifier may comprise a probeselection region. In some instances, assaying the expression level for aplurality of targets comprises detecting and/or quantifying theplurality of targets. In some embodiments, assaying the expression levelfor a plurality of targets comprises sequencing the plurality oftargets. In some embodiments, assaying the expression level for aplurality of targets comprises amplifying the plurality of targets. Insome embodiments, assaying the expression level for a plurality oftargets comprises quantifying the plurality of targets. In someembodiments, assaying the expression level for a plurality of targetscomprises conducting a multiplexed reaction on the plurality of targets.

In some instances, the plurality of targets comprises one or moretargets selected from Table 1 or SEQ ID NOs: 1-1815. In some instances,the plurality of targets comprises at least about 2, at least about 3,at least about 4, at least about 5, at least about 6, at least about 7,at least about 8, at least about 9, at least about 10, at least about20, at least about 30, at least about 40, at least about 50, or at leastabout 60 targets selected from Table 1 or SEQ ID NOs: 1-1815.

Further disclosed herein are methods for prognosing or diagnosingprostate cancer. Generally, the method comprises: (a) obtaining a samplecomprising prostate cancer cells from a subject; (b) assaying theexpression level for a plurality of targets in the sample; and (c)prognosing or diagnosing the cancer based on the expression level of theplurality of targets. In some instances, the plurality of targetscomprises one or more targets selected from Table 1 or SEQ ID NOs:1-1815. In some instances, the plurality of targets comprises at leastabout 2, at least about 3, at least about 4, at least about 5, at leastabout 6, at least about 7, at least about 8, at least about 9, at leastabout 10, at least about 20, at least about 30, at least about 40, atleast about 50, or at least about 60 targets selected from Table 1 orSEQ ID NOs: 1-1815.

In some instances, prognosing or diagnosing the prostate cancercomprises determining whether the cancer is aggressive or willmetastasize. Alternatively, prognosing or diagnosing the prostate cancercomprises identifying the cancer as non-responsive to an anti-cancertherapy. Optionally, prognosing or diagnosing the prostate cancercomprises identifying the cancer as responsive to an anti-cancertherapy.

Before the present invention is described in further detail, it is to beunderstood that this invention is not limited to the particularmethodology, compositions, articles or machines described, as suchmethods, compositions, articles or machines can, of course, vary. It isalso to be understood that the terminology used herein is for thepurpose of describing particular embodiments only, and is not intendedto limit the scope of the present invention.

Targets

The methods disclosed herein often comprise assaying the expressionlevel of a plurality of targets. The plurality of targets may comprisecoding targets and/or non-coding targets of a protein-coding gene or anon protein-coding gene. A protein-coding gene structure may comprise anexon and an intron. The exon may further comprise a coding sequence(CDS) and an untranslated region (UTR). The protein-coding gene may betranscribed to produce a pre-mRNA and the pre-mRNA may be processed toproduce a mature mRNA. The mature mRNA may be translated to produce aprotein.

A non protein-coding gene structure may comprise an exon and intron.Usually, the exon region of a non protein-coding gene primarily containsa UTR. The non protein-coding gene may be transcribed to produce apre-mRNA and the pre-mRNA may be processed to produce a non-coding RNA(ncRNA).

A coding target may comprise a coding sequence of an exon. A non-codingtarget may comprise a UTR sequence of an exon, intron sequence,intergenic sequence, promoter sequence, non-coding transcript, CDSantisense, intronic antisense, UTR antisense, or non-coding transcriptantisense. A non-coding transcript may comprise a non-coding RNA(ncRNA).

In some instances, the plurality of targets may be differentiallyexpressed. In some instances, a plurality of probe selection regions(PSRs) is differentially expressed.

In some instances, the plurality of targets comprises one or moretargets selected from at least about 10, at least about 20, at leastabout 30, at least about 40, at least about 50, or at least about 60targets selected from Table 1 or SEQ ID NOs: 1-1815. In some instances,the plurality of targets comprises at least about 2, at least about 3,at least about 4, at least about 5, at least about 6, at least about 7,at least about 8, at least about 9, at least about 10, at least about20, at least about 30, at least about 40, at least about 50, or at leastabout 60 targets selected from Table 1 or SEQ ID NOs: 1-1815.

In some instances, the plurality of targets comprises a coding target,non-coding target, or any combination thereof. In some instances, thecoding target comprises an exonic sequence. In other instances, thenon-coding target comprises a non-exonic or exonic sequence.Alternatively, a non-coding target comprises a UTR sequence, an intronicsequence, antisense, or a non-coding RNA transcript. In some instances,a non-coding target comprises sequences which partially overlap with aUTR sequence or an intronic sequence. A non-coding target also includesnon-exonic and/or exonic transcripts. Exonic sequences may compriseregions on a protein-coding gene, such as an exon, UTR, or a portionthereof. Non-exonic sequences may comprise regions on a protein-coding,non protein-coding gene, or a portion thereof. For example, non-exonicsequences may comprise intronic regions, promoter regions, intergenicregions, a non-coding transcript, an exon anti-sense region, an intronicanti-sense region, UTR anti-sense region, non-coding transcriptanti-sense region, or a portion thereof. In other instances, theplurality of targets comprises a non-coding RNA transcript.

The plurality of targets may comprise one or more targets selected froma classifier disclosed herein. The classifier may be generated from oneor more models or algorithms. The one or more models or algorithms maybe Naïve Bayes (NB), recursive Partitioning (Rpart), random forest (RF),support vector machine (SVM), k-nearest neighbor (KNN), high dimensionaldiscriminate analysis (HDDA), or a combination thereof. The classifiermay have an AUC of equal to or greater than 0.60. The classifier mayhave an AUC of equal to or greater than 0.61. The classifier may have anAUC of equal to or greater than 0.62. The classifier may have an AUC ofequal to or greater than 0.63. The classifier may have an AUC of equalto or greater than 0.64. The classifier may have an AUC of equal to orgreater than 0.65. The classifier may have an AUC of equal to or greaterthan 0.66. The classifier may have an AUC of equal to or greater than0.67. The classifier may have an AUC of equal to or greater than 0.68.The classifier may have an AUC of equal to or greater than 0.69. Theclassifier may have an AUC of equal to or greater than 0.70. Theclassifier may have an AUC of equal to or greater than 0.75. Theclassifier may have an AUC of equal to or greater than 0.77. Theclassifier may have an AUC of equal to or greater than 0.78. Theclassifier may have an AUC of equal to or greater than 0.79. Theclassifier may have an AUC of equal to or greater than 0.80. The AUC maybe clinically significant based on its 95% confidence interval (CI). Theaccuracy of the classifier may be at least about 70%. The accuracy ofthe classifier may be at least about 73%. The accuracy of the classifiermay be at least about 75%. The accuracy of the classifier may be atleast about 77%. The accuracy of the classifier may be at least about80%. The accuracy of the classifier may be at least about 83%. Theaccuracy of the classifier may be at least about 84%. The accuracy ofthe classifier may be at least about 86%. The accuracy of the classifiermay be at least about 88%. The accuracy of the classifier may be atleast about 90%. The p-value of the classifier may be less than or equalto 0.05. The p-value of the classifier may be less than or equal to0.04. The p-value of the classifier may be less than or equal to 0.03.The p-value of the classifier may be less than or equal to 0.02. Thep-value of the classifier may be less than or equal to 0.01. The p-valueof the classifier may be less than or equal to 0.008. The p-value of theclassifier may be less than or equal to 0.006. The p-value of theclassifier may be less than or equal to 0.004. The p-value of theclassifier may be less than or equal to 0.002. The p-value of theclassifier may be less than or equal to 0.001.

The plurality of targets may comprise one or more targets selected froma Random Forest (RF) classifier. The plurality of targets may comprisetwo or more targets selected from a Random Forest (RF) classifier. Theplurality of targets may comprise three or more targets selected from aRandom Forest (RF) classifier. The plurality of targets may comprise 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 40, 50, 60 ormore targets selected from a Random Forest (RF) classifier. The RFclassifier may be an RF2, and RF3, or an RF4 classifier. The RFclassifier may be an RF60 classifier (e.g., a Random Forest classifierwith 50 targets).

A RF classifier of the present invention may comprise two or moretargets comprising two or more targets selected from Table 1 or SEQ IDNOs: 1-1815.

The plurality of targets may comprise one or more targets selected froman SVM classifier. The plurality of targets may comprise 2, 3, 4, 5, 6,7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 40, 50, 60 or more targetsselected from an SVM classifier. The plurality of targets may comprise12, 13, 14, 15, 17, 20, 22, 25, 27, 30, 40, 50, 60 or more targetsselected from an SVM classifier. The plurality of targets may comprise32, 35, 37, 40, 43, 45, 47, 50, 60 or more targets selected from an SVMclassifier. The SVM classifier may be an SVM2 classifier.

A SVM classifier of the present invention may comprise two or moretargets comprising two or more targets selected from Table 1 or SEQ IDNOs: 1-1815.

The plurality of targets may comprise one or more targets selected froma KNN classifier. The plurality of targets may comprise 2, 3, 4, 5, 6,7, 8, 9, 10 or more targets selected from a KNN classifier. Theplurality of targets may comprise 12, 13, 14, 15, 17, 20, 22, 25, 27, 30or more targets selected from a KNN classifier. The plurality of targetsmay comprise 32, 35, 37, 40, 43, 45, 47, 50, 60 or more targets selectedfrom a KNN classifier.

The KNN classifier may be a KNN50 classifier. A KNN classifier of thepresent invention may comprise sixty or more targets comprising sixty ormore targets selected from Table 1 or SEQ ID NOs: 1-1815.

The plurality of targets may comprise one or more targets selected froma Naïve Bayes (NB) classifier. The plurality of targets may comprise 2,3, 4, 5, 6, 7, 8, 9, 10 or more targets selected from an NB classifier.The plurality of targets may comprise 12, 13, 14, 15, 17, 20, 22, 25,27, 30 or more targets selected from an NB classifier. The plurality oftargets may comprise 32, 35, 37, 40, 43, 45, 47, 50, 60 or more targetsselected from a NB classifier.

The NB classifier may be a NB2 classifier. An NB classifier of thepresent invention may comprise two or more targets comprising two ormore targets selected from Table 1 or SEQ ID NOs: 1-1815.

The plurality of targets may comprise one or more targets selected froma recursive Partitioning (Rpart) classifier. The plurality of targetsmay comprise 2, 3, 4, 5, 6, 7, 8, 9, 10 or more targets selected from anRpart classifier. The plurality of targets may comprise 12, 13, 14, 15,17, 20, 22, 25, 27, 30 or more targets selected from an Rpartclassifier. The plurality of targets may comprise 32, 35, 37, 40, 43,45, 47, 50, 60 or more targets selected from an Rpart classifier.

The Rpart classifier may be an Rpart2 classifier. An Rpart classifier ofthe present invention may comprise two or more targets comprising two ormore targets selected from Table 1 or SEQ ID NOs: 1-1815.

The plurality of targets may comprise one or more targets selected froma high dimensional discriminate analysis (HDDA) classifier. Theplurality of targets may comprise two or more targets selected from ahigh dimensional discriminate analysis (HDDA) classifier. The pluralityof targets may comprise three or more targets selected from a highdimensional discriminate analysis (HDDA) classifier. The plurality oftargets may comprise 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40,50, 60 or more targets selected from a high dimensional discriminateanalysis (HDDA) classifier.

Probes/Primers

The present invention provides for a probe set for diagnosing,monitoring and/or predicting a status or outcome of a prostate cancer ina subject comprising a plurality of probes, wherein (i) the probes inthe set are capable of detecting an expression level of at least onetarget selected from Table 1 or SEQ ID NOs: 1-1815; and (ii) theexpression level determines the cancer status of the subject with atleast about 40% specificity.

The probe set may comprise one or more polynucleotide probes. Individualpolynucleotide probes comprise a nucleotide sequence derived from thenucleotide sequence of the target sequences or complementary sequencesthereof. The nucleotide sequence of the polynucleotide probe is designedsuch that it corresponds to, or is complementary to the targetsequences. The polynucleotide probe can specifically hybridize undereither stringent or lowered stringency hybridization conditions to aregion of the target sequences, to the complement thereof, or to anucleic acid sequence (such as a cDNA) derived therefrom.

The selection of the polynucleotide probe sequences and determination oftheir uniqueness may be carried out in silico using techniques known inthe art, for example, based on a BLASTN search of the polynucleotidesequence in question against gene sequence databases, such as the HumanGenome Sequence, UniGene, dbEST or the non-redundant database at NCBI.In one embodiment of the invention, the polynucleotide probe iscomplementary to a region of a target mRNA derived from a targetsequence in the probe set. Computer programs can also be employed toselect probe sequences that may not cross hybridize or may not hybridizenon-specifically.

In some instances, microarray hybridization of RNA, extracted fromprostate cancer tissue samples and amplified, may yield a dataset thatis then summarized and normalized by the fRMA technique. After removal(or filtration) of cross-hybridizing PSRs, and PSRs containing less than4 probes, the remaining PSRs can be used in further analysis. FollowingfRMA and filtration, the data can be decomposed into its principalcomponents and an analysis of variance model is used to determine theextent to which a batch effect remains present in the first 10 principalcomponents.

These remaining PSRs can then be subjected to filtration by a T-testbetween CR (clinical recurrence) and non-CR samples. Using a p-valuecut-off of 0.01, the remaining features (e.g., PSRs) can be furtherrefined. Feature selection can be performed by regularized logisticregression using the elastic-net penalty. The regularized regression maybe bootstrapped over 1000 times using all training data; with eachiteration of bootstrapping, features that have non-zero co-efficientfollowing 3-fold cross validation can be tabulated. In some instances,features that were selected in at least 25% of the total runs were usedfor model building.

The polynucleotide probes of the present invention may range in lengthfrom about 15 nucleotides to the full length of the coding target ornon-coding target. In one embodiment of the invention, thepolynucleotide probes are at least about 15 nucleotides in length. Inanother embodiment, the polynucleotide probes are at least about 20nucleotides in length. In a further embodiment, the polynucleotideprobes are at least about 25 nucleotides in length. In anotherembodiment, the polynucleotide probes are between about 15 nucleotidesand about 500 nucleotides in length. In other embodiments, thepolynucleotide probes are between about 15 nucleotides and about 450nucleotides, about 15 nucleotides and about 400 nucleotides, about 15nucleotides and about 350 nucleotides, about 15 nucleotides and about300 nucleotides, about 15 nucleotides and about 250 nucleotides, about15 nucleotides and about 200 nucleotides in length. In some embodiments,the probes are at least 15 nucleotides in length. In some embodiments,the probes are at least 15 nucleotides in length. In some embodiments,the probes are at least 20 nucleotides, at least 25 nucleotides, atleast 50 nucleotides, at least 75 nucleotides, at least 100 nucleotides,at least 125 nucleotides, at least 150 nucleotides, at least 200nucleotides, at least 225 nucleotides, at least 250 nucleotides, atleast 275 nucleotides, at least 300 nucleotides, at least 325nucleotides, at least 350 nucleotides, at least 375 nucleotides inlength.

The polynucleotide probes of a probe set can comprise RNA, DNA, RNA orDNA mimetics, or combinations thereof, and can be single-stranded ordouble-stranded. Thus the polynucleotide probes can be composed ofnaturally-occurring nucleobases, sugars and covalent internucleoside(backbone) linkages as well as polynucleotide probes havingnon-naturally-occurring portions which function similarly. Such modifiedor substituted polynucleotide probes may provide desirable propertiessuch as, for example, enhanced affinity for a target gene and increasedstability. The probe set may comprise a coding target and/or anon-coding target. Preferably, the probe set comprises a combination ofa coding target and non-coding target.

In some embodiments, the probe set comprise a plurality of targetsequences that hybridize to at least about 5 coding targets and/ornon-coding targets selected from Table 1 or SEQ ID NOs: 1-1815.Alternatively, the probe set comprise a plurality of target sequencesthat hybridize to at least about 10 coding targets and/or non-codingtargets selected from Table 1 or SEQ ID NOs: 1-1815. In someembodiments, the probe set comprise a plurality of target sequences thathybridize to at least about 15 coding targets and/or non-coding targetsselected from Table 1 or SEQ ID NOs: 1-1815. In some embodiments, theprobe set comprise a plurality of target sequences that hybridize to atleast about 20 coding targets and/or non-coding targets selected fromTable 1 or SEQ ID NOs: 1-1815. In some embodiments, the probe setcomprise a plurality of target sequences that hybridize to at leastabout 30 coding targets and/or non-coding targets selected from Table 1or SEQ ID NOs: 1-1815. In some embodiments, the probe set comprise aplurality of target sequences that hybridize to at least about 40 codingtargets and/or non-coding targets selected from Table 1 or SEQ ID NOs:1-1815. In some embodiments, the probe set comprise a plurality oftarget sequences that hybridize to at least about 50 coding targetsand/or non-coding targets selected from Table 1 or SEQ ID NOs: 1-1815.In some embodiments, the probe set comprise a plurality of targetsequences that hybridize to at least about 60 coding targets and/ornon-coding targets selected from Table 1 or SEQ ID NOs: 1-1815.

The system of the present invention further provides for primers andprimer pairs capable of amplifying target sequences defined by the probeset, or fragments or subsequences or complements thereof. The nucleotidesequences of the probe set may be provided in computer-readable mediafor in silico applications and as a basis for the design of appropriateprimers for amplification of one or more target sequences of the probeset.

Primers based on the nucleotide sequences of target sequences can bedesigned for use in amplification of the target sequences. For use inamplification reactions such as PCR, a pair of primers can be used. Theexact composition of the primer sequences is not critical to theinvention, but for most applications the primers may hybridize tospecific sequences of the probe set under stringent conditions,particularly under conditions of high stringency, as known in the art.The pairs of primers are usually chosen so as to generate anamplification product of at least about 50 nucleotides, more usually atleast about 100 nucleotides. Algorithms for the selection of primersequences are generally known, and are available in commercial softwarepackages. These primers may be used in standard quantitative orqualitative PCR-based assays to assess transcript expression levels ofRNAs defined by the probe set. Alternatively, these primers may be usedin combination with probes, such as molecular beacons in amplificationsusing real-time PCR.

In one embodiment, the primers or primer pairs, when used in anamplification reaction, specifically amplify at least a portion of anucleic acid sequence of a target selected from Table 1 or SEQ ID NOs:1-1815 (or subgroups thereof as set forth herein), an RNA form thereof,or a complement to either thereof.

A label can optionally be attached to or incorporated into a probe orprimer polynucleotide to allow detection and/or quantitation of a targetpolynucleotide representing the target sequence of interest. The targetpolynucleotide may be the expressed target sequence RNA itself, a cDNAcopy thereof, or an amplification product derived therefrom, and may bethe positive or negative strand, so long as it can be specificallydetected in the assay being used. Similarly, an antibody may be labeled.

In certain multiplex formats, labels used for detecting differenttargets may be distinguishable. The label can be attached directly(e.g., via covalent linkage) or indirectly, e.g., via a bridgingmolecule or series of molecules (e.g., a molecule or complex that canbind to an assay component, or via members of a binding pair that can beincorporated into assay components, e.g. biotin-avidin or streptavidin).Many labels are commercially available in activated forms which canreadily be used for such conjugation (for example through amineacylation), or labels may be attached through known or determinableconjugation schemes, many of which are known in the art.

Labels useful in the invention described herein include any substancewhich can be detected when bound to or incorporated into the biomoleculeof interest. Any effective detection method can be used, includingoptical, spectroscopic, electrical, piezoelectrical, magnetic, Ramanscattering, surface plasmon resonance, colorimetric, calorimetric, etc.A label is typically selected from a chromophore, a lumiphore, afluorophore, one member of a quenching system, a chromogen, a hapten, anantigen, a magnetic particle, a material exhibiting nonlinear optics, asemiconductor nanocrystal, a metal nanoparticle, an enzyme, an antibodyor binding portion or equivalent thereof, an aptamer, and one member ofa binding pair, and combinations thereof. Quenching schemes may be used,wherein a quencher and a fluorophore as members of a quenching pair maybe used on a probe, such that a change in optical parameters occurs uponbinding to the target introduce or quench the signal from thefluorophore. One example of such a system is a molecular beacon.Suitable quencher/fluorophore systems are known in the art. The labelmay be bound through a variety of intermediate linkages. For example, apolynucleotide may comprise a biotin-binding species, and an opticallydetectable label may be conjugated to biotin and then bound to thelabeled polynucleotide. Similarly, a polynucleotide sensor may comprisean immunological species such as an antibody or fragment, and asecondary antibody containing an optically detectable label may beadded.

Chromophores useful in the methods described herein include anysubstance which can absorb energy and emit light. For multiplexedassays, a plurality of different signaling chromophores can be used withdetectably different emission spectra. The chromophore can be alumophore or a fluorophore. Typical fluorophores include fluorescentdyes, semiconductor nanocrystals, lanthanide chelates,polynucleotide-specific dyes and green fluorescent protein.

In some embodiments, polynucleotides of the invention comprise at least20 consecutive bases of the nucleic acid sequence of a target selectedfrom Table 1 or SEQ ID NOs: 1-1815 or a complement thereto. Thepolynucleotides may comprise at least 21, 22, 23, 24, 25, 27, 30, 32, 35or more consecutive bases of the nucleic acids sequence of a targetselected from Table 1 or SEQ ID NOs: 1-1815, as applicable.

The polynucleotides may be provided in a variety of formats, includingas solids, in solution, or in an array. The polynucleotides mayoptionally comprise one or more labels, which may be chemically and/orenzymatically incorporated into the polynucleotide.

In some embodiments, one or more polynucleotides provided herein can beprovided on a substrate. The substrate can comprise a wide range ofmaterial, either biological, nonbiological, organic, inorganic, or acombination of any of these. For example, the substrate may be apolymerized Langmuir Blodgett film, functionalized glass, Si, Ge, GaAs,GaP, SiO₂, SiN₄, modified silicon, or any one of a wide variety of gelsor polymers such as (poly)tetrafluoroethylene,(poly)vinylidenedifluoride, polystyrene, cross-linked polystyrene,polyacrylic, polylactic acid, polyglycolic acid, poly(lactidecoglycolide), polyanhydrides, poly(methyl methacrylate),poly(ethylene-co-vinyl acetate), polysiloxanes, polymeric silica,latexes, dextran polymers, epoxies, polycarbonates, or combinationsthereof. Conducting polymers and photoconductive materials can be used.

The substrate can take the form of an array, a photodiode, anoptoelectronic sensor such as an optoelectronic semiconductor chip oroptoelectronic thin-film semiconductor, or a biochip. The location(s) ofprobe(s) on the substrate can be addressable; this can be done in highlydense formats, and the location(s) can be microaddressable ornanoaddressable.

Diagnostic Samples

Diagnostic samples for use with the systems and in the methods of thepresent invention comprise nucleic acids suitable for providing RNAsexpression information. In principle, the biological sample from whichthe expressed RNA is obtained and analyzed for target sequenceexpression can be any material suspected of comprising prostate cancertissue or cells. The diagnostic sample can be a biological sample useddirectly in a method of the invention. Alternatively, the diagnosticsample can be a sample prepared from a biological sample.

In one embodiment, the sample or portion of the sample comprising orsuspected of comprising cancer tissue or cells can be any source ofbiological material, including cells, tissue or fluid, including bodilyfluids. Non-limiting examples of the source of the sample include anaspirate, a needle biopsy, a cytology pellet, a bulk tissue preparationor a section thereof obtained for example by surgery or autopsy, lymphfluid, blood, plasma, serum, tumors, and organs. In some embodiments,the sample is from urine. Alternatively, the sample is from blood,plasma or serum. In some embodiments, the sample is from saliva.

The samples may be archival samples, having a known and documentedmedical outcome, or may be samples from current patients whose ultimatemedical outcome is not yet known.

In some embodiments, the sample may be dissected prior to molecularanalysis. The sample may be prepared via macrodissection of a bulk tumorspecimen or portion thereof, or may be treated via microdissection, forexample via Laser Capture Microdissection (LCM).

The sample may initially be provided in a variety of states, as freshtissue, fresh frozen tissue, fine needle aspirates, and may be fixed orunfixed. Frequently, medical laboratories routinely prepare medicalsamples in a fixed state, which facilitates tissue storage. A variety offixatives can be used to fix tissue to stabilize the morphology ofcells, and may be used alone or in combination with other agents.Exemplary fixatives include crosslinking agents, alcohols, acetone,Bouin's solution, Zenker solution, Helv solution, osmic acid solutionand Carnoy solution.

Crosslinking fixatives can comprise any agent suitable for forming twoor more covalent bonds, for example an aldehyde. Sources of aldehydestypically used for fixation include formaldehyde, paraformaldehyde,glutaraldehyde or formalin. Preferably, the crosslinking agent comprisesformaldehyde, which may be included in its native form or in the form ofparaformaldehyde or formalin. One of skill in the art would appreciatethat for samples in which crosslinking fixatives have been used specialpreparatory steps may be necessary including for example heating stepsand proteinase-k digestion; see methods.

One or more alcohols may be used to fix tissue, alone or in combinationwith other fixatives. Exemplary alcohols used for fixation includemethanol, ethanol and isopropanol.

Formalin fixation is frequently used in medical laboratories. Formalincomprises both an alcohol, typically methanol, and formaldehyde, both ofwhich can act to fix a biological sample.

Whether fixed or unfixed, the biological sample may optionally beembedded in an embedding medium. Exemplary embedding media used inhistology including paraffin, Tissue-Tek® V.I.P.™, Paramat, ParamatExtra, Paraplast, Paraplast X-tra, Paraplast Plus, Peel Away ParaffinEmbedding Wax, Polyester Wax, Carbowax Polyethylene Glycol, Polyfin™,Tissue Freezing Medium TFMFM, Cryo-Gef™, and OCT Compound (ElectronMicroscopy Sciences, Hatfield, Pa.). Prior to molecular analysis, theembedding material may be removed via any suitable techniques, as knownin the art. For example, where the sample is embedded in wax, theembedding material may be removed by extraction with organic solvent(s),for example xylenes. Kits are commercially available for removingembedding media from tissues. Samples or sections thereof may besubjected to further processing steps as needed, for example serialhydration or dehydration steps.

In some embodiments, the sample is a fixed, wax-embedded biologicalsample. Frequently, samples from medical laboratories are provided asfixed, wax-embedded samples, most commonly as formalin-fixed, paraffinembedded (FFPE) tissues.

Whatever the source of the biological sample, the target polynucleotidethat is ultimately assayed can be prepared synthetically (in the case ofcontrol sequences), but typically is purified from the biological sourceand subjected to one or more preparative steps. The RNA may be purifiedto remove or diminish one or more undesired components from thebiological sample or to concentrate it. Conversely, where the RNA is tooconcentrated for the particular assay, it may be diluted.

RNA Extraction

RNA can be extracted and purified from biological samples using anysuitable technique. A number of techniques are known in the art, andseveral are commercially available (e.g., FormaPure nucleic acidextraction kit, Agencourt Biosciences, Beverly Mass., High Pure FFPE RNAMicro Kit, Roche Applied Science, Indianapolis, Ind.). RNA can beextracted from frozen tissue sections using TRIzol (Invitrogen,Carlsbad, Calif.) and purified using RNeasy Protect kit (Qiagen,Valencia, Calif.). RNA can be further purified using DNAse I treatment(Ambion, Austin, Tex.) to eliminate any contaminating DNA. RNAconcentrations can be made using a Nanodrop ND-1000 spectrophotometer(Nanodrop Technologies, Rockland, Del.). RNA can be further purified toeliminate contaminants that interfere with cDNA synthesis by cold sodiumacetate precipitation. RNA integrity can be evaluated by runningelectropherograms, and RNA integrity number (RIN, a correlative measurethat indicates intactness of mRNA) can be determined using the RNA 6000PicoAssay for the Bioanalyzer 2100 (Agilent Technologies, Santa Clara,Calif.).

Kits

Kits for performing the desired method(s) are also provided, andcomprise a container or housing for holding the components of the kit,one or more vessels containing one or more nucleic acid(s), andoptionally one or more vessels containing one or more reagents. Thereagents include those described in the composition of matter sectionabove, and those reagents useful for performing the methods described,including amplification reagents, and may include one or more probes,primers or primer pairs, enzymes (including polymerases and ligases),intercalating dyes, labeled probes, and labels that can be incorporatedinto amplification products.

In some embodiments, the kit comprises primers or primer pairs specificfor those subsets and combinations of target sequences described herein.The primers or pairs of primers suitable for selectively amplifying thetarget sequences. The kit may comprise at least two, three, four or fiveprimers or pairs of primers suitable for selectively amplifying one ormore targets. The kit may comprise at least 5, 10, 15, 20, 30, 40, 50,60, 70, 80, 90, 100 or more primers or pairs of primers suitable forselectively amplifying one or more targets.

In some embodiments, the primers or primer pairs of the kit, when usedin an amplification reaction, specifically amplify a non-coding target,coding target, exonic, or non-exonic target described herein, a nucleicacid sequence corresponding to a target selected from Table 1 or SEQ IDNOs: 1-1815, an RNA form thereof, or a complement to either thereof. Thekit may include a plurality of such primers or primer pairs which canspecifically amplify a corresponding plurality of different amplify anon-coding target, coding target, exonic, or non-exonic transcriptdescribed herein, a nucleic acid sequence corresponding to a targetselected from Table 1 or SEQ ID NOs: 1-1815, RNA forms thereof, orcomplements thereto. At least two, three, four or five primers or pairsof primers suitable for selectively amplifying the one or more targetscan be provided in kit form. In some embodiments, the kit comprises fromfive to fifty primers or pairs of primers suitable for amplifying theone or more targets.

The reagents may independently be in liquid or solid form. The reagentsmay be provided in mixtures. Control samples and/or nucleic acids mayoptionally be provided in the kit. Control samples may include tissueand/or nucleic acids obtained from or representative of tumor samplesfrom patients showing no evidence of disease, as well as tissue and/ornucleic acids obtained from or representative of tumor samples frompatients that develop systemic cancer.

The nucleic acids may be provided in an array format, and thus an arrayor microarray may be included in the kit. The kit optionally may becertified by a government agency for use in prognosing the diseaseoutcome of cancer patients and/or for designating a treatment modality.

Instructions for using the kit to perform one or more methods of theinvention can be provided with the container, and can be provided in anyfixed medium. The instructions may be located inside or outside thecontainer or housing, and/or may be printed on the interior or exteriorof any surface thereof. A kit may be in multiplex form for concurrentlydetecting and/or quantitating one or more different targetpolynucleotides representing the expressed target sequences.

Amplification and Hybridization

Following sample collection and nucleic acid extraction, the nucleicacid portion of the sample comprising RNA that is or can be used toprepare the target polynucleotide(s) of interest can be subjected to oneor more preparative reactions. These preparative reactions can includein vitro transcription (IVT), labeling, fragmentation, amplification andother reactions. mRNA can first be treated with reverse transcriptaseand a primer to create cDNA prior to detection, quantitation and/oramplification; this can be done in vitro with purified mRNA or in situ,e.g., in cells or tissues affixed to a slide.

By “amplification” is meant any process of producing at least one copyof a nucleic acid, in this case an expressed RNA, and in many casesproduces multiple copies. An amplification product can be RNA or DNA,and may include a complementary strand to the expressed target sequence.DNA amplification products can be produced initially through reversetranslation and then optionally from further amplification reactions.The amplification product may include all or a portion of a targetsequence, and may optionally be labeled. A variety of amplificationmethods are suitable for use, including polymerase-based methods andligation-based methods. Exemplary amplification techniques include thepolymerase chain reaction method (PCR), the lipase chain reaction (LCR),ribozyme-based methods, self-sustained sequence replication (3SR),nucleic acid sequence-based amplification (NASBA), the use of Q Betareplicase, reverse transcription, nick translation, and the like.

Asymmetric amplification reactions may be used to preferentially amplifyone strand representing the target sequence that is used for detectionas the target polynucleotide. In some cases, the presence and/or amountof the amplification product itself may be used to determine theexpression level of a given target sequence. In other instances, theamplification product may be used to hybridize to an array or othersubstrate comprising sensor polynucleotides which are used to detectand/or quantitate target sequence expression.

The first cycle of amplification in polymerase-based methods typicallyforms a primer extension product complementary to the template strand.If the template is single-stranded RNA, a polymerase with reversetranscriptase activity is used in the first amplification to reversetranscribe the RNA to DNA, and additional amplification cycles can beperformed to copy the primer extension products. The primers for a PCRmust, of course, be designed to hybridize to regions in theircorresponding template that can produce an amplifiable segment; thus,each primer must hybridize so that its 3′ nucleotide is paired to anucleotide in its complementary template strand that is located 3′ fromthe 3′ nucleotide of the primer used to replicate that complementarytemplate strand in the PCR.

The target polynucleotide can be amplified by contacting one or morestrands of the target polynucleotide with a primer and a polymerasehaving suitable activity to extend the primer and copy the targetpolynucleotide to produce a full-length complementary polynucleotide ora smaller portion thereof. Any enzyme having a polymerase activity thatcan copy the target polynucleotide can be used, including DNApolymerases, RNA polymerases, reverse transcriptases, enzymes havingmore than one type of polymerase or enzyme activity. The enzyme can bethermolabile or thermostable. Mixtures of enzymes can also be used.Exemplary enzymes include: DNA polymerases such as DNA Polymerase I(“Pol I”), the Klenow fragment of Pol I, T4, T7, Sequenase® T7,Sequenase® Version 2.0 T7, Tub, Taq, Tth, Pfic, Pfu, Tsp, Tfl, Tli andPyrococcus sp GB-D DNA polymerases; RNA polymerases such as E. coli,SP6, T3 and T7 RNA polymerases; and reverse transcriptases such as AMV,M-MuLV, MMLV, RNAse H MMLV (SuperScript®), SuperScript® II,ThermoScript®, HIV-1, and RAV2 reverse transcriptases. All of theseenzymes are commercially available. Exemplary polymerases with multiplespecificities include RAV2 and Tli (exo-) polymerases. Exemplarythermostable polymerases include Tub, Taq, Tth, Pfic, Pfu, Tsp, Tfl, Tliand Pyrococcus sp. GB-D DNA polymerases.

Suitable reaction conditions are chosen to permit amplification of thetarget polynucleotide, including pH, buffer, ionic strength, presenceand concentration of one or more salts, presence and concentration ofreactants and cofactors such as nucleotides and magnesium and/or othermetal ions (e.g., manganese), optional cosolvents, temperature, thermalcycling profile for amplification schemes comprising a polymerase chainreaction, and may depend in part on the polymerase being used as well asthe nature of the sample. Cosolvents include formamide (typically atfrom about 2 to about 10%), glycerol (typically at from about 5 to about10%), and DMSO (typically at from about 0.9 to about 10%). Techniquesmay be used in the amplification scheme in order to minimize theproduction of false positives or artifacts produced duringamplification. These include “touchdown” PCR, hot-start techniques, useof nested primers, or designing PCR primers so that they form stem-loopstructures in the event of primer-dimer formation and thus are notamplified. Techniques to accelerate PCR can be used, for examplecentrifugal PCR, which allows for greater convection within the sample,and comprising infrared heating steps for rapid heating and cooling ofthe sample. One or more cycles of amplification can be performed. Anexcess of one primer can be used to produce an excess of one primerextension product during PCR; preferably, the primer extension productproduced in excess is the amplification product to be detected. Aplurality of different primers may be used to amplify different targetpolynucleotides or different regions of a particular targetpolynucleotide within the sample.

An amplification reaction can be performed under conditions which allowan optionally labeled sensor polynucleotide to hybridize to theamplification product during at least part of an amplification cycle.When the assay is performed in this manner, real-time detection of thishybridization event can take place by monitoring for light emission orfluorescence during amplification, as known in the art.

Where the amplification product is to be used for hybridization to anarray or microarray, a number of suitable commercially availableamplification products are available. These include amplification kitsavailable from NuGEN, Inc. (San Carlos, Calif.), including theWT-Ovation™ System, WT-Ovation™ System v2, WT-Ovation™ Pico System,WT-Ovation™ FFPE Exon Module, WT-Ovation™ FFPE Exon Module RiboAmp andRiboAmp^(Plus) RNA Amplification Kits (MDS Analytical Technologies(formerly Arcturus) (Mountain View, Calif.), Genisphere, Inc. (Hatfield,Pa.), including the RampUp Plus™ and SenseAmp™ RNA Amplification kits,alone or in combination. Amplified nucleic acids may be subjected to oneor more purification reactions after amplification and labeling, forexample using magnetic beads (e.g., RNAClean magnetic beads, AgencourtBiosciences).

Multiple RNA biomarkers can be analyzed using real-time quantitativemultiplex RT-PCR platforms and other multiplexing technologies such asGenomeLab GeXP Genetic Analysis System (Beckman Coulter, Foster City,Calif.), SmartCycler® 9600 or GeneXpert® Systems (Cepheid, Sunnyvale,Calif.), ABI 7900 HT Fast Real Time PCR system (Applied Biosystems,Foster City, Calif.), LightCycler® 480 System (Roche Molecular Systems,Pleasanton, Calif.), xMAP 100 System (Luminex, Austin, Tex.) SolexaGenome Analysis System (Illumina, Hayward, Calif.), OpenArray Real TimeqPCR (BioTrove, Woburn, Mass.) and BeadXpress System (Illumina, Hayward,Calif.).

Detection and/or Quantification of Target Sequences

Any method of detecting and/or quantitating the expression of theencoded target sequences can in principle be used in the invention. Theexpressed target sequences can be directly detected and/or quantitated,or may be copied and/or amplified to allow detection of amplified copiesof the expressed target sequences or its complement.

Methods for detecting and/or quantifying a target can include Northernblotting, sequencing, array or microarray hybridization, by enzymaticcleavage of specific structures (e.g., an Invader® assay, Third WaveTechnologies, e.g. as described in U.S. Pat. Nos. 5,846,717, 6,090,543;6,001,567; 5,985,557; and 5,994,069) and amplification methods, e.g.RT-PCR, including in a TaqMan® assay (PE Biosystems, Foster City,Calif., e.g. as described in U.S. Pat. Nos. 5,962,233 and 5,538,848),and may be quantitative or semi-quantitative, and may vary depending onthe origin, amount and condition of the available biological sample.Combinations of these methods may also be used. For example, nucleicacids may be amplified, labeled and subjected to microarray analysis.

In some instances, target sequences may be detected by sequencing.Sequencing methods may comprise whole genome sequencing or exomesequencing. Sequencing methods such as Maxim-Gilbert, chain-termination,or high-throughput systems may also be used. Additional, suitablesequencing techniques include classic dideoxy sequencing reactions(Sanger method) using labeled terminators or primers and gel separationin slab or capillary, sequencing by synthesis using reversiblyterminated labeled nucleotides, pyrosequencing, 454 sequencing, allelespecific hybridization to a library of labeled oligonucleotide probes,sequencing by synthesis using allele specific hybridization to a libraryof labeled clones that is followed by ligation, real time monitoring ofthe incorporation of labeled nucleotides during a polymerization step,and SOLiD sequencing.

Additional methods for detecting and/or quantifying a target includesingle-molecule sequencing (e.g., Helicos, PacBio), sequencing bysynthesis (e.g., Illumina, Ion Torrent), sequencing by ligation (e.g.,ABI SOLID), sequencing by hybridization (e.g., Complete Genomics), insitu hybridization, bead-array technologies (e.g., Luminex xMAP,Illumina BeadChips), branched DNA technology (e.g., Panomics,Genisphere). Sequencing methods may use fluorescent (e.g., Illumina) orelectronic (e.g., Ion Torrent, Oxford Nanopore) methods of detectingnucleotides.

Reverse Transcription for ORT-PCR Analysis

Reverse transcription can be performed by any method known in the art.For example, reverse transcription may be performed using the Omniscriptkit (Qiagen, Valencia, Calif.), Superscript III kit (Invitrogen,Carlsbad, Calif.), for RT-PCR. Target-specific priming can be performedin order to increase the sensitivity of detection of target sequencesand generate target-specific cDNA.

TaqMan® Gene Expression Analysis

TaqMan® RT-PCR can be performed using Applied Biosystems Prism (ABI)7900 HT instruments in a 5 1.11 volume with target sequence-specificcDNA equivalent to 1 ng total RNA.

Primers and probes concentrations for TaqMan analysis are added toamplify fluorescent amplicons using PCR cycling conditions such as 95°C. for 10 minutes for one cycle, 95° C. for 20 seconds, and 60° C. for45 seconds for 40 cycles. A reference sample can be assayed to ensurereagent and process stability. Negative controls (e.g., no template)should be assayed to monitor any exogenous nucleic acid contamination.

Classification Arrays

The present invention contemplates that a probe set or probes derivedtherefrom may be provided in an array format. In the context of thepresent invention, an “array” is a spatially or logically organizedcollection of polynucleotide probes. An array comprising probes specificfor a coding target, non-coding target, or a combination thereof may beused. Alternatively, an array comprising probes specific for two or moreof transcripts of a target selected from Table 1 or SEQ ID NOs: 1-1815or a product derived thereof can be used. Desirably, an array may bespecific for 5, 10, 15, 20, 25, 30, 40, 50 or more of transcripts of atarget selected from Table 1 or SEQ ID NOs: 1-1815. Expression of thesesequences may be detected alone or in combination with othertranscripts. In some embodiments, an array is used which comprises awide range of sensor probes for prostate-specific expression products,along with appropriate control sequences. In some instances, the arraymay comprise the Human Exon 1.0 ST Array (HuEx 1.0 ST, Affymetrix, Inc.,Santa Clara, Calif.).

Typically the polynucleotide probes are attached to a solid substrateand are ordered so that the location (on the substrate) and the identityof each are known. The polynucleotide probes can be attached to one of avariety of solid substrates capable of withstanding the reagents andconditions necessary for use of the array. Examples include, but are notlimited to, polymers, such as (poly)tetrafluoroethylene,(poly)vinylidenedifluoride, polystyrene, polycarbonate, polypropyleneand polystyrene; ceramic; silicon; silicon dioxide; modified silicon;(fused) silica, quartz or glass; functionalized glass; paper, such asfilter paper; diazotized cellulose; nitrocellulose filter; nylonmembrane; and polyacrylamide gel pad. Substrates that are transparent tolight are useful for arrays that may be used in an assay that involvesoptical detection.

Examples of array formats include membrane or filter arrays (forexample, nitrocellulose, nylon arrays), plate arrays (for example,multiwell, such as a 24-, 96-, 256-, 384-, 864- or 1536-well, microtitreplate arrays), pin arrays, and bead arrays (for example, in a liquid“slurry”). Arrays on substrates such as glass or ceramic slides areoften referred to as chip arrays or “chips.” Such arrays are well knownin the art. In one embodiment of the present invention, the CancerPrognosticarray is a chip.

Data Analysis

In some embodiments, one or more pattern recognition methods can be usedin analyzing the expression level of target sequences. The patternrecognition method can comprise a linear combination of expressionlevels, or a nonlinear combination of expression levels. In someembodiments, expression measurements for RNA transcripts or combinationsof RNA transcript levels are formulated into linear or non-linear modelsor algorithms (e.g., an ‘expression signature’) and converted into alikelihood score. This likelihood score indicates the probability that abiological sample is from a patient who may exhibit no evidence ofdisease, who may exhibit systemic cancer, or who may exhibit biochemicalrecurrence. The likelihood score can be used to distinguish thesedisease states. The models and/or algorithms can be provided in machinereadable format, and may be used to correlate expression levels or anexpression profile with a disease state, and/or to designate a treatmentmodality for a patient or class of patients.

Assaying the expression level for a plurality of targets may comprisethe use of an algorithm or classifier. Array data can be managed,classified, and analyzed using techniques known in the art. Assaying theexpression level for a plurality of targets may comprise probe setmodeling and data pre-processing. Probe set modeling and datapre-processing can be derived using the Robust Multi-Array (RMA)algorithm or variants GC-RMA, IRMA, Probe Logarithmic Intensity Error(PLIER) algorithm or variant iterPLIER. Variance or intensity filterscan be applied to pre-process data using the RMA algorithm, for exampleby removing target sequences with a standard deviation of <10 or a meanintensity of <100 intensity units of a normalized data range,respectively.

Alternatively, assaying the expression level for a plurality of targetsmay comprise the use of a machine learning algorithm. The machinelearning algorithm may comprise a supervised learning algorithm.Examples of supervised learning algorithms may include AverageOne-Dependence Estimators (AODE), Artificial neural network (e.g.,Backpropagation), Bayesian statistics (e.g., Naive Bayes classifier,Bayesian network, Bayesian knowledge base), Case-based reasoning,Decision trees, Inductive logic programming, Gaussian processregression, Group method of data handling (GMDH), Learning Automata,Learning Vector Quantization, Minimum message length (decision trees,decision graphs, etc.), Lazy learning, Instance-based learning NearestNeighbor Algorithm, Analogical modeling, Probably approximately correctlearning (PAC) learning, Ripple down rules, a knowledge acquisitionmethodology, Symbolic machine learning algorithms, Subsymbolic machinelearning algorithms, Support vector machines, Random Forests, Ensemblesof classifiers, Bootstrap aggregating (bagging), and Boosting.Supervised learning may comprise ordinal classification such asregression analysis and Information fuzzy networks (IFN). Alternatively,supervised learning methods may comprise statistical classification,such as AODE, Linear classifiers (e.g., Fisher's linear discriminant,Logistic regression, Naive Bayes classifier, Perceptron, and Supportvector machine), quadratic classifiers, k-nearest neighbor, Boosting,Decision trees (e.g., C4.5, Random forests), Bayesian networks, andHidden Markov models.

The machine learning algorithms may also comprise an unsupervisedlearning algorithm. Examples of unsupervised learning algorithms mayinclude artificial neural network, Data clustering,Expectation-maximization algorithm, Self-organizing map, Radial basisfunction network, Vector Quantization, Generative topographic map,Information bottleneck method, and IBSEAD. Unsupervised learning mayalso comprise association rule learning algorithms such as Apriorialgorithm, Eclat algorithm and FP-growth algorithm. Hierarchicalclustering, such as Single-linkage clustering and Conceptual clustering,may also be used. Alternatively, unsupervised learning may comprisepartitional clustering such as K-means algorithm and Fuzzy clustering.

In some instances, the machine learning algorithms comprise areinforcement learning algorithm. Examples of reinforcement learningalgorithms include, but are not limited to, temporal differencelearning, Q-learning and Learning Automata. Alternatively, the machinelearning algorithm may comprise Data Pre-processing.

Preferably, the machine learning algorithms may include, but are notlimited to, Average One-Dependence Estimators (AODE), Fisher's lineardiscriminant, Logistic regression, Perceptron, Multilayer Perceptron,Artificial Neural Networks, Support vector machines, Quadraticclassifiers, Boosting, Decision trees, C4.5, Bayesian networks, HiddenMarkov models, High-Dimensional Discriminant Analysis, and GaussianMixture Models. The machine learning algorithm may comprise supportvector machines, Naïve Bayes classifier, k-nearest neighbor,high-dimensional discriminant analysis, or Gaussian mixture models. Insome instances, the machine learning algorithm comprises Random Forests.

Cancer

The systems, compositions and methods disclosed herein may be used todiagnosis, monitor and/or predict the status or outcome of a cancer.Generally, a cancer is characterized by the uncontrolled growth ofabnormal cells anywhere in a body. The abnormal cells may be termedcancer cells, malignant cells, or tumor cells. Cancer is not confined tohumans; animals and other living organisms can get cancer.

In some instances, the cancer may be malignant. Alternatively, thecancer may be benign. The cancer may be a recurrent and/or refractorycancer. Most cancers can be classified as a carcinoma, sarcoma,leukemia, lymphoma, myeloma, or a central nervous system cancer.

The cancer may be a sarcoma. Sarcomas are cancers of the bone,cartilage, fat, muscle, blood vessels, or other connective or supportivetissue. Sarcomas include, but are not limited to, bone cancer,fibrosarcoma, chondrosarcoma, Ewing's sarcoma, malignanthemangioendothelioma, malignant schwannoma, bilateral vestibularschwannoma, osteosarcoma, soft tissue sarcomas (e.g. alveolar soft partsarcoma, angiosarcoma, cystosarcoma phylloides, dermatofibrosarcoma,desmoid tumor, epithelioid sarcoma, extraskeletal osteosarcoma,fibrosarcoma, hemangiopericytoma, hemangiosarcoma, Kaposi's sarcoma,leiomyosarcoma, liposarcoma, lymphangiosarcoma, lymphosarcoma, malignantfibrous histiocytoma, neurofibrosarcoma, rhabdomyosarcoma, and synovialsarcoma).

Alternatively, the cancer may be a carcinoma. Carcinomas are cancersthat begin in the epithelial cells, which are cells that cover thesurface of the body, produce hormones, and make up glands. By way ofnon-limiting example, carcinomas include breast cancer, pancreaticcancer, lung cancer, colon cancer, colorectal cancer, rectal cancer,kidney cancer, bladder cancer, stomach cancer, prostate cancer, livercancer, ovarian cancer, brain cancer, vaginal cancer, vulvar cancer,uterine cancer, oral cancer, penic cancer, testicular cancer, esophagealcancer, skin cancer, cancer of the fallopian tubes, head and neckcancer, gastrointestinal stromal cancer, adenocarcinoma, cutaneous orintraocular melanoma, cancer of the anal region, cancer of the smallintestine, cancer of the endocrine system, cancer of the thyroid gland,cancer of the parathyroid gland, cancer of the adrenal gland, cancer ofthe urethra, cancer of the renal pelvis, cancer of the ureter, cancer ofthe endometrium, cancer of the cervix, cancer of the pituitary gland,neoplasms of the central nervous system (CNS), primary CNS lymphoma,brain stem glioma, and spinal axis tumors. In some instances, the canceris a skin cancer, such as a basal cell carcinoma, squamous, melanoma,nonmelanoma, or actinic (solar) keratosis. Preferably, the cancer is aprostate cancer. Alternatively, the cancer may be a thyroid cancer,bladder cancer, or pancreatic cancer.

In some instances, the cancer is a lung cancer. Lung cancer can start inthe airways that branch off the trachea to supply the lungs (bronchi) orthe small air sacs of the lung (the alveoli). Lung cancers includenon-small cell lung carcinoma (NSCLC), small cell lung carcinoma, andmesotheliomia. Examples of NSCLC include squamous cell carcinoma,adenocarcinoma, and large cell carcinoma. The mesothelioma may be acancerous tumor of the lining of the lung and chest cavity (pleura) orlining of the abdomen (peritoneum). The mesothelioma may be due toasbestos exposure. The cancer may be a brain cancer, such as aglioblastoma.

Alternatively, the cancer may be a central nervous system (CNS) tumor.CNS tumors may be classified as gliomas or nongliomas. The glioma may bemalignant glioma, high grade glioma, diffuse intrinsic pontine glioma.Examples of gliomas include astrocytomas, oligodendrogliomas (ormixtures of oligodendroglioma and astocytoma elements), and ependymomas.Astrocytomas include, but are not limited to, low-grade astrocytomas,anaplastic astrocytomas, glioblastoma multiforme, pilocytic astrocytoma,pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.

Oligodendrogliomas include low-grade oligodendrogliomas (oroligoastrocytomas) and anaplastic oligodendriogliomas. Nongliomasinclude meningiomas, pituitary adenomas, primary CNS lymphomas, andmedulloblastomas. In some instances, the cancer is a meningioma.

The cancer may be a leukemia. The leukemia may be an acute lymphocyticleukemia, acute myelocytic leukemia, chronic lymphocytic leukemia, orchronic myelocytic leukemia. Additional types of leukemias include hairycell leukemia, chronic myelomonocytic leukemia, and juvenilemyelomonocytic-leukemia.

In some instances, the cancer is a lymphoma. Lymphomas are cancers ofthe lymphocytes and may develop from either B or T lymphocytes. The twomajor types of lymphoma are Hodgkin's lymphoma, previously known asHodgkin's disease, and non-Hodgkin's lymphoma. Hodgkin's lymphoma ismarked by the presence of the Reed-Sternberg cell. Non-Hodgkin'slymphomas are all lymphomas which are not Hodgkin's lymphoma.Non-Hodgkin lymphomas may be indolent lymphomas and aggressivelymphomas. Non-Hodgkin's lymphomas include, but are not limited to,diffuse large B cell lymphoma, follicular lymphoma, mucosa-associatedlymphatic tissue lymphoma (MALT), small cell lymphocytic lymphoma,mantle cell lymphoma, Burkitt's lymphoma, mediastinal large B celllymphoma, Waldenström macroglobulinemia, nodal marginal zone B celllymphoma (NMZL), splenic marginal zone lymphoma (SMZL), extranodalmarginal zone B cell lymphoma, intravascular large B cell lymphoma,primary effusion lymphoma, and lymphomatoid granulomatosis.

Cancer Staging

Diagnosing, predicting, or monitoring a status or outcome of a cancermay comprise determining the stage of the cancer. Generally, the stageof a cancer is a description (usually numbers I to IV with IV havingmore progression) of the extent the cancer has spread. The stage oftentakes into account the size of a tumor, how deeply it has penetrated,whether it has invaded adjacent organs, how many lymph nodes it hasmetastasized to (if any), and whether it has spread to distant organs.Staging of cancer can be used as a predictor of survival, and cancertreatment may be determined by staging. Determining the stage of thecancer may occur before, during, or after treatment. The stage of thecancer may also be determined at the time of diagnosis.

Cancer staging can be divided into a clinical stage and a pathologicstage. Cancer staging may comprise the TNM classification. Generally,the TNM Classification of Malignant Tumours (TNM) is a cancer stagingsystem that describes the extent of cancer in a patient's body. T maydescribe the size of the tumor and whether it has invaded nearby tissue,N may describe regional lymph nodes that are involved, and M maydescribe distant metastasis (spread of cancer from one body part toanother). In the TNM (Tumor, Node, Metastasis) system, clinical stageand pathologic stage are denoted by a small “c” or “p” before the stage(e.g., cT3N1M0 or pT2N0).

Often, clinical stage and pathologic stage may differ. Clinical stagemay be based on all of the available information obtained before asurgery to remove the tumor. Thus, it may include information about thetumor obtained by physical examination, radiologic examination, andendoscopy. Pathologic stage can add additional information gained byexamination of the tumor microscopically by a pathologist. Pathologicstaging can allow direct examination of the tumor and its spread,contrasted with clinical staging which may be limited by the fact thatthe information is obtained by making indirect observations at a tumorwhich is still in the body. The TNM staging system can be used for mostforms of cancer.

Alternatively, staging may comprise Ann Arbor staging. Generally, AnnArbor staging is the staging system for lymphomas, both in Hodgkin'slymphoma (previously called Hodgkin's disease) and Non-Hodgkin lymphoma(abbreviated NHL). The stage may depend on both the place where themalignant tissue is located (as located with biopsy, CT scanning andincreasingly positron emission tomography) and on systemic symptoms dueto the lymphoma (“B symptoms”: night sweats, weight loss of >10% orfevers). The principal stage may be determined by location of the tumor.Stage I may indicate that the cancer is located in a single region,usually one lymph node and the surrounding area. Stage I often may nothave outward symptoms. Stage II can indicate that the cancer is locatedin two separate regions, an affected lymph node or organ and a secondaffected area, and that both affected areas are confined to one side ofthe diaphragm—that is, both are above the diaphragm, or both are belowthe diaphragm. Stage III often indicates that the cancer has spread toboth sides of the diaphragm, including one organ or area near the lymphnodes or the spleen. Stage IV may indicate diffuse or disseminatedinvolvement of one or more extralymphatic organs, including anyinvolvement of the liver, bone marrow, or nodular involvement of thelungs.

Modifiers may also be appended to some stages. For example, the lettersA, B, E, X, or S can be appended to some stages. Generally, A or B mayindicate the absence of constitutional (B-type) symptoms is denoted byadding an “A” to the stage; the presence is denoted by adding a “B” tothe stage. E can be used if the disease is “extranodal” (not in thelymph nodes) or has spread from lymph nodes to adjacent tissue. X isoften used if the largest deposit is >10 cm large (“bulky disease”), orwhether the mediastinum is wider than ⅓ of the chest on a chest X-ray. Smay be used if the disease has spread to the spleen.

The nature of the staging may be expressed with CS or PS. CS may denotethat the clinical stage as obtained by doctor's examinations and tests.PS may denote that the pathological stage as obtained by exploratorylaparotomy (surgery performed through an abdominal incision) withsplenectomy (surgical removal of the spleen).

Therapeutic Regimens

Diagnosing, predicting, or monitoring a status or outcome of a cancermay comprise treating a cancer or preventing a cancer progression. Inaddition, diagnosing, predicting, or monitoring a status or outcome of acancer may comprise identifying or predicting responders to ananti-cancer therapy. In some instances, diagnosing, predicting, ormonitoring may comprise determining a therapeutic regimen. Determining atherapeutic regimen may comprise administering an anti-cancer therapy.Alternatively, determining a therapeutic regimen may comprise modifying,recommending, continuing or discontinuing an anti-cancer regimen. Insome instances, if the sample expression patterns are consistent withthe expression pattern for a known disease or disease outcome, theexpression patterns can be used to designate one or more treatmentmodalities (e.g., therapeutic regimens, anti-cancer regimen). Ananti-cancer regimen may comprise one or more anti-cancer therapies.Examples of anti-cancer therapies include surgery, chemotherapy,radiation therapy, immunotherapy/biological therapy, photodynamictherapy.

Surgical oncology uses surgical methods to diagnose, stage, and treatcancer, and to relieve certain cancer-related symptoms. Surgery may beused to remove the tumor (e.g., excisions, resections, debulkingsurgery), reconstruct a part of the body (e.g., restorative surgery),and/or to relieve symptoms such as pain (e.g., palliative surgery).Surgery may also include cryosurgery. Cryosurgery (also calledcryotherapy) may use extreme cold produced by liquid nitrogen (or argongas) to destroy abnormal tissue. Cryosurgery can be used to treatexternal tumors, such as those on the skin. For external tumors, liquidnitrogen can be applied directly to the cancer cells with a cotton swabor spraying device. Cryosurgery may also be used to treat tumors insidethe body (internal tumors and tumors in the bone). For internal tumors,liquid nitrogen or argon gas may be circulated through a hollowinstrument called a cryoprobe, which is placed in contact with thetumor. An ultrasound or MRI may be used to guide the cryoprobe andmonitor the freezing of the cells, thus limiting damage to nearbyhealthy tissue. A ball of ice crystals may form around the probe,freezing nearby cells. Sometimes more than one probe is used to deliverthe liquid nitrogen to various parts of the tumor. The probes may be putinto the tumor during surgery or through the skin (percutaneously).After cryosurgery, the frozen tissue thaws and may be naturally absorbedby the body (for internal tumors), or may dissolve and form a scab (forexternal tumors).

Chemotherapeutic agents may also be used for the treatment of cancer.Examples of chemotherapeutic agents include alkylating agents,anti-metabolites, plant alkaloids and terpenoids, vinca alkaloids,podophyllotoxin, taxanes, topoisomerase inhibitors, and cytotoxicantibiotics. Cisplatin, carboplatin, and oxaliplatin are examples ofalkylating agents. Other alkylating agents include mechlorethamine,cyclophosphamide, chlorambucil, ifosfamide. Alkylating agents may impaircell function by forming covalent bonds with the amino, carboxyl,sulfhydryl, and phosphate groups in biologically important molecules.Alternatively, alkylating agents may chemically modify a cell's DNA.

Anti-metabolites are another example of chemotherapeutic agents.Anti-metabolites may masquerade as purines or pyrimidines and mayprevent purines and pyrimidines from becoming incorporated in to DNAduring the “S” phase (of the cell cycle), thereby stopping normaldevelopment and division. Antimetabolites may also affect RNA synthesis.Examples of metabolites include azathioprine and mercaptopurine.

Alkaloids may be derived from plants and block cell division may also beused for the treatment of cancer. Alkyloids may prevent microtubulefunction. Examples of alkaloids are vinca alkaloids and taxanes. Vincaalkaloids may bind to specific sites on tubulin and inhibit the assemblyof tubulin into microtubules (M phase of the cell cycle). The vincaalkaloids may be derived from the Madagascar periwinkle, Catharanthusroseus (formerly known as Vinca rosea). Examples of vinca alkaloidsinclude, but are not limited to, vincristine, vinblastine, vinorelbine,or vindesine. Taxanes are diterpenes produced by the plants of the genusTaxus (yews). Taxanes may be derived from natural sources or synthesizedartificially. Taxanes include paclitaxel (Taxol) and docetaxel(Taxotere). Taxanes may disrupt microtubule function. Microtubules areessential to cell division, and taxanes may stabilize GDP-bound tubulinin the microtubule, thereby inhibiting the process of cell division.Thus, in essence, taxanes may be mitotic inhibitors. Taxanes may also beradiosensitizing and often contain numerous chiral centers.

Alternative chemotherapeutic agents include podophyllotoxin.Podophyllotoxin is a plant-derived compound that may help with digestionand may be used to produce cytostatic drugs such as etoposide andteniposide. They may prevent the cell from entering the G1 phase (thestart of DNA replication) and the replication of DNA (the S phase).

Topoisomerases are essential enzymes that maintain the topology of DNA.Inhibition of type I or type II topoisomerases may interfere with bothtranscription and replication of DNA by upsetting proper DNAsupercoiling. Some chemotherapeutic agents may inhibit topoisomerases.For example, some type I topoisomerase inhibitors include camptothecins:irinotecan and topotecan. Examples of type II inhibitors includeamsacrine, etoposide, etoposide phosphate, and teniposide.

Another example of chemotherapeutic agents is cytotoxic antibiotics.Cytotoxic antibiotics are a group of antibiotics that are used for thetreatment of cancer because they may interfere with DNA replicationand/or protein synthesis. Cytotoxic antiobiotics include, but are notlimited to, actinomycin, anthracyclines, doxorubicin, daunorubicin,valrubicin, idarubicin, epirubicin, bleomycin, plicamycin, andmitomycin.

In some instances, the anti-cancer treatment may comprise radiationtherapy. Radiation can come from a machine outside the body(external-beam radiation therapy) or from radioactive material placed inthe body near cancer cells (internal radiation therapy, more commonlycalled brachytherapy). Systemic radiation therapy uses a radioactivesubstance, given by mouth or into a vein that travels in the blood totissues throughout the body.

External-beam radiation therapy may be delivered in the form of photonbeams (either x-rays or gamma rays). A photon is the basic unit of lightand other forms of electromagnetic radiation. An example ofexternal-beam radiation therapy is called 3-dimensional conformalradiation therapy (3D-CRT). 3D-CRT may use computer software andadvanced treatment machines to deliver radiation to very preciselyshaped target areas. Many other methods of external-beam radiationtherapy are currently being tested and used in cancer treatment. Thesemethods include, but are not limited to, intensity-modulated radiationtherapy (IMRT), image-guided radiation therapy (IGRT), Stereotacticradiosurgery (SRS), Stereotactic body radiation therapy (SBRT), andproton therapy.

Intensity-modulated radiation therapy (IMRT) is an example ofexternal-beam radiation and may use hundreds of tiny radiationbeam-shaping devices, called collimators, to deliver a single dose ofradiation. The collimators can be stationary or can move duringtreatment, allowing the intensity of the radiation beams to changeduring treatment sessions. This kind of dose modulation allows differentareas of a tumor or nearby tissues to receive different doses ofradiation. IMRT is planned in reverse (called inverse treatmentplanning) In inverse treatment planning, the radiation doses todifferent areas of the tumor and surrounding tissue are planned inadvance, and then a high-powered computer program calculates therequired number of beams and angles of the radiation treatment. Incontrast, during traditional (forward) treatment planning, the numberand angles of the radiation beams are chosen in advance and computerscalculate how much dose may be delivered from each of the planned beams.The goal of IMRT is to increase the radiation dose to the areas thatneed it and reduce radiation exposure to specific sensitive areas ofsurrounding normal tissue.

Another example of external-beam radiation is image-guided radiationtherapy (IGRT). In IGRT, repeated imaging scans (CT, MRI, or PET) may beperformed during treatment. These imaging scans may be processed bycomputers to identify changes in a tumor's size and location due totreatment and to allow the position of the patient or the plannedradiation dose to be adjusted during treatment as needed. Repeatedimaging can increase the accuracy of radiation treatment and may allowreductions in the planned volume of tissue to be treated, therebydecreasing the total radiation dose to normal tissue.

Tomotherapy is a type of image-guided IMRT. A tomotherapy machine is ahybrid between a CT imaging scanner and an external-beam radiationtherapy machine. The part of the tomotherapy machine that deliversradiation for both imaging and treatment can rotate completely aroundthe patient in the same manner as a normal CT scanner. Tomotherapymachines can capture CT images of the patient's tumor immediately beforetreatment sessions, to allow for very precise tumor targeting andsparing of normal tissue.

Stereotactic radiosurgery (SRS) can deliver one or more high doses ofradiation to a small tumor. SRS uses extremely accurate image-guidedtumor targeting and patient positioning. Therefore, a high dose ofradiation can be given without excess damage to normal tissue. SRS canbe used to treat small tumors with well-defined edges. It is mostcommonly used in the treatment of brain or spinal tumors and brainmetastases from other cancer types. For the treatment of some brainmetastases, patients may receive radiation therapy to the entire brain(called whole-brain radiation therapy) in addition to SRS. SRS requiresthe use of a head frame or other device to immobilize the patient duringtreatment to ensure that the high dose of radiation is deliveredaccurately.

Stereotactic body radiation therapy (SBRT) delivers radiation therapy infewer sessions, using smaller radiation fields and higher doses than3D-CRT in most cases. SBRT may treat tumors that lie outside the brainand spinal cord. Because these tumors are more likely to move with thenormal motion of the body, and therefore cannot be targeted asaccurately as tumors within the brain or spine, SBRT is usually given inmore than one dose. SBRT can be used to treat small, isolated tumors,including cancers in the lung and liver. SBRT systems may be known bytheir brand names, such as the CyberKnife®.

In proton therapy, external-beam radiation therapy may be delivered byproton. Protons are a type of charged particle. Proton beams differ fromphoton beams mainly in the way they deposit energy in living tissue.Whereas photons deposit energy in small packets all along their paththrough tissue, protons deposit much of their energy at the end of theirpath (called the Bragg peak) and deposit less energy along the way. Useof protons may reduce the exposure of normal tissue to radiation,possibly allowing the delivery of higher doses of radiation to a tumor.

Other charged particle beams such as electron beams may be used toirradiate superficial tumors, such as skin cancer or tumors near thesurface of the body, but they cannot travel very far through tissue.

Internal radiation therapy (brachytherapy) is radiation delivered fromradiation sources (radioactive materials) placed inside or on the body.Several brachytherapy techniques are used in cancer treatment.Interstitial brachytherapy may use a radiation source placed withintumor tissue, such as within a prostate tumor. Intracavitarybrachytherapy may use a source placed within a surgical cavity or a bodycavity, such as the chest cavity, near a tumor. Episcleralbrachytherapy, which may be used to treat melanoma inside the eye, mayuse a source that is attached to the eye. In brachytherapy, radioactiveisotopes can be sealed in tiny pellets or “seeds.” These seeds may beplaced in patients using delivery devices, such as needles, catheters,or some other type of carrier. As the isotopes decay naturally, theygive off radiation that may damage nearby cancer cells. Brachytherapymay be able to deliver higher doses of radiation to some cancers thanexternal-beam radiation therapy while causing less damage to normaltissue.

Brachytherapy can be given as a low-dose-rate or a high-dose-ratetreatment. In low-dose-rate treatment, cancer cells receive continuouslow-dose radiation from the source over a period of several days. Inhigh-dose-rate treatment, a robotic machine attached to delivery tubesplaced inside the body may guide one or more radioactive sources into ornear a tumor, and then removes the sources at the end of each treatmentsession. High-dose-rate treatment can be given in one or more treatmentsessions. An example of a high-dose-rate treatment is the MammoSite®system. Bracytherapy may be used to treat patients with breast cancerwho have undergone breast-conserving surgery.

The placement of brachytherapy sources can be temporary or permanent.For permanent brachytherapy, the sources may be surgically sealed withinthe body and left there, even after all of the radiation has been givenoff. In some instances, the remaining material (in which the radioactiveisotopes were sealed) does not cause any discomfort or harm to thepatient. Permanent brachytherapy is a type of low-dose-ratebrachytherapy. For temporary brachytherapy, tubes (catheters) or othercarriers are used to deliver the radiation sources, and both thecarriers and the radiation sources are removed after treatment.Temporary brachytherapy can be either low-dose-rate or high-dose-ratetreatment. Brachytherapy may be used alone or in addition toexternal-beam radiation therapy to provide a “boost” of radiation to atumor while sparing surrounding normal tissue.

In systemic radiation therapy, a patient may swallow or receive aninjection of a radioactive substance, such as radioactive iodine or aradioactive substance bound to a monoclonal antibody. Radioactive iodine(131I) is a type of systemic radiation therapy commonly used to helptreat cancer, such as thyroid cancer. Thyroid cells naturally take upradioactive iodine. For systemic radiation therapy for some other typesof cancer, a monoclonal antibody may help target the radioactivesubstance to the right place. The antibody joined to the radioactivesubstance travels through the blood, locating and killing tumor cells.For example, the drug ibritumomab tiuxetan (Zevalin®) may be used forthe treatment of certain types of B-cell non-Hodgkin lymphoma (NHL). Theantibody part of this drug recognizes and binds to a protein found onthe surface of B lymphocytes. The combination drug regimen oftositumomab and iodine I 131 tositumomab (Bexxar®) may be used for thetreatment of certain types of cancer, such as NHL. In this regimen,nonradioactive tositumomab antibodies may be given to patients first,followed by treatment with tositumomab antibodies that have 131Iattached. Tositumomab may recognize and bind to the same protein on Blymphocytes as ibritumomab. The nonradioactive form of the antibody mayhelp protect normal B lymphocytes from being damaged by radiation from131I.

Some systemic radiation therapy drugs relieve pain from cancer that hasspread to the bone (bone metastases). This is a type of palliativeradiation therapy. The radioactive drugs samarium-153-lexidronam(Quadramet®) and strontium-89 chloride (Metastron®) are examples ofradiopharmaceuticals may be used to treat pain from bone metastases.

Biological therapy (sometimes called immunotherapy, biotherapy, orbiological response modifier (BRM) therapy) uses the body's immunesystem, either directly or indirectly, to fight cancer or to lessen theside effects that may be caused by some cancer treatments. Biologicaltherapies include interferons, interleukins, colony-stimulating factors,monoclonal antibodies, vaccines, gene therapy, and nonspecificimmunomodulating agents.

Interferons (IFNs) are types of cytokines that occur naturally in thebody. Interferon alpha, interferon beta, and interferon gamma areexamples of interferons that may be used in cancer treatment.

Like interferons, interleukins (ILs) are cytokines that occur naturallyin the body and can be made in the laboratory. Many interleukins havebeen identified for the treatment of cancer. For example, interleukin-2(IL-2 or aldesleukin), interleukin 7, and interleukin 12 have may beused as an anti-cancer treatment. IL-2 may stimulate the growth andactivity of many immune cells, such as lymphocytes, that can destroycancer cells. Interleukins may be used to treat a number of cancers,including leukemia, lymphoma, and brain, colorectal, ovarian, breast,kidney and prostate cancers.

Colony-stimulating factors (CSFs) (sometimes called hematopoietic growthfactors) may also be used for the treatment of cancer. Some examples ofCSFs include, but are not limited to, G-CSF (filgrastim) and GM-CSF(sargramostim). CSFs may promote the division of bone marrow stem cellsand their development into white blood cells, platelets, and red bloodcells. Bone marrow is critical to the body's immune system because it isthe source of all blood cells. Because anticancer drugs can damage thebody's ability to make white blood cells, red blood cells, andplatelets, stimulation of the immune system by CSFs may benefit patientsundergoing other anti-cancer treatment, thus CSFs may be combined withother anti-cancer therapies, such as chemotherapy. CSFs may be used totreat a large variety of cancers, including lymphoma, leukemia, multiplemyeloma, melanoma, and cancers of the brain, lung, esophagus, breast,uterus, ovary, prostate, kidney, colon, and rectum.

Another type of biological therapy includes monoclonal antibodies (MOABsor MoABs). These antibodies may be produced by a single type of cell andmay be specific for a particular antigen. To create MOABs, a humancancer cells may be injected into mice. In response, the mouse immunesystem can make antibodies against these cancer cells. The mouse plasmacells that produce antibodies may be isolated and fused withlaboratory-grown cells to create “hybrid” cells called hybridomas.Hybridomas can indefinitely produce large quantities of these pureantibodies, or MOABs. MOABs may be used in cancer treatment in a numberof ways. For instance, MOABs that react with specific types of cancermay enhance a patient's immune response to the cancer. MOABs can beprogrammed to act against cell growth factors, thus interfering with thegrowth of cancer cells.

MOABs may be linked to other anti-cancer therapies such aschemotherapeutics, radioisotopes (radioactive substances), otherbiological therapies, or other toxins. When the antibodies latch ontocancer cells, they deliver these anti-cancer therapies directly to thetumor, helping to destroy it. MOABs carrying radioisotopes may alsoprove useful in diagnosing certain cancers, such as colorectal, ovarian,and prostate.

Rituxan® (rituximab) and Herceptin® (trastuzumab) are examples of MOABsthat may be used as a biological therapy. Rituxan may be used for thetreatment of non-Hodgkin lymphoma. Herceptin can be used to treatmetastatic breast cancer in patients with tumors that produce excessamounts of a protein called HER2. Alternatively, MOABs may be used totreat lymphoma, leukemia, melanoma, and cancers of the brain, breast,lung, kidney, colon, rectum, ovary, prostate, and other areas.

Cancer vaccines are another form of biological therapy. Cancer vaccinesmay be designed to encourage the patient's immune system to recognizecancer cells. Cancer vaccines may be designed to treat existing cancers(therapeutic vaccines) or to prevent the development of cancer(prophylactic vaccines). Therapeutic vaccines may be injected in aperson after cancer is diagnosed. These vaccines may stop the growth ofexisting tumors, prevent cancer from recurring, or eliminate cancercells not killed by prior treatments. Cancer vaccines given when thetumor is small may be able to eradicate the cancer. On the other hand,prophylactic vaccines are given to healthy individuals before cancerdevelops. These vaccines are designed to stimulate the immune system toattack viruses that can cause cancer. By targeting these cancer-causingviruses, development of certain cancers may be prevented. For example,cervarix and gardasil are vaccines to treat human papilloma virus andmay prevent cervical cancer. Therapeutic vaccines may be used to treatmelanoma, lymphoma, leukemia, and cancers of the brain, breast, lung,kidney, ovary, prostate, pancreas, colon, and rectum. Cancer vaccinescan be used in combination with other anti-cancer therapies.

Gene therapy is another example of a biological therapy. Gene therapymay involve introducing genetic material into a person's cells to fightdisease. Gene therapy methods may improve a patient's immune response tocancer. For example, a gene may be inserted into an immune cell toenhance its ability to recognize and attack cancer cells. In anotherapproach, cancer cells may be injected with genes that cause the cancercells to produce cytokines and stimulate the immune system.

In some instances, biological therapy includes nonspecificimmunomodulating agents. Nonspecific immunomodulating agents aresubstances that stimulate or indirectly augment the immune system.Often, these agents target key immune system cells and may causesecondary responses such as increased production of cytokines andimmunoglobulins. Two nonspecific immunomodulating agents used in cancertreatment are bacillus Calmette-Guerin (BCG) and levamisole. BCG may beused in the treatment of superficial bladder cancer following surgery.BCG may work by stimulating an inflammatory, and possibly an immune,response. A solution of BCG may be instilled in the bladder. Levamisoleis sometimes used along with fluorouracil (5-FU) chemotherapy in thetreatment of stage III (Dukes' C) colon cancer following surgery.Levamisole may act to restore depressed immune function.

Photodynamic therapy (PDT) is an anti-cancer treatment that may use adrug, called a photosensitizer or photosensitizing agent, and aparticular type of light. When photosensitizers are exposed to aspecific wavelength of light, they may produce a form of oxygen thatkills nearby cells. A photosensitizer may be activated by light of aspecific wavelength. This wavelength determines how far the light cantravel into the body. Thus, photosensitizers and wavelengths of lightmay be used to treat different areas of the body with PDT.

In the first step of PDT for cancer treatment, a photosensitizing agentmay be injected into the bloodstream. The agent may be absorbed by cellsall over the body but may stay in cancer cells longer than it does innormal cells. Approximately 24 to 72 hours after injection, when most ofthe agent has left normal cells but remains in cancer cells, the tumorcan be exposed to light. The photosensitizer in the tumor can absorb thelight and produces an active form of oxygen that destroys nearby cancercells. In addition to directly killing cancer cells, PDT may shrink ordestroy tumors in two other ways. The photosensitizer can damage bloodvessels in the tumor, thereby preventing the cancer from receivingnecessary nutrients. PDT may also activate the immune system to attackthe tumor cells.

The light used for PDT can come from a laser or other sources. Laserlight can be directed through fiber optic cables (thin fibers thattransmit light) to deliver light to areas inside the body. For example,a fiber optic cable can be inserted through an endoscope (a thin,lighted tube used to look at tissues inside the body) into the lungs oresophagus to treat cancer in these organs. Other light sources includelight-emitting diodes (LEDs), which may be used for surface tumors, suchas skin cancer. PDT is usually performed as an outpatient procedure. PDTmay also be repeated and may be used with other therapies, such assurgery, radiation, or chemotherapy.

Extracorporeal photopheresis (ECP) is a type of PDT in which a machinemay be used to collect the patient's blood cells. The patient's bloodcells may be treated outside the body with a photosensitizing agent,exposed to light, and then returned to the patient. ECP may be used tohelp lessen the severity of skin symptoms of cutaneous T-cell lymphomathat has not responded to other therapies. ECP may be used to treatother blood cancers, and may also help reduce rejection aftertransplants.

Additionally, photosensitizing agent, such as porfimer sodium orPhotofrin®, may be used in PDT to treat or relieve the symptoms ofesophageal cancer and non-small cell lung cancer. Porfimer sodium mayrelieve symptoms of esophageal cancer when the cancer obstructs theesophagus or when the cancer cannot be satisfactorily treated with lasertherapy alone. Porfimer sodium may be used to treat non-small cell lungcancer in patients for whom the usual treatments are not appropriate,and to relieve symptoms in patients with non-small cell lung cancer thatobstructs the airways. Porfimer sodium may also be used for thetreatment of precancerous lesions in patients with Barrett esophagus, acondition that can lead to esophageal cancer.

Laser therapy may use high-intensity light to treat cancer and otherillnesses. Lasers can be used to shrink or destroy tumors orprecancerous growths. Lasers are most commonly used to treat superficialcancers (cancers on the surface of the body or the lining of internalorgans) such as basal cell skin cancer and the very early stages of somecancers, such as cervical, penile, vaginal, vulvar, and non-small celllung cancer.

Lasers may also be used to relieve certain symptoms of cancer, such asbleeding or obstruction. For example, lasers can be used to shrink ordestroy a tumor that is blocking a patient's trachea (windpipe) oresophagus. Lasers also can be used to remove colon polyps or tumors thatare blocking the colon or stomach.

Laser therapy is often given through a flexible endoscope (a thin,lighted tube used to look at tissues inside the body). The endoscope isfitted with optical fibers (thin fibers that transmit light). It isinserted through an opening in the body, such as the mouth, nose, anus,or vagina. Laser light is then precisely aimed to cut or destroy atumor.

Laser-induced interstitial thermotherapy (LITT), or interstitial laserphotocoagulation, also uses lasers to treat some cancers. LITT issimilar to a cancer treatment called hyperthermia, which uses heat toshrink tumors by damaging or killing cancer cells. During LITT, anoptical fiber is inserted into a tumor. Laser light at the tip of thefiber raises the temperature of the tumor cells and damages or destroysthem. LITT is sometimes used to shrink tumors in the liver.

Laser therapy can be used alone, but most often it is combined withother treatments, such as surgery, chemotherapy, or radiation therapy.In addition, lasers can seal nerve endings to reduce pain after surgeryand seal lymph vessels to reduce swelling and limit the spread of tumorcells.

Lasers used to treat cancer may include carbon dioxide (CO2) lasers,argon lasers, and neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers.Each of these can shrink or destroy tumors and can be used withendoscopes. CO2 and argon lasers can cut the skin's surface withoutgoing into deeper layers. Thus, they can be used to remove superficialcancers, such as skin cancer. In contrast, the Nd:YAG laser is morecommonly applied through an endoscope to treat internal organs, such asthe uterus, esophagus, and colon. Nd:YAG laser light can also travelthrough optical fibers into specific areas of the body during LITT.Argon lasers are often used to activate the drugs used in PDT.

For patients with high test scores consistent with systemic diseaseoutcome after prostatectomy, additional treatment modalities such asadjuvant chemotherapy (e.g., docetaxel, mitoxantrone and prednisone),systemic radiation therapy (e.g., samarium or strontium) and/oranti-androgen therapy (e.g., surgical castration, finasteride,dutasteride) can be designated. Such patients would likely be treatedimmediately with anti-androgen therapy alone or in combination withradiation therapy in order to eliminate presumed micro-metastaticdisease, which cannot be detected clinically but can be revealed by thetarget sequence expression signature.

Such patients can also be more closely monitored for signs of diseaseprogression. For patients with intermediate test scores consistent withbiochemical recurrence only (BCR-only or elevated PSA that does notrapidly become manifested as systemic disease only localized adjuvanttherapy (e.g., radiation therapy of the prostate bed) or short course ofanti-androgen therapy would likely be administered. For patients withlow scores or scores consistent with no evidence of disease (NED)adjuvant therapy would not likely be recommended by their physicians inorder to avoid treatment-related side effects such as metabolic syndrome(e.g., hypertension, diabetes and/or weight gain), osteoporosis,proctitis, incontinence or impotence. Patients with samples consistentwith NED could be designated for watchful waiting, or for no treatment.Patients with test scores that do not correlate with systemic diseasebut who have successive PSA increases could be designated for watchfulwaiting, increased monitoring, or lower dose or shorter durationanti-androgen therapy.

Target sequences can be grouped so that information obtained about theset of target sequences in the group can be used to make or assist inmaking a clinically relevant judgment such as a diagnosis, prognosis, ortreatment choice.

A patient report is also provided comprising a representation ofmeasured expression levels of a plurality of target sequences in abiological sample from the patient, wherein the representation comprisesexpression levels of target sequences corresponding to any one, two,three, four, five, six, eight, ten, twenty, thirty, forty, fifty or moreof the target sequences corresponding to a target selected from Table 1or SEQ ID NOs: 1-1815, the subsets described herein, or a combinationthereof. In some embodiments, the representation of the measuredexpression level(s) may take the form of a linear or nonlinearcombination of expression levels of the target sequences of interest.The patient report may be provided in a machine (e.g., a computer)readable format and/or in a hard (paper) copy. The report can alsoinclude standard measurements of expression levels of said plurality oftarget sequences from one or more sets of patients with known diseasestatus and/or outcome. The report can be used to inform the patientand/or treating physician of the expression levels of the expressedtarget sequences, the likely medical diagnosis and/or implications, andoptionally may recommend a treatment modality for the patient.

Also provided are representations of the gene expression profiles usefulfor treating, diagnosing, prognosticating, and otherwise assessingdisease. In some embodiments, these profile representations are reducedto a medium that can be automatically read by a machine such as computerreadable media (magnetic, optical, and the like). The articles can alsoinclude instructions for assessing the gene expression profiles in suchmedia. For example, the articles may comprise a readable storage formhaving computer instructions for comparing gene expression profiles ofthe portfolios of genes described above. The articles may also have geneexpression profiles digitally recorded therein so that they may becompared with gene expression data from patient samples. Alternatively,the profiles can be recorded in different representational format. Agraphical recordation is one such format. Clustering algorithms canassist in the visualization of such data.

Cancer Aggressiveness Prediction

In some embodiments, the methods and genomic classifiers of the presentinvention are useful for predicting aggressive prostate cancer. In someembodiments, the methods and genomic classifiers of the presentinvention are used to predict patient outcomes such as biochemicalrecurrence (BCR), metastasis (MET) and prostate cancer death (PCSM)after radical prostatectomy. In other embodiments, the methods andgenomic classifiers of the present invention are used to predict patientoutcomes such as distant metastasis-free survival (DMFS), biochemicalrecurrence-free survival (bRFS), prostate cancer specific survival(PCSS), and overall survival (OS).

Metastasis Prediction

In some embodiments, the methods and genomic classifiers of the presentinvention are useful for predicting prostate cancer metastasis followingradical prostatectomy. In other embodiments, the methods and genomicclassifiers of the present invention are useful for determining a courseof treatment following radical prostatectomy.

The following examples are provided to further illustrate the advantagesand features of the present invention, but are not intended to limit thescope of the invention. While they are typical of those that might beused, other procedures, methodologies, or techniques known to thoseskilled in the art may alternatively be used.

EXAMPLES Example 1: A Genomic Classifier to Predict Aggressive ProstateCancer in Humans

A genomic classifier to predict aggressive prostate cancer in humansubjects was developed as follows. To build, validate and evaluate thenovel genomic model, a total of 9,901 genome-wide expression profilesfrom assays of biopsy and radical prostatectomy (RP) tumor tissuespecimens. This included genome-wide expression, treatment and outcomesdata from 1,261 prostate cancer patients treated with RP in sevenretrospective institutional cohorts. A second set of de-identified, andanonymized prospective RP cases with basic demographic and pathologicaldata from clinical use of the Decipher RP test (n=6,739) was also partof this cohort. Finally, the third set of patient data included 1,694prospective biopsy expression profiles with basic clinical data and 253retrospective biopsy profiles with detailed clinical data at biopsy andpathological data at RP.

The retrospective RP data from 1,261 patients, as well as a randomlyselected sample of 2,041 patients, which represents 30% of theprospectively collected RP samples, were used as a development cohortfor the novel genomic model. The remaining 70% (n=4,698) of theprospectively collected RP samples, as well as 1,694 prospectivelycollected biopsy samples and 253 retrospectively collected biopsysamples (with known pathological variables at RP) were used asvalidation cohorts for the novel genomic model.

Affymetrix Human Exon 1.0 ST microarray (Affymetrix, Santa Clara,Calif.) data were obtained from the formalin-fixed paraffin-embeddedbiopsy and RP specimens described above. Microarray processing wasperformed in a CLIA-certified clinical operations laboratory (GenomeDxBiosciences, Inc, San Diego, Calif.). Microarrays were normalized usingSingle Channel Array Normalization. (Piccolo et al. Genomics. 2012;100(6):337-344.)

The first step in the model development was to assign a metastasis scoreto a large prospective cohort of 1,539 patients into high metastaticrisk and low metastatic risk using the validated Decipher signature(DV1). Next, these patients were grouped into high aggressivenesscategory (high DV1 and GS≥8) and low aggressiveness category (low DV1and GS≥7). To select gene features for the novel genomics classifier(DV2), we processed a retrospective cohort of 545 patients treated withRP, who had long-term follow-up and clinical recurrence outcomes(metastasis vs. no metastasis) with an additional 400 prospectivepatients, for whom the outcome of interest was low aggressive disease(LAD) vs high aggressive disease (HAD). We selected genes that wereassociated with HAD, and/or metastasis (FDR adjusted p-value 0.05). Fromthis process, a total of 172 genes were selected to train the DV2 model.Next, we trained DV2 on a total of 1,539 prospective samples (HAD: 269,LAD:1,270) using a GLMNET model with Elasticnet mixing parameters 0.5and the 172 filtered genes. Model optimization and performanceevaluation on training data was determined using 10-fold crossvalidation. DV2 generates scores from between 0 and 1, where patientswith higher score will have higher probability of metastasis.

Statistical Analysis

All statistical analyses were conducted using R version 3.3.2 and alltests of significance were two-sided at the 0.05 level. The primaryendpoint of the analysis is high stage disease, which is defined aspathological stage T3b or above or node positive at RP. The secondaryendpoint is high grade disease, which is defined as pathological GleasonGrade Group 4 to 5. Analysis were performed in both prospective andretrospective biopsy sets. Age, pretreatment PSA (log 2 transformed) andpercent positive cores were modeled as continuous variables, andclinical stage, clinical Gleason Scores were treated as categoricalvariables. NCCN risk category was calculated using clinical stage,clinical Gleason and pretreatment PSA. The association between thegenomic models and clinical pathological features were evacuated usingSpearman's rank correlation. The performance of clinical model, DV1 andDV2 were compared using area under ROC curves, univariable andmultivariable logistic regression models. Firth's penalized likelihoodmethod was used in the retrospective biopsy set to adjust for rareevent.

Results

In the retrospective RP data set (n=545) 812 genes were differentiallyexpressed between tumors of patients with metastasis compared to thosewithout after a median follow up 17 years. We used about 30% (n=2,041)of the prospective RP data set to select genes and train the DV2 model.Using the composite endpoint, we identified 1,584 differentiallyexpressed genes comparing tumors with high and low genomic-pathologicscores. We identified 172 genes from the intersection of these twoselection steps. A subset of 1,539 prospective RP patient data were thenused to train the final DV2 model, again using the genomic-pathologicendpoint in a generalized linear model (GLMnet). After training theGLMnet, the final DV2 model was comprised of 60 genes with non-zeroweights (Table 1). In the training data set, DV2 achieved a 10-foldcross-validated AUC of 0.92 to predict high tumor genomic-pathologicscore.

TABLE 1 Gene Targets AC020571.3 FTH1P2 LIPH OR51A6P RP11-159H20.3 SMC4ANO7 FTH1P8 LPAR3 PABPC1 RP11-755O11.2 TIPARP ARL6IP1P2 GLB1L2 LPGAT1PART1 RP11-770G2.5 TMEM100 ASPN GLB1L3 MIR4435-1HG PCAT14 RP11-923I11.3TNFRSF19 AZGP1 GLYATL1P3 MKI67 PGM5P4-AS1 RP13-753N3.3 TOP2A AZGP1P1GMNN MLLT11 PICK1 RPL31P57 TPX2 DEGS1 HIF3A MYBPC1 PTTG1 SCIN TRIQKERO1LB INHBA NADK2 R3HDM1 SESN3 VBP1 FBXL8 KIAA1210 NR4A1 RNA5SP121SETP14 WFDC2 FMO5 KRT15 NUSAP1 RP11-121G22.3 SLC22A3 XPO6Correlation of Model Scores with Clinical Features of Prostate CancerTumors Sampled at Diagnosis and after RP

We first evaluated DV1 and DV2 in a prospective data set of 1,694 tumorexpression profiles obtained from Decipher biopsy testing, which isrepresentative of the spectrum of non-metastatic, localized diseaseobserved in contemporary practice (Table 2). As depicted in FIGS. 1A and1B, both models positively correlated with biopsy Grade Groups (p<0.001)and NCCN risk categories (p<0.001) as well as diagnostic PSA, clinicalstage and percentage of positive cores (p<0.001) (FIGS. 2A-C).Similarly, in the remaining prospective RP data set not used for DV2training (n=6,739) model scores were positively correlated (Spearman'srank correlation, p<0.001) with pathological tumor grade and stage (FIG.3A-B). Expectedly, the model scores in prospective RP and biopsy tumorspecimens showed highly concordant distributions across the tumor GradeGroups (FIG. 4).

TABLE 2 Prospective cohort for testing DV1 and DV2. VariablesProspective Biopsy Total 1694 Age Median (Q1, Q3) 67 (61, 72) PSA ≤5 451(26.6)  5-10 663 (39.1) 10-20 219 (12.9) >20 93 (5.5) Unknown 268 (15.8)Clinical Gleason Score ≤3 + 3 659 (38.9) 3+ 4 569 (33.6) 4+ 3 232 (13.7)8 141 (8.3) 9-10 93 (5.5) Unknown Clinical stage ≤T1c 898 (53.0) T2a 123(7.3) T2b/c 121 (7.1) ≥T3 18 (1.1) Unknown 534 (31.5) NCCN riskcategories Low 340 (20.1) Intermediate 856 (50.5) High 288 (17.0)Unknown 210 (12.4) Pathological Gleason Score ≤3 + 3 3 + 4 4 + 3 8 9-10Unknown 1694 (100.0) Pathological stage pT2 pT3a pT3b pT4 Unknown 1694(100.0) Surgical Margin Negative Positive Unknown 1694 (100.0)Extracapsular Extension Absent Present Unknown 1694 (100.0) SeminalVesicle Invasion Absent Present Unknown 1694 (100.0) Lymph NodeInvolvement Absent Present Unknown 1694 (100.0) Adverse Pathology(pT3b₊/LNI₊) 0 1 Unknown 1694 (100.0)

Genomic Classifier Scores Predict Presence of Higher-Grade Disease UponPathological Re-Review

In the prospective cohort, independent pathological review was performedin order to select tumor tissue among the prostate needle biopsy coressubmitted for the Decipher genome-wide expression assay. We evaluatedthe distribution of DV1 and DV2 scores among cases where tumor gradingchanged (FIG. 5). This analysis showed both genomic models were not onlypositively correlated (p<0.001) with independent histological review,but both DV1 and DV2 assigned higher scores to patients who wereupgraded and lower scores to those were downgraded upon re-review

The clinical impact was particularly pronounced in tumors from patientssubmitted for testing with an initial diagnosis of Grade Group 1(Gleason 3+3) disease and available independent histological review. Ofthis subset (n=534), upgrading was observed in 157 (29%) of cases,including 13 that were upgraded to primary pattern 4 or higher (GradeGroup 3-5). When these cases were assessed by DV1 and DV2, we found theDV1 model showed median scores of 0.39, 0.46, 0.59 in GG1, GG2, andGG3-5 patients, respectively (FIG. 6A). The median scores for the DV2model in GG1, GG2, and GG3-5 patients were 0.05, 0.08 and 0.25 (FIG.6B). The corresponding AUCs for predicting any upgrade among the GradeGroup 1 tumors were 0.61 and 0.63 for DV1 and DV2; compared to 0.59,0.55 and 0.58 for age, PSA and percent positive cores, respectively(FIG. 6C). In MVA analyses adjusting for clinical risk factors forup-grading, each 0.1 change in DV1 and DV2 scores were associated with29% and 30% increased odds of up-grading on re-review (Table 3).Similarly, among patients initially diagnosed with Gleason 3+4 disease,both models were significant predictors of up-grading to 4+3 or above inboth UVA and MVA analyses (data not shown).

TABLE 3 Logistic regression model for predicting upgrade to GG2-GG5 inprospective biopsy GG1 subset UVA MVA Models variables OR CI P-value ORCI P-value (A) DV1 Age 1.04 (1.02-1.07) 0.002 1.04 (1.01-1.07) 0.005log(pre-op PSA) 1.24 (0.98-1.58) 0.07 1.13 (0.88-1.45) 0.332 % positivecores 1.01   (1-1.02) 0.026 1.01   (1-1.02) 0.019 DV1 * 1.27 (1.14-1.42)<0.001 1.29 (1.15-1.45) <0.001 (B) DV2 Age 1.04 (1.02-1.07) 0.002 1.03  (1-1.06) 0.024 log(pre-op PSA) 1.24 (0.98-1.58) 0.07 1.13 (0.88-1.44)0.347 % positive cores 1.01   (1-1.02) 0.026 1.01   (1-1.02) 0.03 DV2 *1.33 (1.17-1.52) <0.001 1.31 (1.15-1.49) <0.001 * per 0.1 increment ofthe model scoresPrediction of Higher Stage Disease at RP and Metastasis Post RP fromAnalysis of Diagnostic Biopsy Specimens

Next, we evaluated the performance of the classifiers in a retrospectivemulti-institutional cohort of 253 men with Decipher biopsy data who weretreated with RP and had detailed clinical and pathological dataavailable for analysis. Demographic and clinical characteristics of thispatient cohort is provided in Table 2. The median patient age at RP was63 years (interquartile range [IQR] 57-68) with a median pre-treatmentPSA of 6.60 ng/mL (IQR 4.75-11.95). At initial diagnostic biopsy, 56% ofpatients had Grade Group 1 and 33% clinical stage T1 disease.Accordingly, pre-treatment NCCN risk groupings classified 42% and 28% ofpatients as harboring low- and intermediate-risk disease, respectively.Pathological analysis of the RP specimens revealed, only 29% remainedwith Grade Group 1 disease and due to up-grading, 38% had Grade Group ≥3(i.e., Gleason score 4+3 or greater) disease in the prostatectomy.Similarly, tumor pathological staging showed that 46% hadextra-prostatic extension, 14% had seminal vesicle invasion and 19% hadlymph node involvement. The composite end-point of high-stage disease,defined as the presence of seminal vesicle invasion or lymph nodeinvolvement was present in 21% of patients. With a median follow up postdiagnosis of 7.85 years, 27 patients developed metastasis and 10 died ofprostate cancer.

TABLE 4 Patient Characteristics Variables Study Cohort No. patients (%)253 (100.0) Age at RP Median (Q1, Q3) 62.6 (57.2, 68) Pre-Operative PSAMedian (Q1, Q3) 6.6 (4.75, 12) Biopsy Grade Groups Grade Group 1 141(55.7) Grade Group 2 38 (15.0) Grade Group 3 27 (10.7) Grade Group 4 31(12.3) Grade Group 5 16 (6.3) Clinical Stage T1 142 (56.1) T2 81 (32.0)T3 or higher 10 (4.0) Unknown 20 (7.9) NCCN Risk Groups Low 90 (35.6)Intermediate Favorable 29 (11.5) Intermediate Unfavorable 39 (15.4) High72 (28.5) Unknown 23 (9.1) Follow up time for Censored Patients (years)Median (Q1, Q3) 7.85 (5.48, 10.9)

We next assessed the ability of the genomic classifiers to predict thepresence of lymph node involvement (LNI) upon final pathology at RP. Asobserved in the prospective cohorts, in the retrospective biopsyspecimens both models had higher scores on average to predict patientswith higher grade and stage disease (p<0.001) (FIGS. 7A-B). The AUC forpredicting lymph node involvement (LNI) was 0.74 and 0.77 for DV1 andDV2 models respectively (FIG. 8). Similar results were obtained for thehigh-grade, extra-prostatic extension, seminal vesicle invasion (SVI)and a composite end-point (SVI or LNI). Using logistic regression, wefound that every 0.1 increase in DV1 and DV2 model scores wereassociated with 18% and 40% increased odds of lymph node involvement atRP in MVA (Table 5). These data support the observation that there aremany clinically lower grade patients at diagnosis that harbor highclinical-genomic risk disease which can be detected using the genomicclassifiers described herein.

TABLE 5 Lymph Node Invasion. UVA/MVA Tables UVA MVA model variable OR CIp OR CI p Model 1 BX Grade Group 2 (ref: Grade 1.99 0.45-8.74 0.363 0.820.17-4.00 0.805 Group 1) BX Grade Group 3 (ref: Grade 5.27  1.41-19.750.014 2.53  0.60-10.65 0.206 Group 1) BX Grade Group 4 (ref: Grade 5.57 1.57-19.69 0.008 1.53 0.36-6.50 0.566 Group 1) BX Grade Group 5 (ref:Grade 18.04  4.76-68.43 <0.001 6.88  1.62-29.18 0.009 Group 1) ClinicalStage ≥ T2 (ref: Clinical 6.38  2.45-16.61 <0.001 4.52  1.55-13.16 0.006Stage < T2a) Decipher* 1.66 1.30-2.12 <0.001 1.43 1.10-1.88 0.009 Model2 BX Grade Group 2 (ref: Grade 1.99 0.45-8.74 0.363 1.01 0.21-4.87 0.986Group 1) BX Grade Group 3 (ref: Grade 5.27  1.41-19.75 0.014 2.71 0.64-11.43 0.174 Group 1) BX Grade Group 4 (ref: Grade 5.57  1.57-19.690.008 1.73 0.41-7.24 0.451 Group 1) BX Grade Group 5 (ref: Grade 18.04 4.76-68.43 <0.001 6.62  1.55-28.22 0.011 Group 1) Clinical Stage ≥ T2(ref: Clinical 6.38  2.45-16.61 <0.001 3.98  1.35-11.75 0.012 Stage <T2a) Decipher V2* 1.48 1.26-1.75 <0.001 1.28 1.06-1.54 0.010 Model 3Partin Table 1.09 1.05-1.13 <0.001 1.08 1.04-1.13 <0.001 Decipher* 1.661.30-2.12 <0.001 1.57 1.22-2.04 0.001 Model 4 Partin Table 1.091.05-1.13 <0.001 1.08 1.04-1.12 <0.001 Decipher V2* 1.48 1.26-1.75<0.001 1.42 1.19-1.69 <0.001 Model 5 Decipher + NCCN Low ReferenceReference 1 — Decipher + NCCN Intermediate 13.84  1.71-111.72 0.014Decipher + NCCN High 48.47  6.20-379.22 <0.001 Model 6 Decipher + NCCN2.37 1.68-3.33 <0.001 — *Decipher and Decipher V2 reported per 0.1 unitincrease

Prediction of Future Metastasis

Finally, we evaluated the models for their ability to prognosticate thedevelopment of postoperative metastasis and BCR. Both models weresignificant predictors of distant metastasis. The addition of thegenomic classifier models to clinical risk factors increased the AUC forpredicting metastasis for DV1 and DV2 respectively. Similar results wereobserved for the prostate-cancer specific mortality end-point.Multivariable analysis further demonstrated that the prognosticinformation in the GC models is independent of clinical risk factors.

These results showed that genomic classifiers of the present inventionare useful for predicting presence of higher-grade disease in prostatecancer subjects. These results further showed that genomic classifiersof the present invention are useful for predicting metastasis inprostate cancer subjects. These results suggested that the methods andmarkers of the present invention would be useful for diagnosing,prognosing, determining the progression of cancer, or predicting benefitfrom therapy in a subject having prostate cancer. The results showedthat the subtyping methods of the present invention may be used todetermine a treatment for a subject with prostate cancer.

TABLE 6 Univariate Analysis of Target Genes coef exp. coef. se. coef. zPr . . . z . . . AC020571.3 −1.018756 0.361043799 0.375053027−2.716298565 0.006601635 ANO7 2.728934592 0.065288812 0.407289095−6.700239767 2.08078E−11 ARL6IP1P2 0.211639304 1.235702092 0.1579380821.340014397 0.180240664 ASPN 0.734576998 2.084600016 0.2899622122.533354234 0.011297672 AZGP1 −1.081098477 0.339222692 0.227282585−4.756626977 1.96854E−06 AZGP1P1 −1.259174028 0.283888413 0.447362548−2.814661249 0.004882867 DEGS1 0.815286842 2.259823792 0.2725779552.99102267 0.002780449 ERO1LB 1.958519505 7.088824322 0.4316960594.536801915 5.71137E−06 FBXL8 −1.902271331 0.149229285 0.527510253−3.606131483 0.000310796 FMO5 −1.562260035 0.209661693 0.801119597−1.950095892 0.051164691 FTH1P2 0.940180631 2.560443872 0.2761999283.403985792 0.000664102 FTH1P8 0.197938579 1.218887527 0.2078779040.952186721 0.341002294 GLB1L2 −4.026340996 0.017839485 0.847895107−4.748631004 2.04798E−06 GLB1L3 −5.550073036 0.003887173 1.064791391−5.212357164 1.86456E−07 GLYATL1P3 −0.620320485 0.537772062 0.23410423−2.649761971 0.00805485 GMNN 2.092700107 8.106774799 0.5510730193.797500574 0.000146162 HIF3A 0.252313025 1.286998838 1.038150610.243040868 0.807973738 INHBA 2.684983887 14.65796519 0.7650964643.509340344 0.00044922 KIAA1210 −1.02505771 0.35877576 0.853948067−1.200374764 0.229993825 KRT15 −1.670025537 0.188242258 0.626029324−2.66764746 0.007638436 LIPH −3.364385361 0.034583266 0.944887437−3.56062027 0.00036998 LPAR3 −0.844270997 0.429870621 0.436019683−1.936313953 0.052829261 LPGAT1 1.220418809 3.388606616 0.3894613653.133606872 0.00172672 MIR4435-1HG −0.367725003 0.692307538 0.604570586−0.608241637 0.543027223 MKI67 6.792362118 891.0157626 0.9468150787.173905732 7.28861E−13 MLLT11 0.81044494 2.248908393 0.7325622531.106315452 0.268590006 MYBPC1 −1.152171977 0.315949788 0.249798588−4.612403886 3.98039E−06 NADK2 0.470137995 1.600215 0.6361598070.739024991 0.459891822 NR4A1 −1.596285011 0.202647956 0.265223126−6.01864941 1.75878E-09 NUSAP1 4.415561211 82.72825585 0.7078494826.237994554 4.43216E−10 OR51A6P −1.959242252 0.140965197 0.66373524−2.951843046 0.003158834 PABPC1 0.755077881 2.127777231 0.2788420852.707905018 0.00677094 PART1 −2.421642916 0.088775647 0.651032126−3.71969803 0.000199461 PCAT14 −0.397683215 0.671874834 0.089040775−4.466304519 7.95823E−06 PGM5P4-AS1 −1.064105371 0.345036396 0.529431364−2.009902402 0.044441519 PICK1 −3.052693795 0.047231521 0.94395319−3.233946162 0.001220925 PTTG1 5.054760024 156.7669056 0.7209619037.011133323 2.364E−12 R3HDM1 1.124121147 3.077510979 0.6887041741.632226417 0.102631798 RNA5SP121 −0.159834272 0.852285025 0.28514785−0.560531219 0.575117152 RP11-121G22.3 0.54826177 1.7302428420.289930617 1.891010254 0.058622975 RP11-159H20.3 1.0869333912.965167109 0.387286134 2.80653836 0.005007695 RP11-755O11.2 −2.215973450.10904731 0.708352751 −3.128347348 0.001757923 RP11-770G2.5 0.6562841611.927616298 0.511472642 1.283126615 0.199447721 RP11-923I11.30.012186678 1.012261238 0.387323413 0.031463831 0.974899637 RP13-753N3.30.391755198 1.479575464 0.350940795 1.116299967 0.264293756 RPL31P57−0.723295796 0.485150661 0.142803819 −5.064961152 4.08484E-07 SCIN−3.777998567 0.022868415 1.097206642 −3.443288093 0.000574687 SESN30.677784496 1.969509438 0.24823972 2.730362794 0.006326466 SETP140.630624885 1.878784237 0.289203892 2.180554631 0.029216374 SLC22A3−2.210758134 0.109617512 0.47027084 −4.701031715 2.5885E-06 SMC45.768903761 320.1865391 0.88769243 6.498764174 8.09824E−11 TIPARP−2.217536636 0.108876982 0.550632508 −4.027253394 5.64322E-05 TMEM100−2.882377174 0.056001479 1.005740682 −2.86592481 0.00415793 TNFRSF19−2.416480569 0.089235122 0.696215197 −3.470881677 0.000518753 TOP2A4.112985372 61.12893806 0.454912893 9.041259181 0 TPX2 5.182498017178.1272206 0.647974958 7.997991208 1.22125E-15 TRIQK 1.1671618543.212861116 0.384612581 3.034642943 0.002408206 VBP1 0.7832079992.188481664 0.471928306 1.659591065 0.096996747 WFDC2 −1.1402443480.319740884 0.746624189 −1.527199849 0.126711324 XPO6 0.3749195471.454874361 0.425155032 0.881841962 0.377862276

TABLE 7 Target Sequences SEQ ID Affy NO. Gene Probeset ID Sequence 1MLLT11 2358694 TCGCCAGGCATTTCGGGGCAAAACGAAGCGGAGCCCCCCAAACCCCCAGACCTAACCAAGTTCAGAGATTCGCAGAAGCACGCCCCCCACCCCAAATTTATTGTGCTCTACCCAAAATGGAATAGGACTAGGTTTATTTACCCATTGTGAGGGTAGAGAGGCGAGTCTGGAGGAGCAGGGATTGGGAGAAGGGGTGGAAAAATACTCTGATTCTTAAAAATACTTTGTAACCTAAAGTCCTTAAATTGTGGAAGAAAGGAATACTCCTCCTTTCCATTGTAGTCTAGAGTTAAGATTTCAAATCCATAAATTAGAGGACCTAAAATTAGAGGGCAATTAACTGCTCATTCATTGGGCCCCCAGTCAGCACGGGGGTGCTGGAAGAGATCGGGAATAATAGCGCAGACCAATGAGCCTAGGGAGATGCTTTCATCGTCTCTCCTTCCCTCAAGTGTTCTGGAACCTATCATTTGAATTAGCCGAGTCAGGCAGGAGGGGGCGGGGAATCCTTCCGCCCTTCTTAGGAGGGGCTGCATTGCAGGGGGAGAGTGAACTGACAGACTCAGTCACTGAAGAGGGAAAAGGAGTGAGAAGACAAAGCCGTCAAAGCCCCAACAGCTTTGTATTTCTCCAGCCCG GCGCAGA 2 MLLT11 2358695GGGACCCTGTGAGTAGCCAGTACAGTTC 3 MLLT11 2358696AGAACTGGATCTGTCGGAGCTGGAAGGCCTGGGTCTGTCAGATACAGCCACCTACAAGGTCAAAGACAGCAGCGTTGGCAAAAT GATCGGGCAAGCA 4 MLLT112358697 GTGATGGCCTCCTTGAGTACAGCACCTTCAAC 5 MLLT11 2358698TGGAGAGCTCCCATTGCCAGCATCCA 6 MLLT11 2358699TCAAGCAATGGAGTACTGGGTCACAGGGATTCCTCCTTTCCCCCCCAAATATTAACTCCAGAAACTAGGCCTGACTGGGGACACCTGAGAGTAGTATAGTAGTGCAAAATGGAAGACTGATTTTTGACTCTATTATAATCAGCTTCAGAGATTCCTTAAACCTTCCTAATTTCCTGCTCCAGGGCAGTAAACACAAATATTTCTTCAAGGGGTGATGAAAACCTCGGAAGTTTTAATTTGAGGTTATCTGCTACGAAACAGTATTTCTAAAAGGCTAAAGTGATAAGTCTCTTGCTTTTTTTTGATCCTGCTCTTATATTCTTTTTTTTCCTCAGAGAAATCAGGAGGGTAGTTAGAGGTATAAAACAGGAGGAAATATTATGGAAAATGAAAATAGGGAAAATAATTGAATCATTTTAGAAGTAGCTAATTTCTTTTCTCAAAAGAGTGTCCCTTCTTCACACCTACTCACTTTACAACTTTGCTCCTAACTGTGGGTTGAAAACTCTAGCTAAAGAAAGTTATCAAATCTTAACATGCATTCCTACTATTATGATAGTTTTTAAGGTTTCAATTCAATCTTCTGAACGGCATAAGTCCTATTTTA 7 DEGS1 2382361GGGAGCGCGCCCAGCATCGCTTGGGCCTCCTCCACCCGCTCAGGAGGGGAAACAGGAGAGCCGGGAGCACAACAGCCTCGCGCGCCCGCCGCCGCCTCAGCCTTAGGGGAGGCCACTACGCCT CTGGTTACATTTCTTG 8 DEGS12382362 TAGTCAGGACAGGATAAACAGTCGCTATATTAAGACCATGTAC GTGTCCCTAGACCTAGTTCT9 DEGS1 2382363 TCCGCCCACGCCTCCGTCTCCTCCGCGCTCCGCCACAGCCGGCCGACACCACACCAGCCGGGGAGCCGCCG 10 DEGS1 2382364CTAGTCTGCAAGCCACCGCTGTCGCC 11 DEGS1 2382365GACTTCGAGTGGGTCTACACCGACCAGCCGCA 12 DEGS1 2382366GTGAGGGCCAGCGGGCGCCCCGTTAT 13 DEGS1 2382367GGGCCCTGCGCGGTCGTGGGCGCCGGAGGCCC 14 DEGS1 2382368CGGAGCCGCGCAGCTCCGACCCTTCCGCGAAGAGGCGCAGGCGCGTCCCCGAGCGCGGGAGTCCCCGCCAGGCCCACGCCGGCCGGTTGGGGCGAAGGGTGTCCCCGGCTGTGCCAGCCTTGAGTAGATCTTTTCGCTAGAAGATTCCTGTGCCCTCAGGTGGGCGCCCTTTCCTCTCACCACTCCCTCTCCTCCGGAGCGGGCC 15 DEGS1 2382369TTGGGGCTGCCTGAGTGCTAGGCAGGGTGTGGTCCTGGGCAT CCTTGGGCCTACCAGCGAGCCCT 16DEGS1 2382370 GGTCTCAGATGATGCGCCTGCCATGGCCTCCCAAAGTCCTGGGATTACAGGCGTGAGCCACCCTGCCAGGCCACATATGATATATTTTATCAATGCCTTATCTACATGTTACATAGGAATAATCTAGCGTCCTACCTGTGTAAAAACCAACTCTGGAATACTGAAACTGAG CTACT 17 DEGS1 2382371TTGATGAAACCTGATCCCAATTTGATATGGATTAT 18 DEGS1 2382372TCTGGAAGTTATCAATACCGTGGCACAGGTCACTTTTGACATTTTAATTTATTACTTTTTGGGAATTAAATCCTTAGTCTACATGTTGGCAGCATCTTTACTTGGCCTGGGTTTG 19 DEGS1 2382373TGGCCAGGCTAGTATTTTGTCAGTCCAAGCAGTTCATTAAAAAAAAAAAAAACAAAAAGAGCAAGAATATAAATACTGCATCTTCCAGCCTACTTTTACAAAGGGTTCACTCTTGGGTCCTTAAGCTTAG TGGT 20 DEGS1 2382374CTGGAGTTTCCTGGATGGGTGCAGT 21 DEGS1 2382375GCTGAATACTATGACAACCTCCCTCACTACAATTCCTGGATAAAAGTACTGTATGATTTTGTGATGGATGATACAATAAGTCCCTAC TCAAGAATGAAGAGGCACCAAAA 22DEGS1 2382376 ATATCATTAGTGCCAAAGGGATTCTTCTC 23 DEGS1 2382377AAGAGCTCGGTGATACCAAGAAGTGAATCTGGCTTTTAAACAGTCAGCCTGACTCTGTACTGCTCAGTTTCACTCACAGGAAACTTGTGACTTGTGTATTATCGTCATTGAGGATGTTTCACTCATGTCTGTCATTTTATAAGCATATCATTTAAAAAGCTTCTAAAAAGCTATT TCGCCAGGCACGG 24 DEGS12382378 AAGCTATTTCTAGTTTATTTCACTATAAAGTTTTGCTTTATTAAAAAGCTAATAAACAGCTATTAATCAC 25 DEGS1 2382379CTATATAATATGGTAACTTGGGTACCGGGGGAACTTTAAAATTTCATCTCAAAAATAATTTTTAAAAAGCCTGAGGTATGATATAGCATAAAAGATTGAGATGAAAATATATTTCCCTGTAAGCTGAATTACTCATTTAAAAATTTTAACTTCTATATGGGACCCGAATTA 26 DEGS1 2382380CTGCTGAATCCTGTACAGCCTTACTCATAAATAA 27 FTH1P2 2384397ACTTTGCCAAATACTTTCTTCACCAATCTCATGAGGAGAGGGA ACATGCTGAGAAACTG 28 FTH1P22384398 GAAAAAAGTGTGAATCAGTCACTAC 29 FTH1P2 2384399TACCTGAATAAGCAGGTGAAAGCCATCAAAGAAT 30 FTH1P2 2384400TCTGGCTCGGCGGAATACCTCTTAGACAAGCA 31 LPAR3 2420617TTCACGGGCCACCTAGACTTTCCAGTCTAGGACTAGAGCTGTAGCAATGATCTGTTGTGCTGTACAAGAAAAGAGAAAGAGGTGTTCATTTGAGAACAGATGTTTTTATACATCAGAGTAAAAGCTGTATTGAAGAGCAGGCTGAATCCCTTCCATATAGAATGAAATATGAGCTTGACCCCAGTCCTTATCTTCAGTTACCTCCATACCAACTGGTGGCATGTTGGATTTAGCATGTAGAATAATTTCCCATCTCTTATTTTTCCCAAGGTTAATGGCATCCTTCTGGTACCTGGCTTACAT GTGAACTGAATTT 32 LPAR32420618 TATATATATTCCTGTTTTTACTGATTTTTATTGATTTTGTTCAAA 33 LPAR3 2420619TTACCTGTCTCTAACAAAGCCCATGTACAGTGTTATTTGAGGTCTCCATTAATCACTGCTAGATTTCTTTAAAAAATTTTTTTTCATAGTTTAAAAGCATGGGCAGTAAAGAGAGGACCTGCTGCATTTAGAGAAAGCACAGAAACGGGAGAGGTTCGGCGGGTCCCTGCTTGTCCTATGAACTGCTCAGAGCTCCTGTCAGTCCAGCTGGGCCTTCTGGGTTCTGGCACCATTTCGTAGCCATTCTCTTT 34 LPAR3 2420620CAGTCTGCAATAAAAGCACTTCCTAA 35 LPAR3 2420621GGTTCTGCTCCTCGACGGCCTGAACTGCAGGCAGTGTGGCGTGCAGCATGTGAAAAGGTGGTTCCTGCTGCTGGCGCTGCTCAACTCCGTCGTGAACCCCATCATCTACTCCTACAAGGACGAGGACATGTATGGCACCATGAAGAAGATGATCTGCTGCTTCTCTCAGGAGAACCCAGAGAGGCGTCCCTCTCGCATCCCCTCCACAGTCCTCAGCAGGAGTGACACAGGCAGCCAGTACATAGAGGATA 36 LPAR3 2420622ATGGGAGAGCTCCAGTGGAGAAGGC 37 LPAR3 2420623ATGGTGGATCGGCAGTACAGCACTGTTAGCGCAG 38 LPAR3 2420624TCCATGCCAAATGTGATCTTGAACTTGA 39 LPAR3 2420625TCAGCGTCAGGGAAACCTGGCAGCAGTTAATGAGGCCTGGCCATGGCTGTAGGCCAGGTTGGGAATCAGGAAGGGTAGATGCAT CCTC 40 LPAR3 2420626ACTGGGAGAACTAGTGAAGATGCTGAGGTGACACAGCAGACCCAGGTTGTTCTGGAGGCTCTACCTGAGTTTGCATGCAGCTTAGAAACTAAAACTGTGTCTTCTCAGTTGCATGGAGTGGACTCTCA GAAGGACATAGAGATTGTC 41 LPAR32420627 GACTCCTTATCACCAGGCTCGAGCACTAGCAGGAGGGACACTGGTGCTACGTGGCAGAGACCTTCTTCCAGTTATCTTAGCAACTGGTGGATCCCAGGGACTCCCCTTAGAGTTTCTACATTATTGGGCTTTCAGAACTGGACTCACCAATGAGTCAGGGAGACAGTGTTCCTGCTCTCTATCTGTGCTGAGTCTGCCTATCTGGGCCCATGAC AAGGCTTATGATA 42 LPAR32420628 ATGCAGGCCCAATTAAATAGGCCTGTGGCCAGTCTTCAGCCCACAGCTGAACTGCCTCATCTGGCAAGAAAGAGCCCATGTAGG ATCTTGAGTGT 43 LPAR3 2420629TGTGGCGGAAAGATCCCATTACCTCAAAGAATCAATACTGTTGAGAGATTTGACCAAGTTCACTTTGTAAATTACTGCAGCATTGTGGCTGCAGCTCTGGACCTTCTAGTTCCTGCTTCTTCTAGTGGGT CCCAACTTCTTGC 44 LPAR32420630 TTGTTTTCAGGGCAGGCCGTCAATCGGTGGGTGCAAAAATGCAGTTGCCACTCAGTTGCTGCCCCTACGCTGCTGTTTGACA 45 LPAR3 2420631GAAGGCAAAGTAGCAGTAAGCAACGAAACGATAGCTCAAGTT CTCATGCTAGGAGGAAATGGGTGA 46LPAR3 2420632 ATACAGCATGATAGAGACAAGGATTCCAAAATCCTAGGTGGAGAGAACAGGACCCTTTGTGAGACAGTCATGGTCACA 47 LPAR3 2420633CCTCATCATGGTTGTGGTGTACCTGCGGATCTACGTGTACGTCAAGAGGAAAACCAACGTCTTGTCTCCGCATACAAGTGGGTCCATCAGCCGCCGGAGGACACCCATGAAGCTAATG 48 LPAR3 2420634ACACTGCTCATTTTGCTTGTCTGGGCCATCGCCATTTTTATGGGGGCGGTCCCCACACTGGGCTGGAATTGCCTCTGCAACATCTCTGCCTGCTCTTCCCTGGCCCCCATTTACAGCAGGAGTTACCT TGTTTTCTG 49 LPAR3 2420635TTCTAATTCTCTGGTCATCGCGGCAGTGATCAAAAACAGAAAATTTCATTTCCCCTTCTACTACCTGTTGGCTAATTTAGCTGCTGCCGATTTCTTCGCTGGAATTGCCTATGTATTCCTGATGTTTAACACAGGCCCAGTTTCAAAAACTTTGACTGTCAACCGCTGGTTTCTCCGTCAGGGGCTTCTGGACAGTAGCTTGACTGCTTCCCTCACCAACTTGCTGGTTATCGCCGTGGAGAGGCACATGTCAATCATG AGGATGCGGGTCCATA 50 LPAR32420636 ATGGACAATAAATTCTTAAGCAACAAAAGAAAATACTGGGTCACAAGCAACTGGGTAGCTCTGATGGA 51 LPAR3 2420637AGGAACTAGTTATCCTGTGGAGATCTGGACGTCTAACTATTTGGACAACACTTACATTGATTGTCACTATCATATAACTAAGAAAATAGGTCATTTTGGCAAAAATTTTTTCTTTGTCTTTAGAATTTGAAACTTTGAGGTTTTGATTTAATTACATATGACACTCCTCTTGTCTAAACCTTTCAATTGCATTTATCAACTACCACTCTTTTTTTTTTTATCAGATCAGACCTATTTTAGATATCTTGCTGTTCTGCAAGATATTTGTTAGAACAGGCCTGCATATGTTTTCTATGAATGGAGACTGAATTTAAAACATTAAAGTATGAGATTGTTTTTCATGTGTGTTCACCGGAATCTGTTTAAGAAACTACAGCATGTTAACTCTCCATCTCATTTTTCAGAAACACACGTGCACAGTGGAAGAAATGCACACACA GCATTGTAGCCAGGC 52 LPAR32420638 GGGCTCGGCGGCGCGGGTGAACGTGAGCG 53 LPAR3 2420639CTGGAGAGGAGGCGCTCCGCCCGCCCGCCGCGTCCTCCGCTGCTTCTCCGCGCCCGGCTGGAGCCCGGCGCCCGGTCGCCCC GTCGCGCTCGACCCCGAGGGCATGCGGCA54 FMO5 2433231 TTGGCAGTGCAATCAGCCTTTGCTAATGGGACTATTCCTTTTAATCTGGTAGCTGCAGCTTCATACTCAGGAGCAAGTCTCTTG 55 FMO5 2433233GTCTGAGAAATTGTCCCGGAATAAAGGGGCCTAAGGAGACATAACATCTAAATGTAATGTAGTATCCTGGATGGACTCCTGCAACAGAAAAAGAACTTTAAGTAAAAATTAAGGGAATATTAATAAAGTATGCATTTTGGTTAATAATGTATCAATATTGGTTTATTAGTTGTGACAAATGTACCAGAGGAATGTAAAATGTCAACAATAAAGGAAATTGGATGTGGGGTACATGAGAATGCTGTACTATTTTTGCAACTTTTCTTAAATCTAAAACTCTTATAAAATTTAAAAATAAAAAGAAATGTGGAGTTATTATTATTATTTTTTGGCTCAGGATTTGACCCAG AGCTATGGTCTGGCAGA 56 FMO52433234 CCAGTTTTTCTCATGTCGTAAAGTGTAGTTCTGAAAAACAGAGCAAATGAAATGCAAAGCAGGTACTTGGGTTTACATCCCAGTGCCACTGATGATTCTGTTTTCTCATCTGTGGAAGTTTCACTGTTCTTGTTTCATGGAGAAATTAACTAAGTGTCAGCTGTCAGGCACACTGAACTCAGGTGATGTTCATTAATAGCTGTTGTACAATATGTTTGTATTTGGATTGCTGCTTATTACTTAACAACAGGATAAACCTGAACAATGGAAAAGACCAACATTAGAGAGTATTATCTTTCCAAATACACACACCTGTAAGAGAACTGGAAATGTGAGAACTACAACTTCTTCTTATTTAAACATTTGAACAATTGCCGGCCCTTTCACCGAATTTACCTGTGGAATGCCTTTTGAGAGTTAGAGAACTGAGAACTGGTATTACTTTTCAGGTCTTTTGCTTTCCCTAATCCTTGTGATACTGGAGATTTATCATCTATTAAAATGGACCTAGTATTTTTAAATCTGCATATCAAAAGCAAATTGAATGTCTCTTGCTTCCTTTTAATTTCTTTTAACATATAAATTTCTCTTTTAGCATGTAAATTTGTTGAATTAACAGCCCTTTGATAATATAATTCCTAGTTATCAGCAATAAGTACACCAGTTTCTTTTTTAAATTAGGAGTATGTAATTCTAAATTAATTGATTCTCTCATTGTACATATTATATGCAAGGTTACAAAAAAAAATCAATGGTTAATGATTTTTTAGCTCAACCAAGCTAAAAGATGTGAACAAGAAATTGAACTCAAAACAACTTAAGATACAAAGCTCTTGTTACTGATAATGTCTAATAATATTCATCAATTTACCATATCTTGCTCTTATATTAAAATGTTCTATCATTTTCCTAATTATTTTAAAGTCGATTACAAAAATATATATATATTCTTGTAGTGCCAGAAAATTGAATACATTAATAAATGGGGTAGAATAGATGAATCTCCCATGAAGAAGAATTCCAAATAATTTATGAACTCTGCCCTCAAGGATATGGAGCAGAACTTCCTACTTCTCTAGTGTGAGCTGAATAGTGACTTCCTTCCAAAAATTACATATGGAAAGGGGGAAAATAACTTTGTAGTGGAGAAATCTGATAAACACTATCTCGGCTAGGTTATCAAGA 57 FMO5 2433235TCCTTGTGGTAATCCCTAGACTGGGAGCTCAGGTACTCTTTTAGTCATCTTTGTATGTCTTTAGCAGAGTTCTTGACATGTGGTAGGTGCTTAATAAATGTTTGTTGTTTATCAAATTTTATGGTAGGGAGAGTAAGTCAGCATCGGTATAAAATCGCTTACTCCACGTAACT CTTCTTCTGATAGGG 58 FMO52433236 TCTTTGCTATAATTATAGCTTACTTCTAG 59 FMO5 2433237GTAGTTCTATGACTTCAACAATGACAATAG 60 FMO5 2433238GCCAACGCCATACCATTCAGGGAGACTACATAGATACCATGGAAGAGCTTGCTGATTTGGTGGGGGTCAGGCCCAATCTGCTGTCTCTGGCCTTCACTGACCCCAAGCTGGCATTACACTTATTACTGGGACCCTGCACTCCAATCCACTATCGTGTACAGGGCCCTGGAAAGTGGGATGGGGCTCGAAAAGCTATCCTCA 61 FMO5 2433239GATGGCAGAAATATCTAAAGCTCAAGAGGAAATTG 62 FMO5 2433240GTCTAAAGACATTGCCCTCACAGAGTGA 63 FMO5 2433241TTCACGGAGACAGCTGCCATATTTGAGGATGGCTCCAGGGAGGATGACATTGATGCTGTTATCTTTGCCACAGGCTATAGCTTTGACTTTCCGTTTCTGGAAGATTCCGTCAAAGTGGTCAAAAACAAGATATCCCTGTATAAAAAGGTCTTCCCTCCTAACCTGGAAAGGCCAACTCTTGCAATCATAGGCTTGATTCAGCCCTTAGGAGCCA TTATGCCCATT 64 FMO5 2433242AAACTATTGACCTGTGGCCTTATCATATCACACACAGAATATTATTGTTACTTGAGAAATCATATATGCACTCCTCAAACAACACTCTTCCTTCACTCCTCCAACACTCTCCCTTTCAGTGCATCCAGGGTCCAACTTCAGATCTGATCTTGATCTGTGCCAACCTAGTATAAATTAGACCTTTTCCAAACTTCATGCATAGACCAAGGGGAAGATTA 65 FMO5 2433243TGGGAGTGCAGGGATAGTGGCCAAAGCACAAGAATAAGGACTCTTCACACTGGCTAATAGTAAAGCCACCTCTACCCATACATTA AGAA 66 FMO5 2433244TCGTGTAGGGGACTACGGATATCCTGCTGATGTGTTGTTCTCTTCTCGACTTACACATTTTATATGGAAGATCTGTGGCCAATCATT A 67 FMO5 2433245TTCAAAGGGCAGTACTTCCACAGTCGAGACTATAAGAACCCAGAGGGATTCACTGGAAAGAGAGTCATTATAATTGGCATTGGGAATTCTGGAGGGGATCTGGCTGTAGAGATTAGCCAAACAGCCAA GC 68 FMO5 2433246ATGAATGTCTTTGATGGAGTCATGGTTTGCACTGGCCATCACA CCAATGCTCATCTACCTCTGGA 69FMO5 2433247 AAGGTCTCAGGACATATAGGGGTCAGGAGAAGAATAGGCATTTAGTGCATGGAGTGTCATAAAAGCACAGGAGAAGCCCAGGCTTTACTCAGGTGTTACAGTGCCTTAGGACCTGGACCAAGAGACCTAGTGACTTGCACTTTTCTAGAAGAGGAGGGTACATTAGCCTGCCAACACTATGTTATTTTTTTCTGTCTTGTGGAAATTTTCTCATTCTGACTACAGCCCCAAACAGTTCTTATTTGTGGAGTATGAAAATCAAATATCCCTGCATGGGTCCTATTATGTGATA 70 FMO5 2433248GAAAAGGAGCCCTATAGCTCAGTCACTTAT 71 FMO5 2433249TGGGCCCGTAGAAGCACATAGTGTTTCCTTAACCTAAGTAGGGTAACCCATATTTATTATTTTTTATAAAGCTAAAAATCATAACACTATCCTGTTTCACAGCCTCTTTCTTTATAGTTCTTTGTAAAATGGGTATTTATGGGAGCCAAAGGGAGATTCATTTATATAAAATGAG AGCCACTGAGGTGTTTTTCTACCCTA72 FMO5 2433250 TGCACATGTATTTATCCTACCCAGGCAAAAACTCCATTCTTTGTCCTCCTTTGCTCCTCAAAAATATTCAAGGGACAGTCTCTCTTTCATATATTTTGGCTGCAGATACAGGAAGCCACCTGGCAGAGTGTTTTCATTACCTTCATTTCACATTATTTGATTGCAATAAACAGATGAAGGGAAATGTTTTCCCCATTACAGAAGGGAACTGATAGGTATGGGAACTTTAAAACTCTCTGGTTCCACAACTTGTCCATTACTGCTTAGCCCTTTTGTACTTTCTGAAGTACTTTCCAATATATTTGTTTACATGAACATCATAAAAACCCAGTAAAGTATAGCTCTTGGGTAGTTAACTCTGGTGTAGAGGGGAGAACATGGAATTGCAGAATAAAAACCTGAATTCTGGTGCTTGCCCTACCACTAACTAACTTAGATGTTAGACAAGCAATTTCCTCAATTTCAATTTTTAAAAATTTTCTTGTTTGTAAAACAAGATGATTGTACCAGATCACTTCTGTGGTTCCTTCCTGCTCTAAAGTATTCTAGGACTTTTCTATAATTTCTGATCACGACCATAAAAGAATTTTATGGTCAGATATTTCTGACAGCTGGCAAAAAGCCCAAACCTTCTGCCTTCTGATCATCCTGCTAAG 73 FMO5 2433251AATTGTGTGGGTATCTTTGTGTTTGAAGTTGTTTGCCAA 74 FMO5 2433252AGGAAGGGCCAGTATTTACAAATCAGTGATCATCAATACTTCTAAAGAGATGATGTGCTTCAGTGACTATCCAATCCCAGATCATTATCCCAACTTCATGCATAATGCCCAGGTCCTGGAGTATTTCAGGATGTATGCCAAAGAATTTGACCTTCTAAAGTATATTCGATTTA 75 FMO5 2433253GAGCGGGCTCTCTTCCATCAAGTGCTGCGTAGAAGAAGGCTTGGAACCTGTCTGCTTTGAAAGGACTGATGACATCGGAG 76 FMO5 2433254GCGACACTAACAGGTGAAGATCTCGGGAGACC 77 FMO5 2433255TGAGATCCGGTACCGCAGCAGAGCACTCTCAGCTCTGGGTCTTGCAGGCGCAGGGCTCCCCCATGCCAGCAGAAAGATTTCCTCTGGTGAAGAGGACCGTCGAATCTGTCCTCCTCAAGACACCTCTTGTACAGAATTTATTCGAATGCCACGGCCAAGGTCTTCCTTGA AA 78 FMO5 2433256AGCCCACGTTTTATTCCCATCGAGGGAGGGAGAATGGGTGCCGCTGAGTGGGCGGGGGAGTGGTCCCTGAAAGGAGGTGGAGTGCTACAGCCCCTCCCCGTTGGCTCTCGCTGTTTGTCCGTTGTTGGTTTATACTAATTTGACAACAGCCGCCTGTTGAGTCTCCTCCAGATCGCAGCTGAAGGATCTGTTGAGCGCTTCAGGAAAGGC 79 FMO5 2433257TCCGCCCACGGCAGGAGCGAAGGAAGGCCCTGGCGCGGGCGGGTAAACTGCCCACCGGGCGGCCCACCCGCTGCGCCCCCGGCCCGCAAGAGGCAGTCCCAATAGGTTGGCCCGCCTGGCCGAAGTCCGCCCGGAGCCCGCTCACCTGTCAGCC 80 FMO5 2433259CTGTCCTTGGTGTATAATTCCTACAACTGGAACTGTTTGTGCATCTTACTTAAATTTATCAGTTAATATTAGGTATTATGAGTTCCCCTTGGCCTTAACCCCTACTCTTATCAAAGAAACATGTTTAGAAAATGAAGCTTATCTTCCACAGGACTTTAGGCATAAAATGTGATTA 81 FMO5 2433261GCTGGTGAAAAGGAGTAGGTTTGGA 82 FMO5 2433263GTAGTAGTATTCTAAGAATCGCGTGATGTTTTCTTA 83 FMO5 2433264AATGTTGGATTAGATACTGAGGCTGTAGTCCCTGCTGTAACGGACATGTTGGAAGCTGGTGTTCTAGATACTTACCTGGGAAAACACTGGTCTATCAAACTCGCTGCTAATGCTGCAGTCACTGTACTT AGAGTGGGTCAGGTAATC 84 FMO52433265 GAAGTAATCTCTAAACTTTATGCAG 85 FMO5 2433266ACTGGCAGAAATACTCTGGAGAAAACTCTGG 86 FMO5 2433267AGAAGTTTGCTGAGGCGTTTGAAGCTATTCCC 87 FMO5 2433268ATATGATGTTAGTGAAGCTAAACTCAAAATGGGATGTCTGAAG ACTCTGTAAAACAGT 88 FMO52433269 AAATAGCAGTGTACTCTTGTCCTTTTGATGGCATGATAACAGA AACTAAG 89 FMO52433271 GAGATACTCAGGTGGTGGTTTTTAAGCATGAAAAGGAAGATGGCATCATTTCTACCATAGTACTTCAGGGCTCTACAGACAATCTGATGGATGACATAGAAAGGGCAGTAGATGATGGTGTTAATACTTTCAAAGTTCTTACAAGGGATAAACGTCTTGTACCCGGAGGTGGAGCAACAGAAATTGAATTAGCCAAACAGATCACATCA 90 FMO5 2433273AATGAAGTATTTCTGGCCAAGCTTATTGTTCAGGCATGCGTATCTATTTTTCCTGATTCTGGCCATTTCAAAGTTGATAACATCAGA GTTTGTAAAATTCT 91 FMO52433275 GTACAGCATATGGACGAAATGGAATGA 92 FMO5 2433277AATTCTCTCTTTGACATGGGCTTTCTTTTTAAGAACCCAAGGCATTGTTTTGTAGAGAGTCTCTAAATTTAGACTTGCATAATTTTTTTCCTTTATTATATTCAGGTTAAATGTTTTTGACACATATACTACATAGGACATGTTGATCTTAGTGGGTCACATCAAGAACCACATTATGTCAGTTTATCTCACAGTAATAATGCTAAATTTGACCACTTAGATAAGGTGGTATAGATACCATCAAGTTTCTCCACTATAAAGATATTTTTTCCCGTTGAAGTTAATCAGTGGGGTGA 93 FMO5 2433279CACAGTGAGGAGGTCTATGCAAACCTACCCCAAAGGCTGAGGAAGCTGAGAGGCTGAAGAAAGAAGCTGACAGATTCAGTTTCTTAGAAACATTTCATAGGGACTTATGAACAGAAGCCATGTCTGTCTCAGGCAGTGGTGAGACAAGATGGTAGATCCCCATACCATTATCTCCTGACCCAGGGATGATATACCACAGGGGAGGGGCACACATACTTCAGAGCGAATGGGTAGGAGTTTGCCCTAAGGGTGGGATTTACAGTAAGTACATACTATTAAACAACAGATTAACTGGAAATCTCAGAGGTATTCCCGAAACCAGGGTTGATCAGAAGTCA 94 FMO5 2433281CAGTTCTTTTTGCATGATACCCAACAACAAA 95 FMO5 2433283GGACCCATGGCGAGAGCCATCTTTAATATCATTGGCTTGTCAAATGGGCAGTTCTAAGGGAGCTTGGCCTTACCTGCTCTGGGGA ATTGCAGGTTGCCACATAACA 96 FMO52433285 CCCAACAGAGAATAGGGATACCTGCACATAGCCCTTCAGTGCCAGTGGCAAATATAGGGCTTCGTTTCATTACCTCAGTTGGCAA CATGGTGATTGGTGCTAATA 97 FMO52433287 TTCATTCTAGTATATAAAAAAGCAAATGACTGGGTGCAATGGC T 98 FMO5 2433289CCAGGTATGCTGTAGAATATCCCTCAGTTGGGATTTATCTTATTTTTTTCTCATGGTTAAATTGGGGTTATGACTTTTGGGGAGGAATATTATAAGGTGCCATTCTCCTCACCTCCCATCAAGGGTACATACTATCCACATTATACCCACTGTTTTTTTTTTTTTTTTTGGAAACTTAAAACTCATTTTATGTTATTATAAGTAAGAAATTAGCATTCAATATATGCCACAATATATCTTTGTTGAAGTGTAAGTTTGTTCCACTTTTCTATTTTTCATTTTCCAACTTTTATTTTAGGTTCGGGGGTACATATGAAAGTTTGTTACAAGGATAAATTGTATGGGGCTGGTATAACTGCTAGCCATATGCAGAAGATTGACACTGGATCCCTTCCT TTTGCCATATATG 99 FMO52433291 AGCTCGATGGGATCCGCATCGTGTGCAATCACCACCAGCTGAGTCTTCTTGTTCTCCACCAAGGTGGTGATTGTGTTAACCCCTGCTGGAAAGACGGGTGGTGTCTCGATGGGGGTATCCCCTTTGCTAGCAGCTTTCTTCTCAGTCCAGGACAACAGTCTCTGCTTCTTCTCTTGTTTTGTCTCTGGTCTGTGCTTGTGGGCCCGCGTAAGC AGTCAGTAGCTGTT 100 FMO52433293 CGTCTGATTGCCTGAACTGCCCGTCAAGGAGGTGGCATGTGTTCATCATTCATTTATTATTTAATCAACATCGACTATCATGTGTCAGACACTCCGCTGGGCCCTGGGGGTTCTAGAAGTAAGACTTGTTCCGTGCCCTCCAGTGATTCACGATAAGATCAAACTGTTCTTGTTCGGTTTACCTAGTGATAAATTGATTTAGTCCCTGAAATCCCTTTCTTACTGCCTGTGACCTGTAGGCCAAAATTGGGAACCTCTGAATAGTAGTAAATTAAAATCACCAAAGACGTCATTGTGGCAGT GGGTATCTC 101 LPGAT1 2454486GACCACTGGGTCTTGGGAATCAGTAGGGGCTGTATCCAGCACACCACTGCCCCATCCTTTTTTTCTTAACTATTAGTGTTGAATAAACTTCTCATAGTTAATCTACTTGCTGAACTCAGGAAATTCCTATCACTGACCCTGGCCAGGGCTTTAAAGGGTAGGAAAAGCATTAATGTCAGTCCTACACAGCGAACTTTTGATTTAGAAGAATGTGACAGAAAGAAAACATTTACTGAAATACATGGGAAGCTTGCATATTTCTAAAGTTGTCTTTATACTTTTCATTTCTCAAAGCTAAGTAAACTGTGGTATAGGCATCTCTAAGATGTTAGCATTTAAAACATCAATTGTTTTATTGATGTTTAAACAATTGTTTAAATCCCACTGAAAAATTTAAATATTAAAATATCTTGCACAGTCTACCAAATGAGTTAAATCGTTACAGTCGTGTCTACCTCTTATTTTTCTATCTGTATTTAGGCTGCTGTTTTGGTGAGATTCTAATTTCTTTTTCCCCTGGAACTACTTTCTGTGGAAGACAAGGAACAGACTGGGGACAGAGGCCTGAAAACAAATTGGAAGCACTCAGAGATCTATTGCTGACCAGCCC TATTCCTCATGAGTTG 102 LPGAT12454487 CTCCAGGGTGACAAATGCCAATAGATATGTGAGTTAATTTTTTTAAATATCTCCGTGAGTTGTAAATAGATGTGTATTTGATCTGCCCTATCCTTCTTTGATTCTTTAACATGTTCTCTCTCTTCTGTTTGCAAAATATGTTTGAAAGCATTGGTAGTGCTTTCCTTATCAGTAACTGGAGTTCTCCTGCTTGCACTAGAGAAGGTAAAGAGAGAATCAGTATTCTTATATGGCAATCTGGGGAAGCAGCAATATGCCACTGTACAAAACTGAAGAAAAGTTCCTAATTTGTACTTTGTGAAGGGAGATGAAAGGACGTTTAAAGTATATATATTTTGTCAAGAGGAAAGAAGATAAAACTATGCCAGTTTTATATCAATAGCTTGTAGAAGCTCAGCTCTTCTTGGTCTTGGCTAGACTGCCTAGATTCCCACAGCAGACAAGGTTGAGAATCCATTGCTGGAATCTTGGTATTGATGAGTTACAGTGATGGAACATGTGCTTGGCCACAGGCAGGTCCAGTCACTGCAAAAGTGACCAAGCCAGCAGGTCACCCTTAACTTCAGAAACAATTATTGGTGGTGAACTGTACTTAAATTGCAGAGAAACCTGTAAGTAATGGAAGGTAAAGAAAAATTACAGAATGGAAAATAATATTTTGGGCAAGCAAACAAATTCACTGAGAATTCCAAAAGTATATTAAAAAAGAAGATAGCTATGAGTTCAGATCTATCTTATTGGTCTTTAATATTACAACCAATCCTTAACTTTCCACTATAAAGGAAGGATTACTAGATTGATTACTTTCTGGATAGATAATCTGGTAATAAATGATAGGTAAATCAAAAATTACTTTTATTTAGGAGTTTGAATTCTTACTCTCATCAGACATTTTTTTTCTAGGGACGCTTACTAATTAAATGATTTAAGTTGTTTCTTAGGGGTTTTTTGCCTATATATTTATGACTGTGTTAATGAGTAGTGAAATGATGCGGAAAGACAGCTATCAGGAAGAGGAAATACAGAAGCCTGAATAATCTATGGGTTAGAAAAGCATCCCTGAATAATCAAAAATTGGCAGTATTGGCATTGTTCTCAAGCCTTTTTATGAAAATGAAATCTGAAATCACCAAATGTAAACCTGGGAACATTATTCTAGTGTTGCTGTCTTGGATTCATGTTAAGAAGCGTCTTCATTCTTTGCTCATGTTGCCCACTTCTTGTGGATTTGTCTGAGTGTTTTTTGACAATCACTTCCTTAAAGACTCTTCTGAACTAGTTGGACCTGGTTAATC 103 LPGAT1 2454488GGTCACCGTAGGAGTTCAGACTTTCTTTCATAAGTGTGCATTATTTTACATGTGCAAATCAGAATATATTTAAAAAAAAGCAAAAGAAATTCAATGGATGGATTAATATTTATCCCCCTTTGGGATATTTTAAAATCTACTAAAATGAGGATTAGTAATATAATGACCTGCTAATATATTTTAAGAACATGTTTTAAAAAGATACACTCTATCACATATTTAAGCAAACATCACATTTGGAGAAGAGGAAATCATAAAATCATCCTAGAAGACTATCTGAGAGAAATTCTGTTGCCACCAGTTATACTTGACAATTTAGTTGAAGCTCAGAAAGTTATATTCATCCCTCTTAGCTGTAGTCTATATTAGGGCAGTTCTCTAGAACGCCCACATTTCCACCAACTCAGTAAACTTGAGGGGAGCTGGTTGGCACCTCGTGAAGAACTCTTTCCCTGTCGTTTGCAGTAACAAACTCCAGTCTGTTGCAGTAACAAACTCCAGTCTGTTGCAGTAACAAACTCTAGAATATTGACATTCTCTGTGGGGGAAAAGCAGTGTCCACTGGACCCCTTCTGGTACTGGATGTGTTCTTTACAAAGGCTAGCTCAGTCCAACACTGTGTTTACATACACTCGTGCTTTTCCTTATCTGACTTCTCATTTTGTATCAGAGGCATATCATAAATTGATAATTTTGCAAAATGCACTTTTTTGAGATGCAGATATAGCAAAGGATTAGTAATATAGCCTGAAAACAAATGGGAGCATAGCAGTGTGTGAGGTTCTCGAGAACTGTCTTGTCTCTGTGTGTTTATTTGCCTGCCAGTGCTCTCCAGCGCCATCCTGCCCTGGACACCACCCTGACGTGATGCCTCTATTGCAGCTCAGAGGCTTTATTTTTTCCATTTTGACATTGGCACTAAATGCATTTGGGGATGGTTAAAACAAATTACTATAGAACATTTAAATGATCAGTTTAAGGGGAAATAGGCTAGTTTATAGAAAAATAAGAGCTAGTGGCTTATAATGGTGACAGGTTCTCATGTGGCACCCCTAGGACCTGTGCAGACAGTAGTCTGTTGAATCATTACATCAAGGAGCTGCCCCTGTCAGGGTGAGTGTAATTAGGAACGATACCAGCACATAAGGCTCCCCCCAATCTCTTCCAGTTGCTTTTTCTTTTTTCTTTTTTTTTTAGACAGGTCTTACTCTGTCACCCAGGCTGTAGTGCAGTGGCATAATCTCAGCTCACTGCAGTCTCTGCCTCCCGGGTTCGAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCACCATCATGCTTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGCCTCGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCTTCCTAAAGTGCTGGGATTGCAGGCGTGAGCCACCACGCCCGGCCTCCAGTTGCTTTTGAAGAGGGTAAAGTCAAGTTTCTATTTCTAGAAAACATTTTTTAGAAATTTGTTGCGATGTTTGTACAATTTACCTCATAAGAGAACCACACCCTTCTCCAAAAGTGCTGGTACTGCATCAGTGAGATGAGTAGGGTTTTTGTTTGGGATTGTAAGACTATTAAGATCCTAGTAAGTCAGTGGTAGTTTACTGTGATGTGAGCATTGTAGATTCCCCCGTTGTCACTAATCACACAACAATTTTGAGAAGTAGGCTATAAAACAAAAAAAGGTTGCTGTTTTCTATTTTTAAATAAACCAAAAAAAAACAGAAAAGATGTGAATTTTCCCCAGTTATGTGGGAAAGGTAAAGCAACACCAAATAAAAGCCCACAGCAGCTTCATCTTTACGATAACTCAGTGCATATGTGAAAGAGAATGATGCATTAACTGAAATACCTCATTGAATATTATACTACTACTGGTAAAATGCAGAAGACAGTGTTAATGTGTTTGGTTTGGGGACTGGTTGTTATAAAATGCAATTTTTTTTTAAATCTAAGCATTTCATTATGTGTTCTACAGTGTCGGTGAATAAATGAAACCAATCTCAATTTAGAGGTATGGATGATGACAGAAAGCCCAATAGAAGCTTAATGATGCTTCTGTTTGAGGCCCAGCAAGCACCACTAAATTACTGGATGAAATGAAATTGTTCACTTGAGGGATTAGTCAACCATCTGGGGGAGAAGTTGCTCACTGTCAAATACAGCATGCACGGTCCTAGCTGATAGACCTTTTCCTCATTGCTACAGCAAGCCACAGGGTAGAGTGACCAGTTCTCCTATCCAAAAATAAATGCGAACATGCATACATAAATGTGGCTGAGGGCCACTTTTGCCATCACTGTGC 104 LPGAT1 2454489GTACAACATCATTCAGTATTTTTACCATTGCCTGTTTT 105 LPGAT1 2454490GACCCTCAGCAACTTGTGGATATTTCTCATACAGTCTTTTGCAT TTTTGTCAGGCTATATGTG 106LPGAT1 2454491 TTCCAATTAAAGATGTACCCCTGGAGACTGATGACCTTACCAC TTGGCTCTATCAG107 LPGAT1 2454492 CTAATGGACCTGAACTCTTGAAAGATAAAGACTAAAGCAAACACAAGAAGGTGACATGGAGGACCAGACTATACAGGGCAAGGTCTGCTTCTAGAATTCCTAATAGTACATGGGGGTTCATTAACCTTTTTCTCTCCTCTTGTGAATGTTTAAAAATTTCCATTATAATTTAAAAAACTTATTATAAACATAAGATATTGTAGCAATAATACAATAATAGCATACTATAAAAAAGACTGAGAACAATAGGAGCTCTTTA 108 LPGAT1 2454493CAAGGTCACGCAACTGGCAAGTGGTAGAGTCAGGATTCAACCCCAGGCAGTCTGCCCAATAGCTTTTTTTTTTTTTGAGACAGAATTTTACTCTTGTTGCCCAGGCTGGAGTACAGTGGTACGATCTCGGCTCACTGCAACCTCCGCCTTCCAGTTTCAAGCTATTCTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCACCTGCCACCACATCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTGGCCAGGCTGGTCTCGAGCTCCTGACCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTCCTGGGATTACAGGTGTGAGCCACCGCACCTGGCGTGATAGTTTGTATGCTTAATCACTAGGCCAC ACTG 109 LPGAT1 2454494GAGGAGATGTAAGCCTAGCATTATATG 110 LPGAT1 2454495GGCCCTAATTGGTTATGAGCCCATTGCTACACCCCAATACTTGTCATGAAGAGAATGATATATGATGACAGGTCTGACATGGGTTTTTAATGAGAAGGGTGCCAAGACTACCAGAATTGGCTGAGTGATAATAGATTGGCAGACATTTGCTTGGGATAAATTTATTTTGTTTTTTAAAGAAAAGCTAGATAATCCTTTCCCTTGGTGAGAGGATTC CTGC 111 LPGAT1 2454496TGTTTGTCAGCTCACATTTTGGAGTCTTGACGTAAAAATTCAAATGCTCCAACTCCAGTATAGGGGGTGCCAGCTGCTAAGTATTATTTTACATTTTTTTTGAAAGTGTAATTTCATCTAGTGCTTTTAAATCTGACTATGGATTTTGGTAGTATATTCTCTATTTAAGAGCACATTCTGAATTACTGATAATAAGAATGTTCATTTCTTGAAAATTAGGAGCTAGTTTTTCATTTGGGTAGCTATTGGTATTGTAAAGGTTTATTTCTGGTGTATATGTATTTACTTATTTAAATCCCACAAGCACTCCTCTGATTTGATTTCAAGAGGACTGGTATTCAATGTATTTAATCCTTTGCCATATTAGGGGATTAGTCATTTTAATATTTTAATCCTA TGGTGACCAATCAGAGTAATA 112LPGAT1 2454497 GCCTTTTAGCCTTACTATGTTTCCATGTGAAAGACCTCAACCCGTGGCAACTACCAAGGACA 113 LPGAT1 2454498ACAGCAAATCAAAAGGCCTCCAGTGGATAATAGATACAACGATAGCTTATCCCAAAGCTGAACCTATAGATATTCA 114 LPGAT1 2454499CAGAGATCGAAAATGGATTGTTTTGTTTCCAGAAGGGGGCTTCCTCAGGAAGAGGCGAGAAACAAGTCAGGCATTTGCCAAGAAAAATAACTTGCCATTTCTTACAAATGTTACTCTGCCAAGGTCTGG GGCAACAAAA 115 LPGAT12454500 TCTTGAGAACTTAATAGCTATCTTAATCATAATCAGTTCACTTCAGCAAACTGACTAACAAAATGTCTTACATGTTTTGCATTTGGGATACATTTGATCTAAAGACTGAAAGCATACTAATTATTTTGAGGA GTTTCTGTAATTTTGTTGGCTG 116LPGAT1 2454501 GAGAAGGCAGCGGAACCAACAATTAGAAAGCTTAGCAGTCTCAGGGATCCGAAAAGCTAGCTGAGCACCTTACCTCATTTCCAGCTTTAGGAAATAATTGAATTTACAGTGTAGTGTAACAGTTGATTCTAATGATGATCATCAGGCATCAAGAAGAGGGGC 117 LPGAT1 2454502GATGTGGTTGATGGATCATATTTTT 118 LPGAT1 2454503TTCTCTATGCTGATAGGCAGTCTGCACTAAGTTGAGCATAAATATGGTGACCTCCTGGGAGCAGTGAACAACTAGGTCACACAAG AAGGGTGAACC 119 LPGAT12454504 CGAGGCCATCCAGGACAACAGGGTGAA 120 LPGAT1 2454505GCAACAGGAGATGTGTGCACACTGAT 121 LPGAT1 2454506ACACAGTAGGCATAGGGCTCTTTTAGTTACTAGTGATTCCAAAAGTGACTTTAATCCCATTACTCAGGATCTCTATGGTACTGTCAATTAGATCTTCCTCATTTTTGCAACATGTTTACGTAGCATTAATGATATTATTGTTTCATAAGTGAGAAAATGAAGACACAGAAGGATAAAATAGTTTGTTGCATCAGCTTGCGGGCATAATAAGCAACCTTTCTTCTCTCTGTTAATTCTGTTTTGTAGGCCAGTATAATGGCTTTAGTGTCACTGTTGTTAAGGAGTTTTTGATGGGTTGTTTCTATTTTCTTTTTGAGATGTGAACTGTCCAGATTAATTCTAATCTATAACTTTTGGGAAAAGTATATTGATATACATGTTAGAATGTGTGTGTGTATGTGTGTGTGTTGTGTGTATGTAGTAGATGATAACCTTTAGCTTTGGTTTTCAATAAGAATTTTAAAATTTATTACAATTAGAAAATTTTTCCTCCAGTTTTTATTCAGTTGTCCTTTTTCCCTTTGGAAATAGTGGACCTGACCCAATTCTTTTTTGAGAATTCATTTCATAGAGCAGCGTGTTAGAATATTTTTGTTCTTCTAATCAAGTGCAGTGTAAGAACTGTAGACATCCATAATTTCTTTTCTATCCCTTGGTTAAGATATTAGCTTTATTACTATATTTACTGGTCCTGGAATAGCAAGGCATAATCTGAGGAGCATAGCTACTTCATCTGTGTAATAAATTGCTCTTTCACTACAAACATTTTAATACTGATTTTGTTGGTCATTTAACTTTCTAATAGTGGTCCTTAAATTATGCTCTAAAAGAAGAATACCATATATATTGGAAATTAAATTTGTTGTTGAATAAAATTAGAATTATTATAAAATTCAACACGACCTTATTGCTACCTCAGGA 122 LPGAT1 2454507CCTACTTCCTAACTATGTAAGTTTGAAAACAGTGCTTAACCTTTTGTGCCTCATTTTCCTCATTTGCATATTGGGGATGATACTATCTGCATATTTGGAATTTTGTGAAGATTAAATCAGAAAATAATGTAAATTATTTTCTATTACTAAGTACTAGTGCATGGCACATAATAAACATTCCATAAATGTTAGCTATTAAGATTATTATTTATATATCTATTTAATAATATCTGCTACTATTATTATTTTAGTTATGTAACCCCTCCAAAAGCTACCTCTTGAGCCTTGCTTTCTCAAATTTTAACCTCTTAAAATTTAAGAGTCAAAGGGACACTGACCATGATTTCCTAGTGT GTACAATG 123 LPGAT1 2454508CCTTGTTTCAAGCTGGAAGTGGGGATAACATAGAGCCCTTCACACATCTGCTTTTCTCATCCCCTTCAACTGTCTGTTCTTGTTTTAAGAGTGAGAGATTAAAATGTTGATTTGTAGCCAAGCAAGTGGCTGTGGCTTATCAACATTGAGCCTCACTGTAGGGTAATCTTATTGGAATATTTCACTGGGGAACCCCAAATGTCAGTATTTTTAGGTCTTTCCTCTTGAGGTGATCAAATTCCCTA 124 LPGAT1 2454509GGTGAAGTGTCCAAGTCTTTTCTTAATTTTTTTAATTGGGTAGTTTGTTCTCTTAATGCTGAGTTTTGAGAGGTTTTTTTTTTTTTTTTGAGACGGAGTTTCGCCCTTGTTGCGCAGACTGGAGTGCAATGGCGTGATCTCAGCTCACTGCAATTTCCACAACCCTGCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCACACCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTTTTCTATATACTTGGGATATAAACCCTTTGTTGGATATGTGATTGCATATTATTTTCTCTCATTTTATTCTCTTAACAGTGTCTTTTCCTCATTAAAATGTTTACATTTTGATAAAGTCTAATTTATTGATTTTTTTAAAAAAATTGGGCAGCCCCCAAGCCAGAATAGGTTGAGAGAGACTCCCCAGTTCATTGATGTTATTTTCTTTTATGGCTTGTGTTTTTCATGTCATGTCTAAGAGTACT TTGCCCA 125 LPGAT1 2454510GGTCTGATTTGTTACCTGATGCTCACAGAGTACT 126 LPGAT1 2454511TTTCTTTAGTAGGAAGTGCTGTACAGATATCTCACGTTGAGGAAATGCTTTATATTGCCTTTGTCTTAATATTTCAAGGGCAAACCAAAAGAGATACTAGCTTAACTAATGATCCACTTCTGCATGCTTTATTTGGATCTAGGATAAATCAGTACCCCACCCCCCGGAGTTTAA GTGATGATTGGTA 127 LPGAT12454512 CATTTTATCCACACACGCAAGAGAAG 128 LPGAT1 2454513GTAAGAGTGAGAACACTTTTCTTTAA 129 LPGAT1 2454514AGGTTTGCCTTCATGGTCGTCAACAACCTGGTTGCTATTCCATCCTACATCTGCTATGTAATTATACTTCAGCCCCTTCGAGTGCTGGACAGTAAGCGGTTCTGGTATATCGAAGGAATCATGTATAAATGGCTTTTAGGAATGGTAGCTTCCTGGGGATGGTATGCTGGAT ATAC 130 LPGAT1 2454515CCTTGCCCTCTGGTCGGAAATCTCATTCTCTTCATCCCCAGTTCCTTGGCTTTTACCTCTTTCTGGCTTTTGCTCCCTTCCCCCTACTCCTGTCCTTCCTCTTTTTCGCATTATAACCCCCTACTTTCTTCCTCTCACCTTGTAAGCTTTTTTTCTAGGCCCCCCATTTTTTTTCTTAAAAAAAAAAGGGAAACAAAAACCCTATTGCTACAAATGAGAATTTTGAGGGTAACTCTTCGCTAGAGCCAGAGACCTTTTAAAGGAATGCATCGGTGTGCAGGAATCGTGGTGGTGAGGAGACTGAGGTCCTCAGTATCTGGGAAATCTTATTGAGGGGACCCTGTTTCGGTCATGTCACTTGTGTCTTCAGTTTGGAGATCCTGAGGTTGTCTGAAGCGAGTGGATCTATTTTTCTAAGTCCAATAGACGACCGCAGTGAGACACGGTGCGGGGACGGCCACCGATTACTGAATGGGAATTGTGTTATCATTTGCTAAATATATTGTGACATACTTCG TGCCTCGGTGAACAGCTC 131LPGAT1 2454516 CAGCCGCGAGGGGAGTAGGGCGCCAGCGCGCCCGCTCGCGCAGCGCCTCGGGCCGCTTGGGCCGCCACCGCGTCCATGACC GCGACCCCTCGGCGGG 132 LPGAT12454517 CCTTGGGGACCGAGTCTCGGCGCCGCCGGGGAACGGGCGCGGGCCGCGCCACAGCCGGAGCGGGGCAGGGCCCCGCCACCGCCTTCTTCCGCCGGCCCCGCCGCCGGCCATGCATTCTTCCG GCTCCTCT 133 LPGAT1 2454524TGAGGCCAGTAAGCCCAAGAACTTAAATGAACATTCTTATACTTTAGTTTGCATTCTCAGAGCTGGGGAACTGTCTGTAGGCACAGAAGATGGAAAAGGGATTTTCTGGTCTGTTTCTGACTTTAAGTTACACATTTTAAAAAGTACTCTGAAGACACTGGGGTTTGTTCATCC CCGGCTTGCTACTAAAGTAGTAATG134 LPGAT1 2454525 TGCCAAAGGAATTCTGCTCAGCAGATTAAGTATGTTCATGTTTTAGAATAAAAATTGCCAAAACTTTGTTGAGAAACCACTTATGAGGAAACCTTAAATACTAATTAGGAAGCTAAAAATTGAATATTGGTATATTGGTATAGAATGAATATATATATATATATATATCTTTTTCCAAATTATGACATTCCGTGTAATATGAGTGAATTACTCAGCTCTG CTGATGAGGACTTATGTTG 135ERO1LB 2462330 CTATGCAATCCTCGAACTCAGTGTGCTTTTCCCTGACAGGATATATAAAAAGGTAGATTAGGTCAACCCTCCTTTAAGCTTACTCTCCCCTCACCTTTTCTTTTCACTGTATATAAACGGTACTTTCTGTGATTCATACCAACAGAGGACTTTCTGTGATTCATACCAACAGTCCTAAACTGTCATTTTCTAAATCTGGGATTTAAAATCTTTAGACAATATTTAAAATCTTGATTTTTTTTAAATGTCAGCAGATACAATTTGGAAGATTGCATCTGTGTAGAAGTAATGCAGGTACAAGATCTAGAGTTTTTCCTTAGACTCTTTAGTCTTTTCTGAATTAAAGAATAAGTGCTCTTAAATCCATATTTTATCCTGTCAAAGTCTGAAATGTGTTCATTGATGATTTGGTGACATCTAAAAAATTGTATTTAGTTGGCTTGGCTCACCCCTCTTAAAAATACTTAGCCATCTCTTGGTGGGATGTGGTGGGGGTATTAAGGTCTCAGAGTTATTTATTTTCTCACCTAATTTCAAACCTTTATAAACTTGGGGTTTTGTTGTTGATGGTGGTAGTATTTTTTGTTAAGTTGTTTAAAAGGCTGACTTGATTGGAGCCTCCTCTACTTTTTCTTGAGGGTTGCAAGTATTGTATGGTGGGGGAGGGGGGCCTTAAGGCAAACTGTCTAAAAAGTGACTATCCAATTAATTTAACTAGTAAATTAGTAAGAATTATTCTTAGTATTCACTCAGAGTTTAAGATGTGAAAAATCTGCACTTTGTTTATCACTCTAAATGTAAAGAACTTTTTGATAGTGTTATTTCACCACTCCCTCAGTTAAAGGCTATTATTTAAACTGTTTACTGGAGAAAATCCTCGCTCATGTCCATTTATTGTTTTTTTCTGTACTGTGATTTGTTTCAAGCTTAGGAAAACTAGTATATTAGAGTATGTTCTAGGAAATTAAAAGATCTGGTTAGAGTAAAAAGTTCTTTTTAAGGTTCTTAACTAATTTTTTCACAACTAAGAAAATAAATGAAGTATTCTTAGGCTGAAATTCATCTTATTTTATCATAAATTAGATTGTAGGGGCAGCCTACATTTTTGTGTATGTGTTTTTATTTCTTAAATGATTGTGTGAGCCTGGTGACATTTTATGGTTCTTGTGATCTAAACTGTTTTTCCAATTCACATCTTTTGTCGTGAAGTGATATTATACTAGAGTACTGTTTGCATTGTAAAAATGCTTTGCTGGTGCTCTGGCATTTTGTCTTTATCTCATCACCTAATTTAAAAACCCAGCACTTGATAATATAACTGACAGAAATGATTGTACCCACTGATGAAGTAATGAAAATGAAGAAAAGGAAAATATTCCTTCCTTCAATGGCGTAAGTTTATTTTTTACTTAAGTGGCATCTATGTAAGTTAGACAAACTATATATTAAAATTGGTAAACTTTGAATGTTTCTCCTGTTTTGATTCTTAGATTATGAGGAGGATCAGACAGAATAAGACTCCACACTTTTGAAATTTGATAAGTCAAAACGTTTTATTTTGACATTTTTAACATTGTGAATTATTCGATATTTGTAATCTCTGTATGTATATGAAACTCTGCCATGTTTTTCAACTTTGCCTATGTGCCACTGTA 136 ERO1LB 2462331CTAGGGAACAAATGTTGCTCAGGGCTGGTGTCAGTGAGAAAAATTTATCAATGCTTTTTAATGTGTTTTTACCCTTGCCTCACTGTGTGTGTGTCACTTTCTATAATATAAAGAAATACTATAATATTTCTAGAATCTGGAACTGTCACCATGATGAATGGCCCTTTCAATGCATAGTTACAGAAATTCCTGAAGATTCCCCAGGACTTCAATTTCATTGGTTTTTATTTGCAGTTTTTAGTTGCTGTAATTGTTGCTGTTTC CAGTCTAAAGGACCTC 137 ERO1LB2462332 AGAGACATAAAGTGACTGTGGAAAGCCTTTTAATTATGGACATTCATCAGAAAGACACTAATCTGACTTCAAGAATTCTGAACTATT AA 138 ERO1LB 2462333TTTAAAGTCTTATTACAACACAGTA 139 ERO1LB 2462334GTACTAACTTAGAGAGGCCTTAATGCTGACAAGTCAGTTTCTCTACAGGTCATAGGAAAAACTAAGTTTCCAATTGCCAGTGTTTTTCAGTTTGCTGCCTTAATTTTGTAAGGGAGATATTCTTCTAATATTCTTTTTGCTTGGCTATAACTTGTTCAACTACAATAGCAGGAGTAAGGAATGTGTGATTGAGAAGGTGATAAAAGAAAATTAAAACCTTCATCTGCTCCTTATTTTTCTTAAATTTTCATTACTATTTTTTTCTTTTCTCACCTTTTTCCTGCACTATGCTCTTTATTTCTGAAGCTCAGAGGTCATTTTTCTTTCACTCATTTCTACATGATTTACTTCTGTATAGAGACATATAATTTGCTTGCTTGTTTATATCACCAGTGG 140 ERO1LB 2462335AGGAACTGCCCTGAAGATATTATTCTCTGAAAAAGAAATCCAAAAGCTTCCAGAGAATAGTCCATCTAAAGGCTTCCAACTCACCC GACAGGAAATAGTTGCTCT 141ERO1LB 2462336 TGTGTCTATGTTTCTATTGATACAATACCAGATTCATTTGTGAAGTTGGTGGTCATTACGAACCGAGTATATCCGTATTTTACATATG 142 ERO1LB 2462337ACATTTCAAGAATATCTCCCGTATAATGGACTGTGTTG 143 ERO1LB 2462338GTCCTTTCCCATGCACTTTGATGAGAAATCCATGTTTGCAGGT GACAAAAAAGGGGCCAAG 144ERO1LB 2462339 TTTATACTTGATTGAGCTTCGAGCTTTGTCAAAGGTGGCTCCATATTTTGAGCGCTCAATTGTCGATCTTTACACTGGAAATGCAGAAGAAGATGCTGACACAAAAACTCTTCTAC 145 ERO1LB 2462340GGAGAAAAGAGTCTTCTATAAGCTTATATCGGGACTTCATGCTAGCATCAATTTACATCTATGCGCAAATTATCTTTTGG 146 ERO1LB 2462341TGTCATATACTTTTAGGGAGGAAGCTACAAAATAAAATTCAATTTCTTTTGGTCCCCATCCATGACAATTTGAATATTCTAGCAAGAATTCCCAATTAGGGAACGAGAACTCAAAAGAATTATTTTTTCTAG TTAGAGGCCACGTGCTTC 147ERO1LB 2462342 AGCATATTTTTGTAAGGTCTAGGATTT 148 ERO1LB 2462343GAGAATCATTCTACACATGGCTAGAAG 149 ERO1LB 2462344AGAGGCCATATTTTTTAGTACGTTGGGTACTAGACTTTTCCTGTTGGCACTTGAGGTGTTTTGAATCACAAGTGATATAATGATAAATGATCCTTACTATATGTTGAATGAATTAATTTGTTAGACGTTTTCATTTTTGTACAAAGTATGAAGACTCTCAGGAGGCAAAGTAATTCCCCACCGTCTAGTTTATCCCTAGACTCCTTACTCAGCTCATCT GAGTGTTCGGTTTTTC 150 ERO1LB2462345 TTTGTTTGTTTCAAGTGTGGAGGAAATTTTTTGTAACAATCAGAATTTGATTTTTCCTTTATGGAATTCAAAAGAAAGTATTCCTG 151 ERO1LB 2462346CCTGGCCAAAATGTGCAAATCTTATACTCTTTGACCTGTATTCTGATTAAGAGGACTCATTTGCAGGGCGTCTACTCAGTGACCAAGGTTTGTGATATAATTAATAGTTTAACAGTTTTAATCTCAAAAAATAGTATTGGGATCTGAGCTATGTAAGACATTT 152 ERO1LB 2462347GCCTCGATCTGTTTATCGTCCTTTAAATCCTCTGGCGCCTAGC CGA 153 ERO1LB 2462348AAGAAGGAACGACTGATAGAGGGTCGGGAGAGGCCGGGTGCTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTGTCAACTAAAAATACAAAAAAATTAGCCGGGCATGATGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTACAATGAGCAGAGATTGCGCCACTGTACTCCAGCCTGGGTGACTAAGTGAAACTCTGTCTCAAAAAAAAAAGAGGGTGGGGAGGGGAGTATTTGTTTCTATTGGAATAAAATTATACACTATAAAAGTTAAAACATTCTATGTTTGGGTATTATGCTTTCTTT 154 ERO1LB 2462349GCTGCTCAGTATGTAGACCTATTGCTGAACCCAGAGCGTTACACTGGCTATAAAGGGACCTCTGCATGGAGAGTGTGGAACAGCA TCTATGAA 155 ERO1LB 2462350CCTGCACAACAAAGTAAGACCACTTTTCTTAAAAAAGAACAATGAAAAACCTGATATAATTGATTTTCCTCTTGTGATTTTTTAGCTCCCTTAAAGTATATTTTAAATCATCATGGTTTAATATCTGAATCATGGTTTTTCTTCTTTATTGGTTATTTGGTTGGTTTTCTTGGGAAAAGAGGTTGGTACTAGTCCAATTTGCACGTTTGTAGAGGATTCT A 156 ERO1LB 2462351CTGGGGAGGACTCTAATTCGACTTCTCCACAGCCCTTTTTCCA 157 ERO1LB 2462352CAAAGAAGCTTTCATTGACTGGGCAAGATATGATGATTCACGG GATCACTTTTGTGAACT 158 ERO1LB2462353 TGCTACTAGTAGTGTATCAGTTATCTGTTCTACAACTTCTCCAGTGATTGGTACTATGATTTTTAAACAGCTTTACTTTGAGGTATAATGAAATATGATACACTGCATATAAAGTATACAGTTTGATGTTTTGACATGTGTCCACCCATATAACATCATCACAATTAAGATACCAT AGGTTGGGTG 159 ERO1LB2462354 ATGATCTAGGGACTAGGCTTAAGTCATTGGAAGATTTTGGGGTAAATTGCCAGTTTATATTCTTTGTCATTTTTTTCTCCATTGGGTTGGATTTTAAAATTATTACTGATTTGTAAGCATTCTTTATATAATGTGATAATTCTTTGTTGGCTGTGTTGTTAGGATTTGTCCTTTAATTTTGCATATAGTTTTTTGTTGTTGAACAGAAATTATTCTTTAAACTTAAAAAATTTAAGTATAATACACATATGGTGGAATAGAAAATTCTTAAGTGTAAAGGTCAATGTAACTTTACAAAGTGAACCCAACTCTATAGCCACCATCCAGAGCATTATACTTGCTGTCCAGATTACCATGTGTACTTTCCTAGTCATTATCACCTTCCAAAGTTAACCGTGATTTTGAGATACTGACAGAGATTAGTTTTAACTGTTTATAAATAGAATGATATAGAACATATTCTGTTGTATCTGGCTTCTTTTTGTTAACATGTGTCTGAGATTCATTCATGTTTTTGGGCATAGTAATGTTTAATTCTTTTTTATTGGCACATAGTATTCTATAGTAAGAATGTGCCATGTTTCCATTCTGCTCTTGATAGCTTATGCTTTGGGGCC ATTTC 160 ERO1LB 2462355GAGCAAGCTAATAAACTGGGAGCAAT 161 ERO1LB 2462356TTCCGGTTGGAATAAAAGCTGGGCATTCTAATAAG 162 ERO1LB 2462357ATGTTCCAGCTACATGCACTTCTCCCATTGGTAAACCCTAGATTAGATTGGTAAACTCTAGGTTAATCGTGTGGGCCAAAAAAAGCTTTCTAGTAATCCAAAATTGCCTACACTTTGTTAGAGCAGAAG 163 ERO1LB 2462358TAATCTGAAGCGACCTTGTCCTTTCTGGGCAGAAGATGGCCACTGTTCAATAAAAGACTGTCATGTGGAGCCCTGTCCA 164 ERO1LB 2462359GGTTGCATACTGAGCACTACTTTAGCAAGCCTGGCCAGGAATGGTCTCTCTGCTTAGGTGTGATATGTGAGAGAGACTTGAATGCGGCGAAAGAGTGAGCCGTCATAAGATCTGGAGGA 165 ERO1LB 2462360ATGAGAAGTGCTGTCCCTTCCATTCGTGGTGGCAG 166 ERO1LB 2462361GCAGCCTCAGTGGAAACCTCAGGTAAGCCTGTGGGGAATTCTTAAGATGGAATAACCCTTCCGAGTTAGTCGTCCCCATTTGGCACGAGAGGTATAGGCCTTTATATCTCTCCATCAGTTGGTCATTGGATGAAGGCCACCAGAGGAAATAAGGATCCAATCTTGGGTAAGGTGGTTCTTTTCACCCAAGCTTGTCTACCTGCAGCATTTCCACAACTGAGGTAATTACATCCCCTTTATTCCTGAAGGGTGATCTGAGTAGTATGTTACAGTGTCTACCACAGTCCACTCGTTGCACC ATGTATTTC 167 ERO1LB 2462362TCCTACCTAATGTGAAAGAGCCATGAGAAGGTTTGGGGAAAGAACATGCCAGGGAAAAGATGTAGAATACCAAGTAAATGGTCTTGAGATAGAAATAAGCTTGGTGTGTTGAATAGGCAGAAAGCTGGTATAGCTGGAGTGAACGAGAGGGAGAGTTGGAAATATAGGTAGGCACCAGATTTAAAAAACAGTAGGACCGTATTGACCATGTAAGGATGCTGGATTTTATTTTAAGCAGGATAAGAAACTACTGAAGGGATTTTTGTGCAAAAAAGACTGTAAGGGTAGAAGACAAGAAATAGAGGAACCATTTAGGAGACTCTTGTGTTAGTTCAGATAAAAACAATACAGATTTGCAATAGAATGCTGCAGCTGAAAAATGTAGAAAATGATCAAATTAGGGTTGTACACAAAAGGCAACACCAGCAAGCTTTTCTGATGAATTGAGTGTGACGTATGATATAGAAATGAAATCAAGGATGATGCCTAAGTTTTGAGTGCACATATACAAGCACAAATGTACATATATGTAAAATCATGACCAAATAGATTTTATTCCAAGAATGCAAGGATGATTCTTGCATTGATGTTGATAATCATCAAAATTCAATATGTGCTCCTGATTTTTAAAATAATAAGAATGATGTATATTTCTTAACATGATGATTTCAGTCCTAACATCAGCATAGCTAACACGTCTTGCATATGGGGAAACACTAGAGGAATTCTCACTTAGGTCAGGAACCAAGACAAGGATACCCACTATCTGCATTAAC TG 168 ERO1LB 2462363GGAACCACTGGGATTTTGTATCAAATTAACTATTTTCCCATATTTTCCAAACTTTATGTAAGAGTTATATTTCTGTCCAGGTACGGTCATATGACCTGTTGGACCAAAAGAAGGAAGGACACCTTGGTTGACAGTCTCATTTGCATGAGTAAAAGTGGAGTCATTGTTTCCCAAAGGGAAATTAGGGACTGTTACAAAAGAAGGAATAATGGAACTTGGATAGGCAAAAGTGACAATGTGGTTCTTGGCTACTCAACAAT C 169 ERO1LB 2462364CCGTTCCTGAAGTACTGCAATACCAGGTCGATGCGAGGAGTGGATGGAGCAAGCTCCTATTCCATCTCCCTACTCCAAAAATCCATGTAATATATTGTTCTCGGGTAGAGGACATATCAGGTATTAACAGATACTTCACTTGATCTTAGCCAAAAGGCCGAGAAGCCATTGGAGAGACAGGTGCTTCTTTAAATTTCCACCACTAAATCTATAAATCTAAGTGCATTTGTAGCTGCTTTCTCTTGTTTCTTTTCTACCATAACATTGAACTATATGAAATTTTTACTTTTATATTTCAAAAATGGTTGAACATGCCAGTTTCATATTGCTCAATGTAATACAGTGGGGGAAGTGTTTCTTGTATCAAAAACCATCTCTTCACAAGTGGTCCA GTTCACA 170 ERO1LB 2462365GTTCTGGATGATTGCTTGTGTGATATTGACAGCATCGATAACTTCAATACCTACAAAATCTTCCCCAAAATAAAAAAATTGCAAGAGA GAGACTATTTTCGTTATTACAAG 171ERO1LB 2462366 CTGAGCTGTGTCTGCCAAGTGGCATCGCCAG 172 ERO1LB 2462367CTGACCGTCCAGTGCGGGAAACATCTGCGAACCGCCCGCAGGGTGGGGGGACGGCGACACTCCGGGTAATGGCAGTCAAAAGAGGAAGATGGTGACGGTCCCCCTGAGCTGTTTTCGTTTTTTCCTCTCGGATGTGTTAAGCGGCTGGGAGTGTGGCGGGAGATGGGACGGGCATGAACCACCTCGGCTGTCTTGCGAAGGGAGCGA GCGCCCAGAGAAACGGTGACGTCCTT 173ERO1LB 2462368 ATGAGCCAAGGGGTCCGCCGGGCAGGCGCTGGGCAGGGGGTAGCGGCCGCGGTGCAGCTGCTGGTCACCCTGAGCTTCCTGC GGAGCGTCGTCGAGGCGCAG 174MIR4435- 2492489 TGTCAACTCTGTGTTGGAGCCAGTAGGGAGCTCTGTGGGTCC 1HGTCGAGCAGGAAAATCCCATGGCTTAAGCAGTGTTTCAGGAAGACTGGGATGTTAGGCTCCGGAGCTCTGAGCAAGTCAGATGGGACTGGGAGTCATAAGAAGGCTTGACTGTGGCTAGTGATAACC A 175 MIR4435- 2492490GTGAGGACCTCTGATGGACCAGGAAATTGGAATTCTGCCTGG 1HGGAGGCAAGCCCATGGAGGCCCTGATCTGCTTGGACAGAGAGTAGCTCCCTTCACCTGTAAAATGAGAGTGAACGAGCTGGTG 176 MIR4435- 2492491TCACAGCATTCCTGTAAAAGGTATGAGGTTCGCCCTGATTGGA 1HGCCAGCCGAGGTCACATGCCTACACATGAGCCAATCACAGTGG ATAAAGGACTG 177 MIR4435-2492498 AAATTGACATTCCAGACAAGCGGTGCCTGAGCCCGTG 1HG 178 MIR4435- 2492499TGTGAAGACTGGACTTAAACAGCTACACCACCAGAAGCCGAG 1HG AGAG 179 MIR4435- 2492501AGATGCTAATCCAGCGTGCGTCCTGACAGAGGTTGAAGGGGG 1HGCTTCTCAAGTCCCAGGTCCAGCTTGGTGTGGTTCAGCTACTCAAGAGACATCTGCTGCTAATGGATGAGCAGTCAACCTGGACGC AGG 180 MIR4435- 2492502CAAAAGGAAGGTGTCGGCAAGATCGTTTTTTTCTGAGAGC 1HG 181 MIR4435- 2492506TGAAACAGGAAGCTCTATGACACACTTGATCGAAT 1HG 182 MIR4435- 2492507CACCTCTACCTGTTGCCCGCCGATCACAGCCGGAATGCAGCT 1HG GAAAGATTCCCTGGGGCCTGGTT183 MIR4435- 2492508 TATTTTGGTCATGGGCTGGTCTGGTCGGTTTCCCATTTGTCTG 1HGGCCAGTCTCTATGTGTCTTAATCCCTTGTCCTTCATTAA 184 MIR4435- 2492509AAAGGCTGCAGTCACCAGCATCTTTTCCAACCTTAATGAACTG 1HGTATCCTCAAAAGAACACTATCAGACTG 185 MIR4435- 2492510GCTCTGCCGACTTCCAGTTCTGGAACAAGATGGTTAAACTCAT 1HGTTTTCCCTGCTCTGCTCCTCTAAATACAACTAAGTACCTTGGAAACTATTCAGCAGACAATGATAAAGGGCTCTGAAAGCTAGAAGAAAAGGTGTACTTGCAAGAAACCTCAGGACT 186 MIR4435- 2492516GCTTCTGCAGTTTGCCTTGGAGTCTGGGCTGT 1HG 187 MIR4435- 2492517TAAGAATGTAGATGCCGGTTGCACCTTCTGTTGTCTTGGAAGA 1HGGACTGCAGTGCTTGGCTGGAAAATAAGCTGCTCGGGACTCCT CTGAGA 188 MIR4435- 2492518CCTACCCATGAGGAACAAGCCTGTGGGGGGACTGATATTATC 1HGACTTCTGTCATCAAGAAATAAGGCCGCAGGCATCCCTGAATATAGAGCATTTATTAATCGAACTGTGAAAATGAAACACAGACAGTGATGACAGCTGGAAGTTGGCCAATGTCCTGTTGTCATATTGCCCTCAGCCTAGGGACTGGCCTGTGGCTCACTGACCCTGTCTCCCACTCTCCACCTCTCATCAGCAACTGGACCTGGTGCACCTGGTCTACCTCATGTCCAGTGTTTTCCGCAGTACCTGACTGGTATCCCCACCCTTGGTTGTTGTGTGGTGAGCTCGTCCCTATGTTGGCAAGTTACTTAATTCCTAGGTGTCCCGCCTTCCTCACTGTAAAA 189 MIR4435- 2492530CCCTGGCATCATATTGGGACTTGTTAAGGGCTGAATTGTGTCC 1HGCATCCCAAATTCGTATGGTGCCACCCCAACTCCAGTACCTTGGAATGTGACCGTATTTGGAGAAAGGGTCTCTGAAGAGGTAATTAAGGTAAAATGAGGTCATATGGGTGGCCTCTAATTCAATATGAC 190 MIR4435- 2492538TTGCTGATATACTTACAAACTGGTAAACAATGCTCTTTAATCAA 1HGCAATTCATAATCTGGGTCAGCGATTTTTATCTCCATATTTGCTCATACTGTATGACATCAATATTTTATATTGGCTTGCCCATAACTT A 191 MIR4435- 2492544GCCAGTTCGCCTTTCGCTTTCTAAAATCATCTTGCTGGAGAGA 1HGACGGTTATCAAATCCCATCCACTGCCCATGTAAAATAAATACCATTCAGAAAAGCGTGGCATGGATGGCCATACTTCTGATGGGTTTATAACTGTAGATTGCATACGATCCCAACGTGAAGCCTGAAATACGACATTCAACGTCAGGCTTATTCCAGGCTACTGCTGTGGCTACTTTTGTAATTCAACCAGTGGGGCGTTTTAGGCTAACGTATATTGCCTCTAAGCTGATAAGCATTTTCCTGATCCCAGGCCCCTTCTAAAATTGAACACACACGTTCAGCTGGGGACACCTA 192 MIR4435- 2492546TCAGTTTTGTGCTTACAGTCCCGCA 1HG 193 MIR4435- 2492548TGGGAGGCCAAGGTGGGCGGATCATGAGCTCAGGGGTTCAA 1HGGACCAGCCTGGCCAACGTAGTGAAACCCCGTCTCTACTAAAAACAAAAAAATTAGCTGGGCATGGTGGCGCACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCTCCACTGCACT CCGGTTTGGGC 194 MIR4435-2492552 CTGGGGACACTATGGCCCCATCCTAGCCTGGTG 1HG 195 MIR4435- 2492554GAAAAGATTTTTATTCGTGTCTACATCAGTGTGAAAGGCTTCAT 1HG CCTGG 196 Ml R4435-2492556 TGGACTTCTCTTTAGCTGGGGTGGTGGCTGCTGGAGAGGGCC 1HGCTGCTTGCTCATCTCTGCCAGCTTCCCAGTCCCTGCAACCAGCAGTGGCCAGCCTCTGGCCACCCCCATGAAAGCACATAAAAGG GTTGGGGA 197 MIR4435- 2492558GGGAACAAAATGTCTGCTCAAACCATGACAAAATTGGCCACAA 1HGTTTGCCGATTGGGCTGATAACAAAAG 198 MIR4435- 2492568AGGTCGAGGCACTGTCCTAGCTTGTGACCTGCTCCCATACCTA 1HGTTTTCTCAGGGTGGAAGCAGACGCTCCAACTCCCACA 199 MIR4435- 2492569AGACCCAAAGCCTGTAGGAAGTATAGCAGGCCTCACCCAATA 1HG CCCTGCAGTT 200 MIR4435-2492571 CCTCAAGAGAACATGGAGTCCTTTG 1HG 201 MIR4435- 2492573TCAGTGGCCTCCGAGTAACCCACCTGCTCCAGTCTGCAGATTT 1HG CCATCTCACTGAC 202MIR4435- 2492575 CAAAGGCTTCTCTTGCTGGCTGAGAATTGTTGGGGAGCTCCCT 1HGGCCCACGGAGGGC 203 MIR4435- 2492577GGGTTCCTGTCGGAATCTTGGAGCTCATCCCCCAAACTTGAGA 1HG TT 204 MIR4435- 2492581AAATGCTTAGGGAGACAGTTCACAGATATATATGTACTTCACA 1HGGGGCACAATTTAATCCATAAATCAATCATGGATCACTGCTAAAGAAAACAAAATATGCTGCCACTAATTTGCCACCACCCTGTGAG CATGATTGGATGATGTTTA 205MIR4435- 2492583 AGGCAGCCTTTTCTGTCACAACACAACGCTGAGCCGGCAGCC 1HGTGGCTCTGTCAGGATCTGGGGCTCCAGCGCCCGAGAAGCCCAGCCTCGCCGGCGGCCAAGTTCACCGCGAGGCC 206 MIR4435- 2492584CCGAGGAGGCGGAGCATGGAACTCGACAGTTAAAACATTTAA 1HG GAGA 207 MIR4435- 2492590TGGCAGCTCCATCTACACAGTGTCGGGCTAGGCATGGGAGCA 1HGTTCTGGGCCAGGAGAAAGGGGATTGGATCCTGGATGGTGGGAACCGCAGGTGTCCCCCTCCACGTGCCTGGGTCCAAGACTGCTCTGCTCTGGACCTTCTACGCCTTCAGAGGTACAAGTTGCAGTGCTACCCTTGCTGAACCTACAACCCTGTTCAAGTGACAACTTCTCTGAGTCTCATACGAGGATATTGAAAGAACCTTCTGCACAGGGCTGTTGTGAGGATTAACCGTAATAATACAAGAATATCTGGCACTTGCATTCAGCAACTCACCGCTTACTTGTTCAACCAGGTAAAAAGGTTCTGATCCCAGTGTTGCAGGACAGAAAGACCTCCCCCTCTGTAGCTGCAGATGTGACCCAGCACAGAAAAAATGGCAGGTGAAAGACAGGCAGGAAGAGCAACTAAGAAGGTGGGAGGCACCTCCATAAGATGCCTGAGGCCATGGGGATGACCGTTCACAGA GCTAGTCCCTCGAGCAATGTGTTA 208MIR4435- 2492591 TGTGGCTCCAAGTTCCGTAGGACTCACTAGTCTTTTTTTCCCTA 1HGGAGGGTCTTGCCATTGAGAGGCAGGTGATGTGCTGTTTCAGAAAACAAAATTGGGACATGTCCTGATATGACATCCATCAAATATATACAGATAGGTGTCACAGCCCCCGAAAAAGCTTATCTCTTCTAGGCCACACATAGCTATTTCCTCCAACTGTGTCAGACATTACAAAGTTTCTAGCAATCAAAACAAGTCAAATGCCATTCTCAGGACCCGTTGGAGGATTTTTTGCTTTGTTTTGGCTTTGTACGGTATCCATACCATTTTCCAAATTCTTTTGTCCTTACATATTTTGTTTTTCTTAAAAAAAAAAAAATCACCTATAATCCCATCACCAGACAAAACCACTAGAAAGAAACCAACATTTTAGCCATGTTTTTCTGTATATAAAAAAAGTGTGTGTGGAATTTTTCATAACAATATTGGGACCATGACATCTATCACATTTTTTATTAGGAAATGGCCTTCAACAATATGCATTTAACAATATGCTTGATGTCTGTGTAATATTTCATCTAACAAATATATCATGATTTATTTAAGTATTCCCTGATTGCTTGCTTCTAACTAGAAAAAACAATTTTTCTAAGTGTCACCACTGGGTTAGAGTAATCTCAGCCAATCCTCCTAATAGCACTGTGAGACCAGAGTTATGATAATCTTCAGTTAATGGACAAGGGACATGATGGTGTGGAAGGATAAATAAACTACCCAAAGACAACTAGCTAGTGAGACCAGCATGGACAGTCAAGCCCAGTGCATGTAATCTGTGCTCCCCTGCACT GTTGCTCATATACTTGGACCCTTGC 209MIR4435- 2492593 CAACCCAGGGTCCTTGCAGAGAGATTGATCTGCCAGCAGTGG 1HGCATCAGCAGCAATAGTAGCAGCAGCAAAGCCCTGGACAGTCCTGGCCCCCAGTCCACAACTTAGACACAGCACATGGCCTAATTCACCCACAGAAGCAGCCACTGTGAAGCCCTGTGTCTCCCCAGACTCCATCCAGTGGCATAAGGAGACCCAGGCCCTGCAGCTTCC TCCCCATCATGGAAGGCTGTCCATCTA210 MIR4435- 2492595 ACTTAAAATAGGAGTGAGGTGAGAGGGGCAGCTGGGCTCATG 1HGGACGTCAAGTGGACAGTTTCTCAGCTGGTATTTCCTATATTTCCTGTTTTGGACAGCAGGTTCCTGCCCTTCTAAGCTGGGGGTAGGGGTGAGGGAGTGTATGTTAAAAAGCTCTGTGGACTTGCT 211 MIR4435- 2492597GGTATTACCTGATCCCAACTTGGCACCAAAAGACAGCCAACAT 1HGAGACTCATTCCTCCTGCTTCCTGGTGAGCCTGGTATTCTCCTCCACTTCCACTGACAGACATGTAGGGTGACTGGGTGGTATCAACAATAGGAACCACATCATAACAGGCAGCCTAGTTTGGGAAGCACTCTTGGTCTCCGTAGGCCTGAGACTCCTTTTGCCCATCTAG AGG 212 MIR4435- 2492601AGACTGACCCTACAATAAATGCTTAAGAGAGTCCTACATCTGG 1HGAAGCAAAAGGGCTATATTCACCATCATGAAAACCCTAAAGTATAAAACTCATTGGTAAAGCAGACACACAAATAAGAAAGAGAATGGAACCACATGTTATCATTACAGAAAACCACCAAACTGCAAAGATAAACAAAGGAAAGAAAGAAAGAAAGAAAGGAAGGAAGAAAGGAAGGAAGAAAAAGGATTATTTAAAATTATCAGAAAACAATTGAAATGACAGGAATAAGACCTCACCTATCAATAACAACTTTTTTAAATGGCTTAAATTTCCCAGTTAAAAGATATAGACTGGCTGAATGGATTTTAAAAGTGACCTAACTCTATGCTA 213 MIR4435- 2492603AGAAGCTTGTTTTGAGCTCATTCAATATGCATCAGGTGGCGGT 1HG AACATCTGGAG 214 MIR4435-2492605 AGGGTGCTGGTTCTGAGCCAACTTTGCATGGAAGGCCCAGCA 1HGGACCACGCTCATTACTTACAGCCAGCATCATCGGGGAACTCC GGCACAGA 215 MIR4435- 2492607GCGGCCCTAGTCCACTCTCATGATGCCTCCATTAATCCCCCG 1HGGTCAGGGACCTTCCAGCCCTGCCCACAGCAGTCGATGCCTTC AGTGCATCTCAGTCTTCCACCC 216MIR4435- 2492609 TCAGGTCATCCGCTCCATGGAGGTCCCCGTTCCTACCTTGGC 1HGCTTGCCTTTCCCCCTGCATGTAACCTTGGTGAACTTTTCACAA GAGTCTGCGCAGTCT 217 MIR4435-2492610 TAAGCAGATTAATGCCGAGGAAAAGCCTTGGTGA 1HG 218 MIR4435- 2492612CCCGTGGAGAGAGCCCCGCTGGTGAGGAAGCACGGGGACCC 1HGTGCTGCAGGGCTGGTGGAGGGCTCCTTCTGCAGACTTCTGAG CTTGGAGCACAGATGGG 219MIR4435- 2492614 CTGGCTCCTGCACTACTATGGCCTTTTGGCTC 1HG 220 MIR4435-2492616 TTCCAAGGTCTCACAAGAGTTTGCCTCCTCTCATTGCCATGTG 1HGAAGACCTCTGTGGGGGAACAATGCATGGGTTCTTGGGGTATTATAGGGGACTACAGAGAAGTGTCACCTCCACCCAACAGCCTGATTCAGTCTACTCCTCAGGAGGAACACAAAGTGGTCTCTCTAGTGCCATGAAACCCCAAAAAGTGTCAACCAGTATTAAAGGCCTG CCTGATATACAACCCTCGA 221MIR4435- 2492618 ATGAAGCTAGGCCCCCCTGTCCTGACAGCTTTCCACCCCTTCC 1HGCTGCCCCTCTCACCCTGCTTTCCAGGGGCAATGCACCTCCCC ACTTCT 222 MIR4435- 2492620CCAGACACCACTGGCCTACATCAAACTCCAGGCCACAGATGG 1HGAAATAGGACTGAGATCCCTGGACCTGGG 223 MIR4435- 2492621AGATCAGGTGGATTGAGGATGTCACTGCCATCCCCTCCAAAA 1HGGCACCTGCAGGAAGGGGGTTGCCATGGTCACCATCTGTGAAC AGGACTCCTCAAAATGTTT 224MIR4435- 2492622 TCAAGGTGGCCTTGCGCTTCACCGAGGAGGTGTCATTACCAA 1HGACGTGCTGGACATTGGCTACCTACGGAAGAAAGATTAA 225 MIR4435- 2492624CCTTCCTACCTGGTAGTAGCACTGACATCCTCTTCATCCACTG 1HGGAAGCTTCCAGATCCTGGCCCCCACAACCCATTCTCTCCCCATAGGGCTTCCACAGAAACACAACGTGTACTGTGTGCCAAATGA CT 226 MIR4435- 2492626TTATACATGGCCTCACTGTTGGGGAGGCAGTAGGGAGTGTTG 1HGGAGACCAGGGTCAGGACTAGGGCTAGGGCAAGGCTAGGAAG GTGCCCAGGATGCATGTTTTAAG 227Ml R4435- 2492628 TAAGAAAAGGATCGTGGTGGTAGCAGGAAATAAGACAGAAATT 1HGTTCCATGGGGGCTCCAGGTCTGAA 228 MIR4435- 2492636GTCTTTTCTTGAACAGGAACTTGCATACTCAAAAACAACA 1HG 229 MIR4435- 2492638GATCCCGTGGAAACACAGCACCGGAGGATATGGGATAAGAGA 1HGCAACAGAGAGGAGTGGTGCTTCCTGAATTTAGGAAACATAGCTGCTACTTTGGGCCCTCTAGATACTTGAAAGAA 230 MIR4435- 2492639AGGGAAGCCAGGTTGTTCATGGACATTCAGTGGAAGAATTAA 1HGGGCAATTAAATGTTAAGTTTTGCAGGGCTGGTCGACAAGAGAA 231 MIR4435- 2492640GTGTGTATTCTCCATTGGTCACAATGCAC 1HG 232 MIR4435- 2492642GACAAGAATAACTCCCCACTGGGACTGGAGGAGAGGAAGGCA 1HG CATGGGGGCCCTTGGCAGGGTGG233 MIR4435- 2492643 TCAGTCACGTCTGCGCCAGAGCTTTGATGACCCACCTGTCAG 1HGCCACACTAAGGGCCCTGCCATGAATAAGGCCTCCGTCACTGAGGATCCTGTACCCCTCTGCCATAAACTCAGTGACCTGACTG 234 MIR4435- 2492645GAACTCCCACTGTATAATTGCTAAACACAATGACAGCTATAATT 1HGGAGGCACTGAAGGAAGGTCAGGGGAGCCCAGGAGGGCGGGGCTGCTGCTGCCTGCTGAGCTGGGAGGGTTGGTGGCACCCCTTGCCCTGGGTTGCCATAGCAGATATCATAATCAATTACGGCCGTCTTTCATGAGGAACCTGGATCTTTCCCAAGGAATC 235 R3HDM1 2507381AGGGGCGGGATTCTGCCAGCCGCGGCTGCCGCTGGAGCCGGTGTCCGGGCTGGTGATGGGGTTAATTCCCTTTCGTAAGACTCT TACTTGC 236 R3HDM1 2507382CTGCCTCCGCGGCTGCTCTTGCAGCCCCAGGGACTCGGGAGCCAGCCACAGCAGGCCTGCCAAGAGCGTGGTACTGCTCTCTCGTGTGGCTGGCGCCGGTGCCCCGGGCTCCCCCGGCCGCCCCACGGCCGCATCCCCTGGCCTTGCACCAAGAGAATTTTCAGCTT CGACCGGTTGG 237 R3HDM12507383 CCCGGGATCAGATTTACACACGTTTTGATTCCTGAGCCTTAGGCTGCCAACAAATCTTTGTGGGCTTTGAAGTTTTTTGGTGTTTTGTTTTCTTTTGTTGCTGTGACTAGGTGCAAAGGGTG 238 R3HDM1 2507384TTGGGTTCTGAGGAAACATCTGAGTTTTGATCATTTCTTCAGGGTTTGAGAAGACTATGGTGGCTTAATGATCTTCTGTATTCCATAACTAGTACACCTAGTTACAGAATTGACATAGATACATTCAGGTCCTGGAGGAAATTTGTGGTATCTATTAAAAAAATGAAAATTGCC AGTCATGTAGTAGTCACC 239R3HDM1 2507385 TATTATGCAGAAGATGTGCATTGCCATGCCTTGCAAGTAATAGGGTTTTTTTTCTTCTTTTTTGAACTGGTACTTTAATATACCTAATTACATCCATTTGAGTTAGTATTAAGTTTTAATTTCTCAGAAATAAAGTAGTGAAAATTGGTAGCAGTTTTGTTTTTCCCATTCTTGAGAATATTACAGTGATAAACAAGGCTTGATAGGTTTGTAAAATACTATTGCTATTTGAATTAAAAAATTTCACTATTGACTTTCCATATTCTATTGTAAATAAGTTGGGGAATTAGTGTGTCAAGGGGGTGTGGTAACAAATGGTAATGTAATTTTCAAATTGCTATTGCAGCACCAAA CCACAGA 240 R3HDM1 2507386TGAGACGTTAGCATCAACATGACTGTATATCATTTCCAGAATTTAATTCAATTAGTTATTGGCTGAGGGATGAAATAGAGATGAAACTAAATCCTGGCCTCAAACTAGTTTTGTACCTTATTTTCCAGCAATTTGGTTTTTTTATATCTAGATTTTATCTTTACTATTTTCCCTCATCTTACCCATTCTTAGTCTCCATACACACCTATTAACTTTAATTTCCTTTTCTGAGAATTTTGAAAGCCCTATAGTTTATGATCTTTTTTCCCTCTTTGCCTTGTGAATTTTATATTTGTGAGTTTTTTCCAAATTTCTACCTGTCAGCTCACTTCTTTAGGCAAGGTGTAAGGTTTTTGAGCCCCCTTATTTCATTTTTTATTTTTTTAAGAGACAGGGATTCACCCTGTCACCCAGACTGGAGTGCAGCGACAGGATCATAGCTCACCACAGCCTTGAACTCTGAGGCTCAAGGGAGCTTCCCAT CTTATGCTCCCAAGTA 241 R3HDM12507387 GTGTGCAGTGGACCGGTGAACATCACCACCTGAGCTCTGCCTCCTGTCAGATCAGCGGTGGCATTAGATTCTCATAGGATTGCAAACCTTACTGTGAACTGCGCATGCAAGGGATCTGGGTTGCGTGCTTCTTATGAGAATCTAATGCCTGATGATCTGAGGTAGAACAGTTTCATCCCATAACCATCCTCCTCACCGCCTGCACCATCTGGGGAAAAATTATTTTCCACCAAACAGGTCCCTGGTGCCAAAAAGGTTGGGGACTGCTGCTCTTAGGACAGAAAGAAAGAAGTTCCATAACTAGAGTAAAATATCACCTTACAGTATGAGGTAGCTTA 242 R3HDM1 2507388GCAATCAGAACACCTACAGCATTTATCAACTAAGTTCACTGTCTTATATGGGTGTGATTTGTGGTCCCCTAAAACAATTACAGTGGTAAAGATCACTGATTGCAGATCACCATCACCAGACATAATAATGAAAGAGTTTGAAATATTGCAAGAATTACCAAACTATTACACAGAGACATGAAGTGAGCACATGTTGGGAAAATGGTACTGATCGATA TGCTTGACTCAAGAGTTGCCACAAA243 R3HDM1 2507389 AAGTGATAGGATTGTTGCCCACCCAGGACGTTATGGATTCACTCAGCATTCATTCATGAAATATTCGTTGATAATTTACTATGTGCCGTGTACTGCCTATATAAAGCAGAGAGTACTTGCCCTTATGGAT TTTATTTTCTAGTGAGTGAGACAAA244 R3HDM1 2507390 AGAAACTAAATCACTGCCTTGTACAATAAAAAGCTCTATGTTGGGGTGATCAGACCCAACACCAGGTCATGGGGGCGATGAGTCCGGTGGAGTCAAAGGAATGAGAAAAAGACAGTTTGAGAGAGAAAGTGGGACCGGGGAGCCTACGCTATTTATTG 245 R3HDM1 2507391TGAAAATTGGGCCTTAAGCACATAAAAAGTTTTAAGTTCATACAGAGAAATAAGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTTTCTCAACCTCGAGACCA GCC 246 R3HDM1 2507392GCACTTCTCTGACTATAGTTTTTTATATGACTTTGACTCTCAGAACCCTGGTAATTTTTTACGTAGTCTCCAGAAATAACATAAAATAACTTAGATGTTGGCAAGTGTGGAGAAAGGAGCCCAAAATGTAA TGCAAGCACTAACAGATGAAC 247R3HDM1 2507393 ATGCCTTGGTCGTTTTGTGTCCCTGGGCTGTTGGCAGTGTGACTCTGCTACAGAATACCACTTGGGGAGATCAGCTTACTCAGTAC AGGGTG 248 R3HDM1 2507394CAGATCTTTCTTCACATCGTGCAGGTAACGTATGAGCATTGTCTGATGGATCCTTACAACATTCCTGTATGCTTTTGGAAAGTATGATCTTTGTTTAACAAAATGGGAAACAGAGGCACATGCTATACCCAGCTATCACAGAAAACAATAGTTAGAATCCAGAAAACATACTC ATCTGGTTTAGTGTGTTGCCCA 249R3HDM1 2507395 AGCAGGCACTCCCAATGCCAGACTAATCAGCTGG 250 R3HDM1 2507396GAGCTCTATAGAGGAGCAATGCAGAGCATCAGTTTACAGGTA CTATGGAA 251 R3HDM1 2507397AATCTTGCCATACTTGCACAGCTGACCAAC 252 R3HDM1 2507398ATTCAACTGCTAGAGAATGTGAAGTTTCACATTTTAAGCCATCA AAGAACCATTGG 253 R3HDM12507399 TGTGCCAAAACAGTCCTGAATGTTCGTGTTGGCCTTAATGAACCACCCCTTAGTGACTCAGTCACCATTCTCCACAAGCCCTACAG CCATCCCGG 254 R3HDM1 2507400CCTCAGCTGCAAACTATGTAATACTGCTTTTATGGGGATTAAATGAATTAATACACTTAAAGCATTGGGAGTAGTGCTTAGTAAATAATAAATAACTCTTTAAGGGTTTGCTGTTAATATTACCAGTTTCACAGCACATATTGCAATCAGTTATTATCTTGTATATTTTGTCTCTGCACTAGAATGTAAGCATTTTAGGTTCTAGGATCCCATCTGCTTGGTTCACTCATGTATCCCTATTACCTAGAACAGTGCTCTGTAC ATAGTATCCAGTCTG 255 R3HDM12507401 GCGCCCAGCCTAATACTAAGCTTCTAATCTTAA 256 R3HDM1 2507402GTCCATTCCAGTCCGGGAATCTACAGTGGTGACAAGGACATGGGACTCCTCCTGCCAGATTACAGATGGTTCACTACAGTTGACATCCTGGCTGACAACTGTGAAAAAGAACCTTGGATTATTTTATTTTATTTTTGTGGGACACCACAATCCCAAATCC 257 R3HDM1 2507403GCTTCAAGCTCCCTGTAGAATTCGAAAATAAC 258 R3HDM1 2507404GATGTCTGATACTGTTACTGTAAAAGAT 259 R3HDM1 2507405AAGTGAAAGATACAACCAGAGTTGAAAATCTTATCAAATCAGAAAACTATGGGAAGATTTTGGTAGAGAAGAATGAACATTGTATT GAGAACAATATAGATTTGCAG 260R3HDM1 2507406 TCATACAAAACTCACTTCTCAAAATTC 261 R3HDM1 2507407TCAGTCAGGAAACGAAGCAAGGCTTGGGCTGAGTGAATTTTCTATTCTACAGGGTATCCAAAGAGGTCCTTTGTTGGCATTTAACAGGCCGGTGGACTTGGTCTGGAGCATCCCGGATTGCTTCTCGC ACCTGTCTGG 262 R3HDM1 2507408CAACAAGGTGGGTCCAAAGTAGTCAGACTTCTTATGTGGCAGCTCAGGGGTCCCAGAGAGAATGTTCCAAGAAAGCCAAGCAAAGCTGCAAGGTTTCTTTTGACATAGGCCCAGAAGTTCCAGAACG TTACTTCAGCTATC 263 R3HDM12507409 CATAGCGACTGTAACGATTTGGAAGGAGGGA 264 R3HDM1 2507410CAATGCCACGCTTCTTCGACAATGAAGGCAGTACATAA 265 R3HDM1 2507411AATCTTAGCTATTTCCTGTTTGTCAAACAAAGATTAAAAGCATGTATGTGGCAAAGCGTGGTGGCTCCTGCCAGCACTTTGGGATGCCGAGGCAGGAGGTTTACCTGAGCCCAGGACTTTGAGACCAGCCTGGACAACACACGAAGACTTTGTCTCTACAAAAATAAAAATAAAAAAATTATTCATGCGTCACGGTACATACCTGTA 266 R3HDM1 2507412CGGCCATTGCAGTCATTTGGACAGAC 267 R3HDM1 2507413CAAGCTCAAAGTTAAAGCTAGTTCGGAGCCTTGCAGTGTGTGAAGAATCTCCACCACCCCCTGCACCAGAGATATCACAGGAGAA CCA 268 R3HDM1 2507414TGAGTGTAAGGAAGTTGCCAGTGTCTTTGGTAAACAAGACAGAGAGTGCAAAAAGCAAGTGTTTGTCATCCTAGTAAAAACTGCCAGTGTGCATCATTTACCCTATATTATGAACACAAATTTTAACTGG TATGATGAATTAAGAAGA 269R3HDM1 2507415 AATTCAGATCCAGTTAACACAATCATTTGAGAAAGAAGAGAAGCCCTCAAAAGATGAAGCAGAAAAAGAAAAGGCCAGTGATAAGT TGCCCAGAAAA 270 R3HDM12507416 ATTCCAGTCAAGAATACACTGATTCAACTGGCATAGATCTACAT GAATTTTTAGTA 271R3HDM1 2507417 CCTCTATAGATGCAAACGTTTTTAAGTTATCCACATAGACATTTTTTAACTGTACGGTTTAATGGTTTTTAGTATATTCAATATACAGATAGGAGCACTATCACCACAGTTATAGAACTTTTTCATTGCCCCAAAAGAAACCCCATACATTGTAGCTATTCCTATGCTAATAATAATAGTAATACTGATATTGGATGATCCCAACCCTAATCTGTTTTCTGTTTCTGTAGATTTCCCTGTTCTGGACATCTCATATGAATGAAATTATATAATGTATGGTCGTTCATGACTGGCTTTTA 272 R3HDM1 2507418ACAGTTTTGTGAGTTCAGGTCAGGAGATGAGGCTGGAGCTGGATGAAGACCAGCTCATGCCTGCCTTGTACATATGTTTAGTTCTAAGAACAGTAAGAAACCCATGACAGATTTAACAAAGGGAGTGATGTGTGATCACATATGTGTTCTTAAAAGATTGTTATGCATGTTTCATGTAGAATAGATTAGGGAAGATCAGGGAAGATACAGGGAGACAATATACTCCTGCTGTAGTAGTCAAGCCAGAAATCCTGTTGCCTGGATCCAGGGTTGTGGCAGTAGAAAAATA 273 R3HDM1 2507419CTGATGTGTAGACTTTCAGGTGACCAAAGCAGGGGCTACCAGTTCTTCTATTGAAATTGAGAATAATCTGCATAGTGTTTATTTTAGGGAATCATTAACCTCTTGGCCTCGTTTTCTTGATCTGTAAACTTTGGAAGACAAAACTGAATGATTTGTAAAGCTGCTTTTAGCTTTAAGTTTCTGTAAGTTACATTTTTTTTTTCACATGTATATGAAATTTCCAATTAGCACAGGAAAATTCTAGAGCCATGTTATGGGTGTGTGAGCAGGGAGGTCCTTTGGGGAGTGATACCATTAATTTGTTGCAGCTAAGAGAACTAAATAAGACCCTAGTGATCTAAAGGAGCACATACAGGTACTCCCTAGAGTCCTTATTTATTTTATATGTTGGAGGTTTTTGGTTCACTTAGATTTTTATGGGAAAATTTAAAAATATATAATGGCAGTTTATAGAATGGGTTGAAATATCCTCTTCTTCTAAATTAGCGATATAATTAATACTTCTCTGCCATAGTCCCATCTACATACTAGTATTAGATTCCCATAGAAGTATTCCTGTTGTTACTGGCATTGCATGTTCTTTAGAATACTGTTTCTATGGAGTTCAGCATGATAACAAAGTCCTGAGCCTAACTAAAGATGTCTGT 274 R3HDM1 2507420ATGCTGCTGAAATTGGAACAAGAAATTTTAGATTTCATTGGTAA TA 275 R3HDM1 2507421GACATCTTACCATAGGATGCTATTACACAGAGTAGCCGCTTAC TTTGGATTAGACCACAATGTTGAT 276R3HDM1 2507422 TGGGAAGTCTGTCATAGTAAACAAAACTAGCAA 277 R3HDM1 2507423CTCCAGCCTTGAATCAGTGGTGTTATGGATGTCAACAACCCAGTGTCCACTGGGGTGTCTCAATGGAGCGGGAAGTTGGCGATTA CAGGGCAGTAAATTCAGGCATCTATAA278 R3HDM1 2507424 AACCTTGTGTTTGTCCTCTAGATCACAGTGGAACTTGCAACATTTCTGTGGAAGAAAGATGAGTCCACTATAAAATGTATTGCTAAGATTTCATAATCGTTACTTTAGGTCACAACTTTGACTTCTATAAAAGAACATCTCTTTTCTAACCTGTTCCAGTTAATGTTAGCAAACCTGTGCCCTACTGTAATTTAAAATTAATGGATGCACTTTGAAGTAGTCTGTAAGTTTTTAGCTAATTGAATGACAAAATATTTTATTACTTTCAGGTATAACACCAAACTAGGTACCATAGGAGTAGCATAAGATACGGCACTGCACTTTCCTTGTCCCAGCATTTTTTCGTAGGTTTAGACGAGGCAGTACAGGCTTTGGGTCTAACTGACCTGAGCTCCAACTATGGCTTAATCATATGCCTGCCTTTGACCTTGCATATTT GCTTAAGCCATTTGAACCTCGGTTTG279 R3HDM1 2507425 AAGGATGATAAAGGTGAAGACTTTCAGAAACGTTATATCCTCAAGAGAGATAACTC 280 R3HDM1 2507426CTAGAACAATTGTAGGATTTGTATAGGTGCAAGACATACTATA CCAGTAGTTCATTTGCCTAAAA 281R3HDM1 2507427 GAGAATACGTTTGAAAGATGACAGAAGAAGCAAATCTATAGAAGAAAGAGAAGAAGAGTACCAGAGAGCCAGAGACCGAATATTT TCCCAAGA 282 R3HDM1 2507428TTACGTTGTAGGGTCTCAGTCTCCCTTTTATCTATTGATCACATTTATTTTTAATCACATTTGTTGCACATAAGGTCATCTTTTAGAAATATTGAGATCAGTTTTGCTTGTGTTATTAATAGTTTATAAAATACTACATTGCAGTAGTTATATAAAATTTTACAAAAGTTGGAAGCAGGTAGACTACAGGAGTCATTAAAAGAATGTTCTCCAGTCTATATAGTTTGTGTGATTTTTTTTCCCCAGACTTGTGACAGACTTGAGATTTTTATTAATAGAAATTGCTCCACTGTCTACAAAATCATATACTCTAGATGCTACTTGTTAGTTGACTTTCTTTGACAAATAATTTATTTCTTCTTTTGAAATAAAGCTAATTGATTTTGTAGGTTAATATCTGTTTTCTTCTTCATAAGTGATTATATAAGATAGGCTTTCTAAATGGCTAATTATTTTATGCATATATGCCAGAAGAGAATCAATTTGTTTTTTGTCAACATCTACTAAGCATCTGTCCTGTAATATGTGTTA 283 R3HDM1 2507429CCTGTGTTCCCAAGAGAATTACATTATTGACAA 284 R3HDM1 2507430ATGCCAGTAGTACCCAGCAGAGGCGCCAGATATTTAG 285 R3HDM1 2507431TGAAGTACTCGGAACCACGACCCTGGAGCAGCACAGATTCAGACAGCTCTCTTCGAAACCTGAAACCTGCTGTAACCAAAGCCAGCAGCTTCAGTGGAATCTCAGTCCTGACAAGAG 286 R3HDM1 2507432GCAAAAGCATAGGCAGGCTTTCAAAA 287 R3HDM1 2507433TCCGGAGCACTTAAGGGGTAATATGTTTCTTGACATGAGGATTCACTCTCTGTCCTGGACACAGATTTACAACCATCAATTACCATAAAAATTCTTCTCTATTGTGACATAAACTTAATTAGGTAGGTTCAATGAAACATTATCTCTTGATTGAATGCCCATAGGTAATTGGAAATTCTTTATTACTTATTCGTAGTTGGTAGAAGGCATGGTTTCTCA CCTAGGATTATTTA 288 R3HDM12507434 AATCAGCTGGGCGTAATAGCACGTGTCTGTAG 289 R3HDM1 2507435TAGGGTCATCTACAGGCTCTCTTTCTCACATCCAGCAGCCTCTTCCAGGTACAGCTCTCAGCCAGTCTTCTCATGGCGCACCTGTCGTCTATCCAACTGTCAGCACTCATAGTTCTCTTTCCTTTGATGGTGGCCTAAATGGGCAAGTCGCATCTCCTAGCACTAGCTTCTTT TTGCTTCCCTTGGAAGCGGCAGGCATAC290 R3HDM1 2507436 TGATCTCTGGTTTTTGACAACAGTATTACAATACATTTAACTTTTTTAAGATGACCCTTAAATTACATTTGACCGCCTTCACCCAAATCTGCTCCACCAATTTTTTCTCCAAATTATTTAGCAGTCAACAAATACCCAGGACAACTTGTTTTTAGTTATCTATAACTGTCACACAAATTATCAGTATACTAATTGATTAAAATAATTTTACTTTAGAGTACTTTTTCTGCTTGATAGCTATAGACTAGTATAGTCTTCTCTCCCAA ATA 291 R3HDM1 2507437ATGGGAGTCCAGTTGTGTATAATCCTCCTATGACTCAACAACC AGTTAGATCCCAAGTGCCTGGACCTCCA292 R3HDM1 2507438 AACAACCAGCAGCTAATCACATTTTCTCACAG 293 R3HDM1 2507439GTTGACTTGCCTTTACATATTTGGGACTAAATTCGCTAATTATAATTGAGATAGCCTAAGTATCTCTTAGAACTTTAATATTCTGCCACTAGTGATATTCCACTCACTACTCATAGGAAAAGAGATAACTTCAAAGGTTTTTCCCCTGATAAATACTGAAAATATGTTGGAAAGAAGGGAATTGTTTTAATCATATGAGCCTGTCTGGTGAGTATTTTATCCCTATTTCACAACAGCAAGAAATGGACAACAGGAGAAATAAAAACAAAACTGTGATTGTTCATTGGCCCAATGAGCAAAGTGAGTTGTTTTAAGATTCCACAGATTAAGCAGTTAGAAGAAACTGAGATAGGCTGCTCAGGTTCTGCAAGGTACTCTTC 294 R3HDM1 2507440GAAGAAGTATGATGATAAACTTGAACTG 295 R3HDM1 2507441TTGTGGTAAAAGTGCAACTCAAATCATTATTATCTATCTATGATGTCATAGACAAACAATGTCTATCTTAGTTGACATAGAAGTTCTCTATTTAAATTATTGCCTGAACAATCTTAATTCCATTAGTTTATCTAACATTTTTAAAGTATTGTCTCTGAAGACAACATGCAGAGATATTGTTCAGAAGGAGATGCATGAATATACATTTTAACTAAGAGTTTTCATCAAGTGAGATTCCCTGGGTTCCTCATCTACTTGCTTATGT GGCTGTCTACAAGTCACTTAATT 296R3HDM1 2507442 TCTGCAGTCCTCTTCACAGCCTGTTCAGTACTCTACAGCCCCTTACCCATCCCCGTTCCTGCCAGTCTCACCCACC 297 R3HDM1 2507443GATAACCTAGGGTCTCAGTTTAGCCACATGAGTCTTGCTCGCCAGCCATCTGCTGATGGTTCTGACCCTCATGCCGCCATGTTCCA GTCCACTGTGGTTCTT 298 R3HDM12507444 GTTATATCATGACAGCAGCCCCTCCACCACATCCTCCTCCACCGCCACCACCACCACCTCCTCCTCCTCCCCTACCACCTGGGCA GCCAG 299 R3HDM1 2507445CCTACTGCTGGATATCCTGCCTCTGGTCATC 300 R3HDM1 2507446ATGGTTATTAGTTGGGTTCTGCCTCTTTATACAGTGATTGGAGTGTCATTAGACCCTTTAAATTTAATATATTTTTGACATGGTATGCCATGTCATACCAGATTCAGGTATGCCACATTGCTATTTTTTTATTTGCCCTATCTGTATTTTATTCTACTTTCCTGCATTTTATATTATTTGAACTTTTTTTTTTTATAATATTGAATGCTTTACGAATTTCCG TGTC 301 R3HDM1 2507447TAGCCTTAAGGTAATATAAGCCATATTTTAAATAATTTCATGCATGATGTAAAGTTTTGACTGTAACCTGTCACATGAGGTCAGGTGTGGAGTTTCTTTTTGAGTACTGACATGACATGATGCTTTTGGCATCATGTTGGTACTCAGAAAGTTAAAGATTTTGGAGCATTTCAGATTTTGGACATTTGGATTTTTAAAATACTCGCCCAGGCTCA 302 R3HDM1 2507448ATGCCAGCCTGTTATTGCGCTCCAG 303 R3HDM1 2507449GCCACTATCACTCCAGCCAACCTCAGTATCGCCCAGTCCCTTCTGTTCATTACAATTCACATCTAAACCAACCA 304 R3HDM1 2507450GTCTCTCAGGATCTCGAATATGTTCATACATATGAGTTTGCAAACCAATGAGATTAAAAGAGTGAGCAAATCTTAGCATCCTCTGGAAAATACCACAGTGTCACGTCTACATGCTAAAGGGTTGGGAGCTGTACTGGGAATATCTTAAGCAGTTTGTTAAGTGGCTGCCATCTCTTACTGCCATTGAGATTGAAACTGTCTTTGCAGCCTGATAAAT CACCTATGG 305 R3HDM12507451 AAACAATTTTGATCTCAGTGTATAAAACTATCTTATTGATTTTTTAATGAACTCATTTCTCTGTATGCTTCT 306 R3HDM1 2507452 TCAGCCTTTTATAACTCTAGGAGTT307 R3HDM1 2507453 AAGTTTGTAGCTTCACCATATACATTTAATATTTTGCAATAATTGGCCTTGTTC 308 R3HDM1 2507454 AGCTGTTGGATTCGGGGCCGTAGCACTGTCTGAGAGGTTTACATTTCTCACAGTG 309 R3HDM1 2507455AGCATGACATCAAACGGACCTAATACACCTAAATGCATTTGAAGCTACTTGGTCTCGGTTCTTACCAACGATATAATTTAATTTTTTTTTCCAAACGATGATGTTGTTGCATACCTGTGGAAAGCAAAATGATTCTGTGAAACTATACTTTTAGTTTTGCAACCATTTGATAACTTCAAAGATTATCAATGTATTATATCTTTAGTCTTAGCTTTCCAGAT AACCCAGA 310 R3HDM12507456 TAACCTGCCGCCACTGAAATCTGGAGCCAAATATATCTGGTAAGTACCCACAGATTTCCTTGAGTTGTATAGACTCTTCCATGGAATAGTTCTTTAAATAGCTGTGAGCAATAAACTCTGTGTGACTGTTTTTGTTAGAATTGGTTTTTGTATATGTATATGTTTATTTCAGGCACAGGAGTGAGAGAAGAGGGGATGAGAGATGAGAAGGGATAATCAAGTGTGATGGCAATTGCATCTCCTTCCAAATACACCCATGGGGCTGGCTTTAGTTGAACTTGCCCACCTACTAAAATAG 311 R3HDM1 2507457TCGCCCATAAAACGTAGCAGCTCTCCTTGCACAAAATGTGTCCAGGTTAAAGCTGGCACTGCCCTGCTGAGTAAAGTCTGACTTCTTGGCAAAGCAGCCTGACTTTGTGGAGAAGACAGCCAGTATCTATGAAAACTCTGCTAGACTAATCTTGTATAGACTCATCTGGAATGTGGCAACAGACTTTTTGAGCAAAAGCAGCCTCCGAGGCAAAACAGCAAAACTAAAGCCCAAAGGGAACATTGGAGATTCACTTGGAAATACTCAGGCTGAGAGACAGAACTGTGGGATGTGGAACCTGAAATAGTGTCACTATTTGAGCCAGTTCTTCTCCTTCCCAATTGTCTTTTGTTATGTTTTAATATTTTTAGAGATGGAGTCTCACTGTTTTGCCTAGACTGGAGTGCAGTGGCCCTTCCTAATTGTTTAATACAATTTATGCGTATAATCTAATTATAGTAAGGCAAGGAAGTGTAACTTTGAAATACATCAGTAGTAAACCACGCATCTTGCGGGTA GTGGACAAACCA 312 R3HDM12507458 GCCTGAGCGATAGAGACTGCATCTGAAAACAAACAAACAAAAAGAATAAGATACCATTGGAAATTTACTCATGCAGCTTTCATGAT 313 R3HDM1 2507459ATGAATTCAGAGCAGGATTTAACTCATTGTACCATTACAG 314 R3HDM1 2507460TACCAAGGAATAGTTGGAGTTCAGCAACCCCAGAGTCAGAGCCTAGTCAGTGGCCAACCCAACAGCATTGGAAATCAGATTCAAG GAGTGGTCATCCC 315 R3HDM12507461 CCATCAGACTTATCAACAGCCTGTTATGTTCCCTAATCAGTCTAATCAAGGATCTATGCCCACAACAGGAATGCCTGTTTACTATAG TGTCATTCCACCTGGTCAACAA 316R3HDM1 2507462 AGTCTTTGGAATTACCCGCAGCTTGGACCCAAATGAGGCAGATAAACTTGAAATAAGGTAGATGTAAGCTGACAGTAGTGATTGGTCACCATGTGACAAACTAGCATTGATCTGTTCCAAGTATAGAGTACCAATGTGAGAAATTGAATGAGTTGTACGTGAAGCAGGGAATGTGTATTCTGTCAGACTCATCTTGGTACATTTTGGA 317 R3HDM1 2507463CAGGGTCTTGATCCATACAGTCTTACTATGTTTTAGATGCTAAATGGACTCTAGTAGCCTTCATTTTATTACAAGATTATAAGGAATAAGATTCCTATAAGAACACAAAGTGAGTCTTTGTTTTGAAAAATGTCTTACTTAGCTTGGGTTGCTTAGCAAAATTGTTTTCTTACAGAGGTTCCTTGTGTAGAAAGGTAGAATTTGAATTATTATGTCTACTTTCAGCTCATCCTTTCAGTTCACTGAGGCAACTTTGTGTTTGGATTGGATTGTGTTGTTACTTATCATTATGAAGATTGAGCACAGCCTGATACAAGTCAACATATACTGTCACTTTAAGCGAGCAAAGTACTAGTCAGGGACACTAATTTTACAACAACTCATGAGATTTTTCTCAGTCCTTAGTGTGGAGAGAAAATTAGTTTGATACCAGCAGCCTTCAAAAGTGGGCAAGTGAGTTGGATATCTTCAAAATGCTCTCATTTTTACCGGTTCTTCTCCTATTTTCCCTTTCATTTTCACTATTTTTATCTTGAAATTCAAAACGATAATACCTTTGTCTTTGATCTATATTCTCAAAGGGGTAGCATACAGACAGGAACTTGAAAAGACTATAGCCTTTTTTTAAGAACCTTTAAAAAATGTTTCACAGAATCTTTATGAAATTATGAAAAAGAAAACCTACTTTTAAGTCTTTTTCCCTTTTTTCTGTCCACAGTCTGTTTTTCCTCATTTTTGTATCCTAGTATTTCTCTAGTGTCCCTTTTGTCCTACTTGTGATACCTCTCTTG 318 R3HDM1 2507464TTTTGGGTGGCAGATAACATTTTACTTAATTGGGGTTCAAAGTTAGTGTTCTTTGTCATCAAGTTGATTTCAGATGTTCATCTGTAAAAACCATTCTTAGCTTGGAGGCAATACAGAAGCAAGCAGTGGTCTGGGTTTTGCCTATAGGCCATAGTTTGCCAACTCCTGTACTAGATGGTTGATAGCCAGCAAAAAAAAAAGACAAAGAGGCAGTGGTCACAAATGAAGACCAACAACTTAGGAAAAAGGAGTGTGGAAG CCAACATACAAGGAGATTT 319R3HDM1 2507465 TCAGCCGACTTAGAAGCAATACAAGCCAGAAGACAGTGGAGCAACATCTTTATTTGAAGAAGTGAAAGAAAGAAAACTTGCATTCTATACCTGTAAAAATATTTTTCAGAAACAGAGATTTCAAACACACAAAAGCTGAATTAATTGCCAGCCACCTCGCACTGTGAGAACTG TTAAAGGAAGTTT 320 R3HDM12507466 AGGCAACTTTGGTGAGGCTTTATGGTGTGCATATACATAAAACTCTTTAAATTATATACTTTATGTGTGGTTTATTTTCTATAAATTATACCTCAGTAAAACTATAAAATAATCTGAGTCTTAAATTTTTTCTTAGAGACTGGTTCTTGCTGTCATTTAGGCTGGAATGCAGTGGTGTGATCCTGACTCACTGAGGCCTCAACCTCCTGGGCTCAAGCAATCCTCCTGCGTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCACGCCACCACACCTGGCTAATTTTTTAATTTTTTTTAAAGATAGGATCTCACTGTATTACCCTGCTGGTGTCGAACTTTTGGGCTCAAGCAATCCTCCCACCTCAGTCTCCCAAACTGCTGGGTTTACAGATGTGAGCCACCTTGCCTAGCCTTCTTTTCTAATAGTTTAAACAAAGACTAGTTTTGGATAAAGTGAAAAGAAATACTGTAAAACTAACAAATTATTAAAAACAAGAGTAAGAATTTGTGAGGTTAAGATAGGCCACAGGGCATTTAATGGAGGAATAAAGGTAGACTTGAACTAACTGTAAAACCTGTTACAGAGTCATATTGAAATGTTAAAATTTAATCAAAAGTGTTTTTTTCAAAAAGCAAATGACTAAAAACTCCTTTCAGCCAGAGGTGAGAGATCGGGGGGAAACAAAAAAACAATAAAAAGAAAGTCCAAATACCTATGTTGCACCAGCCTGACCAACATAGTGAAGCCCCACCTTTACTAAAAATACAAGAAATTAGCTGGAAGTGGTGGCATACTCCTGTAATCCCAACAAAATACATGTAAAACCTTTATGCCCAAAACCATCTTGTGATGTGGAAGATTTGTACTCCCTATGGTTTATATCTTAGAACAGATGTCAGAAAACTACAGCCCACAATCAAAGAATGGTTTTTAAATTTGTAAAGGATTATTATTTTTTAACTCCTAAGTGACCATGTGTTACTCAGAGTTAAAATATATACTAGCTGGCTCTTGCAGAAAAAGTTTACCAGCATCTGCCTTAAAAAAACCTTGGCAGATAGGTATCAGAGACATGTTTATGAATGTTTGTAGCAACAATGTTTAGCCTAATACTGGAAGTAATCCAAATAAAATGGAATAGAATGTGTAAGTATATTTTGATGTATTCATTTCAGACACTACTATACAACAAAGAAAATTACTAAAGTACAACTACTTGTATCCAATTGGTTGAGTCTCACAGA 321 R3HDM1 2507467GTTGGACAAAGTGGGTCACGCCTGT 322 R3HDM1 2507468AGGCAGGGATGCTTCTAAGATACTAGCAATGTTCTGTTTCCCAATCTGAATGAAGTTACATAGATAATTATTTTGTTATTATACTTAATTTAAACTGTAATATATTTCTAAGCACTCTATATTCGTCTGTTCTCGCATTGCTATAAAGAAATGCCTGAGACTGAGTAATCTATAAAGAAAAGAGGTTTAATTGGCTCACAGCTCCGCAGGCTGCATAGGAAGCATAGTGGCTTCTAGGGAGGCCTCGGGAAACTTCAATTATGGCAGAAGGCAAGAGGGAAGCAGGCACGTCTTACATGGCTGGAGCCCGAGGAAGAGAAGAGTGGGGGGAGCACCACACACTTTTTAAAGAACCAGATCTCATGAGAACTCACTGTACAGTACCAAGGGGGAATGGTGCTAAACCATTAGAAACCACCTCCATGATCCAGTCACCTCCCAGCAGGCCCCACCTCCAGCGTTGGGGATTACATTGTGAATGAGATTTAGGTGGAGACACACATCCAAACAATATTACACTCAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAAGATAGATAAGATAGATTGATTAGATAGATTAGATAGATAGATAGATAGATAGATAGATTAGATATTCCAAACCCCAAAAAATAGCAAAATCATTCGAAGAGAGGCCTAAATATATAGAAGACTTTAGGAGAAAAAAAGCTAACAGAATGGGAGGAGAGGAATTGAAGACAATAAATAGAGACAGCCTTTGAAGAGAATTGCTTTCATAAGGATAAGCGTTGAATTGGATTCGTATATGGAGAGGATGAAGTCAAGACAGAGGATCCTTTTTTGATTGAAAGATAGATGCATGTGTTTGTATGCTGAAGGGAAAGGCTTAGTAGATACAGAAGATTTGCCTCTGCAAGGGACAAGAGAGAGAGTTGTAAGGTCCCCAGGGAGGGTGAGAGCCACCACAAAAATGGAAGCGGGTTAGCCTTAGATAACAGTGCAGAGGATTTCATGGGCAGTAAACGAGGACAAGGAGAGTATAAGGATACAGATATGGGTAGATGGATAGATATGGCAGCAAGAGAAATTCTCTTCTGATTGCTTTGCTTTTCTCAGTGAATTAGTCAAGATATCAAGTACATTATCAGAGTAGAAGAATGTTCTAAAGTTTTGTAAATGTAGAAATCCATTACAGCTATATTAAGACTAATATTCAAAGGAAAGAAGCAAGATACAGGGGAAATGTGACAAGTATGCCTAATAAAAGCTTATTATATAGAACATTTTTATCACTTCTCTATGTTCTAAGATGGTAACAGTGAGACTACAAGTAAATAATCCATAGAGATAAATTGTTACTCGAAGAAAACTGATAGTAAGTTTTCACATGGGAAAATGTTGTCTTACCAGCAATCCAAAAAATGAGAATTAAGGCAACTTGAACACAAAAAGTAGGCTAAAACATATAGTTAGCAATACTGTGCATAGAGACGTTTAAACATTACTGGTTGCTAGGCATATCAAGCCCATTTTTCTATAAATCAGTCGGGATATTTAACAAAATGCAAAATTGCTGTACTTTTAAATTCTACCTCTAAAATTTTATCACAAAGATAATCCACCCCAGAATTTAAATTGTGGCTAAACAAATTATAACAGTGCTATTATTAACATAAGAATCCAAATAAAAAGATGCAAAAAAAAAAACATGGAGTAACCTGGTAACCTTTGAATAGTTTAAATTTTCTTCTCCATTTATTTTTCTGCTAGGCTGATTAAGTTTAGCTTAAGTCATAGTGAGATTTACTTAGTTGTCACAGACCGTTTCTCAGATAGTGGGACCAGTGAGTTTTAAAGGTGTTTGTTCTGTGTTAATTGCTCCAGTATCTTCAATTCAGAAGAATAAATGTTTGATATTCAGGCTGCTATAGTTCACAAATGGATTTTATTGATGACTTACAGCATTTTAAGTGAATAGAGCACATGTCTATTAAGTAATATTATTAAGTTCAGGAAGCTTGCTTAACTGCCATTGACAATAAGATGTAGGGTGGTTTAAAAAGGCAGAAAACCAAATGACTTAACACACCTTGACAACTGTTCATAAATTTTCAAAGACATCGCTTCTAGTAGTCACTAAAAGCTGTAGTAGATGTATGACTTGCTTTTCAAATGAATCAATTATTGCTTGAGAAGAATACACTTGTTCCTATTCTCCCATCTAAAAAATAATTTGAAATAGCAGCCATGAAATATTTACAAAAACATAAAGAGAAAAGACACATGATGGCAGTTTATTTTCATGTGGAATTTCCCATGCTATTAATTTTCCTAAGTCTCGACCTTTTGTGGGTGA 323 R3HDM1 2507469CAGGAGCATCAGAGACATCTTTGTG 324 R3HDM1 2507470GGTATATATACCCTCACCACAAAAAATATATATAAAATGGAAATTACTATGACTTTGAGAAAGCTTATGAGGCAGAAAGTTGGTGTTTTCTTCCAGAGACTACAAGCCTAGTTGAGCATCTGACCTGCAA ATGAATTGGTTATT 325 R3HDM12507471 TCTTCAGTAGGTTACCTGCAACATCCAGGATCAGAACAAGTACAATTTCCTCGAACCACTTCACCATGCAGTTCCCAGCAGCTTCA AGGCCACCAATGT 326 R3HDM12507472 TGATGATGCAGCTCAGTGTACCAAACAATCCACAATCTTGTGCCCACTCACCCCCGCAGTGGAAACAAAACAAATATTACTGTGAT CACCAGAG 327 R3HDM1 2507473TGATACCTGATACCAGTGGGACATTTTACTTGACAAATTGGCCCTGTTACTTGAATAGATGGCATTTTGAAATAGGAGCTTGGTCTGTTATACATTAAAAGAGACTCAAGAGGTATAATATCAGATATAATGTATGGATCTTATTTGGATATTGAATGATCAAAAGACATTTTTTAAGGCCAGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCTAAGGCAGACCTGGAACGCAGGAGTTCGAGACCAGCCTGGGTAACATGGTGAAACCCTGTCTCTATAAAAAATACAA AAAATTATTCGGCCATGGCAGTGTGCA328 R3HDM1 2507474 GGCCATCTTGGCTATGCCAGAAAGTAAGGAAGGGATGGAAGAAAAATAGGGACGTCTTGAAGAATACAGGATCAGGAGTGGAGGTTTGGGGCATAAAACAATGATAGAAATGAATGATCATCCATAGAATAAAATAAGAATTCATGAGTCCATACTGATAAAAATCAATAAATGGAAAATGAAACTGTCTTACCTTAGTGTAATATAAAGTGATAAATGTAGAATCGTGAAATTAAAAGATCACCACCAAGAAAACCATCAGGCAAGAGTCACCACTAGAGGCTACAAAA 329 R3HDM1 2507475AGCCCTCAACTCAGTAGCCCCATTATTTCACCAGCTCAGTCGCCAGCACCAGCTCAGCTGTCCACCCTGAAAACTGTACGTCCCTCTGGACCACCACTTTCCATCATGCCCCAATTTTCTAGAC 330 R3HDM1 2507476GAGATTCCAGGTATCCATTACTTGGCCAGCCACTGCAGTACAA TCCTCCTGCTGTTCTGCACGGACACATT331 R3HDM1 2507477 AAGACAACTAACCTCCTAGGCTTTGTTGCAGAACATCATAGCTCCCTCAGAGT 332 R3HDM1 2507478 TGAAGGACAGGAATGCCACTGCCACAGGCAGAATCCAGAAGGCCTGGGACTGATTTTCTTCTGCCAGAGTGCAAAACCCAAACTA 333 R3HDM1 2507479CATTATTAACGTTGTTTCTCAACTATTTGTGGGTTTTCAG 334 R3HDM1 2507480GAAGGAGACAAGCTAAAAAAGCTGCATCCA 335 R3HDM1 2507481GAAGGTCTTGGAAATTACTGAACTACCAGATGGAATAACTCGCATGGAAGCTGAAAAGCTTTTTGGGGAACTCTTTAAAATTGGCGCCAAGATCCGGTGGCTCCGGGACCCCCAGTCCCAACCACGTCGTCACCCCCTCTGCTGTGGCAGTGGGGACAACACTGCCAACC CTGAACGCTCTAAACCCAGTGACTTG336 R3HDM1 2507482 GACTCCTAGGATGTGTGTTCATGGCATTATAGCTTTTGAAGAAAGGCCAGTGATCCAGCAAAGGGGGAAAAATATGCATTTCACCCCACATGACTAGGAATCCACATCAGAATGATACAGAGTTAGCAGGTTTTTCTAAGGAAATGCCATTCAAATGCCTCCTAACTTTTATAGTTATTTTGTTTTATATTTCTAAATTCTTGTATCAGATCCAAAGCTCTATTGTACAGCAAATTATTCTTCAAAATGATTATAACCAGTTGCACCCTGTATTTCTTTTTGCAGCCAGCACAATGTGACCCAACTTAAAATTTGGGGGAAAAAGAATGCAGGAGTGAAATAACCAAGTCAAAACCATGTACTATCTCCTTGGGGGTTAGGGATGCTAAGAAGAGCCCACAAATAGAGGATTACTCTTCCCCTGAATCTCTAAACTCAGAAACAATTACCAAAAAATACATAACTCTTCCTTGTAGGGCCCTTTCCTTATTCATTTAGGTAGTGTGAACATTAAGTATAAAATAAATTATGTTCTTAATGCCTCTTAAACCACTTACATTCAAAGGGGAACAGAAATCATTCTAAGCAGGAAAATACTTCCACTTTTTTTTTTTCAAGTATCTCTCTAATAACTAAATGCCACTTATTTGCATTCTCCTTGTGGATTTTTTGTCACCTAAGGAAATGCATTTGATGAGTGCTGGAAACTTCTTAAGTGCTTTACAGTTTGTTTTCATTGTTTGCAGCGGATCACTGGACATCAAAGATTCATTGCACTTATGAACAAGGAACCTTCTTTTCAATTTCTGTGTAATTTGCAAGGCTGTACA ATGTGTGCTGATGCAAGCC 337R3HDM1 2507483 TCAGTTCAAGAGAATAAATGTTTAC 338 R3HDM1 2507485ATCTTCACTGCTGTTCAACATTATAATGGAGGTATTAACCAATATAGTTAGATACATCGATTTAAGGCATAAGAATGGGTAAAGAAGAAAGACTATCTCTGCAGATTATATGATAACGGGTTGAGCATCCCTAATCTGAAAGGCTCCAAAATTCAAAACTTTTTAAGCAGTCAC ACGATGCACAAAGTAAA 339R3HDM1 2507486 AGGTACAGTAGTTTCTTGTTGGAATAA 340 R3HDM1 2507488TTGTTGAGAAAAGGTTACCCTCTGACAC 341 R3HDM1 2507489GCCTAGACAACATAATGAGATTCCATCTCTATAAAAAAATTAAAAATTAGCCAGGTGTGGTGGTATACACCTGTAGCGCT 342 R3HDM1 2507491TGACTCTCCGGGTCACGACGTTAACCAAAAAATAAGACAAAAAGAGAATATATTCTATATGATTCTAATTATATGAAATCCAGCTGCAGACAAACTAATCTGTTATGTTAAAAATCAGATAGTAGTAGAGATGGGGTGTGGAACTGACTGGGAAGGGACTGGAGGGAACTCTTCCAGGGATGGAAATGTTCTTTAAGGGGGTGGGGGAACAGGGTATGGTTACACGGACTTTTACAGTTGTTAGAATTCATCAGATTCAACACTTAGAATGTTTATTTTATTGATTGTATTGTATGTTAATTATATCTCAATTTCCTTAAAAACTTACACACACACATATGCATGAGT CAGCCCACACATGTAGAAGA 343R3HDM1 2507492 ACAGTCTGGTATGAATGCCGCAGGAGGAACACCTAGCCCAGCCTATTAGGAGGGGTCTTTGTACTGCTGACTATAATCTTATCTC 344 ACO20571.3 2521178AAGGCAACTGGTCTGATTTTTCAGGTAAGAACATATGAGAGGCAGGCTGAGACCAATTTTCTACCAGGCCAGCTAATTCATCACAATGACAAGCTATGGGTCATATGCTTTCAGGAACCAGACACTGGA ACATGTCGTCTGATGTAC 345ACO20571.3 2521179 GAATCCAATGGGGAGTAAGAGAAAGTCCCTTTTCAAGGAGCT 346ACO20571.3 2521180 CATGTGTTCGGAGACAACCAGAAGCAGCAATGCTCAAAACCACAAAACTCTGGATTGCCGACTCTGCACATCCTGGTTCCTCTAGATACAGTTCAGTGGCACATTCACAAATAAACGTTTTCAAAAACTGCCCTCAGGCAGTTCTAGAGAAATGCTTTGACTTGCCTAATGGTATAATGTCAAGAAAGGAAGACGAGCACTGATCATTCATACTCATTATTACAGTCACAGGGCACTGTCTGACTTGACAGATACAGCCGAGCAGTTAAAAGGTTATGGGAATTTAAGTCCATTATGGTCATACGATTCTTATGGACCCAGAGATATGAAATTAATCAGCCACA TGTGTAGGGACAAAGTT 347 ANO72536218 CCCGTTTTGCCAGCCCAAGACTAGGAGCCACGGCACCTGTCC T 348 ANO7 2536219CGGGCACTCACTGGATGGACAGACAGACGCCTGCTGTGCCAGGCCTGCCAGACGCTCCCGCCCCGGCACTGGTTTCTTCCTGGAGCTCGTGGCTGGCTAGGGGGTTCTCCATGTGCTCATGGCCAGGAGAGTCTGCCGAGCCAGCCCAGCCCCATTCTACTCCGAGT CGAGTCTGTA 349 ANO7 2536220ATGCTGCGGCGACGGGCCCAGGAAGAGGACAGCACCGTCCTGATCGATGTGAGCCCCCCTGAGGCAGAGAAGAGGGGCTCTTA CGGGAGCACAGCCCACG 350 ANO72536221 CCAGGTGGACAGCAAGCGGCCGCCTGCAGAGCTGGGAGTCC TGCCAAGCCCCGGATC 351ANO7 2536222 CTGAAGCTAGACAGGCAGCAGGACAGTGCCGCCCGGGACAGAACAGACATGCACAGGACCTGGCGGGAGACTTTTCTGGATAA TCTTCGTGCGGCTGG 352 ANO72536223 TGACCCATGACCTTGCCGCATGAGGCCTGAGGGCATGGTGTCCAGAGTCCCAGAGCAGATCAGGCCCCAAAGTCCTGCTGGACCCCCCAGCCACCGTGAGCTCCTCCGTGTGGCTAGGGAGCTGCTGTCCAGAGGCGGAGGTAAACATTGATCCCTCCTGCACACTCAGCTCTCTCATGGAAGTCGGAGCCCTCAGGGTCACCTGAAAAC TCT 353 ANO7 2536224TTGCCATTCACCTGTCCCGTCTCCAACATTAAAGCTT 354 ANO7 2536225TGTCGAGGCCCGGTTGGCTTTCAGAGGCGTATCCATGGGAGTAGGTGTCATGTATCAAATAGGAGATTCAAAGTCAGCTGTTACCACGGCTACAGAAATGCCAGTCTTTTCCTAAGAGTGCGAA 355 ANO7 2536226AGGACGGGAACACCACAGTGCACTACGCCCTCCTCAGCGCCTCCTGGGCTGTGCTCTGCTACTACGCCGAAGACCTGCGCCTGA AGC 356 ANO7 2536227AGTTACCCAACCAGGCCTCCAACTGGTCGGCCGGCCTGCTGGCATGGCTGGGCATCCCCAACGTCCTGCTGGAGGTTGTGCCAGACGTACCCCCCGAGTACTACTCCTGCCGGTTCAGA 357 ANO7 2536228CTTCCTCGGGAGTGACAACCAGGACACCTTCTTCACAAG 358 ANO7 2536229TATGGCCACGAGAAGAAAAACCTGCTTGGGATCCACCAGCTG CTGGCAGAGGGTGTCCTCAGTGC 359ANO7 2536230 TTCAAGACGCCCCCAGAGGGCCCGCAG 360 ANO7 2536231GCTCCACGCCTCAACCAGCGCCAAGTCCTTTTCCAGCACTGGGCGCGCTGGGGCAAGTGGAACAAGTACCAGCCCCTGGACCACGTGCGCAGGTACTTCGGGGAGAAGGTGGCCCTCTACTTCGC CTG 361 ANO7 2536232CTTCCTGGTGTTCTCAGACATACCC 362 ANO7 2536233GGCAGCAAGGACAGCTTCGAGATGTGCCCACTTTGCCTCGAC TGCCCTTTCTGGCTG 363 ANO72536234 CCGGCTGTTCGACCACGGCGGCACCGTGTT 364 ANO7 2536235CTGCTGGAGTACTGGAAGCGGAAGAGCGCCACGCTGGCCTA CCGCTGGGACTGCTCTGACTACGAG 365ANO7 2536236 CGAACCCCATCACGGGTGAGGACGAGCCCTACTTCCCTGAGAGGAGCCGCGCGCGCCGCATGCTGGCCGGCTCTGTGGTGATC GTGGT 366 ANO7 2536237TGTGCCTCGTGTCTATCATCCTGTACCGTGCCATCATGGCCATCGTGGTGTCCAGGTCGGGCAACACCCTTCTCGCAG 367 ANO7 2536238CATCGCCAGCCTCACGGGGTCTGTAGTGAACCTCGTCTTCATCCTCATCCTCTCCAAGATCTATGTATCCCTGGCCCACG 368 ANO7 2536239GCCAGAACGTGACTTTCTCACTCACTGACACACATGGCCCTCA TTTCTATT 369 ANO7 2536240AAATGCACCGCACCCAGACCAAGTTCGAGGACGCCTTCACCCTCAAGGTGTTCATCTTCCAGTTCGTCAACTTCTACTCCTCACCC GTCTACATTG 370 ANO7 2536241CCAGGCAACTACCACACCTTGTTTGGAGTCCGCAATGAGGAG 371 ANO7 2536242TCTTCCATTCGAGCTTTGATTTGCAGCAATTCCTCCCACCACC GGCTATTTCCATCGCCCAGCCAGGG372 ANO7 2536243 TGGAGGCTGCCTGATCGAGCTGGCACAGGAGCTCCTGGTCATCATGGTGGGCAAGCAGGTCATCAACAACATGCAGGAGGTCCT CATCC 373 ANO7 2536244TGGTGGCAGAAGTTCCGGCTTCGCTCCAAGAAGAGGAAGGCGGGAGCTTCTGCAGGGGCTAGCCAGGGGCCC 374 ANO7 2536245TGTGAGGGTCTGTTTGACGAGTACCTGGAAATGG 375 ANO7 2536246GAGCAGGTTTCTGCCCCAACGCCTGCCCTGAGTTAGTTCCTGAGCTCACCGAGCCGGAGAAGGCCCGTGACCAGCCAGAAGCA CGGAGCGCAGGGC 376 ANO7 2536247TGAGGGCGGACGGTGGCGGAGAGCCCGGCCGTGACCC 377 ANO7 2536248CTGCAGTTCGGCTTCGTCACCATCTTCGTGGCCGCCTGTCCGCTCGCGCCGCTCTTCGCCCTGCTCAACAACTGGGTGGAGATCCGCTTGGACGCGCGCAAGTTCGTCTGCGAGTACCGGCGCCCGGTGGCCGAGCGCGCCCAGGACATCGGCATCTGGTTCCACATCCTGGCGGGCCTCACGCACCTGGCGGTCATCAGCAA 378 ANO7 2536249CTTCTCGTCCGACTTCCTGCCGCGCGCCTACTACCGGTGGACCCGCGCCCACGACCTGCGCGGCTTCCTCAACTTCACGCTGGCGCGAGCCCCGTCCTCCTTCGCCGCCGCGCACAACCGCACGT GCA 379 ANO7 2536250AGAGTATCCTGTTTGGGAAGAATTCCCATTTCAGGCACCCTCGATGAAGAGCCAGGCCAGGAACATGGGATGAGAGAGCGAAATGGTGGAAAAAGGGGAGATAGGCTAATTCCAGA 380 ANO7 2536251CCTGGCTGCGCGCACTGAGTCCTGTGTCTGCTG 381 ANO7 2536252GTATCGGGCTTTCCGGGATGACGATGGACATTATTCCCAGAC CTACTGGA 382 ANO7 2536253TCCCATCCATGGCATGAGGCCCCGACCCTGTGCTTTGCCTAAT TCGAGCACGTG 383 ANO7 2536254TTGGTCAAATCAGAGCTCTTCTCTGCACCTGCGTTTTCCCTGCCTGGCCTCATCCCTGGGTTGTGGTGTGGACATTGTGGGTGTCTCCACAGGAGCCCCAGGGCCACGAAAGCTGGGGTGGC 384 ANO7 2536255CTGGCCCTGTGAAGGCCACTCTGGGCGTTTGGGTG 385 ANO7 2536256ATGTGGTTTTCTCCGTTGGCCGCCTCCTGGACCTCCTGGTGCCTGACATCCCAGAGTCTGTGGAGATCAAAGTGAAGCGGGAGT ACTACCTGGCTAAGCAGGCACTGGCTGA386 ANO7 2536257 TGAACTGTACAGCCCAGTCTCGGCCCTCCCCCCAGCCCTCTCCCTATCCTTGTCAGTGGCTGCTCTACCTCCGGACACTGAGTCA CAT 387 ANO7 2536258ACGGAACAAAGGATGAGCAGCCCGAGGG 388 ANO7 2536259CGTGCACTCCCTGAGGTCACAGGGCCCTGCCCAGCCGCCCACTGTGCCTCGTGGCCATGGCCTGCTCCTGGCCCTAGTCTGAC TTGTCCCTGC 389 ANO7 2536260GCTCCCACTGGACACCCTTCACGGTTCCCAAGGCCAGCCAGCTGCAGCAGTGACGCCTGGAAGGACATCTGGTGGTCCTTAGGGGAGTGGCCCCTCCTGAGCCCTGCGAGCAGCGTCCTTTTCCTC TTC 390 ANO7 2536261TGTGTGAACCGCTGGCTGCTGTTGTGCCTCATCTCTGGGCACATTGCCTGCTTCCCCCCAGCGCCGGCTTCTCTCCTCAGAGCG CCTGTCACTCCATCCC 391 ANO72536262 TTCGAATGTTTCAGAGCGCAGGGCCGTTCTCCCTCGTGTCCTCTGGACCCACCCGCCCCTTCCTGCCCTGTTTGCGCAGGGACATCACCCACATGCCCCAGCTCTCGGACCCTGCAGCTCTGTGTCCCAGGCCACAGCAAAGGTCTGTTGAACCCCTCCCTCCATTCCCAGTTATCTGGGTCCTCTGGATTCTTCTGTTTCTTGAATCAGGCTCTGCTTTCCCCCTAGCCACTACAGGCAGCCTCTGACAGTGCCGCTTTACTTGCATTCTGCAGCAATTACATGTGTCCTTTTGATCCTTGCCCAACTTCCCTCCCTCTCCCAGCTCCTGGCCCCTGGCCCAGGGCCCCTCTTGCTGTTTTTACCTCTGTTCCTTGGGGCCTAGTACCCAGCAAGCACCCAAATGGGGGAGGTTTTGGGATGAGAGGAGGAAACGTGTATACCTGTAACATCTGGTGGCTCTTCCCCCAGAAGTTTGTGTTCATACATAATTGTTTTCCACGCTGGATCATAATGTGACGTGCAGTTCTGCCCTGTGCTGGGGAGCCACATGAAGCTTCCCCTGGCTAACTTGCTACCCCGCAGCAATCCCAGTGT GGCCGTCTGCTTGCTAAAAAATG 392FTH1P2 2545844 TCACTACTGGAACTGCACAAACTGGCCACTGACAAAAATGACC C 393MIR4435- 2570866 GGAAGTCCAGCCTTACCAACTTGTGAACCTTGTCTGAAGGGA 1HGGCCAGGGCCTGCCAATGGAACCACCTCCAGGAGCTGCAACTGCTGTTGTCATTAATACCATTGTGTCTATTTTTTGAGAGAGATAAACTTTTCATGGTGTTACATTTTGGAAAAAAAAAAAAAAGACTAGGTGAACAGTCAGGTAGGAAAGCAGCATAACAGTCCCTTAAATTCTGATCATGTAGGACATTCTTCTTTGCCCTGGGCCTGGGAAAATGCAGCATGTTCCAGAGCAAAAGTCCTAATGAGGGGAACTAAACCAGTGGGACCCAAACCAATGTCCTGGCTCACTGAGGACCCGTTAGAACCAAATCTCTGGGTGTGGACAGGCTCCCATACTTTTCAAAAATTCCCCTGATGACTAATGAACAACCAGAGGTAAGAACCAGTGGCCCAGAGGAATAACCAGCCCAGCTGTTGTACGAGCTCGCTAAGCTGGCTCAGGTCAATGTTGAATTCTCTGCTAGGCAGCTCCTCATAAGAACTGGCAGAGATGGTTCTTACACAACAACAGGTGACAACTCCAGACTCTGCCGGAAGTTCCAGGATCTGGGTTC CCGGACAATGCATGACAC 394MIR4435- 2570867 GGTTATCTTTCCTCCACTCGAGGGATTGAAGCTAGGCTGTCCC 1HGACGGCACCGGGCTCGTGGC 395 MIR4435- 2570868CAAAGCCACGCATGCAGAGAGGTTACCAGTGTCCATCCAGAC 1HGGCCCACTTCACAGACAGGTAGCCAAGCGCCAGAGCCCGGCTA TTGTAGCCCTAAGTG 396 MIR4435-2570869 ACATTCTGGATGAAAGAAACTACTCAAAAAGAATGTTTACTGTA 1HGTGATTCCATTTTTATGTTTAAGAACAGGTAAAATTAACCTGTGATGACAGACATCAGAGTCATGGTTACTCCTGAGGAGAGGGGTT TACTAGATGGGACA 397 MIR4435-2570870 CCTCTCAGATCACCCAGGAATTCTACTCCTAGGTTTTTCTCAA 1HGGGAGAAGTTAAGTGCAAATATCCATCAAAATGCTCATAAATTTTATTTGTAATAGCTAAAAACAAGACACAACTCAAATACCTATTAAATGTTTATCTAGACACAATCCAAATGTAATACAGTCATGCTCTGCACAATCATGGTCCCATGAAATTATAATGGAAGGAAAAATTCCTATCACCCAAGTGCACACTGTTTATAAAGTCCACAGCGGTGT 398 MIR4435- 2570871GCACAAATGGTATTCTGTATCTGAAAATTGTTTGGATTAACTTT 1HGTGATTCTTGCCTGGTTAAAGAATTACAATTCTTACCTCAGATCA TGCTTAAACTATC 399 MIR4435-2570872 TCTGGAAATGTAACTACTATAATGGACCTTACAAATGCACAAAT 1HG GGGGCCGGGT 400MIR4435- 2570873 GCGAGTGTTCTCATTGCATTCGTGACCCCATTGATCTTGCAAC 1HGAGCCCCATGCATCAGTTATTGCCATTATACCATTTTACCGATAAGGAAACTGTGGCAGGGAGGGGTCAAGCACCTTGGGTATTTGACAGCAAAACCAAGGCTTGGTGGTATCATAAAACTTCCAAGTAGTAATTCACAAAGGTGACTGGGAAATGGAAGTGACCAGAAATCTTTGCACTATGAGGACAAGTTCATGACCCTGATACATTCTTGTC CAGGTAGTATAGCTCCAGA 401MIR4435- 2570874 CTACTGCATTTCTGTCACTCGCTGAAAAGGACACTCTGTCAGA 1HGAAATCTTCTAGCAAACTTCAAAGGGCAAAATCACCCCTTGTTACTGATAAAGCCCAGAGAGCTTCAGCAGCTAACATTCCCTGGACAGGGCACAGCAAGGATTTGAACCTAGGTCAGTCTGGCCAGAACACCCACAAGCTTTCCTTAACTCAGTGTGCTATCTCCCCACGACTAGGTCACTACTGCTTTATAATCACCTTTGTAGCCACCAGTGGATTTTGCTCATCAGTATTTTTCAGGCAATTGATACTTTAGATATTCAGCTGCAAGACGTATGCAGTTTTCATTGACATCTTTTGGAGAAACTGACAAACCTGGACTTGACTTAATGCCTTTGGAACCTTCCAAGATGTTATATAACTCTAGATAGAAGGCTGGGCCTCCATGATGTCAGGAATGTTGCATTCTTATTTCCCCATAGATAAACCCATTTGTCCACAAAGTCAAGGAGTCAGGCAGAGGCCCTTGCCATGGGGCTTTTTAGGATAAAGCAACAAGCCTGGACTTTGCTCTACAACAGGGTTTTGCATAGGGAGTGGTATGACCAGATCCCTCAAG AA 402 MIR4435- 2570875GGTGGGATCACTCAGATTCTACAGATATTAAAAGGATAATAAG 1HGGAAGTATTGTAAACTTTTATGCCTATAAATTTTAAAACTTAGATAAAATGGATAAATTCCTGGCAAGGCACAATCTACCAGAGCCCACTCAAAAAGAAAGAAAGAACCCAGACAATCCTCTATTTACGGAATAAATTGAATGTTTAGTTTAAAATGTATGCATGAAGAAAATTCC CGGTTGACATGGCTTCACTAGTG 403MIR4435- 2570876 CAATAATATAAAGGTCAGAAGGGGAGAAATGGAAGTATCCTGT 1HGTGTAAGTTTCTTATGCTATACGCGAACTGGTATAATATCATTTGAAGGTAGGCTATAATAAGTTAAAGATGTGTTCTGTTAATCCTAAGAAATATGAAAATAACACAATAACAAAGAGTTACAGCAAATAAGACAACAAAAGAGATAAAGTTGGATCATAAAAATA 404 MIR4435- 2570877CAAAGGTTTCTGCTCAAGGGTTTCTGCTGCAGTAATTTGTGAT 1HGTCTAAGTATTTTCTTGTCAGTCTTTCCAATTTAAGGGGCAGTAAACCTCACTTCTCTGATGGATCTAAGAGTTGTTAATTAATCAGTTTGTTCAGCCTTTTATTTGTTGTTAGGATGTAGTGACAACTTCCAAGCTCCTTACGTACTGGATTGCAAACCAGAAGTCAAACTATTCCTTAGAAATGAAGGGGAAGTAAAGTCATTTTCAGATGACAGGATACTAAAAGAATATGTCACCAGAAGACTTGCCCTTAAGGAATG ACTAAAGCA 405 MIR4435-2570878 GCCACTGCTTTGCTGAGTCATTCTACTATGCAGCCCCTCAGAC 1HGACAAAGCCCGGCGGCCACCTGCCCACAGAGGCACAGAGGGCCAGCCAACTGCAAGCACGGAACTTCAGGATCTTGCTTTTCGGGTTATTTTCACTACTGTAATTTTTTTGTCCTTAGGTAAAAAGGATAATAATTGTGGAAAATTATGTCCTTAGGTTAAAAAGATCCTGGATCATGCCAGATATTAAAATATGGATAAAATTGGCATGATCTTGGAATCTGAACAGAAAAGAAGCTGCTTTTAGCTGTTTTCAACTGTTTTTAGCTTTTCTGTCTAAACAGCTGTTTA 406 MIR4435- 2570879CTTAGCTGACATTACTTTGATCATGAACTTTGTTGCCT 1HG 407 MIR4435- 2570880TCGCTGGGGTATGACCATTCCCCTGGCCTTCCTATCTTCCCAT 1HGCTATGCCCAACATGGCTGCCAAGGGGATCTGTCCTAAATGCA AAGTTAGCCATGCCTGCCC 408MIR4435- 2570881 GGGGAGGATAAAATTTGGAGCAAGATTCTCAAGGAAGCAACA 1HGAGATCCTAAG 409 MIR4435- 2570882 TCTTGGACGAGCCTGAGGATGTCTACAAGTGGAAGAA1HG 410 MIR4435- 2570883 TGGAGGAGGATCCAAGGCTCAGAAAGAGAAGGAG 1HG 411MIR4435- 2570884 TGCCTATTGTTCTGGATCATTTTGAGAAAAAAAAAGAGATACCT 1HGTGAAGAAAGATGAAGACAAAATATGGAAGGGTGCTGAATTTACAAAAAGCCTAAGGGGAAAAAACTCAAATGTCCCTCAGGAGTGGAATGAGTAAACAAATCATGGCGTGTTCACACAATGGAATGCTACCTACCAATAAAAAGGAATGAACTGCGGATGCACACAGAAAC ATGGGTGAATCCACTAGGCATCATGTTG412 MIR4435- 2570885 CAGCCATTTGCAGAGCATTGGAGTAAGTTTTACCTTCATCCCT 1HGTAGATGTGAATTTGTTATCCTCACTGTGACAATCCCTTATCACATGGCTTTTAGAAGGATTCTCAAAAAGCTAGACTCTCACATTCAACTTTGCAATTGCCTGGCTGGGTGTTACGTTTCTTTGCCTCCTATTAGAGACCCTATCAGCATCTAAAACTAGCGTTGTTTGAGGATGTTGGAGCCAACGGTTCTTTGCCAGATAGAACTTTGTGTGTCCAAATAAATGGTTCAAAATCATCAAGCAAATAAATACCCTGGAATAAGAGAAGCCTCATGAGGATTTGACTCCAAATTGACTTCCTCTGTTCTGCAGTAAGAAGTTAGGAATTAAACCAAACCTTGCCTGAGGTTCAGGTATACTCAAAAGCAATGAGGTGTGGCTCAGGTGTGCGCTGGCAAGGTCACTGTGAAGTTCAGCCAGAGGCTTTGCAAGCCTGGGCCTGAGAAGCCAGACCTCTTAGATCCAGAAGGGCCAATGGAGCTGGGCTGGCCTGCTGCCACTCACAGGCAGAGACTCTGCCAGCAGAAGGGACTCTGCTGTCAGAGCTGGAGGGCAGCGGACCACATGGCTGAGGCCCAACCACAGGTCTCCTGACTCAAAACCTCTTCCCAGGGCTTGTCCTCCTCCCTAAATATATGTGCCCCAAATTGTCACCAGATCTCGGGAAAGCACTGGCTTT 413 MIR4435- 2570886GAGGTAGACACTATTCCCAGCTGGATACTCTCAATGTTGAGGA 1HGTATAGATGCACAAACCAATGCAGGGAGGCCTCCAGGAGCCACTGGAGAAGAAATCTTCAGATCCTACCAGGCCCATAGCTGTTGCCTTTGTGGGCTCCTGGGTTAATTTCCACACATCAGTGGCCCACCTTATGATATCCTCCCTGCATGCCACACTCCCGGCCATGCTCTGTGGACAGCCATTATTTCCAGTAATTGCTAATGGGAGCCAGTCTCCAAAGAGTAATGAATCAGAGGTGTTCCTTGGAATGTGTTACACTAGGACTTCGCCGATCTCACAGGCTCCTTTCCAGATGAGCTGACTGTAATCTCTGGGAAGCTGGATCTGGAGGAACAATGGGATGGGATTTGCGGTGACCCTTCCTGCCCTTCTTGAGCAGCTTGTGAACCAGAAGATGTGCCTGGAGAGAAAGCCTCATTTGGGGAA GTGCAGTAGTC 414 MIR4435-2570887 CAGATCTCAGCTGCCGAGTGGAAACCCCATTCTCACACCATA 1HGGCTATGGGACTGGGGGAAAGGGGAGGAAATAACTAAAGAGTAAGGAATTGGGGGAGGCTTTGAGGTTTGGATGTGACAGGTAGTTTGCATGTAGTTGGAATGCAGTAACATTGGTCCACAAGGTT 415 MIR4435- 2570888GAGCACGTGATCACTTCTCACAACTAATGGAGCCAAGATTCTG 1HGTCCTTATGGCTCCAGAGACCTCTTTTTTTTCCCACTGTACCACAACACTCACCAGGACTGGAGTGCCACCTATGACCTCATTGCATA ATGGATGGCTTGTCCTCA 416MIR4435- 2570889 TTAAAGATCTGTAGGCTTACTAGCCATGACAATGATGACAATA 1HGATGATGATGAAAATGACATCATCATTACCAATAGCTACTGCCATCTATTGATCCCATAACATGTGATCATATC 417 MIR4435- 2570890AGTCATGTAGTTTGAGCACTCCAGATTTATTTTCCTAATTCAAG 1HGATTGTTATAGATACGCTAGATTCTTTGCATGTCTATATAAATTTTAGAATCAATTTGTAAATTTCTACAACAGATTCCTGCTAGCATTATTACTGGGATTGCAATAACTCTACAGATCAATTTGTGGAGAACTGACATCTCAACAACATTGAGTCTTCCAATCTGCAAACATGATACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTCTTTAATTTCTTTCAATAATTGTTTAGTTTTCAACATAGAGATCTTGTCCATCTTTTGTTGTTTATTCATGAGTATTTTATGCTTTTTGAAGATACTGTAAATAAAATTGTTTTTCTAATTTCATTTCCCAAATTCTTGCTGCTGATATATAAAAGTATAATTGATATTTTAATATTAACCTTGTATCCTGTGACCTTGTTCAATTGATGTA 418 MIR4435- 2570891GCTCAGTTTGCTTATCCGTTCTCCTGTTGATGAACATCTGATGT 1HGTTGCAGTTCTCCTCTCCGTGAGTCTTCTTGTAAACATAATTTTCATTTCTCTTGGGAAAAACCCTAGGAGTGGTACTGCTGGGTCAAGGGGGTAGGTGTTTGTATAGCTTTATAAGAAGTTACCACATCCTTACTAATATTTGGTGATAGCTATTCTTTAAGTTAAAAGTGTAGAGGCATCTCGTTGTGGTTTTAATTTTTATCTCCCAAATGAGTAATGATAAGTGTCTCTTCATATACCGAATGGCTA 419 MIR4435- 2570892CTTGCAGGCCCTGTGAACATATATACTTCCTGGTGGGAAGAGC 1HGAAGGGAGCCTCTGGTGGAAAGCAGCCCCAGGGTCCAAGAACCACACAGCCCTGCATTAGGGCCCCCAGGGAGGGAGAAGACCAAGGTCATGCTTTTGAACCTGGATGCCAGAAGAGAACAGCTGTGGGGAAAAGCATGCCTGGAACCAAGAAAAACATGTTTACCAGGGGCCATTCCTCACACCAGCTGCAGGCAGGGTCAGGAAAGCCACAGGCTGCACTGTAGTTGCAACCTTGCATGCGGACGCAAGGCTCAGAATGTTCCTCAAAGATCCTAAAATGTTCCCAGAGTCA GGCTGAGTCCATTCA 420 MIR4435-2570893 CACTACAACTGGCTGTCGGTCTCCC 1HG 421 MIR4435- 2570894ATGTGATGGCCAAGGGAGCTTCATCAATCATGGCATCTCAAG 1HGGGAGCTGGAGCAGATGAGGAGGAGATGGAGGTCCCAGGAAGGGCTGTGATCTGCCTGGGGTCCCACAATGGGAAAC 422 MIR4435- 2570895CTCACACAGGCAGTTAGCCAAGGCCTGATATGCAGAAAGTGC 1HG 423 MIR4435- 2570896ACCCAGGGAGGATAGCACATGTCTTCGGCTACACTGGTGAAG 1HG GCATCGTGCCTGCTCCACAG 424MIR4435- 2570897 TGCAGCTGATACCCAGGATGTATTATTATTACTGTGACACAGT 1HGGAATCTAAAAGAGG 425 MIR4435- 2570898CTCAAGGGAGATTGTATGAGACTCCTATAGGGTAGAACCTACT 1HGCTGAAAGAACTCACCTCAATTAAGCTTGATTGGAGTAAAAGCC AAGGCTAGACACCTAAGCTTC 426MIR4435- 2570899 CTCAGAAACCTGTAGATCTCTATGA 1HG 427 MIR4435- 2570900CCCTAATGACTAATTGTTTTGAGCA 1HG 428 MIR4435- 2570901TCCCTCATAATGTCTGCTCTGTGTCACTATGTACCCTCCCCTG 1HGTCCTCCATTCCCCACACCAAGAGTATTATGAGTATTAAATGCCACGTGGGCAGGTTCCCCAGGCAATGAGGGGGTGGGCCTGTCAAATGCAGGCCATGCAGAATGCCGCAGGGCGGGAGACGGGTGAGCCAAGGGAGCCGAGAGTTCCAGATAACAGAGTGCACAGCAAATGCCATGGCCCGCGTCCAGCAACCAGGAGAAACAGAACT GCTGAGCTCAGAATAGGCCAAGGCCGC429 MIR4435- 2570902 GAACTCCCACTGTATAATTGCTAAACACAATGACAGCTATAATT 1HGGAGGCACTGAAGGAAGGTCAGGGGAGCCCAGGAGGGCGGGGCTGCTGCTGCCTGCTGAGCTGGGAGGGTTGGTGGCACCCCTTGCCCTGGGTTGCCATAGCAGATATCATAATCAATTACGGCCGTCTTTCATGAGGAACCTGGATCTTTCCCAAGGAATC 430 MIR4435- 2570903CTGCAGGCTGGAGGCTTAGCCACTTCTCAGGAGGAGCCTAGA 1HGAAGGATATTGGTCGCCCAGCTGCTGAACCTGCCCCAGCATCCTTGAGGGTCTTGAAAATCTATTTTATGCTGGGCACCTG 431 MIR4435- 2570904ATGCACTATGTAGCCCATGAGAAGGAGACCAACTCCGAGGAG 1HGCTGAGAGTGAGAGGAGACTGCATTCTCAGACACAATTGTCCAGACACTTCCTTTAAAAACTACACGCCAATGCCCAATAATGCT 432 MIR4435- 2570905CGGGACACATATGGGAATACAATTACAGCAAAGCCGGCAAGG 1HGCTCAGTGAGGGGCAGAGGGCCTGGCCACATGAGGAGCCAGTGCTGTGGGCAGGCCCGGGTCTGAGTGCTGGCTGTGTGTCCTGCACAACCACATCTCCCAGAGTGCATTCGTCACCATCCACTCCAGATGCCCCTTGAACAAATGAATTTCACAGTTGCAAAAGGCTGAAAAATGCTCTGTGACCTGGCACCCCCTTGGGGAACCACAGT GCATTAAAGGCTCT 433 MIR4435-2570906 TTGTGATTTTCGTTCCTGAATTCATAGAG 1HG 434 MIR4435- 2570907GGTGCCCTGCAATGTTAAGCAAAAAAAAAAAAAAAAAAAAAAAG 1HGACTTTGGAAATAGAGTTATGGAGCCAGGATGGGTCTTGAGTTAGCCTCACTCTTTATTTCTTTATTCAAGGAATGGTTGTTCAGGGCCAGCGGCTCAGCCCTGGGAGCACTGACTGCTTCAAGACACAGACTCCTCTGGGATGCCAGGCAGAGTCTGCTCCTGAAGGCAGA CTCCACTCTTCATGGGG 435MIR4435- 2570908 CCTCACCTTTGCAGGAGACTCTCAATTTCTCAGTCCACATCAG 1HGCTCTCAGACCACCAAAGCAAGGGTTATTTTTCTAAAAGACATTTGTTCCCATTGCTCCTCTGACTAAAGTTCCTACTATGGGACATTTGCCCTTGGCACTCAAGGACCTTGCAATCAGGCTGAGAACCTCAGGTTCTCAAACTCAAGACCATGGGGAATGTAATAGGTGAATC AGGCAGGTGAAGTCCAGGACTC 436MIR4435- 2570909 CAGGATGACTCAGAACCCGCGTATGAATGCTGTCTATTCATGG 1HGGTCCAGGCTTTTGTTAAAGTCTGGGCCTGCA 437 MIR4435- 2570910TGTTGAGTGCTAGCTGTTGTTGAGTGCTTGTCCTGCCTGGGCC 1HGCTGTTTTTAGCCTTTGATGTACATTTCTCCATTTAACTTCCACAATAGCCCTATTAGGCAGCTAGTATTATT 438 MIR4435- 2570911CAGGGCTTCCTTCAACTCAGGGTTC 1HG 439 MIR4435- 2570912CCCGTGGAGAGAGCCCCGCTGGTGAGGAAGCACGGGGACCC 1HGTGCTGCAGGGCTGGTGGAGGGCTCCTTCTGTAGACTTCTGAG CTTGGAGCACAGATGGG 440MIR4435- 2570913 TCAGGTCATCCGCTCCATGGAGGTCCCCGTTCCTACCTTGGC 1HGCTTGCCTTTCCCCCTGCATGTAACCTTGGTGAACTTTTCACAAGAGTCTGCGCAGTCTTCTTGTAAGCAGATTAATGCCGAGGAAA AGCCTTGGTG 441 MIR4435-2570914 TTCTCTCCCGACAGGAGCGGCCAGGACAGGGAGCAGAAGGT 1HGGACTGCTGTGCTGCCTGGAGCTCTTCTGTCCGGAGGTTTAGT 442 MIR4435- 2570915ACTCCGTACAGAGAGCGTTCCAGCC 1HG 443 MIR4435- 2570916AGAATCAGTTGTCTCCCAGGCGGGG 1HG 444 MIR4435- 2570917ACAAGGGCGGTGCATCAAGACCACA 1HG 445 MIR4435- 2570918CGGCCCCCAGATATCTGAGGAAGGCTGAGC 1HG 446 MIR4435- 2570919AGACTGACCCTACAATAAATGCTTAAGAGAGTCCTACATCTGG 1HGAAGCAAAAGGGCTATATTCACCATCATGAAAACCCAAAAGTATAAAACTCATTGGTAAAGCAGACACACAAATAAGAAAGAGAATGGAACCACATGTTATCATTACAGAAAACCACCAAACTGCAAAGATAAACAAAGGAAAGAAAGAAAGAAAGGAAGGAAGAAAGGAAGGAAGAAAAAGGATTATTTAAAATTATCAGAAAACAATTAAAATGACAGGAATAAGACCTCACCTATCAATAACAACTTTTTTAAATGGCTTAAATTTCCCAGTTAAAAGATATAGACTGGCTGAATGGATTT TAAAAGTGACCTAACTCTATGCTA447 MIR4435- 2570920 GGTATTACCTGATCCCAACTTGGCACCAAAAGACAGCCAACAT 1HGAGACTCATTCCTCCTGCTTCCTGGTGAGCCTGGTATTCTCCTCCACTTCCACTGACAGACATGTAGGGTGACTGGGTGGTATCAACAATAGGAACCACATCATAACAGGCAGCCTAGTTTGGGAAGCACTCTTGGTCTCCGTAGGCCTGAGACTCCTTTTGCCCATCTAG AGG 448 MIR4435- 2570921ACTTAAAATAGGAGTGAGGTGAGAGGGGCAGCTGGGCTCATG 1HGGACGTCAAGTGGACAGTTTCTCAGCTGGTATTTCCTATATTTCCTGTTTTGGACAGCAGGTTCCTGCCCTTCTAAGCTGGGGGTAGGGGTGAGGGAGTGTATGTTAAAAAGCTCTGTGGACTTGCT 449 MIR4435- 2570922GAGCCCTTGTTCAGTGATCCTATGACTTGTCAGCTCAGTGAAT 1HGTGCTCTGACTCTTACTGCTTTCATTTATGAAATGGAGACAATAACCCCTCTCTCATAGGAAGGGTAAGACCAGAAGAGCCTACACTATGGTTGGAATAATATTTGTATACAGTGATCAAGAGAATGTTCTCTGAAACCAGACTCTCTTTAAATCTTACCTCTATCACTTATTAGTTATATGGCTAGCTGTTAAATGAGGTCAAAAGAGTGTGTTCTTCATAAAACTATACAGAAGATTAAATTAATTAAAACATGTACAGTCCTTTTAAAAAAGATCAAGTGAAACAGCATACATGAAAGTGCTTTCAGCACGCTGAGAATAACAATAGCAATGGCTAGAGATTATGGAGCACTCCCCACTGCCAGCACCAGGGGAACTTTGTACCTACAACTTTTTACTTAGTCCACATAACCATGAATTCGTCTCATTTATGTA GACCGGGAAACA 450 MIR4435-2570923 CAACCCAGGGTCCTTGCAGAGAGATTGATCTGCCAGCAGTGG 1HGCATCAGCAGCAATAGTAGCAGCAGCAAAGCCCTGGACAGTCCTGGCCCCCAGTCCACAACTTAGACACAGCACATGGCCTAATTCACCCACAGAAGCAGCCACTGTGAAGCCCTGTGTCTCCCCAGACTCCATCCAGTGGCATAAGGAGACCCAGGCCCTGCAGCTTCC TCCCCATCATGGAAGGCTGTCCATCTA451 MIR4435- 2570924 TTCTTTTTGTCTCCCATATACGCTG 1HG 452 MIR4435- 2570925GCTCTGCCGACTTCCAGTTCTGGAACAAGATGGTTAAACTCAT 1HGTTTTCCCTGCTCTGCTCCTCTAAATACAACTAAGTACCTTGGAAACTATTCAGCAGACAATGATAAAGGGCTCTGAAAGCTAGAAGAAAAGGTGTACTTGCAAGAAACCTCAGGACT 453 MIR4435- 2570926GACATAGAATCAACCAAAATGGCCATCAGTGATAGACTGGATA 1HGAAGAAAATGTGGTACATATACACCATGGAATACTATGCAGCCGTAGAAAGAAACGAGATCATGTCCGTTGCAGGGACATGGATGGAGCTGGAAGCCATTATCCTCAGAAAACTAACCCAGGAACAGAAAAGCAAACACCACATGTTCTCACTCATAAGTGGGAGCTGAAGACTGAGAACACATGGAACCAGGGAGAGGAACAACACACACTGAGGCCTGCCACTGCAGGTGGGGGTTCAGGGGAGGGAGAGCATCAGGAAAATAGCTAATGCATGTCAGGCTTAATAAGTAGGTGATTGGCTGATAGGTGCAGCAAACTGCCATGGCACACGTTTACCTATGTAACAAACCTACAAATACTACACATGTA 454 MIR4435- 2570927TGTCTTGCTGGCCTGAAATCGAGTACGCAGCCCGGGGTGATC 1HGAGGGTCTCCCGGCCCGGATGTGTGAGACTTGCTTCCCCTGGGCAATAGGCGATACGATGCTTTAGGAGGAAGGTGTCTCTCCCTCCTAAGCCCCGGAGGGGAGAACTTCCAAAGACAGAAAACCACAGGCTTCCTGGCACAGAGCTTTCCCTTTATCAGCTAAAGCAGAATCTTTTCTGGCCTTAACCTGGCCCCTTCCTCTAACTGCAGGCAGAGAGGCAGACAGAAAAGCACTTGCTGAAACACAAAGTTTTGTTCTGTCCTCAACGAACTGTCTAGAGCTGATTGCTGATAGTCGTGGTGCATTATGCCTTCCTGGTTTTCATTTAATTGGGCACCACGCTGCCTTTCAAGACGCCTTAAAGGAACCAACAACCAAATCCAAGAGAGCTGGACAGACCATTGAACACACAGTAGGCTGTGTCTCGTGGCTTTCGTTGTCTGGTGCCTCAAAGAAAACACCAGAAAGATTGTTTCTAAGCTAGAGCCACCCCAGATTGCTTAAAGTGCAAAGCTCACTGCTGTTGGGGGTACCCTTGTGAGACACTGGAAAGC TGGTTTTACCGTGGCCCTATGAA 455MIR4435- 2570928 CCGAGGAGGCGGAGCATGGAACTCGACAGTTAAAACATTTAA 1HG GAGA 456MIR4435- 2570929 AGGCAGCCTTTTCTGTCACAACACAACGCTGAGCCGGCAGCC 1HGTGGCTCTGTCAGGATCTGGGGCTCCCGCGCCCGAGAAGCCCAGCCTCGCCGGCGGCCAAGTTCACCGCGAGGCC 457 MIR4435- 2570930GACTCTGAAACTACCCGGCTCTGCAGAAGCACGCTGGGCCCA 1HG GGGGCTTCTAGACTGACAGC 458MIR4435- 2570931 AAAGGCTGCAGTCACCAGCATCTTTTCCAACCTTAATGAACTG 1HGTATCCTCAAAAGAACACTATCAGACTG 459 MIR4435- 2570932GAAAATTCCTATCCCACCAGCAAATCAGCCCG 1HG 460 MIR4435- 2570933CTCCCAGATAAAGAGATCAACACGGGACAG 1HG 461 MIR4435- 2570934GGGTTCCTGTCGGAATCTTGGAGCTCATCCCCCAAACTTGAGA 1HG TT 462 MIR4435- 2570935CAAAGGCTTCTCTTGCTGGCTGAGAATTGTTGGGGAGCTCCCT 1HG GCCCACGGAGGGC 463MIR4435- 2570936 AAACTTTAAGGAAGACAACTGTGCATTCTC 1HG 464 MIR4435- 2570937TGGAACATACGTTCTTGTGAACATAGAGAGTGGCATTTTCTTAT 1HGGTCGATGTAATGTGAACAACTCCTGGTCACC 465 MIR4435- 2570938TTGGTACATGCCAGCACGGTCTGTG 1HG 466 MIR4435- 2570939GATTCACTGTGCGAGGACCCACCTGACACC 1HG 467 MIR4435- 2570940GTAAGGTGACCAATGGCTGGCTGAAG 1HG 468 MIR4435- 2570941TCCGAGCTGTCACGTGGTTTATACA 1HG 469 MIR4435- 2570942TCAGGTTTGCTGGGAGGAATCCAGAA 1HG 470 MIR4435- 2570943CCACTCTAGGCAGGACTTTCATATCCTTTATCTAACTGTCACAT 1HGGATGGGGTGACATGTTGATCCCCCCACAGCCTGGATGATAGAAATATTTGTGGTTTGATATGCGTCAGCGCTTATGACTTTGGCAT A 471 MIR4435- 2570944GGTCATATTTCACGTCTGCCCTGTA 1HG 472 MIR4435- 2570945TGCTTTACAAACACTGACTCCTCAACACACGGTCATCTCTAAA 1HGAGAAAGGGTGTTTGGCAGTTCCTCGACAGTTCTGGAAAGGCT GCCTTACTAGAAGCAGAGTCA 473Ml R4435- 2570946 TATTTTGGTCATGGGCTGGTCTGGTCGGTTTCCCATTTGTCTG 1HGGCCAGTCTCTGTGTGTCTTAATCCCTTGTCCTTCATTAA 474 MIR4435- 2570947CACCTCTACCTGTTGCCCGCCGATCACAGCCGGAATGCAGCT 1HG GAAAGATTCCCTGGGGCCTGGTT475 MIR4435- 2570948 TGACAGACACTGAAAATCACGACTCATCCCCCTC 1HG 476 MIR4435-2570949 TGAAACAGGAAGCTCTATGACACACTTGATCGAAT 1HG 477 MIR4435- 2570950AGCGGCAGAGCAGTTATTAACAGAATCACAGTCTTTCTGGAGC 1HGTGCTGTCAGTCCTGTGCTGTCCTCAGGGCCTTTGCTTGGTCAGGGGCCCCACTTCTTATCCACCCTTCCCTCTACCTCACCGAGGCTGCTAGGCCCAGGTGTATTGTGATTATTTGATGCACCTGGGAGGCCATGTCTCCCGGGGAGTCTCAGGACCTCATTGGGCTGGAATTCCACGGGGATCTCTCATTGGGTCTCTTTGGGCCTTTGGAGAGGGGAGTGCAGGGCACCACCTGGGCGAACACCTGTGCCATCCTGTAAGTCCTTGTGTGACTCTTCATCCAAGTCAACAGGGGC 478 MIR4435- 2570951CGTGGACCCGGCTATGTCTGACTTTGTGCTG 1HG 479 MIR4435- 2570952GGGAACAAAATGTCTGCTCAAACCATGACAAAATTGGCCACAA 1HGTTTGCCGATTGGGCTGATAACAAAAG 480 MIR4435- 2570953GTGTGTACTAATCACTCAGACAGTG 1HG 481 MIR4435- 2570954GAAAAGATTTTTATTCGTGTCTACATCAGTGTGAAAGGCTTCAT 1HG CCTG 482 MIR4435-2570955 CTGGGGACACTATGGCCCCATCCTAGCCTGGTG 1HG 483 MIR4435- 2570956TGGGAGGCCAAGGTGGGCGGATCATGAGCTCAGGGGTTCAA 1HGGACCAGCCTGGCCAACGTAGTGAAACCCCGTCTCTACTAAAAACAAAAAAATTAGCTGGGCATGGTGGCGCACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCTCCACTGCACT CCGGTTTGGGC 484 MIR4435-2570957 TTGCTGATATACTTACAAACTGGTAAACAATGCTCTTTAATCAA 1HGCAATTCATAATCTGGGTCAGCGATTTTTATCTCCATATTTGCTCATACTGTATGACATCAATATTTTATATTGGCTTGCCCATAACTT A 485 MIR4435- 2570958CTGTGCCAGTCAAGCCTGGCCTGTGGCTGTGACACCTGCATT 1HGACCCCAGATGGTTGCCTGACCTAGGCCTGTCCTTCTATCTGCTTTGTTTTTATGTTGATTACTAGGTGAAGCACAGTGTTAAAAACGGGAAGAAAAGGCTAGGAATGCAGTTATGGGAGTGTGAGGCTGGGTTGGAATAGGTGGGAGAAAGTCCAGGGCTGAGTGTGTGGACCCTGCTCTAGGGATCTGACCGGCTCAAGCTCCCAGGCCATT AAACAAAGTTG 486 MIR4435-2570959 CTGTTGCCATTTGAACAAGTTGTTAAGAAAATCTGCCATGTTTT 1HGGCTCTTTTTTAAAAGGAATGACTTTAATAACCATAGCAACACTTACTCAGTTTTGTGATCCACTCCAAGATTATGGGAGCAAGAACAGATACTCCTGAAAGCAACCCTCACCTCCTCCCCCGCCCCCTGCCCTCAGCAAGTCCTGGCCTGTGTGAACTGAAGGGTTTGGAAGCTCTGGTTTCTAGGAGTGCCCAGAAGCTAGAAAGACTAGGG TGTACTAGTTATTGAGGGGCAGTTGTC487 MIR4435- 2570960 AAAGGCATTTCTGATTTAATTAAGAGTTG 1HG 488 MIR4435-2570961 ATGAAGGAGGAGTCGTCTACACTTGTAAAAA 1HG 489 MIR4435- 2570962TCCTTGAGTTAAAGAAATTTGTGTC 1HG 490 MIR4435- 2570963TAATCCAGTGCTCAACATATTTTTGTTGAATAAAAGCACAAAGA 1HGGATTCATGAGAAGAGGGAAATGTTGCATACTTAGGGTAGGAGCAAACCACAGAGGTCTTTCTCAGCCTGGGCAAAGAATGTCAACTCTGTGTTGGAGCCAGTAGGGAGCTCTGTGGGTCCTCGAGCAGGAAAATCCCATGGCTTAAGCAGTGTTTCAGGAAGACTGGGATGTTAGGCTCCAGAGCTCTGAGCAAGTCAGATGGGACTGGGAGTCATAAGAAGGCTTGACTGTGGCTAGTGATAACCAATGAGCACTGGAAACATGGAGGGGAATCTTTCCTCCCTTTTATATCAGGGTTCTCTCCTAGAGGAGCAGGTGAGGACCTCTGATGGACCAGGAAATTGGAATTCTGCCTGGGAGGCAAGCCCATGGAGGCCCTGATCTGCTTGGACAGAGAGTAGCTCCCTTCACCTGTAAAATGAGAGTGAACGAGCTGGTGTCTAAGGAATTCAGAATCCCCCCCCTGGAGTTCCACAGGGTATGTGGGATTTTAGGGGGACCAGGGTGTCCCCAGTGCAAGAAGGAGGCTCCCACCAAGGGGCTGCAGCACTGCAGATAACCCCCAGGGGTATGAAAAGAGGCTGAACTGGGGGCCTCCACAGTCAGAATCCATCCATTGACCCAGGATG 491 MIR4435- 2570964CCCTGGCATCATATTGGGACTTGTTAAGGGCTGAATTGTGTCC 1HGCATCCCAAATTTGTATGGTGCCACCCCAACTCCAGTACCTTGGAATGTGACCGTATTTGGAGAAAGGGTCTCTGAAGAGGTAATTAAGGTAAAATGAGGTCATATGGGTGGCCTCTAATTCAATATGAC 492 MIR4435- 2570965TTTCCATTTCCTAGTAGGGCCAGTC 1HG 493 MIR4435- 2570966TATGTGCATTAGTTTGCTTGGACTGCTATAACGAAATACTACTT 1HG GGTG 494 MIR4435-2570967 GAGCTTTTAGAGAATATGGGCCAGAAACAGGAAGGAGTCAGG 1HGACCTGATAACGGGAACCAGCGGACAGTGAACGCAGTG 495 MIR4435- 2570968GTGAATACAATATTCTCCTTTTGTTTTCACTTTTCCTAAAAGTTA 1HGAATCAAGGTTCAAAAGAAAATCGAGG 496 MIR4435- 2570969AGATGCTAATCCAGCGTGCGTCCTGGCAGAGGTTGAAGGGGG 1HGCTCCTCAAGTCCCAGGTCCAGCTTGGTGTGGTTCAGCTACTCGAGAGACATCTGCTGCTAATGGATGAGCAGTCAACCTGGACG CAGG 497 MIR4435- 2570970TGTGAAGACTGGACTTAAACAGCTACACCACCAGAAGCCGAG 1HG AGAG 498 MIR4435- 2570971AAATTGACATTCCAGACAAGCGGTGCCTGAGCCCGTG 1HG 499 MIR4435- 2570972CTTAGTCGTGTGTACATCATTGGGAATGGAGGGAAATAAATGA 1HG CTGGATGGTCGCTGCTTTTTAA500 MIR4435- 2570974 AATCCCATGGTCTTCAATTTGGTCATTTAAAAATAATCTACAAG 1HGGTATACTGTTTTT 501 MIR4435- 2570975CACCACTCTATTTAACAGTGCTGGAAATATTAGCCAGCAAAAC 1HGAGATAAAGAAAAATAAATAAATGGCATAGACTGGAAAGATTCATAGTTGGCACAATTATGTATATATAAAATCCTCAGGAATGTACACTTTACATACTAGAATTTAAAAGTAAGTTTAGCAACTGTGTTAGTTCGTTTTCATGCTGCTGATAAAGACATACCTGAGACTGGACAATTTACAAAAGAAAGGTTTATTGGACCTATAGTTCCACATGTCTGGGGAGGCCTCACAATCATGGCGGCAGGCAAGGAGGGGCAAGTCACATCTTATGTGGATGGCAACAGGCAAAGAGAGAGCTTGTGCAGGGAAACTCCTGTTTTTAAAACCACCAGATCTCATGACACCCATTCACTGTCAGGAGAACAGCATGGGAAAGACCCACCCCCATGATTCAATTGTCTCCCACAAGGCCCCTCCCATACCACATGGGAATTATGGGAGCTACAAGATGAGATTTGGGTGGGGACACAGAGCCAAACCACATCAGCAACATGTCAGAACACAGAAAAAATGTAAAATATCACTGTATTTCTATGTACTAGTAGTGAACTGTCAGATGTTAAAATTCAATTGCTTAGAATGGCATCAAAAATATGAAATACTGGCCAGGCGTTATGGCTCTTGCCTGTACTCCCATTGCTTTGGAAGGCTGAGGCGGGTGGATACCTTTGAGGCCAGGAGTTCAAGACCATCCTGAGCAACAGGGCAAAACCTTGTCTCTACTAAAAATACAAAAAATTAGCTGGGCATGGTGGCCTGTACCTATAATCCCAGCTACTTGGGAGGCTGAGACACAACAATCACTTGAACCTGGGATGCAGAGGTTGCAGGGAGCTGAGATTGAACCACTGTACTCCAGCCTGGGGAACAAACTGAGACTCTGTCTCAAAAAAAAAGAAAGAAATACTTATGGGTAAATCTGACAAAATAAGTGTAAGACCTGTACACTAAAAACTACAAAACATTGCTGAAATAAATTAAAGAAGACCTAAATAATCGGAGAGATATACTTTGTTTAAAGGTCAGAAGTCTCAGTATTGCTAAAATGAGAACTCTTCCCAATGCAGTGCTAATCAAATTTCTAGCAGGCTTTTTGTAGAAATTGAAAAGCAGATTTGAAATTCATATGGAAGTGCGAACAAAACC 502 MIR4435- 2570977CCACCATGTGATACCACTACATGTATTTTAGAATTGCTAAAATT 1HGAAGAAGACTGACCATATGGGGTGAGGATATGGAGGAAATGAAATTCTCATACAATGCTATTGGTAATGTAAAATCAAACTACCACT TTGGA 503 MIR4435- 2570979GCTTGAACCAGGAAACTGGATATCATCTTAA 1HG 504 MIR4435- 2570980ATGTTTGGGAACCCAACAATTAATGCAG 1HG 505 MIR4435- 2570982CCCGAATGTATCTCCCAGATGTCCAGAATACGCCATCTGCAAA 1HGACTGAACTCATCCTCTTTCCCCAGAATGTATCTCCCGGATGTCGAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCAGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCATCTCCCAGATGTCCAGAATACGCCATCTGCAAAACTGAACTCATCCTCTTTCCCCAGAATGTATCTCGCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCAGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACACCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTGTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCAGAATGTATCTCCCGGATGTCCAGAATACTCCATCTGCAAAACTGAACTCATCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTACAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCAGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTGTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCAGAATGTATCTCCCGGATGTCCAGAATACTCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACTCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCAGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCTCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCGGCAAAACTGAACTCGTCCTCTTTCCCCAGAATGTATCTCCCGGATGTCCAGAATATGCCATCTGCAAAACTGAACTCGTCCTCTTTCCCCCGAATGTATCTCCCGGATGTCCAGAATACGCCATCGGCAAAACTGAACTCG 506 MIR4435- 2570984ATGTCCAGAATACGCCATCTGCAAAACTGAACTCGTCCTCTTT 1HG CC 507 MIR4435- 2570986AAAGAGATTCTCACTTAGAGACATCATAAGGAAACTACTGAAA 1HGACTAGGAACAAAGGAATTATCTTCAAAGCAGCAATGAAAAATGACATTATTTATAAAATTACAATTATTTAAAGGGTTGTAGATTTCTCATCAGAAACCATAGAGGCCAGGCCGGGCGCTGTGGCTCACGCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAGGACCAGCCTGGGCGAAACCTGGGCAAAACCCTGTCTCAACTAAAAAATAAGAAACTTAGCCAGACGCAGTGGTGTGTGTCTGTAGTCCCCGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCCGGGCGACAGAGCATAGAAGCCAGAATGCAATTGAACAACATTTC 508 MIR4435- 2570988TCAGTCACGTCTGCGCCAGAGCTTTGATGACCCACCTGTCAG 1HGCCACACTAAGGGCCCTGCCATGAATAAGGCCTCCGTCACTGAGGATCCTGTACCCCTCTGCCATAAACTCAGTGACCTGACTG 509 MIR4435- 2570989CCCACATTCAAAAGGCTTGCCCGAGAGGCCT 1HG 510 MIR4435- 2570991TCAAGGTGGCCTTGCGCTTCACCGAGGAGGTGTCATTACCAA 1HGACGTGCTGGACATTGGCTACCTACGGAAGAAAGATTAA 511 MIR4435- 2570992CCAGACACCACTGGCCTACATCAAACTCCAGGCCACAGATGG 1HGAAATAGGACTGAGATCCCTGGACCTGGG 512 MIR4435- 2570993ATGAAGCTAGGCCCCCCTGTCCTGACAGCTTTCCACCCCTTCC 1HGCTGCCCCTCTCACCCTGCTTTCCAGGGGCAATGCACCTCCCC ACTTCT 513 MIR4435- 2570995TGTATTTGGCATCTACCATATCTTTGCATC 1HG 514 MIR4435- 2570997CACACATAACTCTGGGCGTAAAGTGAGTAAAAATATGAGACTT 1HGAGAAGAATATTTCATCATGGTATGCTGATTGGGGATTTCACTTA CTGA 515 MIR4435- 2570998TCACTACGATTATCTGAATCTCATA 1HG 516 MIR4435- 2571000TCACCCTTGACATCCGCAGAATCCACCCTCCT 1HG 517 MIR4435- 2571001AGTCCTGGGGAACTCTCATCTGGAAAAAGGCGCTCATGACAG 1HGGTGGTGCCAACCTTCCACGGATGCTTTTCAGCA 518 MIR4435- 2571019TTCAGCGCCGAATTGATGAGGACAC 1HG 519 MIR4435- 2571021ATGGAGAAACAGGCGGCCCAGCCAGGCCCTTTCACTGCCCGT 1HG GATGGA 520 MIR4435-2571023 TCCACCAGACTGATGACACTTATTCCACTTGGTTCCCAGAACT 1HG AAGAG 521MIR4435- 2571025 GGGCATTTGGACTCTAACCGGGACAACCTAGTGGCCGGGCAG 1HGGGGATGCAGGCACCACAGGTCACAGTAGTTTGCTACGAGTGT CAGCTTTT 522 MIR4435- 2571027CCTGTGGGAATCCATAAAGAATTGATTCTCATCCCCCAGAAGT 1HG GAGATCCCGCTTGTGTCATCA523 MIR4435- 2571029 CTGGTGCACCTGGTCTACCTCATGTCCAGTGTTT 1HG 524 MIR4435-2571031 TCCTGCAGTTCCAATGTGAGCAGCAGTTGTTTCCAAGGCTAAC 1HGAATTTCACGCCAACTAGAAGCCTCCACAAGTCAGGTGCCAGGCATTTCTAAGCCAGTAGAGCAGCTCCGCTTGTTTCTC 525 MIR4435- 2571033CTTGGCTGGTGGATCTCGGGTTAAAATCGACTTAGGATGCCC 1HG CCCTTAT 526 MIR4435-2571035 GCTTCTGCAGTTTGCCTTGGAGTCTGGGCTGT 1HG 527 PGM5P4- 2571794TGAATTTATATTACCGAGTGGAGGGTCACATG AS1 528 PGM5P4- 2571795AGTAAATCCATTTGCTGATTGCAATA AS1 529 PGM5P4- 2571796CTCTTGTGTAAAAATCTAACTCATCTCGCTGAATTTCCTGATTT AS1AAAAGTCTAATTCATTTCACCAAA 530 PGM5P4- 2571797CCAGACGTACAGAGGCTGGGAGCCATTGTGGTGTGCTATATT AS1 GATGACGGCAGCAGTGGG 531PGM5P4- 2571798 TTGTGTATCTGCGTTCCTTTCAACAAGTGTGACTTCCTCAATGG AS1CATCATTCGTGAGCGTAACACAGAGCTCAGC 532 PGM5P4- 2571799GAGCTGAAATCGACCAGGGGGTTCTTATCCAACAG AS1 533 PGM5P4- 2571800GCCTACCTAAAATATTGAATGCTGTTAATAAATCTCCTGAGGC AS1CAGCATAAGAAGGTGATGGGCAAAACTAAT 534 PGM5P4- 2571801CTTAGAGGGCCCCACAGTTGTTTGCTG AS1 535 PGM5P4- 2571802TGGTTACAATGGTACTTTCAGCCTGTCCGAATTATGTATTGCC AS1CCTCCCCTTTTTATTAATAACATTGAAGTGTGATGGGACAACCACTGAAGCCGTCAGTTGAAACCTGCTGGGACTTTTTAGCCATTCTCTTCAACATAAAGAATGGGTGTTTTTGGAGGGGGTGAGAGGAATGGGGAAATGTTGTCAAAGAGTACAATGTTTTAGTTGAGACAGGAAGAATATATTTTGTTGAGATCTACAGCACAGCATG 536 PGM5P4- 2571803TGTGCTAGGTTTCTTTGCATGTACC AS1 537 PGM5P4- 2571804AGCCTCCTCCAAAACAGCACACTTTCCG AS1 538 PGM5P4- 2571805TTTCTCCCGCCCACCTTCTCCGCTGCCAGACCGCCCGAGCTG AS1CCCTCAGTTTCTCCCCAAGTTGGACTCACTTTCGGGGTGTCCC ACAAGCCCGATCCCAGAGCCTGCT 539PGM5P4- 2571806 CGACCTCGACGGCCGTCCTGCCGAAGTACCTGCCGTCGCTGC AS1CCACCCCCGTGGTGCGGCCCTGACGGTCGCGCAGGTCGACGGACGACAGCGCGCTCCGGATGAAGTTGGGCGGGTAGCT 540 FTH1P2 2590365AGACTGTGATGACTGGGAGAGCGGGCTGAATGCGATGGAGT GTGCATTACATTTGGA 541 RNA5SP1212602465 CATAGTACTCTGAACATGCCCGATTTCATCTGT 542 FTH1P2 2629711TGACAAAAATGACCCCCATTTGTGTGACTTCATTGAG 543 SETP14 2648928ATGAAACAGACAGACTTAATGAACAAGCCAGTGAGGAGATTTTGAAAGTAGAACAGAAATATAACAAACTCCGCCAACCATTTTTTCAGAAGAGGTCAGAATTGATCGCCAAAATCCCAAATTTTTGGGT AACAACATTTGTCAGCCATC 544SETP14 2648929 TTTGACGAAACGTTCAAGTCAAACACAGA 545 SETP14 2648930GAGGTCATCAAAGATGATATCTGGCCAAACCCATTACA 546 TIPARP 2649130GCGTACAAGGCCCACGAAATAGTCGGCCGCCGCAG 547 TIPARP 2649131ATAAGTCCACCGCACAGAACTCGCGCGCCTCCCCTCGAACGAACGCGCACGCGCGCGCAGGGGGCGGGTCTTCTTCCCGACAC CCACTGA 548 TIPARP 2649132CTCCGCCTCCGCGACGGGCCGTCGGGAGGAGGCGACCGGAAGCCACTTAAAGCAGAGATCGAGGTGACAGGCGAGCTGGCTG GACTCGGA 549 TIPARP 2649133CGCGGTCGAGGCTTTCTGCGTTCGCGGCGGCGGAATGGCCC 550 TIPARP 2649134TCTGTGGTCCCTAGACGTCGGCTCCCGCCCTCGGCGCTGATCTCCGGCGCGGGCACTGCTTTCCACTCGGCTCCTGTCGTCCGT TCTCTCAGG 551 TIPARP 2649135GGGCGCGTCTATGCGGCCTCCCCCGCGGGCCGACCCCGGGT GCTCTGAGGCGCCTAGGAGC 552TIPARP 2649136 GGCACGGCAGCTACGGGAGCCTTCCGGCTACCCCGCGTTTC GGGCTGCAG 553TIPARP 2649137 CATTAACTTTGAGAGCGCACAAGTCTTCGTCTTCCTCCCCGCCGCCGCGGGAAGCGCTCGCCGCCTTTCCCCCGCGCTTCGCGGCTCAGTTCTGCGAGCCCCCAAGACCCGTTGGACGCTCCTCGG G 554 TIPARP 2649138CTCAGCTGCACTGCGCGGAGTTGGCGCGGCCCGGGACCAGGAGCTGAGCAAACCGCCGCGGCCAACAGGAGGCGTCACTCGGACCCGGGCTCGGCGCCGGGGTGTCGCGCGGCGGCGGGCGGGCAGGCTTTGGAGCGGCAGTTTTTTCGGAAAGTGC 555 TIPARP 2649139ATGATCATCTTCCTTCCTTTCCTCGTAG 556 TIPARP 2649140GATTTTTAGACTCTGAGGAGCAGTTGGAGCTAATCCACATT 557 TIPARP 2649141CAGACTGTGTAGTGCAGCCTCCCTCTCCTCCTGATGACTTTTCATGCCAAATGAGACTCTCTGAGAAGATCACTCCATTGAAGACTTGTTTTAAGAAAAAGGATCAGAAAAGATTGGGAACTGGAACCCTGAGGTCTTTGAGGCCAATATTAAACACTCTTCTAGAATCTGGCTCACTTGATGGGGTTTTTAGATCTAGGAACCAGAGTACAGAT GA 558 TIPARP 2649142GGGGACCAGATACCGGAAGCCCATCCTTCCACTGAAGCTCCAGAACGAGTGGTTCCAATCCAAGATCACAGCTTTCCATCAGAAACCCTCAGTGGGACGGTGGCAGATTCCACACCAGCTCACTTCCAGACTGATCTTTTGCACCCAGTTTCAAGTGATGTTCCTACTAGT CCTGACTG 559 TIPARP 2649143GTATTTATAACAACTTGTAGAACTGTTG 560 TIPARP 2649144AAAACTTTGCAGAACAGCGGCTCCCACTTCACCTTCATGAAGC AAATTTCCAGTCTGCTGAGTACTTCAG561 TIPARP 2649145 AAGTTGACTTGTGGTCATTGCAACCTGGTTTT 562 TIPARP 2649146ATAACGGCATGTTGAGCCTTGCTGAGAGATTCACAAACAAGCTGGAGCAGCCCAGGTTCACATGGTTACCACATTATTTGGCTAAAGCTATTAATCTCTGTGGTCAGGCCTGTAAAGCTGGTCTATCTG TGCAGATTGCGCATAACCAGGAAGT563 TIPARP 2649147 GCCTTCTATCCCAGCTGTTCTTACAGAAATTAAGTTTCACTTTCTCATCAGGCTATGGTTGAGAAGTATGTCTCATTTATAGTGCCTT CTGTGATCTTAGGACATGTGACTA564 TIPARP 2649148 TGTGATTTCAGACAGCATCCTTCTCACTAACTTGCTGCCTTCTTGGAATAAGAATTTCCAAGATGTCTCAGGAGGTACCAAGGGAGCAGCAACAAGGCCTAATGATCACTTCTTCAAGAATTTATCCCAAGAAATGCATTGTATCTTAAGTTGGGGAACACTTTTACCTACTCAAAAATCTTTTGAGGTATTCAGATAAATCCATGATCTGAGTTTTATGTTAATAGTTTTACAGTGTCATAGTGTGGTAATTAAGTGTAGAATTTTAACCTCTGAGGCTGGGCGCAGTGGCTCACGCCTGTAATCTTAGCTTTTTGGAAGGCTGAGGCAGAAGAATTGCTTGAGACCAGCCCAGGCAACATGGCGAAACCTTGTCTCTACAGAAAAATACAAAAATTAGCTGAGTGTGGTGGATCATGCCTATAGTCACAGCTACTGGGGATGCTGAGGTGGGAGGGTAGTTTAAGCAAGGGAGTTTGAGGTGGCAGTGAGCCTAGTTGGCACTATT 565 TIPARP 2649149GGACAAGAATTTTGGGCAGATTTGAATGCC 566 TIPARP 2649150TTTGACCAACTACGAAGGCTGTCCACACCACCCTCTAGCAATGTCAACTCTATTTACCACACAGTCTGGAAATTCTTCTGTAGGGAC CACTTTGGATG 567 TIPARP2649151 TGTCATTCGATTGATTGAAGAAGCCAACTCTCGGGGTCTGAAAGAGGTTCGATTTATGATGTGGAATAACCACTACATCCTCCACA AT 568 TIPARP 2649152GGTGGGGTTCCCACACAAGCTCCTCCACCTCTTGAAGCAACTTCATCATCACAAATTATCTGCCCAGATGGGGTCACTTCAGCAAACTTTTACCCTGAAACTTGGGTTTATATGCATCCATCTCAGGACTTCATCCAAGTCCCTGTTTCTGCAGAGGATA 569 TIPARP 2649153ATGAAAAGTTCAAGACGGCCGGGCGCAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATTACGAGGTCAGGAGATCGAGACCATCCTAGCTAACACGGTGAAACCCCGTCTCTACTAAAAATAGAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAAAAAAAGTTCAAGAATCAAGAGAGCTTTATTGTAGCCAGTGTCAAATGAGGAACATAATAGTAAACATTTG CACAGAATTTATGTTC 570 TIPARP2649154 CAGGAAAATGTTTGGCCGTGACAGGATAATAAATG 571 TIPARP 2649155GACCCTCGAGTCTGTGGAAAGCATGC 572 TIPARP 2649156TCCAAAGGAGTCCACTTCATGTTTCTGGCCAAAGTGCTGACGGGCAGATACACAATGGGCAGTCATGGCATGAGAAGGCCCCCGCCAGTCAATCCTGGCAGTGTCACCAGTGACCTTTATGACTCTTG TG 573 TIPARP 2649157TACCCTTATTTTGTTATCCAATATGAAGAA 574 TIPARP 2649158GCTTGGGCCTGGTAGAAGTTTGACCAAATGGAATGGAGGCTGTGAGCAATGTGAGGATTCTATTTATTTATTTACGTTTGATAAAACTTACTGGAACTAGTACTACCATGCGTATTCCCTGTCCAAAGCATCACTGCTTTGGTATAGTATAAGTTCATGAAATTCTGGTGGGTAGAAAGAAATTTTTATTTCTATCAGCAGTACTAAAATGTATCAGCCAACCAGAGAACATCAGTGACTTTAACTTCTGCAGAGTTTGCCCCAGAATTCAGAGTTCTATTTAGAGGAAGTTAAAACAACAACAAAAAACAACCATTTGAAAAATTTTTGTCACCAGCAAAACTTTTCACTAATTAGTGATATGAAATGTGATTTTTGTGTTGTTAAACTTCAGCTTTGGAAAACTCAGTCTCTTTCATTATCATCCATTCCAATTTGAAGGAGTTGGGCAGCTAATTTGGTTAAAGGCAGTCTTGAGGGTTAGAAGTATTACTTCCTTTTCGGGTTCCAGACCTAGCTTG 575 TIPARP 2649159AAACTTGGAAATTGTGCCAGTGGTCCAGCTGGAGCACAACGT TTGGTGA 576 TIPARP 2649160TCAGAGAGGTAGCAACTAGGTAAACTCCTTATAAAAAGCAAATACCTGGATTTACAAAAGTGAAAGTAGTTGTTCACAAAAGAATTCGCCATGGAATTCTTTCAGTTACCAAGCTCTCCTGGTAATGTTTGTGGTTATATCATTTACACAAAACTTTTCAGGAACTTCTGTGTTGTTTAAGCAAGATGTATCTGTACTGATGTCTCAGTGAATCAGTCTGTTTATTAAGCACTTATCAGGGCTTCCACACACTTATTTATT 577 SMC4 2650205ATGCGCAGGAGCGACAATAAGATGGCG 578 SMC4 2650206GCCATTTTCGAGTGAAGGACCCGGAGCCGAAACA 579 SMC4 2650207GTGGGTACTACACAACCGTCTCCAGCCTTGGTCTGA 580 SMC4 2650208GCCAGCGTCCGACTTGAAGTTGCTAGTGGTTAGTCCCAGCCTTCGCCCTTCGCGGTCCGACCGCTGAGAGGAGGGAGACTTCGTTATGCCCCGGGCCGTCAACGGCGCCAGGAGCTAAAGGGCGGGCAGACGAAAGCGGGCGGCGAGTCGCCAGTTAGTCTTCACCGCTCTGGAGAGAGTTGCTAGCCACGGGATCCTGACCCGGACACGAACTCGTTTCTCCACGTCGGTGCGCGCTTGCATCCCTGGCCCCGAAAGCGTGGGAATGTCCGGAAATGCTGGCGTATGGGA GTTCCTTA 581 SMC4 2650209GCACGTCTAGATTTTCCCACTTACATAG 582 SMC4 2650210AGTCCTGCCTTCTTGCCACTCGTGTCTTTCGATGGCTCCCTTCCCGAAGTCCCGCTGCCTCTAAGCGGAGTGTTAAGCGGGGCTC TCGGAAGCCGGTGGACCGAGATTT 583SMC4 2650211 GGCGGGCGCGGTGTAGCGGCCCGCGGGCTGACTTGCTCCCG GCTGTCCC 584 SMC42650212 ATGCCCCGTAAAGGCACCCAGCCCTC 585 SMC4 2650213CCCTGACGGCGCCAGCAGCGACGCGGAGCCTGAGCCGCCGT CCGGCCGCACGGAGA 586 SMC42650214 CCTCCGTGGTGTTAGATTGCCGTTAAAGAGAAGACGATAATTTATTTGAAGCCACTGTAGCTTTTGTGAGTCCAGGAGTTGGGTGACATTATTAAACCCTCGTGGCAGTGTCGCTGAAGTTCATGAGTTTCCAAAATGAAGGTTCCAGGTGCTCAGCGGTACGGAGAATTG CATCTA 587 SMC4 2650215TGAGGAACTTGATAATAGAAGTTTAGAAGAG 588 SMC4 2650216CCAGAACTTCAAATCCTATGCTGGGGAGAAA 589 SMC4 2650217CGCTTTTCCTGTATTATCGGGCCAAATGGCAGTGGCAAATCCAATGTTATTGATTCTATGCTTTTTGTGTTTGGCTATCGAGCACAAAAAATAAGATCTAAAAAACTCTCAGTATTAATACATAATTCTGATGAACACAAGGACATTCAGAGTTGTACA 590 SMC4 2650218TTGAGAAAGGGACCAAAACAGCATGGAAAAGTATCAATTCTTTGCTAAGTTGGGTTATTAATGAGAACTACTGGCAGTTTGTGTGCATGTTCAATTGAAGTTTTTAATCCATAGAATTAGTTTCAGTATGAAATGAGTGAATTTTGAAGTAGGCCTATGACTTAATACCAACAAT T 591 SMC4 2650219AAGGGGATGATTATGAAGTCATTCCTAACAGTAATTTCTATGTA TCC 592 SMC4 2650220AACGGCCTGCAGAGATAATACTTCTGTCTATCACATAAGTGGAAAGAAAAAGACATTTAAGGATGTTGGAAATCTTCTTCGAAGCCATGGAATTGACTTGGACCATAATAGATTTTTA 593 SMC4 2650221CTGTAGCAGCACATCATGGTTTACATGCTACAGTCAAGATGCGAATCATTATTTGCTGCTCTAGAAATTTAAGGAA 594 SMC4 2650222GTAAATATTGGCGTAGTGAAATATATATTAAACACCAATATTAC TGTGCTGCTTTAGTG 595 SMC42650223 GTGTTTGATTTACCTAAGCACCTAGTTAATTTAATCTTTGTAACACTTTGGATGGTTAACTTAACCTTTACTCAAGTTGGTTTTTGTTTTGTTGAAAATGACTTACTTGGTGGAACCACTACTACTGAAAGAACGAAACTTTGATATTACATTGTTAAGTATCAGAGCTGTTACAGAGCAAGTCCTTTTAAAGAGATGTAAAAATTAAGTACCTGTGCCAAACTGATTTTTATTAGAAACCCTGTTTTCTTTAAGTAAAAGTA TATTCTACCAGCATGGCTTGG 596SMC4 2650224 TATCCACAACTAGGGTGAAGGTGGTGGAGAGCAGCAAGGAAGCTACCTCTAACCAACCAGAA 597 SMC4 2650225CTCAAAGAGTGGTATAACTGGATCATAATATCCTTGTTTGCCACTCAAGAAAGTGTTCCATAACTTAAGATAACAGTGGTGGGAAAAATCATTTAAGACCTTGTTTCATATGCTTTAAGATACAAGAAATAGAGATAACACTGGGAACATATGAAACTTTGTCAGCATCAGATAATAGTGTTGTAGCGACTTGAAACATTTTTTGTCTGTGATTGTGCCAGTCACTATTTGTGACTTGGATTGAACCTTGATATGACTTTAAATTCAGGTTGATGTTTTAAAATTATTTCTGAAATATATTGAGCTTATTGCCCTAAATTAAAACTATATTCTGTAATTTTACATGAGTTATGTAAGTTTTCTGAAGAAATAAGGAGGAATCCTTTAGGCACAGA CTGTCAATCTACAGATT 598 SMC42650226 ACTCTTGGCTTTATTATTTAACTGCTCCCAATTCTCACTTAAGATTGATTTAGCTAAACATACAC 599 SMC4 2650227 GAACAAATTGCTATGATGAAACCAA 600SMC4 2650228 AGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTC TTGTGTCGGAGAGTT601 SMC4 2650229 GGAGAGAAAAACATAGCTATCGAATTTCTTACCTTGGAAA 602 SMC42650230 GTAAGTGCCTTGATTGATATTACCAATTTTTATATTAGTTTTTAACCATTAAGTCAAAGCCCTTCTCT 603 SMC4 2650231AAGGAATTATGTGGTGAACTTATCCAATGTGAGGACTATCTGGCTGTGACACCTGTCATCCCGTTGATCACCAGGGTTGAATTTAT TAAA 604 SMC4 2650232TTATGAGTTGCAGAAACGAATTGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATG 605 SMC4 2650233GATAATTGTATTACATGTGTATTTATATATAAAGTTACTTCTAGCACATTGTGAGTGTAAGACATTTGCCAGCATATCAAGTGGTG 606 SMC4 2650234CCCTAGTGGCGTAGCACAGTAACAAACAATAAGCATTTGGCTTCACAGTTTAATCTTTTAGTAGTCCACAAATCTGATAGAGGGATAGGATTTGGGTTTTTCTAGATAGATTTTTAAGGGTTTTATCATGTCCCTACTTGATGCCATTTTTCAATGACACTAGTATCTCTAATTATTTTTAAATAAAAAAATTTGTATAGTAAGTTTATTGTATAGTAACTTGTAAGTATATTCGTAAAAGGTAAAACCAAAATTTTACTCCTATGGTAAAATTTTTATATACCTAGACATTGTAGTCACTGGAAAATGTGTTATTTTCCCTCCAACTTAGAAAGGCAAAATAGCTGTCATAATCAAAAATACAGGTGCTTCTTCAACTATGGGGAGAGGGATCATCTTGGAATAAGGAGAGTTTTAGGATCCTGCCTTATTAAGAGC CTGGACATA 607 SMC4 2650235ATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACAGCTAGATTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCC ACGAGTAAAGCC 608 SMC42650236 TCCGTGTAGTCAGAGCATATTTATAGCTAAAGAAGAATAATTACAACCTGAAATCAGGAGAGAAGGATGACAGACCTGAGGCCCTGCCAGAGACAGTTTTCCTTCATAAGAGGTCAGGTGTTTGTAGAAGTAGTTTTACTATTAGATTGAGAGAATATAGAAATTACAGTGAATAGTCGGGAAAATACTTGTTAAAGCTAGCTAATTTAACTCTGATTATAAAGAAAAGAAGAACTAGAGGACCCTGAGAAATGCCTTTA AATA 609 SMC4 2650237GCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGAAAAAGAGAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAA 610 SMC4 2650238TGAAACCTGAACTGGTAAGTTTGGACTTTTAATGTCCAACATTCCTAAAACTAGTCAACCTAGACTTAGATGACTATTCTTTTAATTC CTGCTGA 611 SMC4 2650239GTCAATGGATAATGCAGTAGCTTTCATGATGGGATACTTCATAGTTAGTGGATTTTCACTGTTTGCTTATTTAATATATATTGAGTACTCATGTGCCCTGCACCCCATGTTAATGACAAAGCTAGGCCTCAAATGTCTTTATTCCTCAGCGTAATGATCGATCTCACAAAGCTCTTGTGAAATCAGTTGGGAAAAGACTATGTACAGTGAATATTGACAACTAGGCAAAAACTGAATCTAGTCCACTTGTGAGAA 612 SMC4 2650240AAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCGTCATAATACTGCAGTGTCTCAATTAACTAAGG CTAAGGAAGCTCTAATTGCAGC 613SMC4 2650241 AAAGAATGAGGTCAGCATTTCAGTATTCCATATGTGAACTGAGACTATCAAGAAACTATATTATCCCCAGAAGCACCATATAGTAAGTAAATCACCACCACCACCCCACTGTAGAAATAATTTAAACAAAAGAAAGTTTGTGTTTCTTTAAATCTTAAGTATAGACAATTTAAAGATAAATAAAAAACAAGTGTATATGTATTTATATAATGAATATACAAACAACTATCTTAATGTGTTTTGGGTTTTGAATTTATGGATGTAGTTTCTTTGCTTGCATTCCAAAATGTTATAAACTAACTAAGATGTATAGCTTATCGGTGCCTGTCCCCCATCCTTGAGTGAATTAGATGTCTAAGGAATTTCGTAAACTTTAATCTCCAAAGATCTCCAAA ACCTCAGTA 614 SMC4 2650242AAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTT GATGCAATAATTCAAGAA 615 SMC42650243 TGACAACCATATTTCAAGTGTCACTGTATATAAAATAAGATTCATTTTGTTTGTTTTAAGGCACATTTATTTTTAAACATTTTGCCCTTACAGTTTCTTGTTTACTTAGCTTTAGATAAATACAATTATTTCATACATATCAAGAAAAATACTAGTAATGTCACACAAAC 616 SMC4 2650244GGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGCTATATCATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATT GATATAGCCCAAGAATGTG 617SMC4 2650245 GGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCGTTTATTTGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGATCAAGCCACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCA 618 SMC4 2650246GAAGAATGGGTTCCTCACTTGTTAT 619 SMC4 2650247CAGTTGCAAAACGACTCTAAAAAAGCAATGCAAATCCA 620 SMC4 2650248GTGAACGAGAAATGAGGAACACACTAGAAAAATTTACTGCAAG CATCCAG 621 SMC4 2650249GGAACTTGAAGCTAATGTACTTGCTACAGCCC 622 SMC4 2650250TACTGGCCAGGCTTTGTTTTAGGTCCTACTGATAGAGCAGTAAACAAAAATAAAGTCTCTTCCCAGGGAGCACACATGTAAGATGGCACATATTTGAGTGGAGGCCCAAAGAAAGTATGAGTGCTAACCCATGTATGTTTGAGAAAAAAGCATTCCAAGAAGAGTATAAAGGAGCAAATACAAAGGCTGAAGCAGGAGTATGCTGGGAACACAAACCATTGTGGCTGGAATAAAGGACGGAAGAACCCAGATTCTCTGAGGCCTTCACCCACACTCCCCTTTCCCTGCAAGCACCCACAACAATGGCTTTGATGGTACCTGATGGTCAATTGAGAAGCCAAAATGTATATCTGTGCTATTAATGGCAACATTTTCATGGAGAGACTGCAAGAGTCTATATGTGTTTCATCCTTATTTGAAAAGGAATCCTTGACTTTGTTAGGAGCTCTATATATCTCCTCTCATAGAAATGCCATATATTATCAGGAGACTGTTAATATCTCATGTGGAGGACCCA TTTGTGCAAGCATA 623 SMC42650251 ACTTTTACTCTTCGTTGTCACAGGAAGGAACGCTAATTCATCTTATATCCTCCACTTTGTTTTAATGTGGAGAACTGCGAAGTTATGTTAGCAGAAGAAAATAACCACAATTTCTTCATTGTGGGCAAGTTAATATTGAGTTAGGCACATAGTGTATCTAAGGCTAAAAATCATTATGAACTCAGTAGTCAAGGAAGTGCCCTAAGAAAAAGTTGTAAAGATATTTTAAAAGAAGCTGAGAACATGAAGCCATTAAGAAATGGTGTGTTTACAGCCGAGCTAGTGTGTTTAACTTT 624 SMC4 2650252GCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCAACAAGACAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAG TAGCAATCAAGACT 625 SMC42650253 GTAGAGTATGCATGTTACCCTAACTTGTTTTCCCTTTCCCTGCCTTCACATTGGAAAGGGGGTTACTATGTAATGTTCCATAAAATGTTTCTCTTACTGTTAATTTATTGAACCTGTCTGACACATTACCTAATGGGACTTCCATGACGGAAAACCTATAATGAACATTTATCCTATGGCCAATTAAAAAGGCTGGTAAACAGGTATGCCATA 626 SMC4 2650254TGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCTGAAAAGTCTTGAGGACAAA GCAGCAGAGGTCGTAAAGAA 627 SMC42650255 TCCAGAAAGAACATCGCAATCTGCTTCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGATGGTCACATTGCTGAACATAA 628 SMC4 2650256AAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCGGTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGT ATAAAAAGAA 629 SMC4 2650257ATTTTCCCTATCATAATCTTTTCACAG 630 SMC4 2650258TATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAATAACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCT TGGATCCTTTCTCT 631 SMC42650259 GTTCATTGGCTTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGA 632 SMC4 2650260 GTGATTTACCTGTTATTACTTAATGT 633SMC4 2650261 GCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACTTATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACT TTGT 634 SMC4 2650262TTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAACTAGA 635 SMC4 2650263CAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAATCTTGGATAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGA 636 SMC4 2650264GCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAGTAAGATGGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAACTTGATAGTTTCAACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAGTGGAAAGTAAGATACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGGACATAAGTTGGCAACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGT TAAATTTCTGG 637 SMC4 2650266GATGTAACTATTTTGCTTTGTAAATATCCTGCCTTTAA 638 SMC4 2650267TGTTTCTTAATAGCTGTACTCTATCTCTTCAGTAAGTAATTTGCCAGGAGAAATACAATGTTTTTAAGGAATATTTTTGTCAGCGTAAACTGTTAAACACTGAATCCCAACTTTTAGCTATCTGAAAAATGTATACTTAAATAATACATTATGGCCATTTGACTCAAATGTAAGTT 639 LIPH 2708858TCTCTTTCCTGGTAAGCAGGGAGTCAAAACAATAGCAAGAAAATGCCAGAAATAGAATTTCTACTACTTTGTAAACTCTAGGCTCGTGGGTCTCCTAGCTCTCAGTACCTGGCTCACTGTAGGATGGGTAGATGGGTGAATGAATGGATAAAGAAAGGAAGTTTGTTCACCGGAGAGGAGATGAATTTCAGTAAGTTTCATGTAACAGTGATCAG GAGAAATA 640 LIPH 2708859GGCTGTCACCTATTTTGCCAACACGTGAATTCAAAACATGAACCGGTTTGCTTTTGGAGAATCTGAAGACTCCAGTTTGAGGAATCCTTTGCTTCCCTGGAGGTAGATGCTGTCTGCAAATCTAGAATGACAGCAGGAGTCCAGTCAAGAGGTCCTGTCAGGCCAAGGCCAGAAAGAAGGGAGGACAATCCCTGGGGCCAGATGCCCAGTGTGAGGGGAGGCATGATCTGTCCCATGGCTGTGGCCACTGCAGGAAGGTCTGTGAAAAGGAGGTGACAGGCCCAGTCACCTCCTCTTCACCCAAGTGATTGCTCCTTCAACTGCTATCTGTGAAAATAGCCTTTGTTATGAAGAAATTGACTCTCTCTCTCTTTTTTTTTTTTTGGAGTTGCCTAGGCTGGAGTGCAATGGTACGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAATTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCACACCCGGCTAATTTTTGTATTTTTATTAGAGACAGGGTTTCACCACGTTAGCCAGGCTCGTCTCGAACTCCTGTCCTCAGGTGACTACCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCAC CACACCCGGCCAAAAATGGATTCTCTATG641 LIPH 2708860 CTGCTGGGACTAGATAGTGGATGAAGAAAGAAGGACGAGGAAGCCGTGGGGCAGCCTCTTCACATGGGGACAGGGGATGGAGCATGAGGCAAGGGAAGGAAAAGCAGAGCTTATTTTTCACCTAAGGTGGAGAAGGATCACTTTACAGGCAACGCTCATTTTAAGCAAC C 642 LIPH 2708861TCGGGCTGTTTGCTCAGGGAAGGCAAGAAAGCCACGTGCTGG CCCTCTGCCTT 643 LIPH 2708862CAAGGCTTTTTTCAGTAGCGTCCTATGGATGTCACATTGTACATCAAACAACCTTGTGATTATAAAACGATCCTGGGAAGGAGCCCCTAACTAGGGCAAGTCAGAAATAGCCAGGCTCGCAGCAGCGCAGCGCTGTGTCTGCTGTGTCCTGGGGCCTCCCTTGTTCCGACCTGTCAATTCTGCTGCCTGTCACGCGGGTGGTTCTGCCCATCGCGGCTGCGGGTCAAGCATCTTCAAGGGAAGGACGGACTGGA GGCCTCACCGTGGACTCAACTCTGCATTC644 LIPH 2708863 GCCTCAGCTGTGTCGGTATGATCTTGTCCTGATGGAAAACGTTGAAACAGTCTTCCAACCTATTCTTTGCCCAGAGTTGCA 645 LIPH 2708864CTCTAATAGGCCCAAGGTACAAGCTCAGGATTCTCCGAATGAA GTTAAGGTCCCTTGCCCATCC 646LIPH 2708865 TCAGAAATATCACCAAGTGAGTCTACTTGCAAGATTTAATCAAG ATCTGGATAAAGTG647 LIPH 2708866 CTTTGTGGATATTATAACATGGAACAAGAATGTAAGAAGAGGGGACATTACCATCAAATTGAGAGA 648 LIPH 2708867TATTATGCTGATAATTGGAAAGACCATCTAAGGGGGAAAGATC CTCCAATGACGAAGGCATTCTTTGAC649 LIPH 2708868 ACCACCAGAGGTCTGTATACCTGTACCTGTCTTCCCTGAGAGAGAGCTGCACCATCACTGCGTATCCCTGTGACTCCTACCAGGATTATAGGAATGGCAAGTGTGTCAGCTGCGGCACGTCACAAAAA 650 LIPH 2708869CTGGGCTACAAGGAGCCATTAGGAAACATAGACTTCTACCCAA ATGGAGGATTGGATCAACCTGGCTGCCC651 LIPH 2708870 CTGCACCCGACCTATATATACATTTCTAGGTCCTCATTTTCTAGAAGTAGTTCCAATCTTTTTACCATCCTAGCTCTCAAATATTTAAAGATTTTATCTACTAAGTAAACATTCATTTTTTCCTGTATCCTATTTATTAGTTATACAAATGCAAATAGAGGCTCAGAAGCACCAGGC AATTAAAGGGTTGCAGC 652 LIPH2708871 CCTGCAGGCCCTTTATTCAACGGGAAACCTCACCAAGACAGATTAGATCCCAGTGATGCGCAGTTTGTTGATGTCATCCATTCCGA CACTGATG 653 LIPH 2708872TGATGACATTTACATGATCGGAGTAAGTCTAGGAGCCCACATATCTGGGTTTGTTGGAGAGATGTACGATGGAT 654 LIPH 2708873TTACAATGATGGACCTCTTGAAATTCCA 655 LIPH 2708874AGGCTGATGCTCTACACAAGGAAAAACCTGACCTGCGCACAAACCATCAACTCCTCAGCTTTTGGGAACTTGAATGTGACCAAGAAAACCACCTTCATTGTCCATGGATTCAGGCCAACAGGCTCCCCTCCTGTTTGGATGGATGACTTAGTAAAGGGTTTGCTCTCTGTTGAAGACATGAACGTAGTTGTTGTTGATTGGAATCGAGGAGCTACAACTTTAATATATACCCATGCCTCTAGTAAGACCAGA 656 LIPH 2708875TATTCATCAGTTTGTTGTGCTTGTCAAGA 657 LIPH 2708876CTCACTGTGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTCTGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTC 658 PART1 2811146TGCAATGTCAGCTATTTAGGACAGAAACATCCAAGGCCGTGTCAGAACTCAATTACGACTACATATGCATTA 659 PART1 2811147ACGCCAACTATAGGACTCGTGCTTCTCGTACGCTGGGCTATAA TCTATGAAACTGAGCTCCAG 660PART1 2811148 CCTCATAACAAGTCTAACTGGCTCTGGAAA 661 PART1 2811149ACAGATGAGATATTCTACACATTAATCTACTTATCTGGAATCAC TTT 662 PART1 2811150CACAGCTTCCTTGTCGGAGGGGAAAAGGACAGGTGATCTGGGGAAAACGCAGCTACACCTGGAGCAAGGTCTCTTCCCGGCTTG GCAATCTCAGCTGTGCCGGCGCTAC 663PART1 2811151 CTGCTGCCTTCGGTGACTATATGAGAATGGAAACTTCTAAGGAAGCCAGGTTGTTAGAATTGTTACCCCCTTTACTCAGAGATAAC ATAGATTATCCAGGCTGA 664 PART12811152 AATTTTCAACACAGACTCCCTGCTTCTCA 665 PART1 2811153TGTTCAAATCTCCATTTGTTGACAGACAAAGCCAACAATACTCT AAACTGAGGCCTGCAAGTCATTTCATT666 PART1 2811154 TTCACCTCCTACAACTCCGAAGAAAACCCTTACTGTCCAAGACCGTCACCAGCAACCATCCGCAGTCATTCAAGTGGAAGCTTTCACAGCTTTTGTACATTCTCTGTGTCAATATACAACTGAGTTACAG ACTGTCCC 667 PART1 2811155CATCAGGACTTGTATTAGCAGGTTCTGGCTAGAGAGACTATCTCCTGTCATCACGATCAATTAATGTTTTCTGGTGATCACATCAGGCCCTATCTAAGAAGCTCATGGTATACAAGGGTCACCCAAATAGCTGAGTGCAGTCCTTGCTCATATTTCCTTCATCTTAACCCCGCAAACAAGAATTAAGATGATCCCAATAAAAGAAAAATTGCTCAGGAAACTGAACCTTTTTCTGAACCAAGCACTGTCAGCAAATCTCAGGTATTAGAGCAACTATGGTTGATTGAAAAGTGTCTCAAAATCTGGGCCAAGAATGATTGCTAGGTCCATAAGCTAATTTGTCTG GCCTTGCCATTTACGTAAGCC 668PART1 2811156 TGGGATGGCCGTTCAGGAAATCTTCTGTTTGCTTTGCACGCTCCTGAGTATAGGACAAAGCGCTGTTGTTTAAGAACATAAATAACAAAAGCTTTGTTCTTCCAAACCGAGAGGGAAACTGTAGATCTATCCAAAATGACTTGGTCTTAAACTGCCTAAGGATGACAAGAATGAAATATTATTTTAGGCTGCCCATCAGCATCCGTCTCTCAATCTCCTGTCTTGGCTTCAGAAAACAATGACTCAATATGGTCTTTTTC TGACACATTGCAGCCTTAGGA 669PART1 2811157 TGCTCTTCTTGGTCCCACTCAAATGGGAAGTTCTGCTCGAGGCCAGAAATAGAAAACAGGAAGTCAACAGAACTGATTTTCCTAACTGCCCAAATGCAAATCACCACACTCCGTTATGGATGAGAATT 670 PART1 2811158TTGCCCTCACATACACATAAGTTTGTCATTGTTCTTCAGTTCTTTGGGTAATCTCTTCCTAGAAACTGCATCTAACAAATAGACCACATCCCCAAATTCCATCATGTCCAAAAAGAAGCACGGTATTTCCATCAACACCCCAGCTGCCATCACCAAGCCAACTCGCCTGACTTCCATTCACTTACTAGCAAACATTTACCAAGTATCTGCCATGTTCATTTTGTCAATGAGAATGACATGGGACTTGTTCCTCTAGGAGA TCACAGTCTA 671 PART1 2811159CCTGCTGCCCAATAACCTGATGTTGTCACTCTCATATTTAAAACCCATAAGTGCTGCCGGGAGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACAAGGTCAAGAGATCGAGACCATCCTGGCCAACGTGGTGAAGCCCAGCCTCTACTAAAAATACAAAAATTAGCTGGGCGGGGTGGCACACACCTGTAGTCCCAGCTACTTGGCAGGCTGAGGCAGGAGAATTGCTTGAACCCGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACTACTGCACTCCAGACTGGTGACGGAGCGAGACGCTGTCAAAAAAACAAAACAAAACAAAAAACATATCAATGCTGATGAACCAAGTGCAAAGCCCTGAGCTTGGCCAGGCAACATAGCCTGGAAACCTGACTTTTAATCCTTACTTTGCTCTATTCCCCCAACATACACACACTTCATACACCACACCTAAAAGAGACTTCCCACAGTTTTCCAAAAATGACTCACATTTATATTTCCTGTTTTTCCCTTTGCCCACCCTGCCCTCTCTCCCTCTGCCTTCATTTTTTTAATTAACCTCTGGAACTCAGGTGCTCCTGCTCCAAGGTTTAGGTCAAAAGTTACCTCCTCCATGAAGCTTTCTCTCATTCTCCCACAATGTGTGAAAGCCCCATTCTCAGATTTGCTTAGTTGTGCATTTGTATATTCTACCTTGCACTACAGTCATTTGTATATTTATCTTATGGTTTCTGTGCCTTAGGAAAGGTACACTGTCTTAATCATCTTTGTTCAATACAGTGCCTAGCAGAGTGCCTCAAGTATAATATGTGCTCAATAAATAATAGATGCATTTTTCCATGCATATTTTCTACTATATCGAAGTGGAAAATATATCCATGTGATATAGTGAAAAATATCTCATGAAGAGAGATACAGTGAGGAAAATATCTCATGAAGACCAAAAAGCAGAAATCCAAGTTTTTTCTTTTCATTACTATCATCAGTGATTATTAATTTTATGTGTCAACTTGGTTGGGCTTAGGGATGCTCAGATAGCTGGTAAAATATTATTTCTGGATGTGTCTCTCAGGGTGTTTCTGGGGGAAATTAGCATTTGAATCAGTAGACTAAATAAAGAAAATCTGCCCTCACAAATGTGAGCCAGCATCATCCAATTTATTGACAGTTTAGATACAACAATAAGGCAGAAGAAGGTGAACTCTCTTTCCTTGAGCTGGGACATCCATCTTCTCCTGCTCTGACATTGGAGTTTCTAGTTCTTGGGACTTCAGATTCTCCCCTGAAGTTTCTCAGGCCTTTTGGCATCAGACTGGAAGTTATGCCATTGGCTCCCCTGGTTCTCAGACCTTTGGACTCAGACTGAATTATACCACTGGCTTTCCTGGTTCTCCAGCTTCAAGATGACATATTGTGAGACTTTTCAACCTCCATAATTGCATGAGCCAATTTCCACAATATATCTCCTCTTATGTATCTATATATTTCCTATTGGTTTTGTTTCTCTACAGAATCCTAATAGATCATCTAATTGTTTATCTAACAAGTATTTTCCTCCCTAGACAATATGTTGGGCACTAGGGACACAAAAATAAAAACACAGACATCTGCACTCAATAAACTTACATTCAATATCAGAGAGATTGGCACAGAATACAAATAAAATGAGATACATGCAAAATAATATGAATTGCAAAATTACGGCAATTCACCACCAACTAGGTGTGTGACCGTGGGAAAATCACACTGTGAGCTAAATATTAGCAAGTTTAAAATGCAAAATCAGAGGCAGTCTATGAATTGGACTTTGCTAATGGCCTCCTTTGCTGATGGATGGCACATTGGTGTTAGAAAGTGCTTATTTTTGCAAAGGTCCATTATTGATGCTTTAATTCTAAGGAAATTATGTAGGCAGAAACTAAAGAAAGGTTAAAAAAACAGCAGCTAAAATTGATACTTAGACAATAAAAAACTAATTATAAGTGATTTATCAGCACCACTAGATAACTACATTGGTGAAATTTAAGGCCATGAAATGCAGGACAAGCCTCGTAGGAAGCAAGGTCCCAGTGGATGAGATGCTGTCCTCTGGGCTCCTAACCTTCCACCACTAGTATTCACCATATCTGATTGGAAATGTGTGCATGTGAGTCGGCCTCCCCTCTATGATGTGAGTAGGGACCTATTTTTGCTCATCTCTGTATCCTCTACACACGATGCTT GG 672 PART1 2811160GGAGCTAAAAGAAGAAATAGTCAAAATTTTCTAAATGAG 673 PART1 2811161CTGCCTTGTACTTCATGCAGGTTGAACAGAAATGTTTTCTGAGCATGTATTGTTACAGCCCTCTGAGATGGTATAAAAGAATGAAAGAAGACACGACCTGCCTTCCAGGAGTTTCACA 674 PART1 2811162AGGGAAAAGCATTTCTAATGGAGGAGATGGCTGTGGAGAGGA GAGG 675 PART1 2811163ACCTTCCACCCTTTCACTATGAAGGACCCTCACCA 676 PART1 2811164AGATTGCATATGTATTGGGAAGCTCCTGGG 677 PART1 2811165TCCACTTTCCTGTGAGGTCAAATGCGGTAAAGGGATGCTCCAACCCTACCCTCCATGTACCTGCCTTTCCTGTGATTCCGAAGAAG GGGTGG 678 PART1 2811166CTATTAATTAATCCAGAGAAGTGTGTTGCTATAAAATATTCTGT GAAGCATTTTCACTTATT 679PART1 2811167 TTTGAAGAACTAGAGAAAATCATCAT 680 PART1 2811168GGGATTTGCTGGCATTGATTTCCCAGGATGGCAAAGTGCTAAGAACTAAACCTTTAAAGCTAACAAAATGTACTGATGTCTTTGCAAAGTATCCAAGACCAACAAGAAAGTAATTTCCCACCTCACCCTACCACCACCCAGAAAAGGAGCACAGAGATGGGGAAGAGAGTGGCTGCATCTGGCATCCAGCCAGAGGAGTCCGTGCAGGGATTC T 681 PART1 2811169GATGATGCAGCTCCCTCAAGTATCACATGAAGATAGTGG 682 PART1 2811170CAGCAATGTATGAGGTCCAAGGACCAGGACCAAAGGGAAAAACAGCCATCTCACCAGACACCTGCCTACGACCAGATGCGTCATCTCCAATATTAGCTAACTCCCTGGAACCTGGACTCA 683 PART1 2811171GGCCTCTCAATCAATTACAAAACTGAGAATTCTGACAGTTTTGTGTATTTCCTCTTTGCATGTGATGTATATGTGTGTATTTGTATATATTAACCATTTTCCTTTTTCTCTCTTCATTATTTTATGAAAGTTGTTGAATATAAACTCTACAATTTAGCCTTTAGGTAAGAGAATATTCAGTGGGACTTTGATTTGAGGAGTATTTAAGACAGCCAGATGAGACTACGATAACTGTTGGAACTGTGTGTCTCCTCATTTGGGGAAAGGGGTGAGAACTCTGCATTTCTCTGAAGAACAGAGTTGACTTTGTGTTATACAGAGTTCAAATATATATATAAAATGGTGCATGTGGAAGCTAAGAAGCCAAAGGAGTTCACCAAGACAGTTATCAATATATTGCCTCTCCGCTCCAAATCCACCCTTCTTTGCCCTGTTCCACGATACTAATCTGGCTCCTCGGTCAGCCAGTGCAATGTCATC TGTTGCTGGTAGAGTGTA 684 PTTG12838202 TTAAACCAGGAGTGCGCCGCGTCCGTTCACCGCGGCCTCAGATGAATGCGGCTGTTAAGACCTGC 685 PTTG1 2838203GGCTTAGATGGCTCCGAGCCCGTTTGAGCGTGGTCTCGGACTGCTAACTGGACCAACGGCAACTGTCTGATGAGTGCCAGCCCCAAACCGCGCGCTGCTCGGGACCTTAGAGCCTCTG 686 PTTG1 2838204TGTTCCGCTGTTTAGCTCTTGTTTTTTGTGTGGACACTCCTAGGATAGAAAGTTTGGTATGTTGCTATACCTTTGCTTC 687 PTTG1 2838205GCACCCGTGTGGTTGCTAAGGATGGGC 688 PTTG1 2838206TATACAAGGCTGCAGTCGGATACACTGGTATTGTGGACGTGGCCTGGAGCTGGACGAGACATTTAGTGTACTTTTTGGGCAATTGGAGTCGTTTGTTATTGGTCCTTTTTCATTTTTAATATCTTAATGAGATGATTTAAGGAAGTTACTGAATCTCTGCTATTAGGCCTATC 689 PTTG1 2838207GATCTCAAGTTTCAACACCACGTTTTGGCAAAACGTTCGATGC CCCACCAGCC 690 PTTG1 2838208GTAAGTGTTGGCTATAAAGACACTGTTTAAACACTTAAGCACTTTTGACTCTTAAAATGACTATTGGCATCATCCTACGTAGCTTTCT TC 691 PTTG1 2838209CTGCCTCAGATGATGCCTATCCAGAAATAGAAAAATTCTTTCC CTTCAATCCTCTAG 692 PTTG12838210 ATGAGACTGTCTGAATCTGGGTTGCTTTGGACAAGTGTACTTGTTGATGGAATTATTTGCAAGGTATCATCTTAGGTCAGGAGGGGAATAGGAACAAAGATGTAGAAGACATTGTTCCTGTCTGTAAAAGCTTATCACCTAGAGGAGGTAAGATGTATTCATGAACATTGAATAAGTCCCATTGTGGACAGTCTTTCTCACAAGGCTT 693 PTTG1 2838211CTGAAGAGCACCAGATTGCGCACCTCCCCTTGAGTGGAGTGC CTCTCATGATCCTTGACGAGGAGAGAGA694 PTTG1 2838212 CTGTTGCAGTCTCCTTCAAGCATTCTGTCGACCCTGGATGTTGAATTGCCACCTGTTTGCTGTGACATAGATAT 695 PTTG1 2838213TCTTAGTGCTTCAGAGTTTGTGTGTATTTGT 696 NADK2 2853389TTATTCTGTGCCCTGTTGACTTCATTCACTGTTAACATTTGACATAGAATGATTAGTTATTAAATCAGGGTGAAGTGCTTACCTGGTCAGTGTAGGCTCTTCAGATAATTTTGACTTAATATTTTTGATAC TCCTTGTGCATTTACATTC 697NADK2 2853390 TCTTAAAGTATCTGCGTAGACATTCATAGCAAAGAATTTATGACATATCAGATAGAAATACATTAAAATGTAGTGTTTTCCCAGAGATTGATCTGGCTTTTTTTTTTTGATATACATAAGATACCACTTTATAAAGAAGCTCCATACTATAGAACCTCCCCTAACAGGCTTAAAATACCTTCTTTTTTTTTTTTTTTTTTTTTGAGAACGGAGTCTTGCTTTGTCACCCAGGCTGGACTGCAGTGGCATGATCTCGGCTCTGCAACCTCCATCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCAGGCACCACTATGCCTGGCTAATTTTTTGTATTTTTAGTAGATATGGGGATTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTTGTGATCTGCCTGCCTCGGCCTCCCAGTATTGGGATTACAGGCATGAGCCACCATGCCCGGCCTTAAAATGCCTTCTTAAAGGAAAAATGCCAACTCCATCCTTAATCTCAAGGAAATCTGATTGTCCAAATAGATCTGTTAATATGTAACATATTAATAGGTAACTTGCTGTGTAAAATTATAAGCCATATTTTAAAAGGTTTTAAAAATACTTATTGTGCTCCATTTGTGATATAATTTCTAACATTTCTGCTCTGTGATGGGGGTTTATTTGTAAGAATAAGAGGCAAAGGAATGTTAGCATAGCAAAAATGTGTTTGAATGAGTTAACCTTTTAATCGCAACCCTATGTGA 698 NADK2 2853391TGCCAAAAGATCCTGTCGTTGCATAATCAAACAGTTGGTATTCTCGTGCCGTTGTTCAAAGTCATGTGTTTCTTTCATTTGGTGCTGAAAATTTCTGTTCAATCATTGACAAATATTTATTGAACACCCACTCTGTGCCATGTAAAACTATGTCAGGTGCTGGATATGTTGATGAATGAAACAGACTCTATCCTTATACAATTTGAGTCTTGTGGGCTCAGAAGTAAATTCTGTGAAAGCTGGACGGATAGTCGAATTGAGT GCTCTTA 699 NADK2 2853392CCTCCTAATTGTGGGATTGTCAGAACTGAACACATATCATTTGATTAGTGCATATTTTTTATAGTACCTGAAAACCAAGATTTTGAAAAAATTTTCAAGACAGAGAATTTTGATAAATCCTGACATTGACCTAATTGACATAGGTAAATATGTTTGTATATGTGCTAATAATTTTCTAATTTCGGAACACGATGATGTTATGACTATTGATT 700 NADK2 2853393CTACCAGTCGTAAAGTGACATTTTTTGGTTATTGTTGAGACTGCTTGCCCGTGGGCTCAGAAGTGAGATTTGCATTATTCTTCTGTTGGATTCTGATAGAAAAAAAGACATTCACTGTATAAGAAAATGGATGGACTGAACCAATTAGAATTGATACCAGTGAAATTTTTATATTGCTTACAATTGGTAACCAAGAGTGCTGATA 701 NADK2 2853394TGTTCGTTCTCGTTGTTGGGATGCCTGTATGGTTGTGGATGGAGGAACTTCTTTTGAGTTTAATGATGGTGCAATTGCTTCGATGATGATCAATAAAGAAGATGAGCTTCGAACTGTGCTTCTTG 702 NADK2 2853395TCACTGCTCTACAGTCCGGAAGAACCAAAAATACTTTTCAGTATTCGAGAACCAATAGCAAATAGAGTTTTCTCAAGCAGTCGTCA GCGTTGTTTCTCCTCAAA 703 NADK22853396 GAGAATTAGTGCTGTTAGAGAAAGAATACTTATGAAGAAATCT G 704 NADK2 2853397GAAATTTGAGTCTTCCATTGAACAGAGAATTGGTAGAGAAA 705 NADK2 2853398CATTCAATATTAACAGGGTTGCAACT 706 NADK2 2853399ATGAGATTTCAGTTGATGATGGTCCATGGGAAAAACAGAAGAGTTCAGGGCTCAATTTGTGTACTGGAACAGGATCAAAGGCCT 707 NADK2 2853400AATGTCTTATTCTTGGGCTGTAGCAGTGGACAATTTAAGAAGA AGTATACCCACTCTAAAGG 708NADK2 2853401 GCTGAGAGCTAGCTTTGCTTTATAATTTTGTACTTACTAAAAAATTAAATAACTTATAAATGGAGGAAAACTTGGATCAGTTGATAGATTTTGGGGGAGTTAGTGAAATTTCTTGAGGGGATTTTCAATCGAATGCTTTTATTTTCTGTGGCAGTAATGATCTGGTTGGTTTATCTCATAAATAACTGATGCTGCTGCTTTTTGTGTTCTTTGATGTCTCACCTTATGTTTTTACTAAGTAAGGACAGCAATGGATTGGCTTC TGATGC 709 NADK2 2853402CCCAACTTCTGCCAGTGAGAGCACTAAATGAAGTCTTCATTGG GGAGAGTCTGTCATCCAG 710 NADK22853403 CATTTGCTGCTTAAATCCAAAATAGTTCTCTT 711 NADK2 2853404TGGAACTGGAGAACACACTTTTTTAGCTCATCACATGGCTTTTGGCAGAAGGCTTCAGTTCCTCACCATGTTGGTCTCTCCAAAGG GTTGTTCATGTTATCTCTTCCTC 712NADK2 2853405 TGGAGGCAGAGAATCAGGTTATACCTTGAAGGGACTGGCATAAACCCTGTACCTGTGGACCTTCACGAGCAGCAGCTAAGCTTG AATCAGCACAATAGAGC 713 NADK22853406 GCTATATCTAGCTCAGTATCTTGGACTTTATGGGTTCTTGATAGAGTTTGACTTAATTTAAGTTACTTGGGAGATTTTGTACAAGCACATTAGGTGTTTCCGTTATAATTGAAAAGAGAATAAATATTCAAA TCTGTCATTGATAAGGAAGCTATAGG714 NADK2 2853407 AGGGTCATTTATGCCTGCCCGTTCGATATACACATTCCTTTCCAGAAGCCTTACAGAAGTTCTATCGTGGTGAGTTCA 715 NADK2 2853408GCTGCTGGCAGCGAGTAAAGTCTTGGACAGACTTAAACCAGT TATAGGGGTAAACACTGATCCAGA 716NADK2 2853409 GGAATTGAGGTTCGTCTAGTAAAGAGGAGAGAATATGATGAAGAGACTGTTCGATGGGCAGATGCTGTCATAGCTGCAGGAG 717 NADK2 2853410TACAGTGGACTTCTTGAACGACATCATATTCACACCAAAAATG 718 NADK2 2853411AAGCAAATCCAAGTGGAACAAAGGTCATCTAACCGCCTCTACAAGTATTAGTTTATCTTTGGTCATCAAGTAGCCATATGCAGTGTG TTAAAAAGTCATCAAGGCTGAGGCA719 NADK2 2853412 ATTAACACTAATGATTTTGAGCCATAAGATTATATTTGA 720 NADK22853413 GAGGCTTTTGGCTAGGCATTAAATTTTGGCACAGGCTGTCTAATCTATTATAGTATATCTTGGTAAGTTAACATCTATTAATTAATTTTCACAATAGCCAAATGCTTCCTCAGCTTCTCTTTTGTGAGAACATAACGAAAATTACAAAGCAAGGACAAAACTATTTAAAAACTCTT AACCCAGTATTCGTAGGCAA 721NADK2 2853414 ATGTATCTTATTTTCCTGGGGCTTGCCGAGAGCCAG 722 NADK2 2853415CATCTCAAGCCAAAGTTCCCTAACAGTCAACGC 723 NADK2 2853416CCCATTGATTGACCAGTGACTTATTTTGTGATATCAGATTTCTGGTCAAACATTTTACCTCTACTGTCTCATGACCTTTCAAAGGCCAGTAAAACTATTATTACAATTTACTTGCATCATTAAGAGATGTAGCTGTTGGCAAATGTGCAATTGCTATTAACAGGGTCCTTGACACAAATTAGAACTCTAGATGAAACAAAACTGACTTGGAAAGGATTTTGACACCAGAAACATACCTCATTGGTCAAAAAAAGGTTTTATTTAAAGCTCTTTTTCACCTGTCACCAGGGATGGGGAACTGAATAAGGAAAAAAAATTTTAATGTAGAACAAATAAGAAGTCAGCAGTTTCTGCCCTCCTCTCCATCATTCCAGGTCTCACAACTCGGCAACC CTTTTACTGG 724 NADK2 2853417GAAAAGGAGAGTGCCCGGTGCTACCATGA 725 NADK2 2853418GTACGTTATTAAGGAGAAATGTCAGGACAAGGGGCTGGTATA CTGGGTAGTGTGTGAA 726 NADK22853419 GCCTTTTCCTTGCTGGAACGTGGTCGTTGGACACTACGAGCTTGTTTTAAAAGCACAGGTCTTTGGTGCTAAGAAGGAAA 727 NADK2 2853420ACTGCGAGGCCTAGGGCACTCCGGAAAGTCCTTCAGC 728 NADK2 2853421CGAGCAGCAGCGGTACCGTTACGCGGAGCTCTCG 729 NADK2 2853422GGCCCACGATGACTTGCTACCGAGGCTTCTTGCTGGGCAGCT GTTGTCGCGTGG 730 NADK22853423 CCGGCGGTAGGGAGCTGAGGCAAGGGGCCCGAGCCCAAG 731 NADK2 2853424CCACTAGCTGGGGCCTCCATTTCTTCCCCGCCCACCTTTCTCCCGCGTGGGGTCTCCCGTTTCCCAATCGCCACGCTTTCCCCGCCTTCGTCAACGCCTGGGTACGTCCCCCTAGCCGCGTGGGCCACGCACGTCCTGGCACTTAACCTCTGCCCGTCCGGCGCGAAG 732 RPL31P57 2858553AAAGAGCTCCGGAAACTTGCCCTGAAGGAGATGGGAACTCCAGATGCACACTTTGATACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGCAACGTCTCATACTGTATCCATGTTCGGTTGT CCAG 733 GMNN 2898603TCAGTTGGTCACGTGGTTGTTCGGAGCGGGCGAGCGGAGTTAGCAGGGCTTTACTGCAGAGCGCGCCGGGCACTCCAGCGACC GTGGGGATCAG 734 GMNN 2898604CTGTGGCCTTTTGCGAGGTGCTGCAGCCATAGCTACGTGCGT TCGCTACGAGGATTGAGCGTCTCCACCCA735 GMNN 2898605 AGGCGCACAGCCTCTAGACGACTCGCTTTCCCTCCGGCCAACCTCTGAAGCCGCGTCCTACTTTGACAGCTGCAGGGCCGC 736 GMNN 2898606GTTGGGAGGTGAGTCGAGGGACTGCCCCATTGGCTG 737 GMNN 2898607ACTGCCCGCCCCCTAGCCTGGCGCTGGGCCTCCGGGACAAG TTGGCTGGGTCCGGGCTTGGGGACTGCA738 GMNN 2898608 TTGCCTCGACCTTCCAGCACTTTGGTGATCATGCAGGTGATCCGCCTGCCTCGACCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACGCCCGGCCTTTCCTAAGCTTTTTTGTTTGCACATGTGTGTGCACGCGCCAGGACACAAGGTAAAATGTATTAATGTTAGAAGCCACTGCACTGAGTAAAGGCATGGCCACAAAAATTAGGGACATCTATCGACGAGGCACAGGCGCAGACACGGCAGGGGCCAATGGGTAGTGGGCAGTGGGCAGTGGGCAGTGGAGCAGCAGTTCAGATGCTGAGTTTGGCCCAGTGGTCTAGTCAACCGCATTA CATA 739 GMNN 2898609CAGGAAAGTTAAGATGCTGCTCTTTAGGATGGACCTGGGCATACCCTAGTATCTGTTTATTTTGCTTTTTCTGGTGACTATTTAATCCAGGACAATATGTTTAGAAATTTTAAACCAGTTTTAGAAATTGGTTTAAAATACATTAATTTCATTTTTTCAGCTATAATTATTATGTGTGTATATATGTAAAATATAGATATCAAGAGTCATTAACTTTAGTC ACCTTAGTC 740 GMNN 2898610TCTTCTGTGCTTCACCATCTACATA 741 GMNN 2898611ATGAAGCAGAAACAAGAAGAAATCAAAGAGA 742 GMNN 2898612TGTAGAAAGCATGGGGCTAAAAGTATTTTGACATAATTTATCCAAATTTAGCCTGGCTATAATTTCTGTAAGCCTTGAGTTAGTCAGAGGATGAGTAACAATAGAGAACATTTTTAAAAAACTAATTACGGT TGAATATTAAGTCTGACCCAA 743GMNN 2898613 GCACTGACATTTTAGCCACCTTCTAATGAATGGGCTTGAAGCAGAACTGCTTCTACTATCAGGTAATGGTTGAGGGGGGATGTCTATTACACATGTACTTTGTTTTGTGTAAAGTATGTTCTGGAAAGTTACATTCTTTTGGTGAGTACATGTAAGTATTTGAGGGATATTCATGATTTAAGGAGGCCTGAAATGAATCTTTTTGATTAGGGAAAGAAATATTTTGCAGTGTAAATGATTAACCATTTCTTCCAGTTTACCTGTTTGGTGAGTTCATACCATAAATGTTACGATGTTTGGTTTTATAAAAGAGTACCTGTAAGTTTTTAGTTTCTGTGTGGAAGATTTTTTCAGAGAGAATACAGATAGCCTTCTTGTATTAGAATTTTGTCATATGTGGTTTGAAACTGTTCATTGGAGCTGAGGAATTTTGTTACGTTTGTTTTAACTAGATATGATTAACAAAATGACCATAGCAAGAGCATGCATTGAAATGAGAGAAGTTACGTGTGTTTGTGTCTAGTTTGGGTAATATGATTCATTCTTAAGAATTCTTCAAACTTTATTATAATTTTTGGAAATAACAAGTTTGTCAGTTGATTAAACCAGTGTCTTGTTCATAGGCGACCTTACGCAATTATATAGCA 744 GMNN 2898614AATAGTTCTGTCCCAAGAAGAACTCTGAAG 745 GMNN 2898615CTGCATCTGGATCTCTTGTTGGAAGAGAAA 746 GMNN 2898616TTCAGCTAAGCTCTTGACCCCAGTCTAATCCAAAATAATTGTTGCAAATAAAATTCCTAAAATGTTACTATATGTTTTGGTAGAATTTTTAATTGTATAACTTTTTTAAAGATCCAGAGATGTGAAAAAGTTA GATATGCGTACTCTTTTT 747 GMNN2898617 TGACCACTTAACATCTACAACTTCCAGCCCTGGGGTTATTGTCCCAGAATCTAGTGAAAATAAAAATCTTGGAGGAGTCACCCAGG AGTCATTTGATCTTA 748 GMNN2898618 TTATGAATTCTGCCAATTACTGTAA 749 GMNN 2898619TGCTGAAGGTCACAGTAACATTTGGACTCATTTTGAATTGCCTTGAAGACAGGAAGAAGAGAAATAGATGGTAGGATTTTTATTAGGCAAAATTAGGAAAGGTTGACTGGATAGAAATAAAGCAGCTCTTTAAAAATATTGTAGATTGAAGAGCAGGATTTGTGACACTCATAT CTGATTAGG 750 GMNN 2898620GTGGAACACATTATCCTTGTAACCCTCTGCGATACATG 751 GMNN 2898621TAAAATAACTGCGAAGAAATCCCAAACTTTATTACATTTGTTGTTTGAACTTTATTATATTTGTTGACAGTGGTATTA 752 GMNN 2898622AGAAAAACGGAGAAAGGCGCTGTATGAAGCACTTAAGGA 753 GMNN 2898623GAATCCCGTTGTGTTGAGAGTCAATTCTATGCTGCATGTCCTC CATGTTATATACTTGGAG 754 GMNN2898624 AAAGGACAATGAAATTGCCCGCCTGAAAAAGGAGAAT 755 GMNN 2898625TGAATGGTGAACCTCTGGATAATTTTGAATCACTGGATAATCAGGAATTTGATTCTGAAGAAGAAACTGTTGAGGATTCTCTAGTGGAAGACTCAGAAATTGGCACGTGTGCTGAAGGAACTGTATCTT CCTCTACGGATGCAAAGCCATGTA 756GMNN 2898626 TGCCGAAGTTTACCTCCACTAGTTCTTTGTAGCAGAGTACATAACTACATAATGCCAACTCTGGAATCAAATTTCCTTGTTTGAATC CTGGGACCCTATTGCATTAAAGTA757 GMNN 2898627 GTGAATAGGATTTTCTCAGTTGTCAGCCATGACTTATGTTTATT ACTAAA 758GMNN 2898628 TTGTGTATAACTTAGAATAATGAAATATAAGGAGTATGTGTAGA AA 759 SLC22A32934522 GGCTGCGGCCGGCACAGCGCCAGGGCGAGTGAGGCGGGTGGCGCGGGGGAGGCGGCGGAGTAAAGAGAGGCCGCCGGCTG GGTCCGCGGGTCACTCCGAGGCGCGG 760SLC22A3 2934523 CTCCTTCGACGAGGCGCTGCAGCGGGTGGGCGAGTTCGGGCGCTTCCAGAGGCGCGTGTTTTTGCTGCTGTGCCTGACGGGCGTCACCTTCGCCTTCCTCTTCGTCGGCGTGGTCTTCCTGGGCACGCAGCCCGACCACTACTGGTGCCGCGGGCCAA 761 SLC22A3 2934524CGGCCAACGACAGCGCCTCCGCCACTAGCGCTCTCAGCTGCGCGGACCCACTCGCCGCCTTCCCCAACCGCTCGGCTCCCCTTGTGCCGTGCCGCGGCGGCTGGCGCTACGCCCAGGCCCACTC CACCATCGTCAGCGA 762 SLC22A32934525 GAAGCCGGCGGGAGAGGACGATGCTGGCTCCCAGGCGGACA AGCCGCGTGTGA 763SLC22A3 2934526 TTCCGGATTCGCTTATGGTCTCCAGGGTCAAAGGAAAGGGCGAACCAACGTTTGAAGGCAGCAGCAGCTTTTTTCCAGTTGCCCA AATGGTTACTCAAAATGCAAGGGGACA764 SLC22A3 2934527 GTGCACGAGAACGTCCCATCCAGGGACCCACGGATACTTCGTTCCTGCCAGGGTCTCCTTTGGGCCGACAGAGTTGTCTCTAATTGAGTGCAGGCAGCCCCGGAGCCCGCCGAGAGCTGAGGCTGGGCTGGGCTCCCGGGGACTCGGGCAGCTATTTCAGGCAGACG C 765 SLC22A3 2934528GAGGGAAGTGACCTGGAAGCGGAGCAGAGGTCGCAGCTGGCCCCTGCTGGGCCTAGTCTCGCTTCTGTCGTG 766 SLC22A3 2934529GCGTGTGCCCAGCTTAGATCCACCTGCAGCTGGCTCTGAACG CTGGATG 767 SLC22A3 2934530GCTCAGTGTCTTCCGCTGCTGTCTC 768 SLC22A3 2934531GTGGTGTTCTTGTCATCCTGGAAGCCCTGCCTTGGGCCATGC CTGAAATGCACTAA 769 SLC22A32934532 TGACTCATGCGCATGGCATCAAGGCAGCCATGCCCAGGCCCAGCTCTTACCTCTGGGGAAGATAGACAGCTGACAGGTCAGGACACAGACTTTGGTGGCAACTGCCCGAGCACCCACATAGCAAGTTGCCGAGGCCAGGGGCATGCAGAGCCAGGAAAACCTGGGAA GATGCATAAACAGGCCCAGCC 770SLC22A3 2934533 CTGACACCTTGCGTGGGAGACACTAACAGGGAGAAGAGCTGAGCCTCCCCCAGCCTTCTGACCTACAGCACCATGTGATCATGAATATGTGTTATTCTAAGCCACTAAGTTGGTGGTAATTTGTTATATAGCAATAGAAAACAGATGCATTAAGTTTGTCTACAATGCCCATGCCTGCAGTCATATTCTTTGGCTTCCTAGAAGGTGACCAGC 771 SLC22A3 2934534CCACTGATTTCATGACCTAACTAGAAAAACTTAGACTCGCTTTTGGCCATGGAGACATACATTTCCAACAAAATTTTACTTCTGCATAATAATTATTTCTTAAAATTTATTACATCTTATTTTTTTATCAATTATGATCTAAAGATAATTGTAATTATAACCCAAGCAGAAAAAATCCAATATTTAGAGACTTATTGCCACAGGAAAATTTTAAAAATTAAATGTCAATTTATATATGTAACTTATTGTACATAGAAGTATGGTGACAAAACCTATAAAATATTTTCTACACGAAATACATTACATTAGAATAAAAGTCTGTGGAAATGAAAATAAGAGCTCAAAGAGAAAAAAATTGATGTCAAATTTCAGACTATTAAAGAACAGTCTGTTTATAGCAATTGGACACCTGATAGCATATAATATTC 772 SLC22A3 2934535TGTCTGTGTCAATGCGTGGATGCTGGACCTCACCCAAGCCATCCTGAACCTCGGCTTCCTGACTGGAGCATTCACCTTAGGCTAT GCAGCAGACAG 773 SLC22A32934536 CCAAGTGCGTAGTATCCCAAGTATGTAAAACTGGTTCAGCATTCTAAAGTCAATTAATGTCATCCATCAATCACATCGACAAACTAAGGAAGAAAAAATGACATGATCATATCAATAGATACAGACAAAGTATTTGTCAAAATCCAACATCTATATATGACAAAAGCTCTCAGTAAACTAGAAATATAGGGGAACTTCCTCAACTTGATAAGGAATGTCTATTAAAAAAACTACAGTTAACATCATACTTAATGACGATAAACTGTACAGAAGCTTTCTCACTAAGATCAGAAACAAGCCAAATATGTCATCTCTAATAACTTCTTTTCAATGCCATGCTAGAAGCCCTCGCTAATACAATAAATAAGACAAGTAAAGAAAATAACAGGTATACTGATTGGAAAGGAAGAAATAAAAACTGTCTTTGTTCACAGATGTCATGATTGTCTATGTAGAAAATCAAAAGAATTAACAACAACAACAACCAAAAAAAAAAACTCCTGAAACTAATAAGTGAGTATAGTGAAGTTGCAGGGTACAAGGCTAATACACAAAAGTCAACTGCTTTCCTATGTACCAACAATGAACAAGTAGGATTTGAATTTAAACACATAATGCCATTTACATTAGCACCACAAGAATACACAACACTTAGATATAAATCTAACAACATATGTACAAGATTTATGTGAGGAAAAGTGCAAAACTCTAATGAAAGAAATTAGAGATGATCTAAATAAATGGAGAGATATTCAACATTCATGGATAGGAAGACTCAATATTGTCAAGATGTCAGTTCTTCCCAACTTGATGTATATATTCAATACAATACTAATCAAAATCCTACAGAGTTATTTTGTGGATATTGACAAACTAGTTCTAAAGTTTATATGTAGAGACAAAAGACCCAGAATAGCCAACGCAGTACTGAAGGAGAAGAACAAAGCCAGAGGACTGG CACTACTTAACGT 774 SLC22A32934537 ATCCTGCCTTGGTGTTGGCGTCACTGGGGTTGTGGTGGCCTTTGCACCAAACTTCCCTGTGTTTGTGATCTTCCGCTTCCTGCAA GGTG 775 SLC22A3 2934538TGACAGAAATAGTAGGTTCGAAACAAAGGAGGATTGTGGGAATCGTGATTCAAATGTTCTTTACCCTTGGAATCATAATTCTCCCTGGAATTGCCTACTTCATCCCCAACTGGCAAGGAATCCAGTTAGC CATCACGCTGC 776 SLC22A32934539 CCCGTTGGCTGATTACTCGGAAGAAAGGAGATAAAGCATTACAGATCCTGAGACGCATTGCTAAGTGCAATGGGAAATACCTCTCA TCAAATTACTC 777 SLC22A32934540 GGAAAAATCATAGGACATATTAAAGAAGAAATGATTATGAAGC TCTATTAG 778 SLC22A32934541 CGGAGAAGGTTAGAATGGATTTGAAAGAATGTGGTTGGATTCAAAGAAGCCCTAGGAGACCCAACAAGTCAGCATTTTTCTCTTGTGAAAAGAACCACCTGCCAACCCCAGCCTGTTCCATTGCTGAC ATCAGAGG 779 SLC22A3 2934542CATTTGCCAAGGTTTCTGGCTGGCCTCTGGCTTTGTTGAAGAG ATAGCTAGCACTAGCAGGGAGAAA 780SLC22A3 2934543 AGGCTCTCTGAACATACAAACAGTATAACTGTTGTTCACTAAATGGAAAAATCCCAAAATCAAAAACCAATGCAAAACAGTGAAGTGGCTTGAGCTCCTAGGAGGTTAGGTAGAAATTAAAGAGAATCAGTGGATGGGTAGAATTTTAAGCAGTAGGTAGTTACCCAATGTAGAACGAGGATTAGCTTAGACACCTAGTCTGG 781 SLC22A3 2934544CTGCCCATTCCTCCCGTTTTTGTATGGGATATACTCATAGAGA ATA 782 SLC22A3 2934545GATGAATGGTGCCAATTCTACCAGCAAAGCCTTCATCTT 783 SLC22A3 2934546TGTCATTCAACACCGAAAGATATTGAGGGGAGGATGTTCTCCTACACCTTTAATTGAAATGGAAATTCAATTTAAAGGTGCTTTAAAGAATGAGATTGCAGCCTTGGAGCAGGCTAGGCAGACTTGTGG GATGCCTCATCAGA 784 SLC22A32934547 ACCTGGTTCTTCATCTGGTCCTGAGTCCTTGCCCATTCTACTGTGGCTCTGGCCCTGCTTCATTCCTGCCTGATTCATCCTCAGAAGGCAGGTTTCTGTCCTGTCCCTACACATC 785 SLC22A3 2934548AATTACTGTGCTTCTCGACTGTGGATAAATGAGAAAATACTCCTCTCTGTGAACGCGCTCCTTCGTGGAGACAGTAATGAGTACAACTTCCAGAGCTCTGCGCAGCCAGCAACCCTGGCAGGAGTCCCTGTGTTATTCATAACCCAGAGCTGTGTTGCCATGGCAGTACTG CTTGCTAGACCTTGGACCCA 786SLC22A3 2934549 GTGTGCTACTGGCTTATGGCTGATACGTAAGAGAATCTCATCTATCTCTAAATGTTCTGCCTTAAGCCGCACAAAGGA 787 SLC22A3 2934550TGTGCAGAAAATATTCTGCAAATCAAGAACCAGAAAA 788 SLC22A3 2934551AAATGGAGGAAATTCCGAGATGACAGTGGTTTTGGTTCT 789 SLC22A3 2934552GCTCTTTGAGAATGTAGTCGGGACTTGCCCCAGTCACCCTTGCCCTGAGAACTCAGTGACTGGGGCTAATGTCACCCTGGCTGTC C 790 SLC22A3 2934553GGAGACACCTACCAGGAATCTAGTGGGACAAGGTTTCAGGGATCCTGGAATCCTGCCCACACCCAACAGCTGGAACAGTTCCCT CAGCTGGCGAGTGGACAGGTGGTCT 791SLC22A3 2934554 GATGTTAAAGACCATGTTCCCATAGAAATAATTCCCAAAGCATTCAGAAGACTGAGAAGAAGTGATGATAAGAATTGTTCTGGGCA GGAGTGT 792 SLC22A3 2934555TTTCAAAAATTGCCGAAGTACTACAG 793 SLC22A3 2934556ACTAACCTCTGCAGTTTAACCTTGAGCGATACCTTTTCCCATGA ATAG 794 SLC22A3 2934557AGAGTGTCGATACTAGGCAACAAGCCTCTGAACAGATAGTGTTACCCGGAACATCACCCTTTTCTCCCTTTGCTTCAAATCAAAACCAGCATCCCCCATTTAGACAGCATAAAAGGTATG 795 SLC22A3 2934558CTTCACTGAGACACAAGGAAACTTTTGGGGATCATGGAAAGGGTCCGTACCACGGTTGTGGTGGTGGTTATAAGACTATATATTTGTCAAAAGTCTTCAAAGTGTGCACTTAGAATTGCTGAAGTTTATTGTACATAAATTACATGTAAATATCATAAAGTGCATGTAAATGG T 796 SLC22A3 2934559CAGATGAGGAAGTTAGTAATCCATCCTTTTTAGATCTGGTGAGAACTCCCCAAATGAGGAAATGCACACTTATTCTTATG 797 SLC22A3 2934560CGCAGTGGTGTATCAAGGACTTGTCATGCGCCTGGGAATTATAGGGGGCAACCTCTATATAGACTTTTTCATCTCGGGCGTGGTGGAACTGCCAGGAGCTCTCTTGATCTTACTAACCATTGAGCGCCTTGGACGACGCCTCCCCTTTGCGGCAAGCAATATAGTGGCAGGGGTGGCATGCCTTGTCACTGCGTTCTTACCA 798 SLC22A3 2934561TATTTGGTAAATTCAGAATTGTACCCAACAACATTACG 799 SLC22A3 2934562GTTTCGCTCTGTTCAGGTCTGTGTGATTTTGGGGGAATCATAGCCCCATTTCTGCTCTTTCGGCTAGCAGCCGTGTGGCTAGAACT ACCTCTGATCATCTTT 800 SLC22A32934563 TTCTTAAGAGCCTTCATCTACATTCTTTGTACTAAAAGAGACCTATAATAATTGTTAGGTTCAATAATGATAATGATAGTCATTTATCTTATTATAATAACTATTTCATTGATAATTATGATATTAATTTCATCTTATTATAATAACTATTTCAGTTTTGAGAGCCAATTCAGTTATAATGAATGGTTTTAATTTACTTTATATTAAAGGGTGCTGATAAATAATGTTCAATTAGCATTCTTTGGGTTCTGAGTTAAATGCTGTGA 801 SLC22A3 2934564CAGAAAGTGCTACTGTCCAGCAAAGACAGAGTAGTCCAGGAG ACAAGACAC 802 SLC22A3 2934565ATGACCTTCAGGACTGCAGCCCACAGCCCAGTGGCAGGCAGGCGGGGCCTGAGACTGCGAGGGGAGACAGCCGAATTTCTAAAAACTCAGCGACAACAGAATGTGATAACTGCT 803 SLC22A3 2934566TTCAAAGCAAGAGGATGCCGCATCCTCAAGCACCTGGTGCTAGAGGATGGAGTGCAGTTGTGAGCTGGGCCTGAAGAGAGGTGGTGCCAGGGCAGGGCAGGGACTGGATCCGGAAGGGCCTCAAGGACATGCCAAGGCTTTGCTCTTTATACACACAGCAGTGGAAAGTGACTGGACAGTTTCACCCTGAGGTGGACAGAGCTGGCCTTGCATTGTAGAAACACAGATATGCAAGTGGGTTGGAAGGACCCCCCAGCATCGTCCCTCTGATGGTAGATATGCAA 804 SLC22A3 2934567TTTGTAAGCCAGTCATCAAGCACAGATATCATCAAAAAGTAAAGAATATGAAATATATGAGAAATAGAGGCAATAAATGCCCAACACTCATCAGTCCCTAATTCAGCTACTACACCTTCAGTATTACCTGTGCTCCTGAGATTGTGTCTGCTGCATCTTTATGGTGGAAGCCCCATTGATGGGGCTCCTGCATCACTTCCCAGTGGCCCAGGCAGGGATGTTGTGTCAGTAGCCTGAAGGGCCCACAGTGGGAGCATTTAAACCATGCACATTGGCAGATGCTGCCAATCAGGGCTTGATTGCCCAAAGAGGGTTGTTAGGCATTTACCAGC 805 SLC22A3 2934568ACTGGAGGAAGGGTTGATCCCTACAGTGAGGAGCCCAAAGAGACAGGCCTAGGAGAAGGCTGGTCCCGGAGTAGACACCAGGA CAAGCTTTCCACTGTAAG 806 SLC22A32934569 AGGGGCAGGTAAGTGAGAGTGTCAGTGAGCGGGCGCAGAGG GGACTCCC 807 SLC22A32934570 TGGACCCTAAGAAGGAACTCAGTCA 808 SLC22A3 2934571TATACAGGGGCCGTGGTGCTACTCAGGGTTTGAGGAAGGGAGAGAACCTTTGAAGCTGTGGTAAGGGAGAGCTGGGGCATTGATCTGGGATGCAGAGGTTGCTGTGGTTGAGAGCTACTCCAGTGAGCAACATGATGGCTTCAGAGTGAGCAGGCCCCATGGGAGAGGGCCCAGCTGTGTCTTCCTGGAGCGGTAACACCTT 809 SLC22A3 2934572GTATCCTGGCATCCATCTGTGGTGGCCTTGTGATGCTTTTGCCTGAAACCAAGGGTATTGCCTTGCCAGAGACAGTG 810 SLC22A3 2934573GTACTGTACAAAATTCAATGCACCCTAA 811 SLC22A3 2934574CCCTCCAGAGCTAGATAAGAGTATGCATTGTTTTTTTTAATGTGGTTGTGAAGAGAGAAGCATTTTCACATAAGGTGCTAAGACTCAGAAGTGATCTAAAGGCAGGAACTGCTGATGTGGGAAAGTGGAAATTGCTGGGACATACAGCAGCAGGGGATTAACAGTGTGGCTTACTCTACAGAGTGAGGATGCGTCAGGTCTGTCTAGATGGAATGGCATAGGCAGGTTTTCAAGACTGACTACAAAGTGAAATGTCACTGAACAACATGTTATAGTATTTATAAAAAACTAAAACCAAAGGTGTTTTCTCTCTGCAGCTGGATAGGAAGACAGATGACACACAGATGATAGATAATAGGTAGATGATAGATAATAGGTAGATGGATGATAGATAGATATAATAGATGATAATCATAGATAGATAAGTGATAGTAGATAAATGATAAATAATAGATGATAGATGATAGATAGATACAGATAGATAAATAGACAGGTAGATGATAGGTAATGTCTGGATAGATAGGTGGATAGATAAATAGATAATAGATGATAGATAATAAACATTAGTAGGAAGATAGAGAGATTGAGTTTTGGAGGGGGGTGTTTAAATAGGGTATAAGTAAAACTAATACCCAGCCAATATATTAACATGAGGAGTAATGTCAAGAAAAATTCACATTACACAAATTCTTTCTAATTGTTTGAAATTTTTTCATTAAAACATAGAGATATGAATATGAGAATGTATAGTACAAGATGTAAAATATTAATATGTGCCCTCTGTGGACACAAATGGGCTGGGAAGAGGGGTAGGGAAGGGAGGACCATCACTTTCTTGCCAGAGACTTCCATACTGTTTGATTTTCTTTAAAAATTAGAACACGTAGTCTTGTGTTGCTTGTGTAGTTTTAAAAAATGATGTAACAGCTAATTTAACAACTAAAAAGCAATCTTAATAATGACTTAGGAATTAAGAACATGGAGCTCTAAATATTTTTAATATATAAAAAATCCTGAGGAACAGCTTTCTTCCCTTTGATTCTATTCCACTGACTGCCTTCTGTTTACACAATGAGAGTGATGCTTTCATTCTTTATCCCCAAACCAATCAGGATCAGATTTGCAAACTCATCAGGAAAAAATGGAAGAAAAGGGAGTCCTCTGAAATCAAGACTTTTCTACTGCTTCAGTAACATTAAAAATAAACAGCTAGGAGAGGTTTTTTTGTTTTTGTTTTTGTTTGTTTTTGGCTTGGGGAGTGTGGGTGGAAGGGGGTTGTCTAAATGGTGTGCAAGGAAAATCAATACCCAACTAACATATAAACATGAAGGATTATACCAGCAAAAATTTAAGGTACCCAGATTCTTTCTAATTTTTTTCTGTTTATAATTTTTCATAATGAAAAGTTGGGTACATTAATTAATTATACCTAGTCTCTATACATGAAAAAAAATATAGTAGAAGTATGGTTTACAGTGCTACAATTTAAGCACATTAATTGTGATCCATGGTTATTTACTCTACAAAAATTACTTAGTGCTAAATTACTAAAACTTGCTAGCATTTCCCTTTTAAAAATCACACTGGATTATTTTATCGTTTCTGCTGGTTTTTGTTCATGTTAACAGCTCATTTCCAAATATATGTTAATTCAGTAGAAGTTCATAAAGAACTTAAATGCTATAATGCTAACAAACCCCTGTATCAGAGGAACCAGCCCCCAATATTTCAGCATAGGTTCTATTTTCCATAAGTGTTGGCCAGCTGAGAAATAAAAAGAGTACAAAGAGAGGAATTTTACAGCTGGGCCGCTGGGGGTGACATCACATATCGGTAGGACTGTGATGCCCACCTGAGCCTTAAAGCCAGCAAGTTTTTATTAAGGGTTTCAAAAGGGGAGGGGGTGTAAGAACAGGGAGTAGGTACAAAGATCACATGCTTCAAAGGGCAAAAAGGAGAACAAAGATCACAAGGCAAAGGGCAAAAACAAACATCACAAGACAAAGAGCAAAAGCAGAATGACTGAAAAGGGTCTATGTTCAGCGGTGCATGTATTGTCTTGATAAACATCTTAAACAACAGAAAACAGGGTTCTAGAGCAGAGAACTGGTCTGACCTCAAATTTACCAGGGCGGGGTTTCCCAATCCTAGTAAGCCTGAGGGTACTGCAGGAGGCCAGGGTGTATTTCAGTCCTTATCTCAACCGCATAAGGCAGACTCTCCCAGTGCGACTGTTTATAGACCTCCCCCTAGGAACGCATTCCTTTCCCAGGGTCTTAATTATTAATATTCCTTGCTAGGAAAAGACTTCAGCAATATCTTCCCTACTTGCACATCCATTTATAGGCTCTCTGCAAGAAGAAAAATATGGCTGTATTCTGCCCGAT CCCACAAGCAGTCAGACCTTA 812SLC22A3 2934575 CCACATTCCTGTAAATGTGGCAGGAATAAGAAAACCCCAGTTTCCCGCTCTCACCTTTGA 813 SLC22A3 2934576 TGTGCCTTGCAGAGATGCACGTGTG 814SLC22A3 2934577 ATCTGGTCAAGGGACTAAGCTCCTAGCTGACCATTCATTCTGAAGATTGCATGGAGGATGAACATCTGGGAATCCTGTTAATGAGAAGGCTGAATCACAGGCACCTGGGCCAAAGGGTGTGAGCATTCATGTTCTCTGCTCACCTTGGTTTCCGCACACCTTCGCAATGTGAACAGGTCAGGAGTCCCTCCCGTCCACCTCCTCTGTAACAGCTGGGGTTCCAGGCATGGTTTAGGCCCTGTTCCAGCAATAAGAACCAATCTGCTGTACAATCTGAGGACTTGGCTCTGTTATTTACAAAATGATGCTGTGGTTCTGAGATTATTTGGGACATTTTTGGCTCTCCTTTAGTGGACACCTAGAGCCACAGATTCCCTTCTTTACTAAACAAATCCCATGGATTCTGATTTCTGGGTCTTAGGATTTTAAAAGTGAAGGGATATTTTTCTTATATTTGTGAGTTCAGTTCCGATGG TGCCCGTGGTCAAAAGCGAAAA 815SLC22A3 2934580 ATTGCTGACTCATGGCTGTATCTGGCCTAATATTGTTCTGGTTAATCCATCTCTGACTCATGGCCATATCTGGCCTAATATTGTTCTG GT 816 SLC22A3 2934582GTGGGTTCTTGTGACTGTACCATTCA 817 SLC22A3 2934584GCAAACAGCAATTAATTAGCTAATAGAACAACAAAAGGCCCCATATCCTGTAGCCAATTGAAGATCTGAGTTTAATCAGACCAGTG CTTCAAAATGGGTAGAGCCTTG 818SLC22A3 2934585 CTGTCCTTTGCATGTGAGTTTCTGCTGGATCCTTTCAT 819 SLC22A32934586 TGCTGGCTACAATTTGGAACTGTGCAGTTTAAATATTTATTTATTTTGTTTTGTTTTTACTCTTTCTAATTTGGATATTAGGTTTTGCTTCATCTGTGTTTTTTTTCTCTTACTCAGTCAATAACCATATCTCCAAACTAAATTAACGTTACTAAAGTGGGGAATTTCCCCTTCCTATATTCTCATAAGTGATTGAGCATCTGTCCTCATATAGGACTTGCTGCCTTGGAGGGGAGGGGCCAGACCTGGGAAAAAGAGGAGCCATGAATAACTCTGCTTCCTACATTTGGCTTCTTCTCTTCCTCCATATCCATGATTTATATATGTGAAGGAAGAACAAGAAATAACTTAATAGGCCATTTGTCAATGAGAGTACAGTGTAGGAAGGGTGGAAAGTGAATATAAAATCTAGATTGGGGCTTCTGGTTTCCTGTTCAGCCTATAAGGAGCTTAGAATTTGCCACTCAGTCTTGACAACAAGTAAAATGCTGAACAAACTGAAAAATCAATAATTCTTCTCAGATCCATAAGAGAAGTGAGATTACAGGGCAAACTACTACCTTCAGCATCACCCCGCACCCCCAACCCCACTAAATAGAAAGACAGGAGAATACAGAGAATCATAACACAGGCGCAGAAACCTCCTTGAGAGAGCCAGGGTAGATAAACATGAACTGTAATTGATGAATTCCTGGAGGATCACTGTGGATGACCTGAAGGATTAAAAACTCTAGAGGGACTCACTCAAAGGAGGGCCCAAGCTTTTGTGATTTTTTTTTTTTTTTTTTTTTTTTTTGCCACCTGAAGCTCTACAAGGTTCCAAAGGTGAATATTAAGGAAAATCCCTCATGCTCTGGCAGCCAGAGGGGAAAAGGAACAATTTTGAAATATGCCAGAATATCGTTCTTAACAATGTCTGCCCTCAGGAGAAGATGTTTAACCAGAGCCTAATCTTCTGGGGTTTTCTGAGAGCCTCATTGATCTGGGGGAAGGGAAATACCAACTCCAGCCCCTTCTAGCCTTCCAAGTGGAGAAAGAGAAACACCAAATTCTAGCCTCCTCTAGCTTTCAACTTGGAAGAAGGGAAATACCCAGCTCCAGCCCCCTCTAGCCTTTCTCCCCTAGTTCAGAGGAGAGGGATAGAGAAGCATTTGTGAAGTTCACCG TTTAGAGACATAGGTTC 820 SLC22A32934587 ATTAATGGCAGACACCACAGATCCAGGAAACTCAAAGGAAATCAAGCAAGATAAACATAAAAAAGTATACCTAGTTATATCGTAGTCAAACTACAGAAAGCCAAAGATAAAGGAAAAATTCTGAAAGAAGAGTGGGGGGATAATGTCTTACTATAGTAAAAGAGCAATGATAAAAATTACACCCTACTTCTTTTCAGAAACCAGGTAAGCAAGAAGAAAGTGGAATACTTAAAGTGTCAAGAAAAAAAATCCAATCTAGAATTCTATACTGTGCAAAGTTATCATTTAAAAGTGAAGGAGAAATAAAGACTTTGTTAGACAAAAATTGAGGGAATTTGATGCCTTGTAATAAATGTTAAAAGAAATTATTTAGAGAGAATGAAAATGATCTA GGTTAGAAATCCAGATCTACATAAA821 SLC22A3 2934588 AGGTACTCATACTACTCATGAAGTGATACAGTGTTATTT 822 SCIN2990412 CATATGGAGACCTTTTCCCTACAAAACACTTTTTTGAGAATTAG CAAAGCATGGTGG 823SCIN 2990413 TGGATGACTATTTGGGTGGCAAGCCAGTGCAGAATAGAGAACTTCAAGGATATGAGTCTAATGACTTTGTTAGCTATTTCAAAGGC GGTCTG 824 SCIN 2990414CCCTCCACACGTGTTCAGTTAAAGTGTGAGGAATACCCTCCCCAGACAAACATCACAGATTTCCGAAATCAAACACGCTCCAGCAA GTGTTCTGCACACCCCACTG 825SCIN 2990415 GGCGTGGCATCTGGATTAAATCATGTTCTTACGAACGACCTGACAGCCAAGAGGCTCCTACATGTGAAGGGTCGTAGAGTGGTGAGAGCCACAGAAGTTCCCCTTAGCTGGGACAGTTTCAACAAGG GTGACTGCTTCATCATTGACC 826SCIN 2990416 AAGCTTTTTCATTTATTCGTCCAGCAGCATCT 827 SCIN 2990417GTTAGTATAGAAACAGCACTCCTCTTCTAAAAAGATAC 828 SCIN 2990418GGTGTGGTTCCTCGTGCAACAAATATGAACGTCTGAAGGCAAACCAGGTAGCTACTGGCATTCGGTACAATGAAAGGAAAGGAAG GTCTGAACTAATTGTCGTGGA 829SCIN 2990419 TGGCTTCCATATGGAATGCCGAGTATGTCAGCCTG 830 SCIN 2990420TCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAA 831 SCIN 2990421GGGCTGCCAAACAAATTTTCGTATGGAAA 832 SCIN 2990422GTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAGA 833 SCIN 2990423CCAGAAGGAGGTGAAACACCAATCTTCAAACAG 834 SCIN 2990424GCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTC 835 SCIN 2990425CGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACAC CTATCCCAGAGG 836 SCIN2990426 TGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACA 837 SCIN 2990427GGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAA CCTGGCATCTATCACCAGA 838 SCIN2990428 TCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGA 839 SCIN 2990429AAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAA 840 SCIN 2990430AAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGA TGAT 841 SCIN 2990431ATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAA 842 SCIN 2990432GTAAGCTCAATCGATGGACCATTATAGCAGTAACCGGGCACCATTATGACCGAGTGTCTGGCTTGCTCTTTGCCACCATGTCTTA CAAAAATAC 843 SCIN 2990433GAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCC 844 SCIN 2990434ACAAGGCAGTTATCTCATTGCTGTTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTT AACAATTGGTTGCTA 845 SCIN2990435 GAATTGTATTGTTATCCACTTAGATACATGTACATGTACAGTAC ATGTTTAATA 846 SCIN2990449 AAACACTATAAAGTGGCGGCGAATAAGGTTCCTCCTGCTGCTCTCGGTTTAGTCCAAGATCAGCGATATCACGCGTCCCCCGGAG CATCGCGTGCAGGA 847 SCIN2990450 CCGACGCACCAAGGCCGGCGAGGGGAGGGCGTAG 848 SCIN 2990451TTATTTGTTGCTTTCGGGCACTGGCTTATTTTCTCTATGATTGCGGGAATTATTGTTCTGGGCTTCTTTAAAACAG 849 SCIN 2990452GATTCTACCCGCACCATGCTGCTTGTGGGTCTGGTAGACAAAAACTCCGCTTCATTCGGAAGCTGGCGTCCTCAG 850 SCIN 2990453CTACATCTACATCTTTATGGTATTCTCA 851 SCIN 2990454TTAGGGTTCGGATCCCAAATCGGCAGAAGAATGACA 852 SCIN 2990456GCGGGAGCTATACCACGAAGAGTTCGCCCGGGCGGGCAAGCAGGCGGGGCTGCAGGTCTGGAGGATTGAGAAGCTGGAGCTGGTGCCCGTGCCCCAGAGCGCTCACGGCGACTTCTACGTCGGGGATGCCTACCTGGTGCTGCACACGGCCAAGACGAGCCGAG GCTTCACCTACC 853 SCIN 2990458GTTCTACTGTTGTATAGTGCTATGTGGTGAATACAGTTAACAATAATTTATTGTATATTTTTTCAAAGCTAGAAAAGGATTTCGAGTGTTCCCAGTACAAATAAGTGATAACTATTTGAGGTGATTGATGTGCTAATTACTCTGATTTGATCATTACACACTTTATACTTGTATCAAAATATCACTCTGTAGCCAATAAATATGTACA 854 SCIN 2990459TTTGTTAGCCATTAAAGCAGTTTGAACTTATCCTACCCATCCTCTTTTCCATCCCTCAGGAGTAGGGGACATATATGTAATATTGTAGCCTGGGGGTGGGGAGTGAGGATGAGGATGGATGTGTGAGTCTGGTTTGTACTCATCAGTCCTCACTAATCTATAACCTTCGTTGAGGTGTAGTCATTCCATTAATTCTTGAGCTTTCGGCTTTGGCCT CTGTTC 855 SCIN 2990460AGCCACTACTGCATTCTTCTCAGGAACTCTGCTTTGTTTTTCCCAGACTACCCTAGAATTGTGGGACACGGTATCCTCATCGTACCAGTGCCCCTTGGCCCAGTGGCTTGGATGCTACCCTCAGTCATTTCTGCTCTAATGCTTAGGCTCATGGAGGGGTGTAGGACAAATCAATTGGAAGGGAAGTGTGCTGGGCTCTTCTCAAAGATTGATTGCTTTGGGTTAGATTTCCTACTTTTTTCAGTCTTCTTTTTTACTTTTTGAACCAGACAAACTAGTCTTACACCACCTCACATTCTTGCCTACTCTGTGTTTCCTGCAAGATACACTCCAGCCCCTAAGACCCA CACCGTACTGCTTAAGATG 856 SCIN2990462 AGCTGCTGTCCCTTAGTATTGAATATCTCTATTTTCTTTTAATCATAGAATTCACTGATATTTTAGCAGATAATGTGGCCGTCCAGGCAGGCATGAGATTTCTCAGCCTTACTTCAACTTGATTATGACCATGTGACCCAATTCTGACATTTGCCTAAAGGAAAATTTACCTAAAA AGGCGTTTTCTTGCTATGGCA 857SCIN 2990463 TTCTGAATGCATCACGGCAAAGATGCATGTACTCATGAAGCATAAAATTAAAAATATGATACATTCACTACATGAAAATATGATATACGGTTTTTCTTCAGTATCCGCGGGAGATTGGCTCGAGGAACCCCATGGATACCAACATCCTTGAATGCTCAAGTCCCTTATATAAAACGGCATAGTATTTGCATAAAACCTATACCATTCTCCTG 858 AZGP1P1 3015108ATGGTGTCTGTCCTGCTGTCTCTGCTGCTGCTTCTGGGTCCTG CTGTCCTCCAGGAGACCCGAGATG 859AZGP1P1 3015110 TCATGCCTTGCAGGAAAGGTTTGGTTGTGAGATCCAGAATAACAGAAGCACTGGAGCATTCTGGAAGA 860 AZGP1P1 3015111AGATGTTCTTCACGGTGGAAACGGCACTTACCTGACCTGGTTG TTGGTGCATGTGCCC 861 INHBA3047577 GAGGCAGCCCTTTCTTATGCAGAAAATACAATACGCACTGCATGAGAAGCTTGAGAGTGGATTCTAATCCAGGTCTGTCGACCTTGGATATCATGCATGTGGGAAGGTGGGTGTGGTGAGAAAAGTTTTAAGGCAAGAGTAGATGGCCATGTTCAACTTTACAAAATTTCTTGGAAAACTGGCAGTATTTTGAACTGCATCTTCTTTGGTACCGGAACCTGCAGAAACAGTGTGAGAAATTAAGTCCTGGTTCACTGC GCAGTAGCAAAGATGGTC 862 INHBA3047578 CTTTTACTCTGAACTAGGTGGGCGCATTTCAAAAATTCGGATGGGAAAAAGCCTGGAAATTCCAGTGAATATTCAGCAAGGCCCTCTTTCATTGTACAGGGATCAAATTTCCTCCTCTTTTTTGTGCCCCCTCCCACTTCTACAAGTTATCCCCTGTGGGGAAAACAGGATGATAATCAAAACTCTGGGCTGATGTTTTTCCAACTTAGTGTCTATTGGAATCAATCTTAAATCAGAAGCTTTTTCAGAAAAATAATATTTAGGCCAGAATTAGAGTTGAGTGTATTTTTTAAAAATGATTAAGGCTTGGTTGTGAGAAATATTACCTGTACCAGCTGGGAAAAATAATGTCATCACTAACTAAAAGATAATTAATTTGAGAGAAAGTGTTAAGAGAGGGAGAGTAAGGAAGAGAACAGTTAAGAGGAGGCAGAGGTGAGGGCAGTAGTAAAAATCTCTAAAATTTTAATTTACAGCCAAAATTCTTCATGTGTAAATTTGTATTGATTCAGATGCAGAAATGAAAAAAAAACACCTTTGTTTTATAAATATCAAAGTACATGCTTAAAGCCAAGTTTTTATCTAGTTTATTCTAGTACTTAGCTTGCC TGGAATA 863 INHBA 3047582TGGAAAAAATCCTTAGCCAGGGCTCAGAGATGAAGCAGTGAAAGAGACAGGAATTGGGAGGGAAAGGGAGAATGGTGTACCCTTTATTTCTTCTGAAATCACACTGATGACATCAGTTGTTTAAACGGGGTATTGTCCTTTCCCCCCTTGAGGTTCCCTTGTGAGCCTTGAATCAACCAATCTAGTCTGCAGTAGTGTGGACTAGAACAACCCAAATAGCATCTAGAAAGCCATGAGTTTGAAAGGGCCCATCACAG GCACTTTCCTA 864 INHBA3047583 TATCATGCCAACTACTGCGAGGGTGAGTGCCCGAGCCATATAGCAGGCACGTCCGGGTCCTCACTGTCCTTCCACTCAACAGTCATCAACCACTACCGCATGCGGGGCCATAGCCCCTTTGCCAACCTCAAATCGTGCTGTGTGCCCACCAAGCTGAGACCCATG 865 INHBA 3047584GGAAAAGGAGCAGTCGCACAGACCTTTCCTC 866 INHBA 3047585GTGAGCAGTGCCAGGAGAGTGGCGCCAGCTTG 867 INHBA 3047586TTGCTCTCTGAAAAAGTAGTAGACGCTCGGAAGAGCACCTGGCATGTCTTCCCTGTCTCCAGCAGCATCCAGCGGTTGCTGGAC CAGGGCAAGAGCTCCCTGGACGTTCGGAT868 INHBA 3047587 AGACGCTGCACTTCGAGATTTCCAAGGAAGGCAGTGACCTGTCAGTGGTGGAGCGTGCAGAAGTCTGGCTCTTCCTAAAAGTCCCCAAGGCCAACAGGACCAGGACCAAAGTCACCATCCGCCTCTTCCAGCAGCAGAAGCACCCGCAGGGCAGCTTGGACACAGGG GAAG 869 INHBA 3047588GGCTGTCATTTGTTGACCCCTATTCAAGAGGGTCTGTCACAGAAGACTCCTGCTTGCCTGAAATTTACGAGTGCATGTAAATG 870 INHBA 3047589CTGGAACTGAGTGGTTGCTAAATTCAACTGCCCTGACAATGTGGGGATTTCCTGTCCATTAGCAGCGATTGCTATTTGACATATGTTTCTGGTGCCCATTAATCTGCCCTGTAATGGGTCAGAGGCAAAAATGGGGGATTCAGAGGTACTAGGTGGCTCTCTTAATTTAATAGAACTCAATGCTAAGGACGCCTCTATTTGTTAATAAGTAATCAAGTCATTGGCTACTTTCTGCTAAACACTAGACTATGATAGTGACCTTAGACCCCGGGCATTCTAAACCAGGCTGGCA 871 INHBA 3047590CAGATTTGTGCATGGGATACATGTACAGCAGACAGTTGTAAGG AGGTCCACGGTCATGGAAAAGA 872INHBA 3047591 GCTGGATTTCCGTTAACTATAGAAATCCAGGCAGGGAGATCCTCCCAGGGAGTTGCAA 873 INHBA 3047592 AGAACTTGAAACTGTGCCTAAAATTTATAG 874INHBA 3047593 GCCCTTGCCTCAGTGAATTTACCACTATCATAATCACAGTGTGCAGAGTGTGTTAAATTAAGAACAGAATCCACAGTACGCAATGC 875 INHBA 3047594ATGAGGTCGGAGTCAGAGGAACTCCCCTTACCAC 876 INHBA 3047595CTCCAGGCTAGTTATCCAAGGCTTGGGAGGTTTCCCTCGGCCTTCTCCTAAGGCCTTGGCAGGACCCTGCCACCCTAAAATCAACTGCTGATTGCCTTTTTAGATTTAAATGATTAAGCTCTGCTTATGGGAATCTTCTTCTCTTTTATTTTGTTAAGAAACAAACAACAACAACAAAACCCACACCAATTCTTAGCAAAGGGGAATATCGAATTCAGATTTTGAAAAAATAAGTCATCATGCTTCCTAAAATAAGACAGCTTCTCCCTCTAACTGCTCTCTCTGCTCTGGTATTCTATCTA 877 INHBA 3047596AGGATGTACCCAACTCTCAGCCAGAGATGGTGGAGGCCGTCAAGAAGCACATTTTAAACATGCTGCACTTGAAGAAGAGACCCGATGTCACCCAGCCGGTACCCAAGGCGGCGCTTCTGAACGCGATCAGAAAGCTTCATGTGGGCAAAGTCGGGGAGAACGGGTATGTGGAGATAGAGGATGACATTGGAAGGAGGGCAGAAATGAATGAACTTATGGAGCAGACCTCGGAGATCATCACGTTTGCCGAGTC A 878 INHBA 3047597TGCTTTGGCTGAGAGGATTTCTGTTGGCAAGTTGCTGG 879 INHBA 3047598CACACAAAAAAACCTGCGCGTGAGGGGGGAGGAAAAGCAGGGCCTTTTAAAAAGGCAATCACAACAACTTTTGCTGCCA 880 INHBA 3047599CCTTCTCTCTTACTCGGAGACAGTCAGAACTCTCCTCCCTGAC AGCCACAAACC 881 INHBA3047600 GTGCCAATACCATGAAGAGGAGCTCAGACAGCTCTTACCACATGATACAAGAGCCGGCTGGTGGAAGAGT 882 INHBA 3047602TTGGGGCATCTTGAAAGTGTCACTGCAGTATAGCAATCTCTCTCAGGTAATATAGAGATAAAGGGAATATAATAAATTGACCTGTTATTTATTATCTTTTTCATACCTAGGACATTCCGAGGCTTAATATATTTCTGAAGCCTACAGCCCTGATAAACATCAATCCCACGTCAGTTTCCAGCAGTCTCATCTCCCCACACCCTTCTGCAATGAAAGCTAATGTAAAAGAAAGAAATATGCACTGCTTAATAAGTCAGAATACAATAGAACTTGTAAAATGTACCTGCATATAAGGTAGACATTAGGAAGACTTGAATCTCTCTCTTCCCCCTGTTCTCCTGAGCATTAT GGCAACAGCATTT 883 INHBA3047604 ATGCCTTTAGGGGTTACACGCTCTCTTCCGTGAATAATGGGGAAGAGCGGCCACAAGAGGGCGCGTTCCAAAGACTTTTGCTCCTTGTCAGTGTATCCAGGGAAAGGCAGTTGCGCGTACTGGAAGCCCCTGTCTGTAGCGCCCTAATCTTGGTGATTATCAGTTACCGC CTGCTC 884 INHBA 3047606GAGGGTTGCTTCCTGTCTTTGTATACCAACCTCCACACATGATGGATTCAATGACAGCTCGTATCCAGTTGCCTTTAACCATGTCATATGACTAAGTATACCTATGCCTTTGACCACTTTTAACCGCACTACCGTTACTAGCAATATGCCCCTCTTTCTGACTTACTGGACTT G 885 INHBA 3047608ACCAGGGCATCTTTCCGGGGGTGCAGATAGCCTGCTGGCTGTGTGGCTTCCCCTTGCAGGAGAAGCCCTGGTGTCCTACAAGCT TCCCAGTTTGGCTCTCTCAC 886INHBA 3047610 AGTGACAGTCATTTTTACCTTTAGAAAATGTCTATAAGTGCACAGGCACCACATTCAAGACAGGGAAGAGCTACTTTGGGGGACAG TTGTCATTGAACCAGCAGTTACTT 887INHBA 3047612 AGCCGGAGGAAAGCCGCGGCATTTTCGGGTGCTAGGGGAGC AGA 888 INHBA3047613 ATTAGGTGATGGTAGCGGACTAGCCGACGGAGGGCAGGCAGGGGAGGGGGAGAGGACTTTACAGAAAAGGAATTCTCGGTCGAGCTCTGCCTGGAGATGACTGGCTTACACTTACTAAACCCAGCG GGTCA 889 INHBA 3047615ATTGATGTTTCTGGAGCTGAAACCCCAAAGGTGTTAGGTTACTTGTAACAGAAAAAGTCTTACAAATAGTTGTTTTGGAAAAGGGGACAGTATATATAATTCAGAAAGCATTGTTAACCTGTGCAAACTGTAATTATAACTTAGTGTCACAATTTTCTTGCCCTCTTCCCCTTGCACTCAGATCTTATCTTGTAGTAATGATATTTATTAACTCTTTCCACCTAAACTGCATTGCTTGACTGTAATGCTATGAACACACTAG GTG 890 AZGP1 3063591CACAGTCAATGGATCCACAAGGCCTGAGGAGCAGTGTGGGGGGACAGACAGGAGGTGGATTTGGAGACCGAAGACTGGGATGCCTGTCTTGAGTAGACTTGGACCCAAAAAATCATCTCACCTTG AGCCCA 891 AZGP1 3063592AGCCCCTCGTGGTGCCCTGGGAGGCCAGCTA 892 AZGP1 3063593TCTTCACAATGGAAATGGCACTTACCAGTCCTGGGTGG 893 AZGP1 3063594GGCAAGAGGGAAAGCGTCAGCCTTCCCTGATATTCTGGAAAGTCTCCCGGGGCTGGGGGTGGGCAGGTACAGAGCTTCGAGCT CTGCTGATCGCTGACATCCAGGG 894AZGP1 3063595 AGGGTAACACTGTCTGTAAGAGGCAGAGCTGGGACTCAAATTCCAGATTTCAGATTCCAAATCCCATCGTTTTTTATCTCTACAATGATGCCTCCCATCTGGGTGGTGGAGAGAAGGGAGGCGTGTAAAATGTCAGCCCCAGAAGGACAAGAGCAAGCCAGTGTGAGCGGAATTGATGGCTGCAAGCTGAGACTTGGATTGGAGACGTAGTGAGACTCAGGATTGTGCAGTGCTGCAGGGAAGTGGTTGCTGGATAGAGGCATGGGCTGAACCAAGCAGCTGGACTGAGACTGGGGGACAGAACTCCAAAGCCCACTGAGATGTGGGAAAACATGGAGAAGCACACGGAGCATTCACAACTTATTGCCGTCAGAGTC 895 AZGP1 3063596GAGCCCAGAATAAAAGACGATCTCAGGCTAGGAGCTCAGGCAACATCTTAGTCCGGTCTCATCTGTTCCTGGATGTCCCTCAGACCCCCAGCTTTCATCTTTTAGGATTTATTCCTTCCCTGGGATAATATAATTTGTGGTCCAAAAAGAACATCATCAAAATTTCAGGCAGA ATGGGCCAGGAAG 896 AZGP13063597 CCAGTCTACGTGCAGCGGGCCAAGGCTTACCTGGAGGA 897 AZGP1 3063598TGAGATCGAGAATAACAGAAGCAGCGGAGCATTCTGGAAATAT TACTAT 898 AZGP1 3063599GATTTCGCCATATCACCCTGGCTGGTCTGGAACCCCTGGGCTCAAGCGATCCACTCGCTTCAGCTTCTCAAAGTGCTGGGATTACAGGCATGAGCCACAGCGCCCAGGCTGTAGCTCTCTTAAGGAGGAACATATCTCATCTGAGACAAACCTGAAATGCCAAACCAAACTGAGTTAGCCCCTCTCTGTCTGTTGTATATATTGGAGTAATAACCTATTTGTCTTGATAAAGGGATTGCATGCTTGAATTGCAAAAACCTTTATTTCTTTTGGGTTGCCCAATGTGCAAGACTAAGAGT 899 AZGP1 3063600CATACGATGCAGACCCAGGAAGGGCCACCTGCGCTATGGTCA GAGGA 900 AZGP1 3063601GGAGACCCTGAAAGACATCGTGGAGTATTACAACG 901 AZGP1 3063602ACACTGGGCTGTCCAAGCATGTTGAAGACGTCCCCGCGTTTCAGGCCCTTGGCTCACTCAATGACCTCCAGTTCTTTAGATACAA CAGTAAAGACAGGAAGTC 902 AZGP13063603 TGCTGCTTCTGGGTCCTGCTGTCCCCCAGGAGAACCAAGAT 903 AZGP1 3063604CCCGTCCTGGCACTCCCATTGGCCTGTAGATTCACCTCCCCTGGGCAGGGCCCCAGGACCCAGGATAATATCTGTGCCTC 904 TRIQK 3144581GAGTCTGTCACAGTTTCTTTGTGTAA 905 TRIQK 3144582GCCGGTGTTATTTACTAGATTCTTCCCTTTGAACTCACAGACTCAAGAGACAGACCAAGAGTTCTTATATACTCACCACAGCGGACCAATCCAAGTGGCATTTTTAGGAAAGGTTGCAGCATTTAATGCCATGTGGTATGTCTGTTCGTCAAGTGGGTGGCAAGGGAATATCCAAGCTGGCATTTTGGATATGATGGGCCTTTTACTTTCCTGAGTGACATGCCACATGTCAAGAAATACTGCTCCCCACCCCCCCACTCCCATCACATTTACGTGAACAATTTTCATTTAGTTATTTCCCGTTCCATATGGTGTTAAAACAGTCGTATTAAATAAAGATTATTTCTAGTTTTCAGTGGTAATTTAAATGAGAGGATATGTAATAATTGCTTATTAGATACTTATCCAAATGAAATATAACAGAGTTTACAGTACTTAAAATGGCTGGTTATGGTCTTGGAAATGTTTGAAAATTCATTATCCTGAAAAAAACTTTACCATTCTGTTTTACCCTTGAGGTATTTTTTGGGGAAAAATGTTTTTGATAACTATTAATCTAAATATAGTATAATTATAGGCAAATTTCACTGCCTAGTTTTATTGATATCCTGAGTCTACAGCTAGTCCATTCGTATGACTGATTGATTTATGATAGCTCCAGAGAACCATAAATTTCAAAGGCTAAACTCTCTGATTTTAGTAAATAGTAGGTAAAGTGACACAATATATGTTTACACAACACTGTTTTCATGAAATGCAAACTTTGCAAAACTCACATTAACTGGGAAGCAGCCAACCCTCTGTAGAGAAATCCCAGATTGGGAGTCTGGTTTGAATCTTTGAAGACAGAAAGGTGATATCCGGCCTGCTGTTTTAAAGGGACCACACTTTTGAATACCTACTGGTGTTTGGCAGAAATCTGAGACTGGCACCAGACACAAATTTTAGACATGGGTATC TTCCCTCCAGTA 906 TRIQK3144583 TGCTTTGACAGCCACCCTATACATGGTACATTTAGATGAAATGGGAACCAGATCCTAAATTTTTCAAATGTCATTGCCAATTTATGTGTATAATTCCATCACTTCCTGATGAGTAAGTCTATTTTTGTTCTATATACATCATAAGTTAGTATATATTCTTATTTACAGAAACATGCTCAAATCACATTCAGAAAGAACAAAAAGTCATGGGAAATTTTTTATTTTACAACAAAGCCCTGCTTTCTTTCTGGACGTATTTTACATCATTAGAGAGACTATCTGCACATACATCTACCATAATCTTTTTCCTTCTTTGCCAACTGTTCAGTGCACATGTGCTGCATCAGAAATGGCACCTGGATGACAGAAGCTCAAAGAGTCACATATGTCTCTAAAATAGAGTTCTTTTCCTCTTGGGCTGTCTGAACTGGTGTAAATAGAAGCTCAGTTGATCTTGGTTTTAATTAACTTATTACTCTATTAATATAACCTTGGAATTCTATTCTAATTATGTTGTTCTGGCTGCTTGTAGTATCAGTTCGCCCCTCTTGTTAGGGAGATATGTAACAATCTGTCATTTAATTGAGCAGTCTTTTTCACATAACAGTAATAGCAAAAATCCTACCTACTCAGAATCATCTTCTTAGGTTGTCTCCTAAATCTGAACAATACAGTTGTTTTATAAAATTACATTTTGTCTCTTGAGATTTAATCAATTAGAACTCTTTAGGGAGAAAATAAATAATAGAAGAAAATATATGCCTCATATTTCATATGTAATTATCTGTTGATATAATTTTTCAATGTATTTTGTATTTGTGGGAGCATAATGACCT GTACATTC 907 TRIQK 3144584CTCACCACGGATGTTGACCCTGATCTGGACCAAGA 908 TRIQK 3144585GAAGTTGGCCTTGTACTTGCAGCTATATTGGCACTACTACTGG CTTTCTAT 909 TRIQK 3144586GCCAAGGTATTACTACCAAGCTGTAACAGCTGTTGAACTGCCAGATGATATATTTGGTTGTCTTCCAGAATTTGCTATTATGATCACGAAACACTGCCTTCTTTTCGCTCCTGATTG 910 TRIQK 3144587TTTACGAGCAACCAAATTAAAAGCAG 911 TRIQK 3144588AAAGGAGGCATTACAAGTGATATTTCAGAAATAAAAAATACAAGCTACTTTGGGTAACTGAATGCCAATAAATTAGTTAACCTAGAGGAAATGGATAAATTCCTAGACTCATACAACTCACTAAGATTG AACCATG 912 TRIQK 3144589ACCTGATGAGCAAAATGGCTGAACAGAATCCTCTAGCGATCATCCCCCCACAGGAACACCAAACTGAACAACTATTCACACAAAACAAGCACCTTCATAAGAAGCAAAAAACAGGTGAACCGGTACCTGGCTTTAACATCGTATTAAGGAAAGAGGCACTGAAGAGGATTTGAAAGACAATCTTGAGTCACCTATACCACCCCTTTCCCGTACTTCACCTTTGGCCATGTGGTGTTAAGAGACAATCTGTGCACTTGCATGAGGGAGAGTGCAGTGATTGTGGGAATTTGCCTTGGAACTCAGTGCTGCCCTGTCACAGTGGAAAGCCACACAGGGAAGAAC TTAGCTGGTGCCCACA 913 TRIQK3144590 CCTCCTAACTATGCATGTACCTTTCACATTTTATTGCAAAACTATTAGGCTATAATAAGAACATGCATCAAGCAGGGACACCAATATCTTGCCTGGCATTTAATTATCAAAAACACCTGTGCTACAATAGTATATTCACGTGTATAATTCTTTATATGTAGACATTTAAGTGCTTGAATTATTTAAAAAATCTACTGTCTGGATAAAACTTCCATA 914 TRIQK 3144591GCTACTATAAAACTTCCTGTTGATCAGTACAGAAAACAA 915 TRIQK 3144592TTGCTTGTGACATGACTAGTTCTTGTCTGACTTCATCTTCATCTTGTAATGCCTTACTAGAAGGAATGAGGAACAACTTGCAGACACCAGTTTGAAGAATACTTACGACTGTAACATTGTATTCTATGAATAATGACATATTGTAATTGAGGCTAGGAAATAGAGTCTGTGCTAGGAAGAAAAGGAGAATATGAATGTGGTAATCAGGTTGTACTCT CTGCTGCAATA 916 TRIQK3144593 AAACAAGTTGGTTGGATAGCTGTCCTCCATGCAGTCATTCATGATCCAGGCTGTCATCATCTTCATCACTCATGTTCAGAGTTACCCTAGAGGTCATCTCCATTTCATCCAGATAAATGAGTATGCAAG GAACGTTTTTA 917 TRIQK3144594 CTGCTGGGATGTTGGCTTAAATGACTAGAAAGGAATTGGGGGAAGCATAATGAGTAACCATTTTGGCAGATAGCCTCAGTGATTTGCTTTAAGAAAAAATTAAGCATAGTCTGTAAAGGCAAAAAACAAAACTAAATTGAAAAGGGAATAATATCTTGAGTGTTTATTCATTTAATCCAACTTCTCTCCTAAAATGGAGTGGTATCTTCCCTAGCC ACACACA 918 TRIQK 3144595GCTAATGTCTCCCTGGATTTCTTGGGAGTTTGCTATCTAACCATCAAAGCAATAGAAATGAATGATGATTACTGCAAGGCTTTGAAGAACAAAGAAAAGTCAGAACATTTTAAAGGTTCTACATGTCTGA GTC 919 TRIQK 3144596ATGGGGACTCCTCCATTTACCAAGGCTACAGCTGACTCCTGGA GAGGCCTGAGTACTCATTGCAGTTT920 TRIQK 3144597 CCTTTTGTTTGATTAAGCTCTTAGCGTGCAGTG 921 TRIQK 3144598CAGTCTGAAGGTTTGTCGGGTAATAGTCAAGTGGATATGAAAC TGCCCTTTGTGAACCTCAG 922TRIQK 3144599 GGGAAGCAACGTCAATCAGTGGTACTGGAAAATGAGT 923 TRIQK 3144600TTGGTGTTTGCCTCATTTGAGCCTGGTTTGAACAGTTGGCCACCTTTGGCCAAAACTCAGTGATTGGCACAAAAGTCGGTTGCAGTCTGTTTACACATGGAAAGGTTACAGTTTACTGTGCACAGAGAAACCATTAGGTCACATTTAGAATATATAAGGAGGCAGCATTGGG CTAAACTTGACAATTGCTTATT 924TRIQK 3144601 CGATTAGAGATTAAGTTGCCAGCTTTAAAAATGGGGACTAGTGTGTAAGCCTTTTGTATGTACATATGTACATGCACTAAGTATGTAAATACATACATATTGTGAGACTAGGTTCTCACAGTAAATATCTGATAAAAATCCCTGGGGGAGGGGAAAAGGAACCATTTTGAAATACACCACAGCACTCTGTTCTTAAAAAGGTCTCTCCTCAAGAGAAACTAGTGTATATAAAAAACTTACTTTCTAAATGTAACTGTTACTCTACTAATCCAGAGTTTCAAACATGTGTGAACAATAAGATAGCATACATAATTTGGCATTTTAAAAGTTATCCAAAGATACTTTTGTAG AAGCCACTTAGC 925 TRIQK3144602 TTTTCTGGCAATGAACCTGGGTTCCAAGCATAGGTTTTTCTTATGGAAGGCAGTTTTACAATAAGGAAATGTTTTTACTTGTATTTATTTTGTGATATTTCAGCAAATCCAAATAAATGTAGTAACATTTATAAAGCTATACATTTATAACTGATTTATTTGTTAAATATTTAGTATTATCAATTGTCTGTTAAAGATTTGTTGCTACATTAAATGCTTGGTCTGTCTTGATGTTCAGTACATTATTATACTTTGGTATATTGCAATATTTTGATAATTATGTATTGGTTTTAGTCACTGTTCCTGCATATTAAGTAATAAACAGATTAATATCATCATAAAATATCATTTACTCAGCAATATTTCTTAGTAAATTGATACATCCATTTTTCTTATGTATTGTGGAGAGAGGAAATATGACATAAAATGGAAGAATATGGGCCTCTGTTTATCTCTGACCTCATCGCTTACTGTTCTTTCCCACTCCTCACTCTACTCAAAGCCTTTAAATAGCTCTCCATTTTACTCAACATCAAATCTAAATAAAGCTCTTAAACTGGTCTAAATGTCTCTACAGTACTTGAACCTTTGTTATTTCTCTAATTTCATCTTCAACTCTGCTCATCGTTATTCTCTTGCCCTGGGCATACTGCCTCCCTTTTTGTT CTCTGAACGTGCCAGGCATTTT 926TRIQK 3144603 CAGGAATGCAAGCACTGCTACCTAACTAAAGACCTTGGCTTTGGAAACATCTTACCCCTTGGCAGCTCTCCAGAGTTTAGACTTGG CAGCATCAAAGAC 927 TRIQK3144604 TCTTCCAACGTCAAAGCCAGCAACATTGCAGCAATCTGACTTATTTTGTTGTCATGTCTCCTGACCACATCTGGAAGGGTTATCTACTTTTGAAGACACATCCAGATAATTCAGGACAATCTGTCCATTTT GAGGTTCTTC 928 TRIQK3144605 GGAGCTTGGTGTATTCCTGAATCCATCAGATGTTGGTGTCCGCGTGGATGACTAGGAAAAGGGGATTGGAGATTAGGTTTCTTCTACTTGGAGTTCTCTGCTGCTTGTTTGAGCTTAATAAGCCTCCTGAAGAAGTTGAAGCAATTTATTGCTAGAGGAGCCCCAATGTATAATCTCCCTTTCATTCTCTACTGTGGAGAGGTGTGCTAAACCTGTAGAGCTGTTTTTGCTTCACTCGGCTCATACTTAATG 929 TRIQK 3144606CCGGGAATGAAAGCGGGCGCACCTCTTTAGCGAGCCCTAAAGCGTTTGGGAGACGATCGTTCCGTCCCTGGGAGCGGCACTTGGTGGGGCTGGGCGGAGGGAGGCTCTGCAAGAGAAACCCGGAG TCCG 930 TRIQK 3144607CCTGAGTGACAGAACCGTGGACAGCAACATTTCCCACAGGAC ACGAAGTTTGTCGGCCCTTGCCTTGGCAG931 TRIQK 3144608 GATGTCCAGCAGCTAGTAGATGTAGAAGTGCTGTTTGTTACTGGGTATGTCCTTGCTGTCAGGGAAGTGCACCTGTTTCAG 932 TRIQK 3144609GCTAAAACTGGTAAGGTGCCCATGGGTTCCATGGAACCTCCACATCCATTTACAAAGCCCTCTAGGAAGACTGGGCTAGTTGCTT TCTTCAGCTTCAGTATTATGG 933TRIQK 3144610 ATACACCTTAAGCAACCAGGTATCCTTGATTGTGGGAGTTCCTTGGAACATGAGCAGA 934 TRIQK 3144611TAACCTGGACTTTCATAAAACTGGCATATCTTCTGTTTTACATGGAAAATTATTTTATCTTAAGTTTCCATTTAGTTGATTAAAAATAGGGTTATGAATGTTAAATAAGTGATGATTTATTGCAAAGGAAATA TGTTTCGAAAGGTCGAATA 935TRIQK 3144612 GAGTCCCCTGGTCTTTACATATTAAAAATATTAGGCTGTCCTGGAAATGTTGTCTTATTTGTCTGACTTCACCACTAAAGTATGAGTCCCTTAAGGTTGTCATTTCATTTTTGTAGTCCTTATGCCTAAAA TAGCAACA 936 TRIQK 3144613TATCCTGCTGGTGAGTTTGGGAAAAGGAATTGGATCGGGGCATGCAGCGTCTCCTTATCTGCAAACAGGCCTGCCGGTGGGAATCATGGTACTGTTCCCCAGCAACACAACATTAATTTCAGAGGGA GATGCTCTGCCACTACAGGAGTG 937PABPC1 3146782 TGACACCGCCATGAAAACGATCAGCACCGTCGAATCCTCACGCCCCACTCAAGTTCCTTGATTGCTTCAATAATGTCCTCCGTAGCAAAAGGATCTAGTTCAAAATCGGGAGTTACATTTCATTGTCATGCCTAAAACGTAAGAATTGCTCATTCACTTTGGAGCAGTTCTTCAGTCTATCCTTGATTTTCATGACCTTGACACTTTTGAACATTATAGACCAGTTATTCAATAGAATATCTTTCAATCTGGGTTTGTCCGATACCTCTTTATTATTAGATTGAAATGATACATTTTGGTGGAACTATCACAGAATTGACATTGCATTCTTCTCATTACATCCTGTCT GGTGGCCTG 938 PABPC13146783 AAAGGAATCCTAGTGACGAGTTGTCTTGAAAGAGAAGAAAAAAAGTTAAAAAACAGAAGAAAAAGGAGATCTTTAACCGTGCTGGGTATAAAATTCTAAGTCAGGATACTTTTCTTCCTTTGAGCATCTTTGACTGCCTGGGGAATATCAGACATTCTTTTAGTGGCCTTGTGATCATTTTGCTGAGCTTGTTCATATTCCTGTTC 939 PABPC1 3146784GCATCAAACTGAACCGCGACTTGTCCAAAGTCACATAGTAAGTGGAGGTGGAACTGGGCTTTAAATCCAAGCCTACATACAGACTAGAGTTCACACTTTTAGGCTTGGCATAAACTGCCTATAAACTATAAAAAAGTAAAACTCCATAAAATCTCAGGTACTTGGACTACCTTC AGTCTGA 940 PABPC1 3146785AGTATGGGTGACTATTCTTTACAAATCCATTTGTGATGCAGTGGTAATTTGGTGGCACTGCAATTATGGCCAGCAATGAAGATTATAAAATAATTGCCTGAGGAACCAAGCTCATGTGCACTAAAAAGA AGCAGG 941 PABPC1 3146786CTGCACTTGGCCCTACACCGATGAATTTTT 942 PABPC1 3146787TGCTGAGCCGACATAAGAATCTTTTATGAAAAATGTACTGTTAAGTTCAGGGGGTCTATTGGTTTTATGTAAAAGGCACAAGACAATTCCTGTAGTGCATTTTATGAGTTAAGGTTTCCATACGGATTATTGAAACAATTTGTTACATGTATTTGTTACATGATCTTAATATTTCATGTACAAGACTGACACCCATCCACTTTTGAAGATAAGCCAGTTTATGGGGTTTTTTTTTTTGCGGGTAGAGGTTGGGTCTCCCTATTTTGTCCAGGCTGGTCTCGAATTCCTGGGCTCAAGCATAAGCA TAAGGC 943 PABPC1 3146788CCTTATGTACCGAGCAAATGCCAGGTCTAGCAAACATAATGCTAGTCCTAGATTACTTATTGATTTAAAAACAAAAAAACACAAAAAAATAGTAAAATATAAAAACAAATTAATGTTTTATAGACCCTGGGAAAAAGAATTTTCAGCAAAGTACAAAAATTTAAAGCATTCCTTTCTTTAATTTTGTAATTCTTTACTGTGGAATAGCTCAGAA 944 PABPC1 3146789TGATCAGGGACCATGAAAAGAAACTTGTGCTTCACCGAAGAAAAATATCTAAACATCGAAAAACTTAAATATTATGG 945 PABPC1 3146790CAACCTGGAGTGCATTGACGCGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCGGCCTCCCGAGCAGCTGGGATTAACAGGCCCATGCCTGCCACCGTGCCCAGCTAATTTTTGTATTTTTACTAGACTTGGGGTTTTGCCATGTTGGCCAGGCTGGTCTGGAACTTCTGACCTCAAGTGATCCGCCCACCTCGGCCTCCCAAAGTCTTGAAATTACAGGCGTGAGCCACTGCGCCCTGCCAGATTTTGTATAGTAATATATATATAAAATGACCTGTCACAGGTTGGCTTTCATAGTTTTACCTTTCCTTTTTGGGTGGTGCCCTTGGGTCTCTACTACTGTCTTTCATCACTCCCAAGAAATTGAGTAGTGCAGCCAGGATCAGGACCAGGGATTGGCAAATGTTTTTTGTAAAGGGCCAGATAGGAAATATTTTGGGCTTTGAGGACTGTGTTATCTCTGAAATGATCTTGTTCCAGTGTTACCATGTCA AGAC 946 PABPC1 3146791ATGAAGCTGTAGCTGTACTACAAGCCCACCAAGCTAAAGAGGCTGCCCAGAAAGCAGTTAACAGTGCCACCGGTGTTCCAACTG TTT 947 PABPC1 3146792GTACAGTTGTAAAGTCTGCATAATAACCTGTGGCGCTATTTATCCCCATTTTATAGATAGGTAAACTGAAACAGGCTGAATAATTTGCCAAATGCTCACACAGCTCTTAAGTGGCAGAGCCTGGCTTCAAATCCCATCAGCTCCAACAGCCATACTCTCAACTGCTGCTGCTTTCTCTAGTGGAGAAAGAGAAATATTTTTCGAGTGTGGGGAGGACAAGGAAAGAGTAGTGCAGGGGAGCGATTCATAATTCT 948 PABPC1 3146793GCCATGCACCCTACTCTTGCTGGTA 949 PABPC1 3146794 TCCTCAAGAGCAAAAGCAAATGTTG950 PABPC1 3146795 AATGGGTCCACGTCCTGCAGCTGCA 951 PABPC1 3146797TGCAAACCTCAGATCGAAGAAGACAGCATAAACACTTTTCACT CAGTAAGTTTTCCCAGTTAATGTA 952PABPC1 3146798 TCAGGTATATTTATAAGTGTGGGCGGCAAACCACCC 953 PABPC1 3146799AACCGTGCTGCATACTATCCTCCTA 954 PABPC1 3146800CAACCAGAACCATGAAGGTTTTCGTATTTGGTCATT 955 PABPC1 3146802TTATGATGGAGGGTGGTCGCAGCAAA 956 PABPC1 3146803CTGACCTGGCTAGGGTAATGCATATGTGTAGTTTGCCCTTAATAATTGGGTATTAAGGAAAAATTGTGAACTCAATGGGTAAATACAAGATGATTAAGCATTAACAGGGTTTAGTTATTTGATTCAGTGA TTTATAATTGTCTAA 957 PABPC13146804 GGAGTACGATAGAATTTATTCCTGAATGTTTTTGTCTTCAGTGTGTTCCCTGGATATTGTTTAAATTGAGTGTTGTGCATCAGCATATTTTGAATGTATGAAGCATGCATGTTTTTCTGTTTCTTGAGACAGGATCTCATTATGTTGCCCAGGTTGGAGTGCAGGGGCATGCCACAATCACAGCTCACTGCAGCCTCAGCCTTTCCTGGGCTTAAGCCAAGCTTGTCCAACCCGCTGCTTGCAGGCCACATGCGGCCCA AGAATGCTTTTA 958 PABPC13146805 GATGATGGTATTGATGATGAACGTCTCCGGAAAGAGTTTTCTC CAT 959 PABPC13146806 TTATGTTGGTCGAGCTCAGAAAAAGGTGGAACGGCAGACGGAACTTAAGCGCAAATTTGAACAGATGAAACAAGATAGGATCACC AGAT 960 PABPC1 3146808TGCCTTGGCCCATACATCTTCTAAATTTCTGTAATCAAATGTGATTTTTAACCTTTTCTGCCCCACTTGCCTGAGATACCACCCGCCTCAGTTACCTGTCTCTCCTACTTTAGAGGGAGTTAGGGGAAAACATGTCTTCAGAAATAAATGCTTCCTCTTCCAGGTAGTTCACCTGTGTCTTTAAAAAGAATTTTTTTTCCCTGTCTTTCAAATTCCTGTATTACCTATGTCTTACCAAAGAGTCCAACTATGTATTCCTTCCACTCCTGTTGAAAGTCGGGTAGGCCAAGGCTTAATAAATACTTGTTTCTTAATTGATACAAAGAAAATCAAATTGGTCTTAGCACAATAGCTCATGCCTGTAACCCTAGCGCTTGGGGAGGTCAAAGAGGGAAGATACTTGAAGCCACAAGTTTTAGACTAGCCCGG 961 PABPC1 3146809TTTGTTGGACGATTTAAGTCTCGTAAAGAACGAGAAGCTGAACTTGGAGCTAGGGCAAAAGAATTCACCAATG 962 PABPC1 3146810TTAGAGTACACGATTGGGAAGTTTAAATTTTTATTCTAGGAGATGGCAAAGAAAGCGCAAGCGCCACTTTAAAATGACGATGAAAGCTTTTTAATTTGATAGAGGTCTTTTTATTGGCATGGTACACATGCACTTCCACTCATTTGTATTGATGGGAGTGATCCCTTTAACCCT AGGTTAGCTAGAGAAGA 963PABPC1 3146811 GTTATAAATATCTAGCTAATCATATTTTGAATCTTATTTTTAATAATTCCAAATCCATTCATTTTAAGTTAATATTTGTCAGGGAGAAGTTAGATGCACATAAGATAAAAGAATAAAAACATTTTAAAGATGAATAACAAAAATTCATGTAGTTGTACTGGAGTGAAAATTAATAAGCTAATCTTGATTTTTACAATTGAATTTTCTACACAGTAAGTGTAA CATACA 964 PABPC1 3146812TGAAAATGGTTCCAAGGGCTATGGATTTGTACACTTTGAGACG CAGGAAGCAGCTGA 965 PABPC13146813 GCTACATTTAGTTTAGTGCTTGAAATAGGAACTGTGCAGTAATGGATATCTTTATTTCACAAATATCCAGGTTAGATGGCTAACAGA TTGTCTCTCAACA 966 PABPC13146815 GGAGCGTGCTTTGGACACCATGAATTTTG 967 PABPC1 3146816TTTAGGAAATGGACTAGTTTTCATATAATATTGTTAGTTATTAGCAATGAAATGACCAATTTTAGCAAGTAGTTGGGAAGAAGTTAAAATATTTAAATCTATAAACTACTTCCAGCTTGTAGATAAATCTGTT GCGTAATGTC 968 PABPC13146817 AGGCAGGATGTATCAATGCATGTCAGATGGGGGTAGATAACTTTGGGGCAGGTTATCACAACCTAAGAGTTGGTGGAGAAAACATGGGAATGAATTCTAGAGACCACAAAATGAAAACTTGAAAGTGTTACTCTTTCTCAGCTTAACGTTTTTAAATCCAAAAAACAATTTTTACATTTCTTGGGATTCGAAGAGTTGAACTTCAGGTTGCCGTGGTTACAGTGTACAGTATATATTATCAGTCTGTACCAGTAGACCAGTACCCTAACTACTGAAAAGAATATGGCAGTTTTCCATTTGTCTAGTTTCTGTATGTACAATTTACTATCCAATTAATTACTTAAGTGGATTTCTTGTTCTTTTTTAAAAACTTATTGCTACATTGATAGGCAGAATAGCTTCTGAAAGTGACCAGTTTTCAATTTCATAGGAAGAGGTGACTCATTGAAAAATAGCTCAAGCAAAGTCAGCTAAAAAAAAAAAAAAACTAGGGAAGCTGAGTAGGTGTGGTCAATTGATAATGAGCTAACAGCTGATTATCACTATATTCTAGAAACTGGAACTTTCATTTATAAAAAAAGAGGTGGCCGGAAAATTCATCCTGTC 969 PABPC1 3146818TGTGGCAGCCGACCACTTTGAAGGCCAGTTTTCTCAGGCAACTTAGACCATTTTTAGTCAAATTTTATCTTAGATTCACAGTACTGGTGGTTTTCGAGTATATTATGTTACCTTCTGAAATAGTTCCTGTCGTTTTGAGGGGCTTTTCTTTATAAAATAGTCAACTTTGGCTATAAAATGTTACTTTAGTGTAATTCCAACTGGACCAGTCTTATCTGTAGCATGCAAGAAGTTCAAGTTTCTCTTTTATTTTTAAAAGTGGC CCATGATACCTGTAAATC 970PABPC1 3146819 CTACGAGAAGTTCAGCCCGGCCGGGCCCATCCTCTCCATCCGGGTCTGCAGGGACATGATCACCCGCCGCTCCTTGGGCTACGC GTATGTGAACTTCCAGCAGC 971PABPC1 3146820 GTCGCGGCCTGTGGCCCTGCGGGCAGC 972 PABPC1 3146821CCCGGCACTCGCTCTCCTCCTCTCACGGAAAG 973 PABPC1 3146822GATTTTTGTCCCTCTGCGCTTGCTCCCCGCTCCCCT 974 PABPC1 3146823TCGCTCCCCGCCGGCAGCCGGCAGCCAGCGGCAGTGGATCG ACCCC 975 PABPC1 3146824CCAAGAAGGAACCAAGAGACCGAGGCCTTCCCGCTGCCCGG ACCCGACACCGCCACC 976 PABPC13146825 GCTGGCTCCATCTACGCACGTTTCGGAAACCGGGCCCGGAGGGGACCACGCCCGCTCACCCGTGCCCGGCGTCCCCCGGAGCTGGGGCTAGAGGAGCCGGGCCGGCCGCAGCGGGAAGAGGCCACAGGCGGCCGCGCACGTGGGGGGTGGTTAGCGCGGAGGAACCCGGAAGCCCTTTGCACCGCCCACCGCCGCGGTGACGGGTTAACGCTCCTCCTGGTGGAGGCAGGGGCGGGCGGGGCGGAAGGCGGGGACGCCTCAGCCAACACCCCCGAGGACCGCCCGCGAGCCGTCCTCCCCACCCCCACGGACGCGACGCAGCGCGGGCTCCGCTTCCCCGGCCGCGGCGCCTGCGCAAAAGCCCCGCCCCTTCGCCCGAGCCCCACCCCCACACCGCAGCCTCCACCGCCGCCACCTCTCCCTTCCTCTCTGCTCTTTCCTCCTGTTTTCTCTTCCCTCCTCCCCCTGGCCTCCGCGTCTCCTCCTACTCCGGCGCTGACGCTCGCGTAGGGGCCCTGGCGTCAGACGCGCGGGGGCGGGGCGAGTGCGGCGCGGGGTATAAGTAGAGGGTGCAGGAGGCGGTGCTTCCCCTTCTCCCCGGCGGTTAGTGCTGAGAGTGCGGAGTGTGTGCTCCGGGCTCGGAACACACATTTATT 977 PABPC1 3146826AGGCACCGCTTCTGCGGCCGACGCGCGTGGCGGCGGTGCCG GCTGGGACTCGTAGTGCGGTCCGG 978PGM5P4- 3159288 ACTATGTTGTGAGCCTGCGAAAGAAGTTTGTGTG AS1 979 PGM5P4-3159289 ATGGAAAACTGGGAGCCGCCTTGGAATCTACAGGGCCGG AS1 980 PGM5P4- 3159291CGACCTCGACGGCCGTCCTGCCGAAGAACCTGCCGTCGCTG AS1CCCGCCCCCGTGGTGCGGCCCTGACGGTCGCGCAGGCCGACGGACGACAGCGCGCTCCGGATGAAGTTGGGCGGGTAGCT 981 PGM5P4- 3159293AGCCTCCTCCAAAACAGCACACTTTCCG AS1 982 PGM5P4- 3159294TGGTTACAATGGTACTTTCAGCCTGTCCGAATTATGTATTGCC AS1CCTCCCCTTTTTATTAATAACATTGAAGTGTGATGGGACAACCACTGAAGCCGTCAGTTGAAACCTGCTGGGACTTTTTAGCCATTCTCTTCAACATAAAGAATGGGTGTTTTTGGAGGGGGTGAGAGGAATGGGGAAATGTTGTCAAAGAGTACAACGTTTTAGTTGAGACAGGAAGAATATATTTTGTTGAGATCTACAGCACAGCATG 983 PGM5P4- 3159295GCCTACCTAAAATATTGAATGCTGTTAATAAATCTCCTGAGGC AS1CAGCATAAGAAGGTGATGGGCAAAACTAAT 984 PGM5P4- 3159296TTGTGTATCTGCGTTCCTTTCAACAAGTGTGACTTCCTCCATG AS1GCATCATTCGTGAGCGTAACACAGAGCTCAGC 985 PGM5P4- 3159297GCTCTGAGAGGCTCTTCCTAATAGAACTGCTGCTTCAGTTTAG AS1CTTGAAAAAGCCCACACCCAGTTCCTAATGACAAACATCTGAACACCGGGTCTTCCCACGAGCAAGACCATGCTATGCCTCCTGCTCGCTCTGTTCTATAAGCAACCCACAGATTGCTCCCTGTGAAG A 986 PGM5P4- 3159298AGTAAATCCATTTGCTGATTGCAATA AS1 987 PGM5P4- 3173158ACTATGTTGTGAGCCTGCGAAAGAAGTTTGTGTG AS1 988 PGM5P4- 3173159TGGTTACAATGGTACTTTCAGCCTGTCCGAATTATGTATTGCC AS1CCTCCCCTTTTTATTAATAACATTGAAGTGTGATGGGAAAACCACTGAAGCCGTCAGTTGAAACCTGCTGGGACTTTTTAGCCATTCTCTTCAACATAAAGAATGGGTGTTTTTGGAGGGGGTGAGAGGAATGGGGAAATGTTGTCAAAGAGTACAGTGTTTTAGTTGAGACAGGAAGAATATATTTTGTTGAGATCTACAGCACAGCATG 989 RP11- 3175548CCTCAATGGGAACCCTGGTGCAGAA 159H20.3 990 RP11- 3175571GTGCGGGGTGGTGGCACTGTCAGCAGGGACCACTGGGAAGT 159H20.3TGAGGATGAGGACATCAAAAATAAC 991 RP11- 3175573AAAGGTTACCAGTTCACCAACTGTGCTTTACGGTGAAAAACA 159H20.3 992 RP11- 3175574CCACCATGACAGATGACCTGGCAGGTTATG 159H20.3 993 SETP14 3190668AGAACAGCAAGAAGCGATTGAACACATTGATGA 994 5ETP14 3190670ATATAACAAACTCCGCCAACCATTTTTTCAGAAGAGGTCAGAA TTGATCGCCAAAATCCCAAATTTTTG995 SETP14 3190675 AGTGGTGATCCATCTTCGAAGTCCACCGAAATCAAATGGA 996 5ETP143190678 AGAGAGCTTCTTTACCTGGTTTACTGACCATTCTGATGCAGGTGCTGATGAGTTAGGAGAGGTCATCAAAGATGATATTTGGCCAA ACCCATTACAGTACTACT 997PGM5P4- 3208467 GGGAGCAGCATTCCACCAGACCCTGATTTAGCAAGATATTTCC AS1GTATCATTCCCCCAACCAGCTGGAA 998 PGM5P4- 3208469CCAGACGTACAGAGGCTGGGAGCCATTGTGGTGTGCTATATT AS1 GATGACGGCAGCAGTGGG 999PGM5P4- 3208471 TTGTGTATCTGCGTTCCTTTCAACAAGTGTGACTTCCTCAATGG AS1CATCATTCGTGAGCGTAACACAGAGCTCAGC 1000 PGM5P4- 3208473CTTAGAGGGCCCCACAGTTGTTTGCTG AS1 1001 PGM5P4- 3208475TGGTTACAATGGTACTTTCAGCCTGTCCGAATTATGTATTGCC AS1CCTCCCCTTTTTATTAATAACATTGAAGTGTGATGGGACAACCACTGAAGCCGTCTGTTGAAACCTGCTGGGACTTTTTAGCCATTCTCTTCAACATAAAGAATGGGTGTTTTTGGAGGGGGTGAGAGGAATGGGGAAATGTTGTCAAAGAGTACAATGTTTTAGTTGAGACAGGAGGAATATATTTTGTTGAGATCTACAGCACAGCATG 1002 PGM5P4- 3208476AGCCTCCTCCAAAACAGCACACTTTCCG AS1 1003 PGM5P4- 3208477AAAAATGAGCAGGTGCGGGATGTGCGCAGAGTCGGAGAAGA AS1GTCCAGGGCGCCCGGAGTGGCTCCAGGAACGACGGAAAC 1004 PGM5P4- 3208478ACTATGTTGTGAGCCTGCGAAAGAAGTTTGTGTG AS1 1005 ASPN 3214846TCATGTCTTAGAGCCCGTCTTTATGTTTAAAACTAATTTCTTAAAATAAAGCCTTCAGTAAATGTTCATTACCAACTTGATAAATGCTACTCATAAGAGCTGGTTTGGGGCTATAGCATATGCTTTTTTTTTTTTAATTATTACCTGATTTAAAAATCTCTGTAAAAACGTGTAGTGTTTCATAAAATCTGTAACTCGCATTTTAATGATCCGCTATTATAAGCTTTTAATAGCATGAAAATTGTTAGGCTATATAACATTGCCACTTCAACTCTAAGGAATATTTTTGAGATATCCCTTTGGAAGACCTTGCTTGGAAGAGCCTGGACACTAACAATTCTACACCAAATTGTCTCTTCAAATACGTATGGACTGGATAACTCTGAGAA 1006 ASPN 3214847CTAATTCAATTGCAAGAGTGGGAGTAAATGACTTCTGTCCAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAACAACCCGGTGAAATACTGGGAAATGCAACCTGCAACATTTCGTTGTGTTTTGAGCAGAATGAGCGTTCAGCTTGGGAAC 1007 ASPN 3214848TGACAACTCTTAACTGGCTGGAAGGGGCCACAGATTCCTTGGAGAATCTAATAAAGATTTAGATCTTCCCAAGAACAAAAGTTTTCATCTTCCAAGGAGCTTGAGAACAAAACTGGGCAACAAGCCACTCTGCCTCTTCTCTTTTTCTTTCCGGTGTATCTTTAAACAAGTTTCGTTCACTGTACTCCTTTGAGATACAAACCATCAAAATGAATGTAATATAGGCAGGTGCTAATCTCAAGATCACAACTTTTGCTTTGACTTTTCCAAATGCTGCATTTGGATGTCTGTTTAGCCAGTGACTACAACTTGAGTCCGTCCTCTCTCAAGCTGCCCCATCCCTGATGTCATTTCTGCTTAATTTGCTCCACAACTCTGCTTCCAGCTTCTGG TCTCTCTTAAATC 1008 ASPN3214849 ACATTCTACTTGTGTTCAGTAGATATTGGTATTTTTCTTCAGTTTTTATAACACACTTTAGCACACCTCAAGCAAAGACCAAGTAAGCAGCAAGGGTGATTCAAACATAATGACTCTCCAGGTTGCATGAG GTG 1009 ASPN 3214850ATCACAGATATCGAAAATGGGAGTCTTGCTAACATACCACGTGTGAGAGAAATACATTTGGAAAACAATAAACTAAAAAAAATCCCTTCAGGATTACCAGAGTTGAAATACCTCCAG 1010 ASPN 3214851TAGGACAGGCTTATATTCTAACTAGTTTGCGGTGTTTTCAGCTAACTCTATCACACCTAACCATCTGTGTAAGACTTGATGCATT 1011 ASPN 3214852GCTTACCACCAACTTTATTGGAGCTTCACTTAGATTATAATAAA ATTTCAACAGTGGAACTTGAGGAT1012 ASPN 3214853 GATAAATGATATCACATGGAAGCTGTCAGCCAAATCCACAAAAGGAGTGTCTCAAACAAATTAATATGGAAATAAATCAAAAGAAGAGGGAGAAAAAAGGAGGGAGTATGTTGTACATTAAGAGAGATTTCAAGAGCGATAAGAACCAAATGTATTCTGTAAACTTCATTTAATCCTAACTTGAACAAATCAACTGTAAAATGACGTATTTGAGA 1013 ASPN 3214854CCGGTACAAAAGTGTGCTAACATTTGTCAGCAGTTACTGAGCTTCTGCCAAATTCACACCTCTGCTCGTTTTATCCTAGAGGCTACACTTCAATCTTCTCTCTGGTTACCCACCTTCCCCATTTCCTAAGGGACACAACAGTTCCCTCAACTTCTACAAGTCCTCTCCCAGAG ATTA 1014 ASPN 3214855CCCAGGCATTTAGCCACAGTTTGAGGTGAAGCCTATGAGCCCAGACTGGGCAGCCCCTGGCTCTGGCAGGAATGGACATGCCATTCAAGGCAAGGCATTTTGTACCCAGCTTCTTCCCAGGTGTACTGTGAAGACTAATGGGCCAATACACAGAAAGGTCTGAGGACAACATCCAGCACGTAGGAAGTGACCACCTGTGACATAATCATTACCAAGATGAGCACTGTGCTCTTTATCATGGCTTTGTGTGACCCAAGGCTAGCACCTCAAGTAGAATGCTCCTTAAGTCTGCCAGATGACCAGTGTTCTAACCCATTACTTCCAAGCTCCCTGTCTGATGA TTAGCTGCATA 1015 ASPN3214856 TAATAATGGGATAGAGCCAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCT A 1016 ASPN 3214857CCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAAGGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAA CTC 1017 ASPN 3214858AATACTGGTAAATCAAATCCACTTCC 1018 ASPN 3214859ATTCCATTTGATACTCGAATGCTTGATC 1019 ASPN 3214860ATGGGTCTTAAGCTTTACCTGTGGAATTCTCATGAGAAAGAGATTAAGATGCAAGTACTGTTTGAGAAAACTTGTTCATGTAGAAC GACTGTGGA 1020 ASPN 3214861TGCTATTCTGACAATTTAAAGGATGGAAAAAGTCTCATTGAAATTTCAAAAATAATCTGAGTGTATAAGTTTTTTTCATTTAAGTTTTTAGGTGGAAAGTACAGCAAACCCCAAAGTACATCCAAACTTATTTTTAAAATTAAGAAAATCAAAGGAAAACTAAGGGAATGTTGTCCATAGAACATTTCCTTCTCTTCCCCAGTTAAATCAAAGCATTTAATTTTAATTCCCTTCAGAGAGAATGGACATCACATGCAGTTCTATCTCAGGGTGCTAGCAGGTTGAGACTGTACTTTTCAGTAAAACTCCATGATAACAAAATAAGCTGCATGTCTAGAACAATGAAATGAGTTATAGAAAGCTTGTGAAATCTCTAATCTA 1021 ASPN 3214862TTTGATCTGTTTCCAATGTGTCCATTTGGATGTCAGTGCTATTC ACGAGTTGTACATTGC 1022 ASPN3214863 TGTGCTCCTATTATTCCTGGCTTTGTGCTCTGCCAAACCCTTCTTTAGCCCTTCACACATCGCACTGAAGAATATGATGCTGAAGGA TATGG 1023 ASPN 3214864TCCTAGACTGGTCTTCTACACTAAGACACC 1024 ASPN 3214865GAAGTTTGGGGATATCACAGCTATATTAAATGAAACAGTAAATATATTTTTCAATATTTAAAATATTTTCTAATGTGTATTTAAAATGTGTGAATTACTGAAATGTCAATTTTACTTATACATTTGAATATTCATTTTTTTCCTTGATAAATGTCTTCCTTATTATAATGAAATGGCACTGAAAAGTTCAAATGGAAATCTATTCAATTCCAAGAAAGAATACTTATCAGCAATAGTTTAGCTAGCACTATATTCAATATGAAAGATTAGGAAATTTTCACAGCATGTATACAGTCAGAATTTAACACTTTCAAAGATTTCCTTTGTCTACTCCCAAAGTAAATTTCTGATTAAATTTTAGATTAAAAAATTTAAGCAATGTATTCAATATTCTACTCCCTAGTAATCTAAATAGCGCACAGCATTCTTTCATGTTAATCTATTCA GAGGTGTGGCACCCAGGAAACA 1025ASPN 3214866 TGGACTAATCTGTGGGAGCAGTTTATTCCAGTATCACCCAGGGTGCAGCCACACCAGGACTGTGTTGAAGGGTGTTTTTTTTCTTTTAAATGTAATACCTCCTCATCTTTTCTTCTTACACAGTGTCTGAGAACATTTACATTATAGATAAGTAGTACATGGTGGATAACTTCT ACTTTTAGGAGGACTACTCTCTTC1026 ARL6IP1P2 3242825 GGAAACGCCTCTTCACACTAAAGGAAGAA 1027 ARL6IP1P23242826 TGACTTCCTTACTATTGCTTCCTGGACTAA 1028 MKI67 3312496ACTCGTGAGCACATCTTTAGGGACCAAGAGTGACTTTCTGTAAGGAGTGACTCGTGGCTTGCCTTGGTCTCTTGGGAATACTTTTCTAACTAGGGTTGCTCTCACCTGAGACATTCTCCACCCGCGGAATCTCAGGGTCCCAGGCTGTGGGCCATCACGACCTCAAACTGGCTCCTAATCTCCAGCTTTCCTGTCATTGAAAGCTTCGGAAGTTTACTGGCTCTGCTCCCGCCTGTTTTCTTTCTGACTCTATCTGGCAGCCCGATGCCACCCAGTACAGGAAGTGACACCAGTACTCTGTAAAGCATCATCATCCTTGGAGAGACTGAGCACTCAGCACCTTCAGCCACGATTTCAGGATCGCTTCCTTGTGAGCCGCTGCCTCCGAAATCTCCTTTGAAGCCCAGACATCTTTCTCCAGCTTCAGACTTGTAGATATAACTCGTTCATCTTCATTTACTTTCCACTTTGCCCCCTGTCCTCTCTGTGTTCCCCAAATCAGAGAATAGCCCGCCATCCCCCAGGTCACCTGTCTGGATTCCTCCCCATTCACCCACCTTGCCAGGTGCAGGTGAGGATGGTGCACCAGACAGGGTAGCTGTCCCCCAAAATGTGCCCTGTGCGGGCAGTGCCCTGTCTCCACGTTTGTTTCCCCAGTGTCTGGCGGGGAGCCAGGTGACATCATAAATACTTGCTGAATGAATGCAGAAATCAGCGGTACTGACTTGTACTATATTGGCTGCCATGATAGGGTTCTCACAGCGTCATCCATGATCGTAAGGGAGAATGACATTCTGCTTGAGGGAGGGAATAGAAAGGGGCAGGGAGGGGACATCTGAGGGCTTCACAGGGCTGCAAAGGGTACAGGGATTGCACCAGGGCAGAACAGGGGAGGGTGTTCAAGGAAGAGTGGCTCTTAGCAGAGGCACTTTGGAAGGTGTGAGGCATAAATGCTTCCTTCTACGTAGGCCAACCTCAAAACTTTCAGTAGGAATGTTGCTATGATCAAGTTGTTCTAACACTTTAGACTTAGTAGTAATTATGAACCTCACATAGAAAAATTTCATCCAGCCATATGCCTGTGGAGTGGAATATTCTGTTTAGTAGAAAAATCCTTTAGAGTTCAGCTCTAACCAGAAATCTTGCTGAAGTATGTCAGCACCTTTTCTCACCCTGGTAAGTACAGTATTTCAAGAGCACGCTAAGGGTGGTTTTCATTTTACAGGGCTGTTGATGATGGGTTAAAAATGTTCATTTAAGGGCTACCCCCGTGTTTAATAGATGAACACCACTTCTACACAACCCTCCTTGGTACTGGGGGAGGGAGAGATCTGACAAATACTGCCCATTCCCCTAGGCTGACTGGATT TGAGAACA 1029 MKI67 3312497ATGAGCGCACGGATGAATGGAGCTTACAAGATCTGTCTTTCCAATGGCCGGGGGCATTTGGTCCCCAAATTAAGGCTATTGGACATCTGCACAGGACAGTCCTATTTTTGATGTC 1030 MKI67 3312498AGGAACAACTATCCTCGTCTGTCCCAACACTGAGCAGGCACT CGGTAAAC 1031 MKI67 3312499ATTTGCTGGGTCTGAATCGGCTTCATAAACTCCACTGGGAGCACTGCTGGGCTCCTGGACTGAGAATAGTTGAACACCGGGGGCTTTGTGAAGGAGTCTGGGCCAAGGTTTGCCCTCAGCTTTGCAGAATGAAGCCTTGAGGTCTGTCACCACCCACAGCCACCCTACAGCAGCCTTAACTGTGACACTTGCCACACTGTGTCGTCGTTTGT TTGCCTATGTCCTCC 1032 MKI673312500 GGACAATGTGTGTGTCAAGAAAATAAGAACCAGAAGTCATAGG GACAGTGAAGATATTTG1033 MKI67 3312501 GTTCAGCAAACGAAACTCATGTAGCAATAACCTCTTCAGATACAGAATTCTGGCAAGTACAGCTGTCCAGACAGACCCTCTTCGG CACAAACTAGGAAGCTTCAACTG 1034MKI67 3312502 CAGAAGAGTGCGAAGGTTCTCATGCAGAATCAGAAAGGGAAAGGAGAAGCAGGAAATTCAGACTCCATGTGCCTGAGATCAAGAAAGACAAAAAGCCAGCCTGCAGCAAGCACTTTGGAGAGCAAA TCTGTGCAGAGAGTAACGCGGAGTGTCAA1035 MKI67 3312503 GAGCCCGGAAACCCATACCTAGAGACAAAG 1036 MKI67 3312504TATCCCTGCGCTCCAGACGCCAAAAT 1037 MKI67 3312505GAGCAAAGTACCAAGGCATTACCTTGA 1038 MKI67 3312506AAGAGGCTGCGCTGCATGCCAGCACCAGAGGAAATTGTGGAGGAGCTGCCAGCCAGCAAGAAGCAGAGGGTTGCTCCCAGGGCAAGAGGCAAATCATCCGAACCCGTGGTCATCATGAAGAGAAGTTTGAGGACTTCTGCAAAAAGAATTGAACCTGCGGAAGAGCTGAACAGCAACGACATGAAAACCAACAAAGAGGAACACAAATTAC AAGACTCGGTCCCTG 1039 MKI673312507 CCCGTGCTCTAGAAGACCTGGTTGACTTCAAAGAGCTCTTCTCAGCACCAGGTCACACTGAAGAGTCAATGACTATTGACAAAAACACAAAAATTCCCTGCAAATCTCCCCCACCAGAACTAACAGACACTGCCACGAGCACAAAGAGATGCCCCAAGACACGTCCCAGGAAAGAAGTAAAAGAGGAGCTCTCAGCAGTTGAGAGGCTCACGCAAACATCAGGGCAAAGCACACACACACACAAAGAACCAGCAAGCGGTGATGAGGGCATCAAAGTATTGAAGCAACGTGCAAAGAAGAAACCAAACCCAGTAGAAGAGGAACCCAGCAGGAGAAGGCCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGACCTGGCCGGCTTCACAGAGCTCTCTGAAACATCAGGTCACACTCAGGAATCACTGACTGCTGGCAAAGCCACTAAAATACCCTGCGAATCTCCCCCACTAGAAGTGGTAGACACCACAGCAAGCACAAAGAGGCATCTCAGGACACGTGTGCAGAAGGTACAAGTAAAAGAAGAGCCTTCAGCAGTCAAGTTCACACAAACATCAGGGGAAACCACGGATGCAGACAAAGAACCAGCAGGTGAAGATAAAGGCATCAAAGCATTGAAGGAATCTGCAAAACAGACACCGGCTCCAGCAGCAAGTGTAACTGGCAGCAGGAGACGGCCAAGAGCACCCAGGGAAAGTGCCCAAGCCATAGAAGACCTAGCTGGCTTCAAAGACCCAGCAGCAGGTCACACTGAAGAATCAATGACTGATGACAAAACCACTAAAATACCCTGCAAATCATCACCAGAACTAGAAGACACCGCAACAAGCTCAAAGAGACGGCCCAGGACACGTGCCCAGAAAGTAGAAGTGAAGGAGGAGCTGTTAGCAGTTGGCAAGCTCACACAAACCTCAGGGGAGACCACGCACACCGACAAAGAGCCGGTAGGTGAGGGCAAAGGCACGAAAGCATTTAAGCAACCTGCAAAGCGGAAGCTGGACGCAGAAGATGTAATTGGCAGCAGGAGACAGCCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGATCTGGCCAGCTTCCAAGAGCTCTCTCAAACACCAGGCCACACTGAGGAACTGGCAAATGGTGCTGCTGATAGCTTTACAAGCGCTCCAAAGCAAACACCTGACAGTGGAAAACCTCTAAAAATATCCAGAAGAGTTCTTCGGGCCCCTAAAGTAGAACCCGTGGGAGACGTGGT AAGCACCAGAGACCCTGTA 1040MKI67 3312508 GGAGAACTCTTAGCGTGCAGGAATCTAATGCCATCAGCAGGCAAAGCCATGCACACGCCTAAACCATCAGTAGGTGAAGAGAAAGACATCATCATATTTGTGGGAACTCCAGTGCAGAAACTGGACCTGACAGAGAACTTAACCGGCAGCAAGAGACGGCCACAAACTCCTAAGGAAGAGGCCCAGGCTCTGGAAGACCTGACTGGCTTTAAAGAGCTCTTCCAGACCCCTGGTCATACTGAAGAAGCAGTGGCTGCTGGCAAAACTACTAAAATGCCCTGCGAATCTTCTCCACCAGAATCAGCAGACACCCCAACAAGCACAAGAAGGCAGCCCAAGACACCTTTGGAGAAAAGGGACGTACAGAAGGAGCTCTCAGCCCTGAAGAAGCTCACACAGACATCAGGGGAAACCACACACACAGATAAAGTACCAGGAGGTGAGGATAAAAGCATCAACGCGTTTAGGGAAACTGCAAAACAGAAACTGGACCCAGCAGCAAGTGTAACTGGTAGCAAGAGGCACCCAAAAACTAAGGAAAAGGCCCAACCCCTAGAAGACCTGGCTGGCTTGAAAGAGCTCTTCCAGACACCAGTATGCACTGACAAGCCCACGACTCACGAGAAAACTACCAAAATAGCCTGCAGATCACAACCAGACCCAGTGGACACACCAACAAGCTCCAAGCCACAGTCCAAGAGAAGTCTCAGGAAAGTGGACGTAGAAGAAGAATTCTTCGCACTCAGGAAACGAACACCATCAGCAGGCAAAGCCATGCACACACCCAAACCAGCAGTAAGTGGTGAGAAAAACATCTACGCATTTATGGGAACTCCAGTGCAGAAACTGGACCTGACAGAGAACTTAACTGGCAGCAAGAGACGGCTACAAACTCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCTGGCTGGCTTTAAAGAGCTCTTCCAGACACGAGGTCACACTGAGGAATCAATGACTAACGATAAAACTGCCAAAGTAGCCTGCAAATCTTCACAACCAGACCCAGACAAAAACCCAGCAAGCTCCAAGCGACGGCTCAAGACATCCCTGGGGAAAGTGGGCGTGAAAGAAGAGCTCCTAGCAGTTGGCAAGCTCACACAGACATCAGGAGAGACTACACACACACACACAGAGCCAACAGGAGATGGTAAGAGCATGAAAGCATTTATGGAGTCTCCAAAGCAGATCTTAGACTCAGCAGCAAGTCTAACTGGCAGCAAGAGGCAGCTGAGAACTCCTAAGGGAAAGTCTGAAGTCCCTGAAGACCTGGCCGGCTTCATCGAGCTCTTCCAGACACCAAGTCACACTAAGGAATCAATGACTAACGAAAAAACTACCAAAGTATCCTACAGAGCTTCACAGCCAGACCTAGTGGACACCCCAACAAGCTCCAAGCCACAGCCCAAGAGAAGTCTCAGGAAAGCAGACACTGAAGAAGAATTTTTAGCATTTAGGAAACAAACGCCATCAGCAGGCAAAGCCATGCACACACCCAAACCAGCAGTAGGTGAAGAGAAAGACATCAACACGTTTTTGGGAACTCCAGTGCAGAAACTGGACCAGCCAGGAAATTTACCTGGCAGCAATAGACGGCTACAAACTCGTAAGGAAAAGGCCCAGGCTCTAGAAGAACTGACTGGCTTCAGAGAGCTTTTCCAGACACCATGCACTGATAACCCCACGACTGATGAGAAAACTACCAAAAAAATACTCTGCAAATCTCCGCAATCAGACCCAGCGGACACCCCAACAAACACAAAGCAACGGCCCAAGAGAAGCCTCAAGAAAGCAGACGTAGAGGAAGAATTTTTAGCATTCAGGAAACTAACACCATCAGCAGGCAAAGCCATGCACACGCCTAAAGCAGCAGTAGGTGAAGAGAAAGACATCAACACATTTGTGGGGACTCCAGTGGAGAAACTGGACCTGCTAGGAAATTTACCTGGCAGCAAGAGACGGCCACAAACTCCTAAAGAAAAGGCCAAGGCTCTAGAAGATCTGGCTGGCTTCAAAGAGCTCTTCCAGACACCAGGTCACACTGAGGAATCAATGACCGATGACAAAATCACAGAAGTATCCTGCAAATCTCCACAACCAGACCCAGTCAAAACCCCAACAAGCTCCAAGCAACGACTCAAGATATCCTTGGGGAAAGTAGGTGTGAAAGAAGAGGTCCTACCAGTCGGCAAGCTCACACAGACGTCAGGGAAGACCACACAGACACACAGAGAGACAGCAGGAGATGGAAAGAGCATCAAAGCGTTTAAGGAATCTGCAAAGCAGATGCTGGACCCAGCAAACTATGGAACTGGGATGGAGAGGTGGCCAAGAACACCTAAGGAAGAGGCCCAATCACTAGAAGACCTGGCCGGCTTCAAAGAGCTCTTCCAGACACCAGACCACACTGAGGAATCAACAACTGATGACAAAACTACCAAAATAGCCTGCAAATCTCCACCACCAGAATCAATGGACACTCCAACAAGCACAAGGAGGCGGCCCAAAACACCTTTGGGGAAAAGGGATATAGTGGAAGAGCTCTCAGCCCTGAAGCAGCTCACACAGACCACACACACAGACAAAGTACCAGGAGATGAGGATAAAGGCATCAACGTGTTCAGGGAAACTGCAAAACAGAAACTGGACCCAGCAGCAAGTGTAACTGGTAGCAAGAGGCAGCCAAGAACTCCTAAGGGAAAAGCCCAACCCCTAGAAGACTTGGCTGGCTTGAAAGAGCTCTTCCAGACACCAATATGCACTGACAAGCCCACGACTCATGAGAAAACTACCAAAATAGCCTGCAGATCTCCACAACCAGACCCAGTGGGTACCCCAACAATCTTCAAGCCACAGTCCAAGAGAAGTCTCAGGAAAGCAGACGTAGAGGAAGAATCCTTAGCACTCAGGAAACGAACACCATCAGTAGGGAAAGCTATGGACACACCCAAACCAGCAGGAGGTGATGAGAAAGACATGAAAGCATTTATGGGAACTCCAGTGCAGAAATTGGACCTGCCAGGAAATTTACCTGGCAGCAAAAGATGGCCACAAACTCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACCAGGCACTGACAAGCCCACGACTGATGAGAAAACTACCAAAATAGCCTGCAAATCTCCACAACCAGACCCAGTGGACACCCCAGCAAGCACAAAGCAACGGCCCAAGAGAAACCTCAGGAAAGCAGACGTAGAGGAAGAATTTTTAGCACTCAGGAAACGAACACCATCAGCAGGCAAAGCCATGGACACACCAAAACCAGCAGTAAGTGATGAGAAAAATATCAACACATTTGTGGAAACTCCAGTGCAGAAACTGGACCTGCTAGGAAATTTACCTGGCAGCAAGAGACAGCCACAGACTCCTAAGGAAAAGGCTGAGGCTCTAG AGGACCTGGTTGGCTTCAAAGAA 1041MKI67 3312509 AACAACAGTTGAAGGCATCCCTGGGGAAAGTAGGTGTGAAAGAAGAGCTCCTAGCAGTCGGCAAGTTCACACGGACGTCAGGGGAGACCACGCACACGCACAGAGAGCCAGCAGGAGATGGCAAGAGCATCAGAACGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAGCCCGTGTAACTGGAATGAAGAAGTGGCCAAGAACGCCTAAGGAAGAGGCCCAGTCACTAGAAGACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACCAGGTCCCTCTGAGGAATCAATGACTGATGAGAAAACTACCAAAATAGCCTGCAAATCTCCACCACCAGAATCAGTGGACACTCCAACAAGCACAAAGCAATGGCCTAA GAGAAGTCTC 1042 MKI67 3312510TGCAAACAGGTCAGGAAGGTCTACAGAGTTCAGGAATATACAGAAGCTACCTGTGGAAAGTAAGAGTGAAGAAACAAATACAGAAATTGTTGAGTGCATCCTAAAAAGAGGTCAGAAGGCAACACTACTACAACAAAGGAGAGAAGGAGAGATGAAGGAAATAGAAAGACCTTTTGAGACATATAAGGAAAATATTGAATTAAAAGAAAACGATGAAAAGATGAAAGCAATGAAGAGATCAAGAACTTGGGGGCAGAAATGTGCACCAATGTCTGACCTGACAGACCTCAAGAGCTTGCCTGATACAGAACTCATGAAAGACACGGCACGTGGC 1043 MKI67 3312511CCCAGTGAAGGAGCAACCGCAGTTGACAAGCACATGTCACAT CGCTATTTCAAATTCAGAGA 1044MKI67 3312512 TGGCCTCTAGATCCTAGCAGGGAGGCCTATGGGTCTCAGGAGCCCGTCACCAGCCTCCGTGCTCCAGAGCTCACGTGTGGGGTC TTGTTAGGAGGACCCAGA 1045 MKI673312513 TAAAAACGTAGTCTTAGATCTTATAAATCTTTTGACTCTACTGTTTTTTACTGTGTTAATGTTTGTTTTGCTAACTTTGTTTATCTGCTG 1046 MKI67 3312514CGCAAACTCTCCTTGTACCATAATAATAGGGAAAGCTCATACTGAAAAAGTACATGTGCCTGCTCGACCCTACAGAGTGCTCAA 1047 MKI67 3312515AGCCTGTGGGCGAAGTTCACAGTCAA 1048 MKI67 3312516CATGGGCAGATGTAGTAAAACTTGGTGCAAAACAAACACAAACTAAAGTCATAAAACATGGTCCTCAAAGGTC 1049 MKI67 3312517AAGAGAGTGTCTATCAGCCGAAGTCAACATGATATTTTACAGATGATATGTTCCAAAAGAAGAAGTGGTGCTTCGGAAGCAAAT 1050 MKI67 3312518AAACAAGAGTCAGGTTCAGAAATCCATGTGGAAGTGAAGGCACAAAGCTTGGTTATAAGCCCTCCAGCTCCTAGTCCTAGGAAAACTCCAGTTGCCAGTGATCAACGCCGTAGGTC 1051 MKI67 3312519CCTTTGAAAAGAAGGCGTGTGTCCTTTGGTGGGCACCTAAGACCTGAACTATTTGATGAAAACTTGCCTCCTAATACGCCTCTCAAAAGGGGAGAAGCCCCAACCAAAAGAAAGTCTCTGGTAATGCA CACTCC 1052 MKI67 3312520GGACAGATGTGCTCTGGGTTACCTGGTCTTAGTTCAGTTGATA TCAACAACTTTGGTGATTCCATT 1053MKI67 3312521 TTGAGAGGAAGATCCAAAAGGATTCCCTCAG 1054 MKI67 3312522GAAGCTTTCAACTAGAAATCGAACACCAGCTAAAGTTGAAGATGCAGCTGACTCTGCCACTAAGCCAGAAAATCTCTCTTCCAAAACCAGAGGAAGTATTCCTACAGATGTGGAAGTTCTGCCTACGG AAACTGAAATTCACAATGAGC 1055MKI67 3312523 CCAGCGTTAAATTAGTGAGCCGTTATGGAGAATTGAAGTCTGTTCCCACTACACAATGTCTTGACAATAGCAAAAAAAATGAATCTCCCTTTTGGAAGCTTTATGAGTCAGTGAAGAAAGAGTTGGATGTAAAATCACAAAAAGAAAATGTCCTACAGTATTGTAGAAAATCTGGATTACAAACTGATTACGCAACAGAGAAAGAAAGTGCTGATGGTTTACAGGGGGAGACCCAACTGTTGGTCTCGCGTAAGTCAAGACCAAAATCTGGTGGGAGCGGCCACGCTGTGGCAGAGCCTGCTTCACCTGAACAAGAGCTTGACCAGAACAAGGGGAAGGGAAGAGACGTGGAGTCTGTTCAGACTCCCAGCAAGGCTGTGGGCGCCAGCTTTCCTCTCTATGAGCCGGCTAAAATG 1056 MKI67 3312524AGCCAGCACGTCGTGTCTCAAGATCTAGCTTCT 1057 MKI67 3312525GGCTCTCAGATCCACCCTAAGTATCCACCAGCCAAGAGGGCGCACATGCCAAGTGGAGCCTCAGTTCATCGACAGGTCCTATGGCCCATTTATGAGAAAACTGATGACGCAGTCAGTAGTTCTGA 1058 MKI67 3312526TTCAGAATGGAAGGAAGTCAACTGAATTTC 1059 MKI67 3312527CCAACACAAGTAAATGGGTCTGTTATTGATGAGCCTGTACGGCTAAAACATGGAGATGTAATAACTATTATTGATCGTTCCTTCAG 1060 MKI67 3312528TGTGACATCCGTATCCAGCTTCCTGTTGTGTCAAAACAACATT 1061 MKI67 3312529GGCTCCTTGTGGCAATAGGAAAATGGGACAGAAAGTCTTCCTGCCTGGAATTCGAGAACGTTTCCTCTTATATTGCTGTCCTGTTT GGTGG 1062 MKI67 3312530CCTGAGCCTCAGCACCTGCTTGTTTGGAAG 1063 MKI67 3312531CCCACGAGACGCCTGGTTACTATCAA 1064 MKI67 3312532TTTGCTTCTGGCCTTCCCCTACGGATTATACCTGGCCTTCCCCTACGGATTATACTCAACTTACTGTTTAGA 1065 MKI67 3312533GACTCGGTGGGAGCCGCTAGAGCCGGGCGCCCGGGGACGTAGCCTGTAGGGCCACCGGGTCCCCGTCAGAGGCGGCGGCGGGAGCAGCGGGGACTGCAGGCCGGGGTGCAGCGAACGCGACCCCGCGGGCTGCGGCCCGGTGTGTGCGGAGCGTGGCGGGCGCAGCTTACCGGGCGGAGGTGAGCGCGGCGCCGGCTCCTCCTGCGGCGGACTTTGGGTGCGACTTGACGAGCGGTGGTTCGAC AAGTGGCCTTGCGGGCCGGAT 1066GLYATL1P3 3331888 ATGGCTCTCTGTTTCACATCAATCACGGGAACCCCTTCAACATGGAAGTGTTGGTGGACTCCTGGCCCGAGTATCAGATGGTTAT TATCCGACCTC 1067 GLYATL1P33331891 TGCGTTACATCAAGCGCTGCCTAGGAGCCCTGCCAGCAGCCTGTATGCTGGGCCCAGAGGGGGTCCCGGTCTCATGGGTAACCATGGACCCTTCTTGTGAAATAGGAATGGGCTACAGTGTGGAAAAATACCGAAGGAGAGGCAATGGGACACGGCTGATCATGCGATGCATGAAGTATCTGTGTCAGAAGAATATTCCATTTTACGGCTCTGTGCTGGAAGAAAATCAAGGCGTCATCAGAAAGACTAGTGCACT AGGTTTCCTTGAGGCCTCC 1068GLB1L3 3357343 ATGGACGATCTAGGAAACTTTCAGGGAGCTAAGGTGTCGGAG AGCAAAGTATCCTT1069 GLB1L3 3357345 GTCCCGCTACTTCGTCACCAAAGCGCCCGCCGCGCTCGCATCTGCTGTGAGGCTGTGCTCGGGCCGCTCCCGCCGAGGGAACGGCCCTCCCAAGGCTCTGCGCCCCAATTCTCGCTCGTTTGCCA AGA 1070 GLB1L3 3357347TGTCGACCCAGGTTAGGAAGCCCGAGGTCGGGGCGTTACCCCAAGGGCCCTCCCGCTTCCCCTCCGAGGGCAGAGAGGCGTCCGCGCCCGGACGCACTGCGGGAACACCTGGAGCGCCGGCGGAGCTCGGCTGTCCCCGCGGGAGGGAGCCCGACGCGCATCCTTGGGACCCGGACCCGGCGCCCGCGCCTCGGGACGGATTTCTGCCTCGGCTGCAGGCGCAGCGCGCAGACCTGAGCCT 1071 GLB1L3 3357348CCTGGAAGAGAATGGCGGGCATCTTTTTCCTGCCATTTATCTCATCAGGTTTTGCTCCTCGGTTTAAGCAGGAAGAGAACTTCATG CTTGGAAGAGCGCATCCG 1072GLB1L3 3357349 GCTGAAGAATCGATCTGTGGGACTTGGAACTGAAAGCACAGGTCGGGGTAAGCCCCACTTCACACTGGAGGGCCACAAGTTCCTGATCTTCGGGGGCTCCATCCACTATTTCCGGGTGCCCAGGGAGTACTGGAGGGACCGCCTGCTGAAGCTGAAGGCCTGTGGCTT CAATACTGTCAC 1073 GLB1L33357350 ATGTTCCGTGGAACCTGCATGAGCCAGAAAGAGGCAAATTTGACTTCTCTGGGAACCTGGACCTGG 1074 GLB1L3 3357351 GCTACTGGGGGTGGATTAGCAACCAAA1075 GLB1L3 3357352 CCCGATGGGGCTGTGCAGAGGCTCTGAGGCTGGGAGCAGCTCAGGCCACCGACCTG 1076 GLB1L3 3357353CCTCATCCTGGGCCGTCGTGGGAGGGGCTGACGATGTGGAC CTCCCTAG 1077 GLB1L3 3357354CCTTCGTCCTGATGGCCGCAGAGATCGGGCTGTGGGTGATTCTGCGTCCAGGCCGCTACATCTGCAGTGAGATGGACCTCGGGG GCTTGCCC 1078 GLB1L3 3357355CTGGCTCCTGCAAGACCCCCGGTTACTGTTGAGGACAACCAA CAAGAGCTTCATTGAAGCAGTTGAGA1079 GLB1L3 3357356 GCGCCCAACAGCATTGCCTTTTTTATGGTGTACCCAGACCTCATGCACTTGATAAGAAACGCCTTCATTTTTACCATGGCAACCTA GAGCACACAGTCA 1080 GLB1L33357357 AGAAGCACAAATGCCGTTCACAGGCACATGTATGCAACGAGGAAAGCTAATTTACAGGCATCCCATTGAACTGTGGGAAATGCTA GGAAACTTTT 1081 GLB1L33357358 TAAGTGAAATGTAATGCCCCATACCTCGCATACCTTGCACTAA TTT 1082 GLB1L33357359 TCATCGCGGTGCAAGTGGAGAATGAGTATGGCTCATTCA 1083 GLB1L3 3357360AGAAGAGGGATTGTGGAGCTTCTCTTGACCTCTGATG 1084 GLB1L3 3357361GTGAGAAACATGTGCTGAGTGGCCACAC 1085 GLB1L3 3357362AGCCAGCCCGTGTAAATCTTGAACACACTGCAGAGAAAACCAAGTGCATCTCGATACCTCCCTTTCCCGTGTCCACTGGGATGGATCCTGGAGTTCGATGTTACAATAAATGAGGACTCAAGGTTAAGGCTCAGGGCCACTCACAGCTCCCTATCTTGGCCTTGCTCCTGCCGTCTTTAAACACAGCAGCACTGGAGCTCCTCTGTTCTCAGGACGCCTTTCCATCTCCCATAGTTTTTCTGTGGCAAGAAATCTGCATTGGTGCTGCGCCTGGCTTGGGATCAGGGCCATCTCCACTA ACTTGGGAAA 1086 GLB1L33357363 TGTTGGCCGCCATCAATTTGCAAAAACTTCACCAGGATACTTT CAATCAGCTTCATA 1087GLB1L3 3357364 CTGGTATTCCGTGAAAACAGGTTTGACAAGAAGACCGCAGGTT TTCACC 1088GLB1L3 3357365 GGAGGAGGGAACCCTGCTTGTGTCACCTCCGCTTGTGGATCACGTCATGGAGATGAGTGGG 1089 GLB1L3 3357366ATACTGTCTTGGAGATCAGCCTGCCTTTCATTCTGCTAGGCCATGTGGGATTTTGTGTTCCCCTCGTCTGGAGTTAGGCTGGTTGTGGGGTTTGTTGTTGCTGTGTTATCCTTTGTGCATCATGGGCTTCAAATGTTTCTGGTGGTACCTTGTGTCAAGGGCAAGTGCTGGTTTGGCAGAGGTTGTTTTCTCTGTGTCTGCATTCCCCTCTGAGTCTCGCCTTTGCATTGAGTCCCACAGAGAATCTGTTGCTTGCGG ATCTCTCAGCTATAGTATG 1090GLB1L3 3357367 CTCTCAGATGCCTCACAAGCAGCAAC 1091 GLB1L3 3357368CCATAATTTTGTCCTTCTAAGCTTCTGATGCACTGAATTATGTAAAGTGCATTCCCTTCACCAGCTTGTGCACCCTATTCTGTAACT GATA 1092 GLB1L3 3357369CCTTCTGATTATGGAATACTGGGTCGGCTGGTTCGACAGATGG GGAGATAAGCACCATGTTAAAGATG1093 GLB1L3 3357370 ACATGCTGTGTCTGAATTCATCAAATATGAGATCTCCT 1094 GLB1L33357371 CTTTGGTTTCATGAACGGGGCCACATATTTCGGGAAGCACTCG GGCATTGTCAC 1095GLB1L3 3357372 GTCGCTGGTGTAGTAGCCTCTCCAGC 1096 GLB1L3 3357373GAGGCTCCGGAAGCCTGTTCTGGCACCACTGGGTTCTTGA 1097 GLB1L3 3357374CCCAACAGGCTGTCATTGCAGTAGACAGGGCTTTCCGGGACTTAGAGCTCCGCTTCACACATCTGGTATACTGCCCTGTTGGCTTGAACCTCTGAAGAGAGGCAGGGTAGGAACGGTGACTGCTGTAAAGGCACAGACCTGCACGGCCGGGCGATACAGACTGAGCAAAGAAAAGAGTACCCGTTGAAGGGGTGTCCACTCTTTTGGCTTCCCTGGGCCACACTGGAAGAAGAAGAATTGTCTTGGGCCACACATGAAATACACTAACACTAATGATAGCTGATGAGCTTAAAAAAAAAACACAAAATGTTTTAAGAAAGTTTATGAATTTGTGTTGGGCTGCATTCAAAGCCATCCTGGGCCGCCTGTAGCCCATGAGCTGTGGGTTGAACAAGTTTGCATTAGAAAGTGAAGAAGTGGGGGCAAGCCCAGTGTCATGGCTTGACACTGGAAGCCAGTGGAAGGTGCCCAGGAAGAGTTGTGGGGAATGTCCTTAGACTGGCATC 1098 GLB1L3 3357375GCAGTGCTCACGGAGGCTGGAGATTACACA 1099 GLB1L3 3357376GTACTCAGCACCCATTTAACTTACGGGCCAGCCCTCCTCAT 1100 GLB1L3 3357377TGTGGGCAGCAGTTACACCAAGCTCCTGAGAACAAGGGCAACCTTAACTTCGAACCCTGGGGTTAAAATCTGTGTGATTTTTTAAAATCAGGGTTTCTAAGCATTTTATAAGCCTCAGTTTCTTCACTGAAGCATAAAGATAGTAACCTTGGTCTCCTGTGATGACTGCGAAGATTGAGTTACTCTTTGTAAAGCTCTTATACCATGGATGACATAG TA 1101 GLB1L3 3357378AAGGCTGTGTATCCCCCCGTGAGACCGTCGCTGTACCTCCCG CTGTGGGACGCCCTATCCTACTTAA1102 GLB1L3 3357379 GACTGTGTGGTCCTTACGGAATCCACGTAGGAAAAGCTGCTGAGCTGGAATCGGGAGACTAGCTTCTGCCCGTGCTTCACCAGCAGCTGGGCCTGAACTTCCTGGGTCACTGCTCCCCCTTTTCCATCAGCCTTCCTGTCCTATTTTGAAGAAAGGTGAAAGCTGTTTGGAACTGAAACTGTAGCCCTTGGATTCACATTGGTTTTACCTCTGCTATCACTATTTTAGAGAAAAGGTAGTGACTGGTACACTAAAGAAACTACATTTATTTAATGTAACTAAATTTAATTTAATGAAATAAACATTTGCTTGGTGCCTCATTCATTGCTAGACTTCAACTATTTTAGAATACAATTTATTTACTCTTTTTTTTTCTTGAGACAGGGTCTTGCTTGGTGGCTGTGGCTGGAATGCGGTGGCACAATCATGGCTCACTGCAGCCTTGAACTCCTGGGCTGAAGCAATCCTCCGGCCTCAGCCTCTTGAGTAGCTGGGATTACAGGAGGGCACCACCACGCCCAGCTACATTTTTAAGTTTTTTGTAGATGTGGGTCTCACTATGTTGCCCAGGCTGCTCTCAAACTCCTGGCCTCAAGTGATGCACCTGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCTGCGCCCCATCCATTTCCTCTGTTAATCAGTTCTTAGGATTATAACGATTGCTCCCTCATCACCATGCCCTGCATTTCCCTGAGTTTCCTTCCTGGGCAGTGGAGACGTAAGCACAGAGCAGTGTC ACATGGCATCTGTTTC 1103 GLB1L33357380 CCAGTCAGGTCGCGTCAGCCCGTCAAC 1104 GLB1L3 3357381GCGGCCAGTCCTACGGGCTTGTCCTGTATGAGAAGTCCATCTGCTCCGGAGGCCGCCTCCGTGCCCACGCTCATGACGTGGCA CA 1105 GLB1L3 3357382GTTTTTGGATGAGACAATGATAGGGATTCTGAATGAGAATAAT AAGGACCTGCACATTCCTGAACTCA1106 GLB1L3 3357383 CCTGGTGGAGAATCAAGGACGAGTCAATTTTTCATGGCAAATA CAGA1107 GLB1L3 3357384 TGTCAGCATCAATAACTCTTCCCTGGAGGGCTTTACCATCTATT CCCTG1108 GLB1L3 3357385 CAGGGCCCGGCCTTCTACTGTGGGA 1109 GLB1L3 3357386TTATGGATTTGTGTTCATCAATGGACGTAACCTTGGGCGATATTGGAATATTGGGCCTCAGAAAACACTGTACCTTCCTGGAGTTTG GCTTCATCCAGAAGACAATGAG 1110GLB1L3 3357387 AAGATGATGAGTGGCTCAGATATCAAATCTACAG 1111 GLB1L3 3357388CCACTCCCGGCCGTGAACATATTTTTTGGGTTGCTGGAGTTCATCTATAAGTCATTTTTGAGGAATAAGATTTATGTTAAGACTATCAAACACAGTGTTGCCTACAATAGCAAAAATGTGAAAATAACAACAACAACAAAACAGCAGAGGAATTGTTATGTATTTTGTAGTCTATCTATATGATGCCTATTTTTAGGCTTTAAAAAGTCTTCAAAATCTTTAATGACTGATTTATCTAGTTAAATGCTTAATCCTTAGCAGGCTCTTATTCTTTAATTAAACGTGCCTTTGAGTAGATGTG 1112 GLB1L3 3357392GGTCACCGAAGCTTCTCTGAAAATGTGACATCTCTGAGGAAGGTGGAACATTAATCATCTCTAGCAGTGCATAGGCCCTCTCTATGGCATTGTCAACTAAGCACTAATAATAGTCAGGGGACAACATGCAGCGATAGCCAAGAGCATGGATCTTGGAGCCAAAGAGATCAGGTTTTAATCTCAGCTCTGCAGCGCTAGCCATGCGCTAGCTTC ATGCAGGCTTCCTTCA 1113 GLB1L33357393 CCACTATCACCACCATCACCATCAA 1114 GLB1L3 3357395TGAGATCTCATAAACTTTCAGATCAAAAT 1115 GLB1L2 3357398AGCCGCGAGCCCCAGCCAATGAGCGCCGGCGGGCCGGTTGCCCAGGCGACCAGTGCGCGGCTCCGCCCCCCGCGGCGAGGCTCCCGCGCGCGGCTGAGTGCGGACTGGAGTGGGAACCCGGGT CCCCGCGCTTAGAGAACACG 1116GLB1L2 3357399 CACGTGGAGCCTCCGGCGGAGGCCGGCCCGCACGCTGGGACTCCTGCTGCTGGTCGTCTTGGGCTTCCTGGT 1117 GLB1L2 3357400CCCTCCAGCCGTCAGAGCCCTCTCAGACGCACCCCATCGCGG CCCCGTCCCCACTGCTCCGCGGAGAGCTC1118 GLB1L2 3357401 CCTCTGGGAGGCGCCTTATTCCGCAG 1119 GLB1L2 3357402TGACCCTATCTTTCAGGTCAGCACTTTCCATATTCAAAACCTCCAGTGGGAAGCCGACCGGCAGTATCGAATGAACTGA 1120 GLB1L2 3357403CAGGTAGAACAGAAGCTCAAGGAGCTCTGA 1121 GLB1L2 3357404CGGCGGTCATCGTACTCCGGATGTTCACGGCACTCCGGATGTTCTGCTGTGCCCGGTTGCATGGATCCTGGCCTATCTGTGTCTG GTCATACTCTGCATGGCA 1122GLB1L2 3357405 TGCCGAGAGGCGCTTTCTCGCGGACCGGAGCCTTCGACGGC C 1123 GLB1L23357406 TGAAGACCTGGAATCGGGTGGATGGGTGGACGCCGCCAACG CAGAC 1124 GLB1L23357407 TCTCTGCTCCTGCGGTCGGGCGGCTGCGACCGTGCCGGGGCTCGGAGGTACCGTGTGAAGTCGCTGTCGCGCGTGGCCGC 1125 GLB1L2 3357408CCTCCATGCCGAGTGCTGTGCTTGCTGCCGGCTGCAGCCTC 1126 GLB1L2 3357409GGCGGAGGGGAGCTTTTCCCAGCCACCTGGACGCAGGCGCCCTCGAGAGAGAAATGCCGAGGACCTGCGAAGGGGCGAGGAA GCCGATCTCTCTGCGGCCCGGAG 1127GLB1L2 3357410 TCCCTCTGCGGCTCCGCCATCGACAGCTGGGGCTGCAGGCCAAGGGCTGGAACTTCATGCTGGAGGATTCCACCTTCTGGATCTTCGGGGGCTCCATCCACTATTTCCGTGTGCCCAGGGAGTACTGGAGGGACCGCCTGCTGAAGATGAAGGCCTGTGGCTTGAACA CCCTCACCA 1128 GLB1L3 3357411ATGTTCCGTGGAACCTGCATGAGCCAGAAAGAGGCAAATTTG ACTTCTCTGGGAACCTGGACCTGG 1129GLB1L2 3357412 CACCGACCTGGTGTGGGAGTCCCCG 1130 GLB1L3 3357413CCTCATCCTGGGCCGTCGTGGGAGGGGCTGACGATGTGGAC CTCCCTAG 1131 GLB1L3 3357414CCTTCGTCCTGATGGCCGCAGAGATCGGGCTGTGGGTGATTCTGCGTCCAGGCCCCTACATCTGCAGTGAGATGGACCTCGGGG GCTTGCCC 1132 GLB1L2 3357415GGCAAAAAGCTCACAGACATAGGTCTGGTTTGTTTCTGTGTTCCAGTTCCCATTCTGTACTGAATTGTGTTCCAGTTCCCATTCTGTACTGAATTTCCTTTTCAGGAAAAGCAGCACCCAGAGGGGATCGCTTTCAGTGATGCTGCAGTGAGTGCCCTCACGTAGCCATGC ATG 1133 GLB1L2 3357416GGGGCATAGCTTCTGTCTCCACTACCCAGGGCCACTTCTCAG GCACTGATCCATCCAGCC 1134GLB1L2 3357417 CCTGACCCTGTTTAGGACTTCCAGACCAGGGCAAGAGGAGCCTCAGAGCCTTTTGTTAGAAAATATGTGTCTTCTCAGAACCTGAAGTGAGAAGGAAGAGCCCTGACTCCAGCTTTGGAACCAATCCACGCTGCTGTGTTCCTCTGGGGAGTTTGGGATCATAGCAACAGGGTGGAGGGAGAATTCAACTCTTGCTCACCTGCTGCTCTGGGCTGTGCGCCACTGATGCCAAGGCGTTAGCCACGTTGGCAAGGATGGGGACTGCCTCCTGCTCAGCCCCTCGCAGTCTCTGTCAGGCTTGTTTTTTGGGGTGACGCTAGAAGGTTGTGTCTCCTCCTTCCACAGCCTCAGTGATTCCTAACCCTTTTGACTTCACTTTTTGAAATGGGATCACAGAGCAAGTTGTTGAAAACTAGGCCTGGAGT CCTGTGAAAAGCTTTTC 1135 GLB1L23357418 GGACAACTTACAAGGGCTTCACCGAAGCAGTGGACCTTTATTT TGACCACCTG 1136GLB1L2 3357419 ACAAGCGTGGGGGACCTATCATTGCCGTGCAGGTGGAGAATGAATATGGTTCCTATAATAAAGACCCCGCATACATGCCCTACGT CAAGAAG 1137 GLB1L2 3357420ACCGTGGCATTGTGGAACTGCTCCTGACTTCAGACAACAAGG ATGGGCTGAGCAAGGGGATTGTCCA1138 GLB1L2 3357421 GTAACTGCACTTGTGTTGGGCCGTGGGGGCTGGCGGCGGCCCTGGGCTGGCTGTGCACGCTCCCGCTGTGGG 1139 GLB1L2 3357422TGTTCTCAGCATATCAGCCTCCGTGTGCCTCTGAAAATGTCGTCCAGATTACCCTATCCTGCTGAACGCCAGGCATCTCTGTCACACTCAGAGTGAAGCGCAGGTTCTGGGAATGACCTCGAAAGGCCTCTCCACTTGGCCTCCAGGACCTAGCTGAGCTCACCTCCTGCTCCTTCCCTTTGCTCACACCGTTTCACCCTCTTTACTGTTCCTCCAACATCCAGATCCCCAGCCTGGGGGGCTTTGCTCTTCTTCCAGAGAGCTACATGGCTGTTCTCCGAAGTTAGCGAGGCTTTCTGT AGCACCACACTTG 1140 GLB1L23357423 GTAGTTTATTTATGTCATTCATCTGTTTCACCCAGCAGTACTCT TGGCGGGGCTT 1141GLB1L2 3357424 AGCAGCGCCTAGCTGGCACCCAGGGAGTGAAGGTCCATGAATGGCGAGGAAAAGGCTTTTGTCCCCAGGCAGAGTCAGTCAAGGACCCAGACCTCGTGTCTCCGGCATGGGGAGGACCAGCAGTG ATCCCCACGGCT 1142 GLB1L23357425 CTCCCGGTTTCAGGCCTTGCAAGGAAGCCCGGGAGCCGCCACTGCTTTTCCCTGTGGCCCTCCCACCTCCAGGCACCCACCTGCGTGCCCCTGTTGCCACCTGCTGCCCGGAATAACTTCTTTTTTTTTTTTTTAATTAAAAAAATTAAATGGTCTAAAAGTGAAATAATCGAAAATGTTGGTAGAGAAATACAGTGTTGCCTACTCTTCGTTACATTCTCCAGAAATGACCATTTTCAACTCTTTGACTTTTTCTTTGGATATTTTCCTTCTTATTTCCAAATACTGTGAACATACAGCCCTGCATCGTTTGCTTTAAAAGTTCTGCCTATTGGCCGGGCAGTGGCTCAGGCCTGTCATCCCAGCGCTGTGGGAGGCCGAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACCAGCCTGCCCAACATGGCGAAACCCTGTCTCTACTGAAAATACAAAAAATTAGCCGGGTGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGCTGAGGCAGGAGAATCCGTGAACCCGGGTGGCGGAGTTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGACGACAGAGCAAGACTCCGTCTCAAAAAAAAAACAAAAAACAAAAAACATTATCCGAGCGTGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAATGTGAGAGGCAGAGGTTGCAGTGAGCCCCGATGGTACCCCTGCACTCTAGCCTGGGTGACAAGAGCAAAACTCCGTTAAAAAAAAAAATTCTGCCTATTGACTTCTTGTTCCAGTAGGTGATGAGTGTTCTTTCCTGCCAGCATGGCTGTTCAGCCCTGATAGGCGCCAGCGTGGGCCTCGCGGATGTG TATGACAACG 1143 GLB1L23357426 CTGCTTGGCTGCATCCCGCGTGGAATCCTGCTTCCTGGAGTTCCAGGAAACAGGATGTTTCTTGGTGCTCCGTGGCTTCCCG 1144 GLB1L2 3357427ACTCCGGCTCCCGAGCGTTTCCTGGGTCTTCTTCCTCCTCGCCCCCGGCCAAGTTCCTCAGGGAGCCCGCCCTCCCCTTCTCGTGCTGCTGCGCATCCGGGGAGCGGCCCAGTTAC 1145 GLB1L2 3357428CAGCTCGGGCCCAGGGTTCTCAGGCAGG 1146 GLB1L2 3357429TCTTGGCCACCATCAACTTGCAGTCAACACACGAGCTGCAGCT ACTGACCACCTTTCTCTTCAACGTCCAG1147 GLB1L2 3357430 CTGCTCAGCGGCCTATGGGAATTCTGAATGCCTGTCAGCGTGCTCAGCTTCCCCAGCGCAGGGAGCTGGACTCAGGGCTGATGGCCTCTGGCCCCCCGCCCATGCCACTGTGTGCCTGCAAGGCCCGCTGCCCAGAAACACCTCTGAGGGCTGCTGTGTAGGCTGATGCAGTGTGGACATCACCCACTGCCCTGAGAGAGGGGCCCTTTTGGTGCACTCCTAGAGGACTCGACTTTTGTGGCCTCAACTAGCTCCAGACTTGCTCCCAGGGATTGAGGGGGGAAGGAAAAACTTCCCTGTCCTATACTACACAGGCATCCGACCTTAACCTGTGAGG 1148 GLB1L2 3357431CTCTGGGCTTCTGCAAACGTGGCAGAGTGGAGCATGGTCCCA GGAATGATCTTGGCCTCCTTGGG 1149GLB1L2 3357432 CAGAACCTGCACCATGAATAGCTGTGC 1150 GLB1L2 3357433AACTGGTGTGCAGGCGAATTTGGCCCTCACCTATGCCC 1151 GLB1L2 3357434ACTGGACGGGGTGGTTTGACTCGTGGGGAGGCCCTCACAATA TCTTGGATTCTTCT 1152 GLB1L23357435 GTTTTGAAAACCGTGTCTGCCATTGTGGACGCCGGCTCCTCCATCAACCTCTACATGTTCCACGGAGGCACCAACTTTGGCTTCAT GAATGGAGCCATGCACTTC 1153GLB1L2 3357436 CTTCGTGTCTTTGGCAATAGAGTACCT 1154 GLB1L2 3357437CAGTCATGTTACACTCCCAGAGGAGGGA 1155 GLB1L2 3357438ATGCTGTGCTGACAGAAGCCGGCGATTACACGGCCAAGTACATGAAGCTTCGAGACTTCTTCGGCTCCATCTC 1156 GLB1L2 3357439TCTCAGACCCCTAAAGAGTTACTTCCTTACTGTCCCACCTCGACCCCAGTTGATCTGCGTGCAAGAATATCCTAGACA 1157 GLB1L2 3357440ACCTTCTTCCCAAGATGCCGTATGAGCCCTTAACGCCA 1158 GLB1L2 3357441CTCTGTGGGACGCCCTCAAGTACCTG 1159 GLB1L2 3357442GTGAGTGCTGTGGGCAGTCATCGGGAG 1160 GLB1L2 3357443AACCTGCCAGTCAATGGGGGAAATGGACAGTCCTTCGGGTACATTCTCTATGAGACCAGCATCACCTCGTCTGGCATCCTCAGTG GCCACGTGCATGATCGG 1161GLB1L2 3357444 GTAGGAGCTTCTCTTCTAAATTCCTGTGACCTTCTG 1162 GLB1L2 3357445GTGTTTGTGAACACAGTATCCATAGGATTCTTGGACTACAAGA CAACGAAGATTGCTGTCCC 1163GLB1L2 3357446 GGTTACACCGTGCTGAGGATCTTGGTGGAGAATCGTGGGCGAGTCAACTATGGGGAGAATATTGATGACCAGCGCAAA 1164 GLB1L2 3357447AATCTAGCTAAATGTGGGTGGTTTCA 1165 GLB1L2 3357448TTAATTGGAAATCTCTATCTGAATGATTCACCCCTGAAAAACT 1166 GLB1L2 3357449CTGGCCCGCACCCAGGTGTGAACGCCTCCAGGGGCCAG 1167 GLB1L2 3357450GTTCGGCCTGGACAAATGGAGTTCCCTCCCAGAAA 1168 GLB1L2 3357451ATGAACACCCTTCCCCTCTGTTTCAA 1169 GLB1L2 3357452TGGCCAGAACCTTGGACGTTACTGGAACATTGGACCCCAGAA GACGCTTTACCTCCCAGG 1170GLB1L2 3357453 CCTGTTCCCCATGACGCCCTGCCCACCTGCCGTCCCAGGGAG CCTTCG 1171GLB1L2 3357454 GACAGACGTCAGCTGCCCTCCCAGCCGGGCCCTCTCTCCACA 1172 GLB1L23357455 TCATCGTTTTTGAGGAGACGATGGCGGGCCCTGCATTACAGTTCACGGAAACCCCCCACCTGGGCAGGAACCAGTACATTAA 1173 GLB1L2 3357456TGCCAGTGGGAGACTGCCGCCTCCTCTTGACCTGAAGCCTGGTGGCTGCTGCCCCACCCCTCACTGCAAAAGCATCTCCTTAAGTAGCAACCTCAGGGACTGGGGGCTACAGTCTGCCC 1174 GLB1L2 3357457CCCTGCTCTTGTGCCGAGGCTGTCGGGCTGTCTCTAGGGTGG GAGCAGCTAATCAGATCGCCCAGCCTTTG1175 GLB1L2 3357458 AAAAGTGCTGAAACGTGCCCTTGCACTGGACGTCACAGCCCTGCGAGCATCTGCTGGACTCAGGCGTGCTCTTTGCTGGTTCCTGGGAGGCTTGGCCACATCCCTCATGGCCCCATTTTATCCCCGAAATCCTGGGTGTGTCACCAGTGTAGAGGGTGGGGAAGGGGTGTCTCACCTGAGCTGACTTTGTTCTTCCTTCACAACCTTCTGAGCCTTCTTTGGGATTCTGGAAGGAACTCGGCGTGAGAAACAT GTGACTT 1176 GLB1L2 3357459GAAATCCTCACCCTGCGTCTTCCCAAGTTAGCAGGTGTCTCTG 1177 GLB1L2 3357460GTGAGTCCTGGCAGAAGCCATGGCCCAT 1178 GLB1L2 3357461CCCAGCTCACATGTGAGTCCTGGCAGAAGCCATGGCCCATGT CTGCACATCCAGGGAGGA 1179GLB1L2 3357462 GTGAGTCCTGGCAGAAGCCATGGCCCAT 1180 GLB1L2 3357463TCTGCACATCCAGGGAGGAGGACAGAAGGCCCAGCTCAC 1181 GLB1L2 3357464GTGAGTCCTGGCAGAAGCCATGGCCCAT 1182 GLB1L2 3357465TCTGCACATCCAGGGAGGAGGACAGAAGGCCCAGCTCACA 1183 GLB1L2 3357466AGAGCAGCCCTCCTTCGAAGTGTGTCCAAGTCCGCATTTGAGCCTTGTTCTGGGGCCCAGCCCAACACCTGGCTTGGGCTCACTGTCCTGAGTTGCAGTAAAGCTATAACCTTGA 1184 GLB1L2 3357467AGCTGTGTATGAGCTGGTTCCGTCAGAAAGTGATGGAATGGAAGGGAACCTTCCTGCAAATCCTCCTGTAAGGTGGAGAAGCCC CTTGGATCACACTTCCACGCAGACCTG1185 GLB1L2 3357468 AGCAGGCTGAGCAACGCTTGTTCCGCCTGGTGGAGAGTTCGTTCTTCTTGGGCCCGGGGAGCTGCATGTCAGGGTGTTGCTGCTTCGCTCAAGGGTCACTTATCACGGAGGCCTCTGTGGTCACCC TACAGAGCACTGAC 1186 OR51A6P3360298 TGATGTTTTCTTGCTAGTGCCACCTCTTATGAATCCCATTGTAT ATTGTG 1187 OR51A6P3360299 CTTCTATGCGCCCGTCATTGCTTTGGCAT 1188 OR51A6P 3360300AAGCTGGCCTGCTCCGACAACACTGTCAACTTCTTCTATGGTTTCTTTCTTGCCCTCTGTATGATGTCAGAAAGTGTGTTCATTACTGTGTCTTATGTGCTCATCCTGAAGACGATCATGGGAATTGGAT CCCATAGGGAGCGGCTCA 1189OR51A6P 3360301 TGCTGTTAGTACTCCCATTTCCTTTCACTCTTACAAGGTTGACATATTGTAGGAAAAGCCTACTCTCTCATTCCTATTGTCTCCATCA G 1190 OR51A6P 3360302TTTTGACCGGTTTTGGCCATATGCCACCCTCTGAGGTACATATCTGAGGTACTGGTGAGCTGTATCCTCACCAGTGCCAGAGTTG CCAAAATG 1191 OR51A6P 3360303TGGAGCATGCCCATATATGGATATCTGTCCCCATCTGCCTCATGTACTTGGTAGCCATCCTAGGCAATTGCACAATCCTCTTTGTTATCAGGACTGAGCCCTCACTCCATGCACCCATGTACTATTTCCTTTCCATGTTGGCTGTCTCTGATCTGGGCCTGTCCCTCTCCTACCTACCCACTATGCTGAGGATCTTTGTATTCAATGCCACAGGAATCTCCTCAAATGCTCGCTTTGCTCAAGAATTCTTTATTCATGG ATTCACAGATATGGAGTCCTCAGTG1192 FTH1P2 3375656 AAGCTGCAGAACCAACGAGGTGGCCGAATCTTCCTTCAG 1193 RP11-3377879 AGGTGCTGGTCATCATTCTGTCCCATTTTTTGCCACTGTGCTA 770G2.5AGGCTTTTGACTCAACCAAGAAAAGGGCCGGTCTTCCAGCCTGGCCCTGCAAGAGTGTCCTAGTGCTTCAGGTAGTGGATGGGCATCGTCATTCGTCCCACCTTCCTGCCCCCTAAAGCCCCAGGAGGACACACTCTCAGCATCAGGCCAGCTCTCCGGGTCACTGGGGCTTGGCTCAACAGGATGTGCAGGGCAGAGCCGGGAGGGAAGAGCAGAAGATGCCATGGGCTGTTCGCAGGAGCAGCCGTCCAGGGCGCCGCTGGAGGAAGATCTTCTAGTGGCTGTCTCAGCA CGTACAAAGAA 1194 RP11-3377880 CAGAGCTTCATGACGGCCTCGGATTGGCAGTCAACCCAGGGA 770G2.5TACAGAAATGTAAACAAAAACAGAGCTTCCAGATAACATTACTGTGTGCTATGTGACTTTCAGAATACAGCAGCGTCCCAGACACTCTAAAGTCAAGTGAAACAAGAGATTTTAGAATCAATCTATACAC ATTTCAGAGGGCAGTCCAGG 1195SESN3 3387255 TCTTCTCTCCAGCTAGGTGCACTTGAGGTTGTTCATAAATGTAAAATTATGTCAGGTTTCTAACATGGGACACTGCACACAGTTGTCTGACCTGATGAACCATCCCATTTGAAAGTATAGATTATTATTATTTCTTGTAGTATTTGGTTGTTTTCCATCTCATTCATGAACAACTCAACCTGATAGTAGTATCCAATAAATGCCTTTCAGGGCTCAGGAATGAATTGACATCCTAGTTAAGAAATGAGACTTAATAATGGAGACTGAATGAGGCGGTTTGTATTAAATTATATGCCATGAAGTGTTCATTTTAGCTTTAACCTAATTATGACTGTACCACCATGAAGTACAGAATGAAAAATTATATATATGGGGGGGAAACAGAATGAATATCTGATTCTTTTGAATGCTTGTGGAAATCTTTGAGATCGTGCAGGGCATACCACAAAATAGCCTTTAGAACAGATACCCAATTTTACAGTTCATAGGACAACATCAAACATTAGTAAGTCTAAATAAGATGAATAGAATTTTTGTTATGTAAATTTTGCTAGAACAGTCTATTTTCTTGCACCCCTCAAGTTAACCTCTTAAAAAAATGAATGTATAATTTCTACCGAAAGAATATCAGAGAGAATCTCTCTGGCCTATAGTGTTAAAATATTGTTCACAAATCCTGATTAGTTAAGTGCATACATTATGAAACTTACAGAATAAAACTTATTATACATCTCTTTCTTAAATTAATATCTTTACACATTTTCAACTGGCTCCCCAAGTCTGATAAGGAAGGATTAAAAGAAAAAAGAAATGTATTAGTTGGGTGGCCAAGGAGTTTCCTTTGTAATGTTGAGAGACTTCCGCTTTCTGAATTTCGCTGGTTCTCTAAGGTAAAAGAGTTAAATAGTACCCTTGTTCACCAAGGAAAGTGATCCAAACTATATATCTAGTGCAGATATTTCCTTTGCATTATTTAGTCTTCTCTGGAGAGAAAATACAGTTTCCCCTTCCTCTTTCTCTTCACATTTACTCTTTTCAACCCAAAATAAGAGACATAGAAAGCAAACCACAGCCAGTTTGGCATCTTCTCAGTG CTACTAGTA 1196 SESN3 3387256TGACTTGTAACCCTTCAGTGGAATGGGAAATTTCTG 1197 SESN3 3387257TGGCTTAGTTAGCAGACCTAGAATCTGCCCAGGTGAGACCTAGAACAAAAATAGCTGGGGTGAAATGGATAAGAGAGGTAGAGGTATATGTCAAGGCAGAGCCCTATGAGGAAGGAAGAGTTTTCAAAGAATATGAGGAACATAGTGCTGAGAGTGTGGCTGCCTTCAGCACCGTACACCTAATCTAGAGAAAATATTTCCCATGTGGGAGGTCCTGTCTGCATTCAGTCCACCCTTTTCTGCCTGCTTCTTCCTCCAAGTGCCTCAACCTCTACATGCTCACTCTCCTCCCCTTCCCTCAGCCCATCTTGGTCTAAGCAGCTTTCACAATCCAAACCAAACATCACCAGCCACCCGCTGATAAGTCACCAGCATTTACTTTCCTGAGTTACTTTTTCTCCATTCATTGAGACTATGGATTCATCCCAACTCCTTCTAAATCCCTCAACCATCCAGCTATATTTTGGCTAACCTTTGCCCTAGACACTCTACCAGATGTTAATGCAGTATCAAGTGTAAATTGTGTCACCCTATTCTGTTCTACCCTTTTCCCTGCTGCCGAAATATCTTGCTCTCCTCTACCTCATCCCCAAAGAGCCTATAAATTCAGAGTATCCAACCTTTTCATGGATTCACTCACTGTTGTTC A 1198 SESN3 3387258CGCTGTTGAACCAAGCTGCTCACTGGACACATATTTGTGTCCCCAGGAGATTATTTGTCAGGCACTGTTTTTTATTTGTTTGTTTGTTCATTTATTGTTGTTTTACTGCTATTGGCGATAACATGAAATGTGATACAGCTATTGCCCATAATTTAATGTGAAATTAATCATGATGAATTCTATAGCATGCTACTGAAATGCCAAATTCAGCTATTTTCTTTCTCTTCTAAAATGGAAGTTTCAGTTTTCCATATCAGATGTATATAAGTGGAATTATAACACAATCCTATCACTGACAGTAATCCTCAGTCACCTTAAATAATCAGTGCTCACAGTGCTGCTTACAGTTCATTTAGTTGGCACATATAAACCTGTACCCACACAAGACTGACCAAAAATTTTCTTTGCACATTTTTCCTTTCTCATAGTTTTTTTCTATATTTCGTTAAGCAAAGGAAGGTTAATATGCCTATTTTTCCTGTTAGGCTTTTAGAAATTATTTTCCATGACTTTTGTTCTTATAATAGGTTAGACAGTTTATTTTTCAAAGGTAAAAATTGTGTTTCTATGCATTAATGTGATTGAACTACAAAAACAGAGTGCAATATGTTCAAAAAATACTCAACTAAACTTTCCCCCTGTCATATCACTGCAAAAGTGTCCTTTTAAACAGAGCCATAAAGAAATTTTTTTCAAATTTCTTTATTGCACAGGCTTTTTTCAGTTTTACCTTTCTGGGATTGAACAATGTTCCTTTCATAATGCCAAAGCATTCCCTTCCCCAGAAAAATCTCCTTGGACAACTGGTTTAAAAACGTTATTAAGTCATAGGGGAGGAATAAGCGGCCAAAAAGTCACATTTTTGCATTGGTTTACGTTGCTTGATTAGACTATCTTCAGAGAGCACATTATGTGTTTATAGCTTTAATTTGTATTATGTCAATGAACCAGTGAAGTGCCTAAAGAGATGCTTACAACTATCCAGTAGGACACAACTGCACTGCTTTTTAAACACTTTTTGGTTAGTTAAGGGTGACTTGAATTGTACACATACATGCTAATTTTTGAAAACTTATCCATTTTTCATAGTAAATAATATAGATAAAATTTTCTGTTAGAGTTCCCGCAAATATTTCATTTTAGACTTACTTGTGATATAAGATTTAACTTTTCTTTTGTGAAAGAATCGTGAACTAGTGTTTCATGAAATCATTTTCCTCTTCCATTTATCATCCTCCTCTGGTACAATATATTGGGTTGCTTTCTTTTAGATTTTGTTCCAGATAGGAAAACAAATATGACTGTATACTTATTAACATAAGGTAGTTCTGCATTTTTGGATTCCAGGATCCTGTTTGAAATCTTCCATGTGAGGAAAAAATTACTAATATTTTTAAAGACAGGGTGGTTTATTTAAAGAGATTATTCAGAGAACTTGTGCCATATCTCGTCTGTTTTATTGCATATGCCATATGTTAACTTTTATTCAATATTACATTATGTAGATATGTAATACAAAGAAAATATTTAGGAGAATGGCAAAACACAAATGGCAACATAAATGTCCATTTGACTTACCTAACTTCACAACTTTCAAGTTGAGGATGTCATTTATTCTTGAATTTGTTTTTTTACTAGATGCTTTCAATTAATAGCCCTATATTTTTGTGCAGGCGAACTGTATAACAGGATAAAAAATGATTTGTATGTATTGAAAAGGAGGAGAAATTCTCACAGAACACCATATGAGCTTTAGACCAAAAGGGGAAACAAGGTTTAAGTAACTAAAATGGCCACTTAGTTTGTGTTTATTTTTTTCCCTGGAAATGTAAGTAGTTGGAGTTTAGGCTATGGAAATATTAGTGCCTTTAATAGATCTCTTTCCTTGCAAAGTTTCTTTTTAGCTCAGCATTGATCTATCTTATCAATAGGAAAATAAGTTGACTTGGAACTATAAACAAAAACAACACCATATATTTATGAACCTCAGTGAACCAGCCTAGAAAAATTGACTTCTGCAGGTGCTAAAGCACCTACTAATACGCAGCATGCACAGCATTTCAGGTTGTGAATACCATTTTACAACGAGTTTGCTGTTAACTCTCTTTATCCAATGCAAACTTGAAATTCTGATGCGGTTTTCCAGGGTGGTATTTTTTCAGAGTATTGAATTTACTATTTAGTAATTTATAGTATAGCTTTTTATATTAAAATGTGATATTTTTAAAAGAGATATCTGGTTCAATTGGTATAATGACGTGATTATGCAATATGCTGATCTACACCTTGCGCTCACATTGTGCCAAACTTAAATGTGCAAGTGTACGTGAGAAAAGCACATGTGAATGTGAATTCTTTAATTCTTTGCTTATTATGTTAAAATTAGTCTTCATAGTCCACTGATGTGTATGCTTGAATAATGTCTATTTACTTTGGAATTTCAAGATTTCCAGCTTCAATGGTAATTTATAATTTCTCAGATCACCTTAAGAAATATTGAGATACTCTCCCACCTGAAAATAATCTGTTCTTTAACCCACCTGACTATGGGAGTAGCCAGGCAGGTGCCTCACTGGCTTCTTCAGACGAGGCTTCCTCAGGTGGATATATGACTATTAGGGGAAAAGAGGCTTTTGAGACAGCTTATTACCTCCTTCCCCTTTTTGAACTAAGTACATTGTCTCAGTCCCAGTATGAATTTGTCCCATTTGGGGTATTTTTAAAATAAAAGATGGCTAACATGGAATCTGGGGCATAGCCTTGGCCTTTAATTATGGTTGTAAGCCCAAATAATGGCAGAGAAACACAGGGCTGTTTTTACAACAGAAAACTCAATATAAGTTTTATATAAGAATCCTATAAAATTTGAACCAGAGCTCCTATTTAGTTGTTATAATGTCTCCTAAAGATCTTAAATGCTTCTAAAAGCTAATTATTATTCCAGAGCAACTTTTTCCTTTTCCCCCTTATAAAGTTTTTTTTTAAATCCAAAATCTTAGATTTCTGTGCCACAGCAAAATAAAATGATCAACAATTAAAGATCTGTACTTAAAATAGTACACCATTTTTAGTGGAGGGAGGGTGCATGCCTATATGATGGTAAGATTCTTTTGAACTCTAAGGACAATTCCTCATGGAAAAAATAAATTTCAGTGCATATTATAAAAATGATTTGCACTGTGTTAGCAAAATAAGGTGTTTTAGGTTGTATTTTAAAGACAATTCTAAATCATTTCTCTGGAAAGCAAGACCTTAAATTCTTCTCTTTAATAGAACTGCTTTTATGCAAAGAGATGGTCTTAACATGGACTAAACAGTACATAACAATAATGTTTGTTATGTAAATAGTATATCACATTTGCTTAGTAGCACAATTCAACAGCAGGCTGAAAGTCGTGGCTCCTCTGCTCAGATTGAGTTTTAAGTTACCTAATTTATGTAATCAGAATCTATTCTAGGTGGCCGTCAACGTA AACTGTGTTTC 1199 SESN33387260 CTAGTGTCAAAGTTTAGCCGTTTGTTTTTTTTTTTTTGTTTTTTGCGGCTGTAATGTGCAATGATGTGTTTTATTTTCCTTGATGCTTAACATTACTAACAATTGCAAAAATAATACTGAGGAGCACTACTTTGCATTGTTTGTAGTTGGAGTTTTGGATACTGATCATAAATCATG AATCTGGCGTATTAATGCTTAAC1200 SESN3 3387261 TACTTTTAATGGAAGCACGAATGCAAGCTGAACTTCTTTATGCTCTTCGTGCCATAACTCGGCATTTGACCT 1201 SESN3 3387262TATGGCTTCAGTACCTAACAGATTTTTTGAAGTCTTAGAGCCACTCACATCAGGTAAATACCCATTTTACATCCAGCATTTCCCCTTGATGGGTCTTTATCCCATATTTATATGTTTGCTCTAGATTTTCTTCCTTTTCTAGATTGTATCTAGAAATTCTCTTTACTCTTCAGGAGAATATATCCAACCACATATCCAACTGGTATAAATATATCAAAAGAATATAATATTAAAACATATTTTTATAGTAAATTTTGAAAACTTGTGGATACCCATTTTAACTTATCAGCCGAGATGTAACCCCGAAAGAAATGTTCTGCAGAATTTTATCTGAAAGACTCTAGGGAAGCTAT GTATGTCTA 1202 SESN33387263 GTACGTGTTTCAGTATTAAGCATTATACCATAG 1203 SESN3 3387264GAAGCCTGAAGGTTTACATTAAGACAGTGACCTGCTATCCTGAGAGAACTACAAAACGCATGTATGATAGTTACTGGCGGCAGTTC AAACACTCAGAAAA 1204 SESN33387265 GGTTCTCCCTGGTGAACAGACTTTATTCTGACATTGGACATCTTCTTGATGAAAAGTTTCGGATGGTCTACAATCTCACATATAACACTATGGCCACCCATGAGGATGTTGACACAACCATGCTGCGCA GAGCTTTATTTAACTAT 1205 SESN33387266 TGACATGATTATAACATCTGATGTCTCTCGATATATTGAAGACCCTGGTTTTGGGTATGAAGACTTTGCCAGACGAGGAGAAGAGC ATTTGCCAACATTCCGAGCTCAG 1206SESN3 3387267 CAGTGGTGTTAGTAAGATACAGTTAATTTATTTCTTAAATGGATATTTCTTCCTGTATTAATGAAACAAAAAATAGATAGTAAGTGTGTAGTATAGTACTTGGTATATGGTAAGTACTCAGTAAACACCGTCTCTTTTCTTTATATGTAATGAAGTTTGTTAAGAATTTTAATAAGATTTATCTGAAATTGGGTAACCGGAGCACTTAATCTTTCCTG 1207 SESN3 3387268TTGACCAGCGTTATAAAGTATTCCAGATTCTATGTAAGGATTCTAAGAATAGTTTTTCAAGTCTTTTGAAGAAAATAAATGTTTAAAGTATTCTACAGGGGTCATATTCTGTAGCTTGGTAACAGGGTTAACTAGCTTTTACTGTTTTTTGTATTTTCAGTTACGCATTCCATTACTGCAACAGAATGTTTCCCGTATTATGTCAGTAACTACTTCTTAGGGGCAGAATAATGCAGATAATGAACAAAATACTATTTCTTTTGAGTACAGACTTTGAAATATTTGTTTAGATAGAATTAAAGCTAGAGTTTTAGATTTAATAATCAGAATGCTAATTTTAACTTCTTAAGATAAATTTAGGAAAAAAGTATTTGTGGATTGAGGGACCTTTGTACAT TTC 1208 SESN3 3387269TTTCAGTCTCTACCTTCTTGGAACTTTAAGCTGGGACTACAGCCTTCAAAAGTGAATTTTGACTAGAAAGTCTTGGACCTTAGCCA A 1209 SESN3 3387270CTCTTCTATCTTACCCTCATGCTATTGCTTTCCCTCAGGCTGGTTCATCCTTGAATGTATTTCAGATTGAGTTGAGAGAAACTTTCAGCTTTGTAGTTCATACTCTATCCTGGATA 1210 SESN3 3387271GGATTCTCTAAGTGAGCTAGAGGCCTTAATGGAAAGGATGAAAAGACTTCAAGAAGAAAGGGAAGATGAAGAGGCGTCTCAAGAAGAAATGAGCACTCGTTTTGAAAAGGAGAAGA 1211 SESN3 3387272TGGTCTCTGCCTGAACTGGTACATGCTGTGGTCCTCCTGGCACATTATCATGCTTTGGCAAGCTTTGTTTTTGGTAGTGGTATCAATCCAGAGAGAGATCCAGAAATCTCCAATGGATTCAGGCTAATATCAGTCAACAATTTCTGCGTTTGTGATCTTGCTAATGACAACAACATAGAGAATGCATCTCTTTCAGGCAGCAACTTTG 1212 SESN3 3387273TTTTAAAGACTGGAGGTATTGCTGAGTGGTTGAATGGTTTGGAATATGTGCCACAAAGACTGAAAAATCTTAATGAAATTAATAAGCTGCTAGCACATCGACCTTGGCTGATCACAAAAGAGCACA 1213 SESN3 3387274GTGCTTATTTTCCTATGTTCACATAACACCTTCCTCACTTATTCTTTCTCCCTTCCAAAATAGGCATGTGTCCTTGTGTGTGTATAGAGCTAAGTATAATTTATGGACATAAGAACTGAAGAAGCCTATGGCCTTTTGGATACCAAGTGTCTTGGGTATATTTGGA 1214 SESN3 3387275GAATACTCTACATCCGGTCGTCTGGACAACATCACACAGGTCATGAGTTTACACACTCAGTACCTGGAGTCTTTCTTGCGGAGCCA GTTTTACATGTTGCGCA 1215 SESN33387276 TCTGTTTCCAGTATGAGCAACTGCATAATTTCAGTGTCTGTTAATATCAAATGAATATTCATTTGCTTCAATAGTGGCATAATTTATT 1216 SESN3 3387277GACAAGAGGACCAAGTGCCTTTATTCCAGA 1217 SESN3 3387278AGTGAGCGTGCCCTTGATACTTTTCTGGGGACTGTAATGTAAGCAGAAATTGAGACAAGGGTCCTTGGAACTGGCTGATAGTTTTTTTTCTTCCTAATTTGCCCAAATAGGACAAATAGGTTGATTGGTTCAGAGCATTTCTGCAATTACACTAAAATGCTTGGTTCTGGGATTGAGTAGGTGTGACCATCAAATGAATAACTCTGTGGAGCAGTCATTTAACATTTCAAAAAGTTATAAAAATGTCTGAAAATGCAATTTTAAAAAAGCAAAACCAAATGAGTCCAGAGCAGCACTGTCCGGTAGAACTGTCTGCAGTGGAAGATGGAAATGTCTGCGCTGTCCT GTAGAGTACACGTGGTCCTATG 1218SESN3 3387279 CGGAGAAGAGCTAGCGAGTTCTCTAGATAAAAAAGATTCAGGAGGCAGTTGCATGGGTTGCTCATTTTCGTATCCTGTGCCCTTATTTTTTCCTTCATCTGCTCCATCGTCTTCCCTACAATATAGTCACCATAACAAATTTGAGTAGAATTTTGTTTTGTGTAAAGAATATGG TAGCCATAGAAGAGAACATTGA 1219SESN3 3387280 TAAAAAGTAGTAATGTTGGCCGCGCGTGGT 1220 SESN3 3387281CCATTATCTAGGTTGCACATTTGTGAAAGCATCAGTATATGATGCGTTCCATGGTTGGGATCTAATGATACCCAGATCAAGCCATGACATAACTAGTGCAGTGTGCAAGATTCAAGCCCTATTC 1221 SESN3 3387282AGGTGGTACCTGATGCAGGAATATGTGAGTGTTGGTGTTGGAGAGTGTTGTGAGAGGAAGATTATTCAGCAGAAACAAACCCTTC CTCTGATGAGCAGAAGTGGTGGAT1222 SESN3 3387283 TGGCGAGATGTGGTTCTGCTATTTATTTTAAGTTAGAACTCTTATTCTGAGAGTTTTCCATAGAAACACAGTAAGATATGTGGTTAAGTTCCAGAGTACTGTTAATATTACAGGTATGTTCAGGCATTTGTTAATTAGCCTAGAAACCTAACCACTGGGTATAACGTTTCCAGAGGAACATATATCCTGAAATTCAAGTAACCGCTTCACTAGAGACTGTCTTTCCTAACTTGTTTACTCAGCATTAAAAAGGTAATGATTTTGGCAAAAAAAAAAATATTTTTCAATATGTTTACTCCAAGGATGTGCTTGTCGGTTGTGCTGTGTCTAATAGGAAAACTGTGTTAATGAAGTTCCATCCAATATTTAGGTAGGAGTTGAATGAAGAAAGAGATAAAGTTGGGTAATAATAAGCAGGGTGTTGGGACAACTGATGGCCAATATCAAACTGGCTTATCCTTGTTCACTTTGTA 1223 SESN3 3387284AAAGATCACATTTACCTCATGGGTAACTAAAGCTGGGTTTTGTGGAAGATCATTGTAATTATCTGAAACTGTGACTCTTACTTCCTTTTTTTTTTGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCAGTGAAACCACCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGATTACAAGCACCCACCACCATACCCAGCTAATTTTTTATATTTTTTGTAGAGACGGGGTTTCACCATGTTGGCCACGCTGGCTTCGAACTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTAGGATTAAAGGCACGAGCCACCCAGCCCGGCTGTGACTCTTACTTTCAAAACACATTTTATAATATCTATAATGACAATAGCTTCTACTGAATACTACTTATGTGCTAAGCATTTAAACTCTACATATGTTATCACATTCAAGCATCACAATTAACCTGCGATGAATTATTACTCACAGTTTATGGATAAAGAAACTAGGGCTCACAGGGC 1224 SESN3 3387285TGTGCAGGTCTTGAATTACAATTTGTTCTGCTATCTTTGTACAGATATTTGAATTTTTTTTTGTTACTGTGTCATGTATGAGAAAGATTGTCATTGATTGTGAAGGAACTGGCTTTTTAAAAAGAATTCCTTCCATATTTACTTAAGTTAAATGTTTACTTGTGAGAACACAAATTTATTGTTATCAGTAGTTGTAACTTTATTACTAAAATACTTGAAAGTTGCTTGGTATATTTATATGCTTTATAGTTCAGGTTCAATAGAAGATTTAATTTGTAAAAAGTGTTCTGCTGCTTC 1225 SESN3 3387286GTCGGCCGCCGCCAACTACCTGCTCTGTACCAACTGCCGGAA AGTGCTGCGGAAG 1226 SESN33387287 CCCTCCGCCCGCTCTCGCCTCGGCG 1227 SESN3 3387288CGTCTCCGCCGTCGCTGGGGCAGCTGCCGCGGTGGTCGCCTCTGGCAGTGCCGCTAGCTTTCAGGCAGTCGCCTCTCCTCCCG ACATCCCGCCTTGA 1228 SESN33387289 GCCAGTAGGCGATGCAAGTTATCTCTGGGGCCCGGAGGACACGAGTGAGGACCGGGCACCAATCAGGTTCTCGCTCTGCGCCGGCCTTTGTTCTCACTCGGGAGCAGGTTGCGGGCGTCTAGCATCGGGAACCCGCATTCGACTCGGACGCGCATTGCTA 1229 NR4A1 3415226CAGGAGGGCCCCCTGCGCTAATCTGCCCTGGCAGCAGCGAGCTGGCACGCCCTGGGTGCATCATCCGGTGTGCTCT 1230 NR4A1 3415228GACCCGCCGGGCCAGATCCCATCTCTGGCGACGCGGAGAAA AATCTGGAAGCCGTCGTCGGA 1231NR4A1 3415230 CCGCGCGGCCGGAACTGCGGGCGGGG 1232 NR4A1 3415231GGCGCCCCTGCGGTGCAGAGCAGCTCAGGGCCGGCTGGTGC GCGACCCCGGAAAGCGGG 1233 NR4A13415232 AGTCCAATAGCCAGTGAAGGCCTGGTCCTGCCCT 1234 NR4A1 3415233GCCTCCACCATGGACAGAGGCCAGGCCCTGC 1235 NR4A1 3415234GCCCTGAAGGCAGACGGGATAATGTGGTTGGCCAAGGCCTGT TGGTCCATCCAGAGTG 1236 NR4A13415235 CCCAGGGTCACGCTCATGCTGGGGCTCCCGTCAGCTGACTAT TTTG 1237 NR4A13415236 GTCAGGTCCAGTCAAGAGGGCCCAAAGTG 1238 NR4A1 3415237CCAACCAATCTTGGGATTCTCCCTTCGTGCGGTTGTCTGGGACCTTTTTCCAGGGTCAAAGCAGATCGTGAGGAGGAAGC 1239 NR4A1 3415238ATTTGGATGTGGAGCCTCTCCTTTCCATTGTGAACTGAATTCTACCAGCACTGGGCCTGGTGATGTCTGCATTAGGCAGATGAGGAAGCAGTCTTGGAGAGGACAAGGGACTGGCCTCAGGTCACACATCAGGCTTGCTAGCTCCTGGACAAAGATGCCTCTGATAGCTCT TCCATA 1240 NR4A1 3415239CCTGCCCTGGGCTACTTACTACTGAGGATGCACAAAGGATCTTCCCACCACGGACTAGGAGACAGTGCCCTTGTCCTCATGTTGTTCACATACTGGTCGGTGAGGGATGGGTCTGAGTACATGATAAATCCCTGGGCCCCATAAGATTTGACTAGGAGGGGTAAGGGCCTGGTGAACTGCTCAGAAAATAAACTGTGTTGTCAGCAGGAGGACCCCTTTCTACTATGAGATATTGCATTCCCTGCTAATCATACTTGTGCTCTATCTGTTGATAGAACAAATACATAATGAGAAACAGCCACTGTGCTTTCAGAAGAACACACTTGAAAGAATTTGTTCTCAATAAATTACATCTGCATCTGGATCCATATGAAGAAATACGTTCCT CTCATTCAGGCGTGGCTATTT 1241NR4A1 3415240 ATGGCCAAAGCTCGACGGGCGGCCTGCGTCAGTGGCGC 1242 NR4A1 3415241GGCTCGGCCGGGGAGTCCCAGTGGCGGAGGCTACGAAACTTGGGGGAGTGCACAGAAGAACTTCGGGAGCGCACGC 1243 NR4A1 3415242GACCAGGGACCAGGCTGAGACTCGGGGCGCCAGTCCGGGCA GGGGCA 1244 NR4A1 3415243TTCCCTTCGGGGAACGTGCATCTGTTTTTAGGAGCGGTGCATGAAGGAGATGGGTGTACGCGCGGGCAGAGAGGATGTTGTAGG GCCGGCATGC 1245 NR4A1 3415244TGTTGGAGTCTTGGGGCGGTGCTGCCTAGAGGATACCTCCCAACCATTCCAGCTCCAGATGCTGATCATCCCTATG 1246 NR4A1 3415245TGAGGCTTGTTCAGCAGAACAGGTGCAAGCCACATTGTTGCC AAGACCTGCCTGAAGCCGGATTCTCC1247 NR4A1 3415246 TGTCCTAGTGCAGGCAGATGTGGCCACCCTCACCTCTCGCAGGGTGCTGCATGCCTG 1248 NR4A1 3415247GTACTGTTGTCCATTCTCCTGAGAGTCCAGGGGGCTGTGGTCTCCTTCCTCCCCCCTTGCCCTGTCCCCAGCAAATGGCCTTTAAAGGTCTGGAGCCAGGTTACCGATGAGGAGGCCTAGGTTCCCTTCCTCTTTGCTTCTGGGAGCATCTCGAGCAGTGCAGAGTGGCTTCCCAGCCCCAGATGGCAGGATTGGGGTGGGTTTGGGATCTGCTGCCTTTGCTCAGTGTGCAGGGTTGGGGTGGAAATGGGGGACAGGCTAGGGCCTCTGCATTAGGCTGCCTTCTTAGGCAGGTGGGCTTTCACTTCCAGCTCCTCTTCCATTTTCACGATGTCCTTCTTCCTAGGCACTGCGAGGGGAGGAGAAAAGGGGCTTTGCAGAGGCCTGGGAGTATTCCCAGGAAGTGCCTGGTTGGCGAAACAACCAGGGAGCTGCTCCTGGGAGCTGGGCTGAGGCTTTGCTGGGCTGCCTCTCCCACTCACCCTTCTCCCGGCCCCCACCATGCCTTCCCCATGGGGGAGGGGCAGGGGGCTGGAGGAACACAGCTTCCCCCTGTTCTAGCAGAGAAATGCTGGCTGTATGCCTCCCCTAGGGTTCCCAGGCTGACTAGGGTGTGGCTGGCCTTCTGATGGAGCCCACTCATGCTGGGCCGCTGCCCAGGGGCTTTGTGGCACCTAGGTCGAGATGGTACTCAGGCCAGGGGTCAGGATTCCTGGGTGCTCTGGTCCCGGTGCCTCTGTCTCATCTTTAGGCTGGGAT TCCTGC 1249 NR4A1 3415248TCCAAGCCCAATATGGGACACCAGCACCGAGT 1250 NR4A1 3415249GACCACCTGGCAAGCGACCCCCTGACCCCT 1251 NR4A1 3415250CCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAG 1252 NR4A1 3415251CTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTC 1253 NR4A1 3415252GACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGG CCCAGTGGATGAG 1254 NR4A13415253 GGCTCCTTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGC 1255 NR4A1 3415254AGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGATACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCC AGCATTATGGTGTCCGCACATG 1256NR4A1 3415255 CGCGCAGCCCCAGGTGGGGCCTTTTGTTGGAAATGGAGAGAGGCTGGCCTCATCCCATTGGGACCTGTGGTCTCCC 1257 NR4A1 3415256GAAGCTTTCATTTGCCGGGACACTCGGGCCCATGGGATTGCACAGAGCTGGAGGGAGGGGTGAGATAGGGGCAGATAGGAGCTGCAGGGGTGCCTGGCGAGCCTCTGGTTTTCCTCTGCTCCTCTGCCTGTCCTCTCCCAACTCAAGGTTCTAGTGGGAAGGGGTGCCCCCAGGCTCTCATGTTCCTGGCGTGAGATGAAAGGATCCCTGCGGAGGGTTTGGTTCTTGAGGGCTGGGGGTGGACTTGGGAACAGGCTGTGTGTTTGTCCCAGCGATGGTGCCTGCTTAGCTTCCCGTCCCCACCCCCCAGCCCCTTGGCCCTCTCCTGTCTGCCCTAGGGAGAAGGCAGGTGGACAAGGGCCCATGAAAAAATACAGGTGTCTAGACTGCCAGGGAGACCCTGGCCCCCAGTAGTGTGTCCTGGGGACTTCCTCAGAGCGAGAAACCTCCCCCAATGTCTTCAAGACTTTTCTCTCCCCCCGCCCAACCCCGTCTCTCCCTCCCTTGCCACCCAAATGTTAGAAAAATAGCTGTGAACAGAGAGCGCTTTTGTCTGCAATGGCAGCAGGATCTGGACGGTCCCCTCCCCTAAGTTCCCCCCTCCCCACCCCACACTCTGACAGCTTGTTCCG TGTTGCCC 1258 NR4A1 3415257GCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAGGACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAG TTCTGCCGCTT 1259 NR4A1 3415258CCCAGCGGGGCAAGGGTAGGCTTGAGTGGAGTGGGACCAGCAGGGCCCCCAGGCTTCTGCCCTGGAGGACCCAGAGGAGGGCACGTCTTATTTCCACCCCACCTCTGAACCCCAGGCCTTGGAGGGAGGCAGCCTACACCTGCCTGGATTGTGAGGGTGGTGGCAGGGGGAGGTTCCTATAGGGTACCTTGGATCTCAGGGACTCTGGGTCCTAGGGACTCGGTGGGGCGCGTCTCAGCAGTGGTGTGC ACGGCTTGGGCTGAGAGGCC 1260NR4A1 3415259 TTGTCCGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCCCTGGTCCGTGCACACCTGGACTCAGGG 1261 NR4A1 3415260CCCAGCACTGCCAAACTGGACTACTCCAAG 1262 NR4A1 3415261CTTTGTGCGTGTTAGGAGAGCTACCCCCTCTGGAAGGACTGAATGAGAAAGGAGGTTTAAAAAAGAAAGAAAGAAAAGCGACTCCCTCCAGTTCGACAGATCAAAGAGAGGATCCCCCTCTCGGCTGACCAGATGGGAAAATGCACCCCCTCAGGCAGGTGGCCAATTA GAA 1263 NR4A1 3415262GGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGG A 1264 NR4A1 3415263GTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTTGCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTC CTGGAGCTCTTCATCCTCCGCCT 1265NR4A1 3415264 CTTTCCCTGATACACCTGCCTGTGAACCACCCTGATCGCTCTT CGTGCC 1266NR4A1 3415265 CTAAGCCAGGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTGGCCTTCTCAAGGTCCCTGCACAGCTTGCT TG 1267 NR4A1 3415266TCAGATGTACAGCTAATCCTGTACCCTTCC 1268 NR4A1 3415267ACCGGCATGGGCTGCAGGAGCCGCGGCGGGTGGAGGAGCT G 1269 NR4A1 3415268GAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAGCCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAGCTGGAGGACTTGGTGCC CCCTCCACCCATCATTGACAAGATCTTC1270 NR4A1 3415269 TGCACATGCGCACTCTCATATGCCACCCCATGTGCCTTTAGTCCACGGACCCCCAGAGCACC 1271 NR4A1 3415270CTGGGCTTGAGCTGCAGAATGACTCCACCTTCTCACCTGCTCC AGGAGGTTTGCAGG 1272 NR4A13415271 GGGTGACCCCACGATTTGTCTTATCCCCCCCAGCCTGGCCCCGGCCTTTATGTTTTTTGTAAGATAAACCGTTTTTAACACATAGC GCCGTGCTGTAAATAAGCCCAGTG1273 NR4A1 3415272 ACCCTCCTTCCACATGTACATAAACTGTCACTCTAGGAAGAAGACAAATGACAGATTCTGACATTTATATTTGTGTATTTTCCTGGATTTATAGTATGTGACTTTTCTGATTAATATATTTA 1274 RP11- 3424282GTGTAAAAGTGTGAGACAACACATTTCTGTTGTTTAAGACACA 121G22.3CAATCTGTGGTACTTTGATACAGCAGCCCTGACAAACTAATACATGGGGTGTCTCATTGTAGTTTTAATCAGTAACACCCATTATGA ACTGAAAACGTCTGCTACTT 1275RP11- 3424283 CAAGAGGTGACCATCAGCAAGCCCAGGAGAGAGGCCTCAGAA 121G22.3GAAACCAGACCTGCTGATTCCTTGATCTTG 1276 RP11- 3424284CAACTTGAATGCTTCCTGATTAAATATATACAGGAGTGATTTCA 121G22.3 GAGGAATTT 1277RP11- 3424285 CCATTAAGACTAACCGTTTTTGCTGGAGCTGCAAGATTTTCCAT 121G22.3TTCTTCATGAGTCACCCAAACGTTGCCTGAAGGCTAGTG 1278 RP11- 3424286GTGGCTCTTGAACAACACAGGTTTGAACTGCATCATTCCACTT 121G22.3 ATACACAG 1279 RP11-3424287 ACTCCTGAGACAACATGACCAATCTCTCCC 121G22.3 1280 RP11- 3424288CGTACTTTCAACATAAAGACGACGAGGATAAAGGCATTTATGA 121G22.3 TGAACTACTTCCACATA1281 RP11- 3424289 GCTTACTTTATTGTACGAATGGAGCATATATGTGTACATATAAA 121G22.3ACACATAATACATGCTTATCAACTATTTGTGTTATCAGTAAGGCTTCCAGTCAACAGTAGGCTCTTAGTAGTTAAGTCTTGGGAGAGCCAAAAATTCTAGCTGATTTTTTGACTGTGTGTGGGGGGTCAGCACCCTTAACTCCTATCTTATTCAAGGGGCTATTGTATTCTAAATTGTCTTTTAGCTTGAGTCATAATCCAGGTATAGTG 1282 RP11- 3424290GCAAAATACAGTGCCAAGAGCTCTGGACCACAAATCAGAAGA 121G22.3CCTGAGCCCTAATTCCTTTCCA 1283 RP11- 3424291TTTGTTCGTCGCTTGCCAAAATAGCAGCGAACTCTCTGTCAAA 121G22.3CTGCAACTCATTTTATCGGAGCAAAAACT 1284 RP11- 3424292GAAGCAGCTGATCGCTAATATCTGATGGCTAATATGCTAAATT 121G22.3 TCCCTGTC 1285 RP11-3424293 GAGGCAGTGCAGCTTGTGTTACAACTCAAAAGAGTAATACTCT 121G22.3GAAAAAAGAAAAAAAAAGATGGCGCTGAAAATAAACATGTTCAGCAGCCATTGTGATTCAACTTACCCAGATGTGCTTTTCATGAGATGGAGAAGGACGGATGGAAAAGAAAAGCACACAAATGTTAATGGATACAGTTCAATCCAAAGAAAACCATGGAATAAAACAAGAGCATTATTTAAGATGTGAGAAAGCTCAGGTATGAGAAAGACATGGTGCCATTTTGTATTTCATCATGACACACATACTCACTGCGTCG AAAAGCATAGTCA 1286 MYBPC13428597 GCGAATGCAACTTTGACCCTAAGAAATCCTTTATGCAGGTGGAGACACAGCTTCTTCAACCAATGAAAGAAATAATATCTGGCTTCTTGAATAGTTTCATGGTGCCACCAACAAAAACTATCATAGACCAACAATGGCAAGATGGCATCGGCAAGAATGAGCTG 1287 MYBPC1 3428598CCAGAATCTCATCGTGCAGGCTACAAATAGCAGCTGCAGCTGCAGACCAAGGGCTGGCCTTTACATGTCCATGGTGCAAAAGGA CTCCTG 1288 MYBPC1 3428599CAACTGCTTGTCACACCGACCTGCACCATCTCTCGCCTGCCTGTGGGGTTTCTGTCAACTAGTCGTGGAGGGAAG 1289 MYBPC1 3428600ATGCCAGAACCCACTAAGAAAGAGG 1290 MYBPC1 3428601AGTATCCCCGAATCAAACATGAATGTTGAAGTCAACTACCCAG ACTGAAG 1291 MYBPC1 3428602TACACACTAACTTTAATTTGGAATACAGTAAATATTGTATTAGTGTGTCATATATTTACTGAATTAAAAATTAAAATTGGTTGGGCATGGTGGCTCATGCCTATAAACTCAGCACTCAGGGAAGCAGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAAATTAGCTGAGCGTGGTGGTGGACCCGTGTAATT 1292 MYBPC1 3428603TGCCAGGGGACGGTTATGGATTTCTTGGCAGCAAGGAGAAGCGGCTTTTGTGCAGGGAGGAACAGCCTGCCAGTCAACTATATTTATGGAGCACCTGCTGTGTGGAATCTGAAAAGGAGAAGGAGAAGGGCCTTGTCCTCAAGAAGCTTGTGATCAAAGGGAGAAGAAA AGTCCCCATCTACTGT 1293 MYBPC13428604 TGAACAACGGCTTTGAATGCGAACCTGGGGAGTGTAGACCTA ACCAAATAATAAT 1294MYBPC1 3428605 ATTTGGCACGGGAAATGCTATGCTCTTTGTTCATGTGGATGCCTTTACCTACTTGGAAATAGTATGTTCTTTAACAGAAGTTTCTTTGTCAGACTTCATAGCCAGACTGCTCTGTAATAACCAGA 1295 MYBPC1 3428606AAAATGAAGTGCCAGCCCCAGCCCCACCCC 1296 MYBPC1 3428607CACTCACACACGTTTGGGCTGCAAATACAGAGGGTCCATCCCAGCATGATTTGGCCTCCACGGGTGCTGTGAGCTGTGAGCTTTAACCTAACTCCTACTGAGAAGTTGGATGGTGACCATTGTGATAAGTTGAGAATAATAAAAATAATACACTGTGTTTATATAATCCTCTTGTGTTAATCTAATTTGGATGGCACTTCATATATATTAGGGGGACAATTCTTATGAAACCTTTCAAATTATGTAAAAGTTATTATGTCCGCATTTTACAGTGTGGAGGCTGAGCCTCCATCCAAGGGGCTGAAGAATTTGTGAGGCTTTTTCCTATATAGTGAAGGTCAAACAAACCCACATCTTCTTTATGAGAGTGGGGAGTGGATCCATCTCT ACCCTG 1297 MYBPC1 3428608CTGGCAACAGGAAATGAGTACAGAGATCCAGTGAGACCCTT 1298 MYBPC1 3428609AAAAATATGCTTGTACTTTCTACACAG 1299 MYBPC1 3428610AGAGAAGGAGGCCGGAACTACACCAGCAAAAG 1300 MYBPC1 3428611TCTGCAAGTCCCAATCAGTATAATGACAAATGGTGCATTGCTAAGTTTCCATTACATGTATTTCTAAAAGAAAAACAACAATGATAAAAATATCACAAGCACTTGTTGAGATGCCAGCAAATTAATTGGT AGTTTCCAAGTTTCGACATGCATGCTA1301 MYBPC1 3428612 GACACTACTGTTGGGTGATCTAGACGAAGACTATTTCATGATACTCTGAAGCGCTGCATTCATATGTATTCCTTCATGGTCTAAAACAACTGTGCATGTCCTCCAAATAGTCTTAACATTTAGTAGACTTTGAAACTACTCACCTATCAAATTTTTGCTTAAAAAACAGATTGCC GGCCAGG 1302 MYBPC1 3428613GCACAATGTTGTGGAATGTGAATGCATGCATATTAGTTCAGGAGAAAAAATTCAAAATGAACTAAGTTTGGGAG 1303 MYBPC1 3428614TGCTAACAGGAAACAATACCGACGTTCTTTTTCTTATAGCATTTGTATTATAAAAAGCACAAAGCTCCAGCCCACTGAA 1304 MYBPC1 3428615ATGAAGTCTTTTCTCCTTGACTTTTTACTCCTATTTCTTG 1305 MYBPC1 3428616GAAGAGGAAGTCTCCCCGCCTAGCGCCTTGCCT 1306 MYBPC1 3428617GCTTTCATACTTGGAGCTCTACTGATTTTCCATCCAAGCCAACTTGTAGGGTTTTTTCCTTCCTATCACCAGAGGAGACAGGGTTTAGGGGAATCCAAGAAGGTTGAAGTCAGCACT 1307 MYBPC1 3428618TTTGGGTAGTCGGGCCCTGGAGAGAAAAGATTCAG 1308 MYBPC1 3428619GAGCTCATTTCTTGAAGCTGTATTGATTCTAATCCTTGTCTTATTCAGATTGTAGTTTTTACGGCAATCTTTCATTACGTTTCCTCTTACAAGAAAACTAATGTATTGAGAAACAATTAATTTTGCATGATACACACGCATTCAAGGATCTAGCCAAAAATACCACAGGTTTGTT CTATCATTTTTA 1309 MYBPC13428620 ACTGGCCACCATTGTTTACCTGTTAGGGGACAGGCAAGATGGGGAAGCAAAGGAATTATTGCCATCAAAGAGAGAATAACAGCTTACCTGGAAAGTTCCACTATTTCTAAGAATTACATAATGTTCATTTGCCCCATCATGGAAGAGATACCCCTGTAAGAATGGGAATCTGTTCCCCTCTACTGATGGCTGCTGGGGGCAGAAAGAATGATGTTGTATTTATCTAGGTTTATTAGACAAAGAAAAGCTACAGCGTTGGTGAGAACAACAAATCCAGGTAAGACTGCCTAAGAAGAGCC TGGCCCTGAAATAATCCTTTT 1310MYBPC1 3428621 TGGACCCTTGTCGAAACTCCTCCTGGGGAGGAACAAGCCAAGCAGAATGCCAACTCCCAGCTGTCCATCT 1311 MYBPC1 3428622AGCAAAACAAATGACGCTTGTTAAAGAGCAAGCTGAATCCCTT ATGCTTCTTCTAG 1312 MYBPC13428623 ATCACCTTCATAGCCAAAGTCAAGGCTGAAGATCTTCTGAGAAAACCCACTATCAAATGGTTCAAAGGAAAATGGATGGACCTGGC CAGCAAAGCCGGGAAGCACCTTCAG1313 MYBPC1 3428624 CATTTGAGATGCAGATCATCAAGGCCAAAGATAACTTTGCAGGAAATTACAGATGCGAGGTCACCTATAAGGATAAGTTTGACAGC TG 1314 MYBPC1 3428625TCTACTGGGACTACTCCAAACATTGACATCAG 1315 MYBPC1 3428626AGGATGCAGGAGAACTTGACTTTAGTGGTCT 1316 MYBPC1 3428627AGTGAGACATTGTGGCCTGGAAGTCTTTCAGACACCCACTCAGAGAAGTCAAGTTTAAAGTGGATGTTCTTCAGAGAATTTTTCATTTCTGAAAATGTGTTTTGCTTATAGAATATAACAGAGTTGACTAGAAAGAGAGAAACAACTGCATACTAATCTTTTAAAGCCTTTAACAGTTGCTTTTAAACTTTCTTTTTAAATGTTTCATGACTCTTCACCTATTTTTTTTTAAATGGGGACGAAGAGATATGAAAACTGAGACATAAGACAAATACCTAGAAACCTCTAAGACTGCACATATGATTTGGTAGAAGTCTGAAGGTATACACATTGTAAGAGGCAGACCTA 1317 MYBPC1 3428628ATAGATACACTTTTGTGGGAGGAAAAATAGTGGTAAAAACATGGACTGGAGTCTCAGCTCTACCATTTACTAATTATGTGACTTTGGTCAAATATTTGACCCCTCTGAGACTTGGATTTCACATCTGGAAATGTGAAGAATAAACACTACTTAATAGAATTATTGTGCAAATTAAATTAAGTGTAAAAAGCTTGGTTCACAGTAGGTGGCAAATAAATATGTACTTCCTCTAAGGAAATGTGTCATTTTCTCTAACATAGTT TATATTCATAAGGAGACAACA 1318MYBPC1 3428629 CTCTGTACAACGAAAGATCTTCCTGCTCTGAACAAAGCCAGCTTACTTCAAATAGACATTAGCTAAATCAGATTAAATCTTTTGGGCAGCATCCTGTTATAGGAATTGACCTGTATAAATACTTGTAAGTTGTACTCTACATAAAATTTCTATAACTGTTATACTCTTCACTAGGATCACCAAGTTATTGAAATTTTGATGTAGATGAAAATACAGTGAGTATTATACAGGTCTATCCCGAGGCTTGGAAAAGAATCAGAAGTGCCTACAGAAATTTGGCTTTTTCTCCTCACTGTAACTTAACATAGCCATGCAGACAGGGTCATGTGCAGCCACCATGGTA 1319 MYBPC1 3428630CAGTGAGTACGAGAAGATCGCCTTCCAGTATGGAATCACCGACCTGCGCGGCATGCTCAAGCGACTCAAGCGCATGCGCAGA 1320 MYBPC1 3428631CTTGATCCTGCATATCAGGTTGACAAAGGAGGCAGAGTGAGGTTTGTTGTGGAGCTGGCAGATCCAAAGTTGGAGGTGAAATGGTATAAAAATGGTCAAGAAATTCGACCCAGTACCAA 1321 MYBPC1 3428632TACATCTTTGAACACAAAGGATGCCAGAGAATCCTGTTTATCAATAACTGTCAGATGACAGATGATTCAGAGTATTATGTGACAGCCGGTGATGAGAAATGTTCCACTGAGCTCTTCGTAAG 1322 MYBPC1 3428633TGGTCACCAGGAGCTGTTGGCTTCTTCTCCCAGGGATAATGAT CAAAGTGA 1323 MYBPC1 3428634AGCCTCCAATTATGGTGACCAAACAGCTGGAAGATACAACTGCTTATTGTGGGGAGAGAGTGGAATTAGAATGTGAGGTGTCTGAA GATGA 1324 MYBPC1 3428635TCCCTGGTCCAAAATCAAGATACCGAATTAGAGTTGAGGGTAAAAAACACATCTTGATCATAGAGGGAGCAACAAAGGCTGATGCTGCAGAATATTCAGTAATGACAACAGGAGGACAATCATCTGCTA AACTTAGTG 1325 MYBPC13428636 TGACACCTCTGACTGATCAGACTGTAAATCTTGGA 1326 MYBPC1 3428637CCTGTTCAGGAGAGTGACCGTCTAAAGGTGGTTCACAAG 1327 MYBPC1 3428638TCCACAAGTTAGTGATAGCCAATGCCCTCACTGAAGATGAAGGTGATTATGTATTTGCACCTGATGCCTACAATGTTACTCTGC 1328 MYBPC1 3428639AGGAAACAAGCTTCGTCTTGAGATCCCCATCAGCGGAGAACC ACCTCCTAAAGCCATGTGGAGCCGGGGA1329 MYBPC1 3428640 GGCAGTGGCCGGATAAGAACAGAATCTTACCCTGATAGCAGCACTCTGGTCATTGATATAGCTGAAAGAGATGACTCTGGTGTTTACCACATCAATCTGAAAAACGAAGCTGGAGAGGCACATGCAA GCATCAAGGTTA 1330 MYBPC13428641 CTGATCCTCCAGTGGCACCGACTGTGACAGAGGTGGGAGATGACTGGTGTATCATGAACTGGGAGCCTCCTGCCTACGACGGAG GCTCTCCAATCCTAG 1331 MYBPC13428642 AAGAAACAAAGCTCCAGGTGGATGAGGCTGAATTTTGATCTCTGCAAAGAAACAACTTTTGAGCCCAAGAAGATGATTGAAGGTGTGGCCTATGAGGTCCGCATCTTTGCAGTCAATGCCATTGGCATC TCCAAGCCCAGTATGCCCTCCAGG1332 MYBPC1 3428643 CCTCCTACTCTTCTGACTGTGGACTCTGTCACTGACACGACTGTCACGATGAGGTGGCGCCCCCCAGACCACATTGGTGCAGCAGGTTTAGATGGCTATGTGCTAGAGTATTGCTTTGA 1333 MYBPC1 3428644GTGCCTCAGGTCAGAAGCCACAGTCTGCACAGAGCAGGCTGTGCTCTCCTGAGGAACCCCCCTAACACCGTTTGGTCTCTTCCGTCACTGCTCTGAGGACAAATCTCTTTGCACACTTTGCATACTTTACTAACAGAGAATGCTGACTGCTGATACGATATTATTC 1334 MYBPC1 3428645GTACATCAGCAAAACAGTCTGATGAA 1335 MYBPC1 3428646TCTGATTGACAAGACGAAGTTCACCATCACAGGTCTGCCAAC 1336 MYBPC1 3428647TGCGTGTGAAGGCTGTTAATGCAGCTGGTGCCAGCGAGCCCAAGTACTATTCTCAGCCCATTCTCGTGAAGGAAATCATAG 1337 MYBPC1 3428648ACCTCCAAAGATTCGCATTCCAAGACACCTGAAGCAAACCTATATCCGCAGAGTTGGAGAAGCTGTCAATCTGGTTATACCTTTCC AG 1338 MYBPC1 3428649AATAAAACCAGAAGTGGCAACAAGGCAG 1339 MYBPC1 3428650ATAAACATTCGCAACTCTGAGACTGATACAATCATATTTATTAGAAAAGCAGAGAGGAGCCACTCTGGGAAATATGATCTGCAAGTCAAAGTGGACAAATTCGTGGAGACCGCATC 1340 MYBPC1 3428651CCAAATTGTGAAGATTGAGGATGTCTGGGGAGAAAATGTCGCTCTCACATGGACTCCACCAAAGGATGATGGAAATGCTGCTATCA CAGGCTATACCATTCA 1341 MYBPC13428652 CTTTCTCTGGTTCATCAGTAGCAAAAGG 1342 MYBPC1 3428653CCAACTGGGGCTATGGAGAAGTGATGTGGCAGAGCAGAAAGGAAAAGACCTGTGGAGCCACAGAGCTGGTCTTAAACCCCAGCATTGCTACTTAAGACCACATGTATAAGGACCACACGTGACCACA ATCACT 1343 MYBPC1 3428654GGTTTACTGTCATTGAGCATTATCATCGAACCAGTGCCACCATTACTGAATTGGTCATAGGGAATGAATATTACTTCCGGGTCTTTTCTGAAAACATGTGTGGCCTCAGTGAGGATGCCACCATGACTA AAGAGAGTGCAGTGATCGCCAGG 1344MYBPC1 3428655 TCAGAGGCACCCATGTTTACTCAGCCTTTGGTTAACACCTATGCCATAGCTGGTTACAATGCCACCCTAAACTGCAGTGTG 1345 MYBPC1 3428656GTACCATGTTCTTCTATCACATCAGTTAAAGTCCCTGTCTTGTA 1346 MYBPC1 3428657CACTACACTGTCTGCGATAGGTTAAAGTAAACAACAATTACACTACACTGTAAGACAGAATATGAATGTGCTTTGATAAGGGTACAGTGTGCTAAGAAGGGAGCTATCATATCCAGTTGAAGAGATTAGAAAGGTTTCAAGGTTTCATGTTTGCATTTGAAAAGAACAACGAATTAATGAATATCGCCCATAGAGATGTACATATCCCTGGGTGCAAGACAGAAAGTACCCTAGAATTGGGAAAATTTATGAACTTCTTTTTTTCCTGTATATACCTTGATCAGAAATAGGGAAGTCGTC 1347 MYBPC1 3428658CACTGGCTTTGATGGTCTATTAATATGCCAATTACAGATATGTT TTGACCTAAGTTTCTTCA 1348MYBPC1 3428659 GGATGATCCAAGATACAGGATGTTCAGCAACCAGGGAGTCTGTACCCTGGAAATTCGCAAGCCCAGCCCCTATGATGGAGGCAC TTACTGCTGCAAAGCAGTCAATGACCTT1349 MYBPC1 3428660 GCCTTACTATTGAGATAACCCTTACAAATTTAAACATTTTTAGCTGCTTTATTGGCTTTAAATGATTAAGTTCATAATTGCAAGTCATCTGGTTTCTAAACTGCTAGCCTTATTAGTTCCAAAGTATTGTTG ATGCTTTTG 1350 MYBPC13428661 TATATCAAGGAGTAAATACCCCTGGACAACCAGTCTTCCTGGA G 1351 MYBPC13428662 TTATATCCCACTGGATATTCTACTTTCCGTTCCATTCCTCTTACATGAAAATGCACCTTGCATGTAAAGCTTGACTTTCTCATTTGCTTTTAATTGTACCCCTTAGCAGCTCATGGCATACAGTGCTTATGCCATGAACAAGGAAGGCCAAATTATTCAAGGATATTAAG 1352 MYBPC1 3428663TGTACACTAACACTTTGTCTATTGTCTATGTTTTTCTTTTGTTGAAAAACACGATATATATATGTTGTAGGGTTTTGGTTTTTGTATTTGTTTTAAGCTAATGGTTTGGAAGCTCTT 1353 MYBPC1 3428664GTCATAAGCCATACCAAGCCTGTGGAGTATGGCATGATTTTCATTACATAATCCAATGAAAATAGACTTATTTTAAATCCCTAACTTTGTAGTTTTAATTTGTATTTCACTATCTTGAAATTAACAGCTAGTACTTATCCATCACAGCAGTCTCCTACTGACATGAAGCAAGTTGTTGAATGCAGTAGAGCATGAATGAAAGCATTTAATGTAGACAAAAATGGGTGATACCCAAGCATTCTGAATTATTTGCATCAAGGAATGGACATGTACATAAGTGGCATCATTTCTACCAATATGTGACTTGAGTTGTTTTTTTAAAAAAAGGAGAATGACTTTCTCAAATTTGCATTAAAGAAGTTTTTAAGAATGTTCAAATGGCATGCTGCTTTGTCTGGACGTGAATTTATTAGCAAGTAGTAAAGCACTTCACTAAAGGACCATGAATTTTTGTGGTTTCATGGATTCTCTCTTGAAGGGTACTTTTATTTTTTTAATATAATTCAGAAACTCAGAAGGTAGGTATGAAATATTGGTAGGTGTTTCTCGCACCTTCAGAAAGTATTGGACCGGTCTTATTATTATAATTTTAACAAAATATTTCCAATTTTTGTGCTTTTGACATGCATAAATGACCAAAGTTAAAGGGAGTAGTTTTTATCTTTTCTAATGTGCTTGAATCGAAACTCTCTGTGCCTAATTAAAAAGAACATTAACAAACTGGAAGCAGATCTTCCCACTGATCCATAATGTGGTATGCATTTATTCTGCTGTTCAGTCAGAACATTTAAATCATCTATGAGGAATCACAAAACCTCTCAAAGAGCAATAAATACTTTCCAACCACTTGGGAATTTAAATGAAGATTGAACAATAGTAGGGGAAAAACTGCTGTGGTTCTACTGGGAAC 1354 MYBPC1 3428665AGACTCCTCTTGCAAGGCGTACCTCCAAACATAATTGATTCGT ATCTGCGAGACTTACACTCAAGCAATC1355 MYBPC1 3428666 TGGCTACTGTCTCTCTGCACTCTGCTGCTTTGAAATCTGGTTGAAATGAGAAAAAGCATTTTCTGTTTTCCCACCAGGCCCCCAAGTGTGGTCTTTTTCTTTCCTCCTAATGTTGAAGAGA 1356 RP11- 3454981GGCTGCGCTGCTCTTTGATTGGCTTCGTTAATATTTGGCAAAG 923111.3CATTGCCACTTACCCACTCAGCGAAGATGCACAAAAACGTCATCACTGATTCTTTCAGTTCGATGCCTGTTAACTGCGGGTGTAAACTGCTGGTGATGGTGTCATTTACTACCAAAGAAGTGTGGAGCAGGATGGGTGAGAGAGTGAGTGAGTGAGCAGGTGGAAGGACAGTGGGTGAAGGATAAAAAGGTGGGAAACATTTTTTTTTTAAAAAGTGAAACTTCAAATACAGCGGAGGTGGCTTCTTTCCTATGAGGCTGGCTGATGGGTGCCAGATACCAAGGCCCATGTGTTACTGAGGAGACAGCCTGCTGGGCTGGGGTCAGGAGCTAGCGGAGGGAAACGGTTAGATCTCAGAAAAATCTCATCACTATGCCCTAGTAGCTTAATGACATCACTAGCATGAGCACATGGTGTACTTGGCG GGATCTT 1357 RP11- 3468066TCACCGGCTGTCACATAATACTCTGAATCATCTGTCATCTGAC 755011.2AGTTATTGATAAACAGGATTCTCTGGCATCCTTTGTG 1358 RP11- 3468067ACCAGAAGACTCATTAGGATCCATAATAGCTGCCAGTGTAGAG 755011.2GAGCCTCAGTTACTTTCACTTTGATCATTATCCCTGGGAGAAGAAGCCAACAGCTCCTGGTGACCACAATAAGAGATTTC 1359 RP11- 3468068TGTGTGAAACAAGGATTATCCAGTAAAATCTGTTGGGTTTCAA 755011.2AGCTATAACTAGAATAATTATTTTTGCAAGATAGTGCTTGGCTTGAGTCAAAACATGAGGCATTTGTACTCAACAGGTTCTCTTTCT CCC 1360 RP11- 3468069GAGCCACCTGCTCGCACTCAAGATGAATCAGGTGCAACTGCT 755011.2AAGAGTGGATATTACCCCCATGTAGGCTCTTGAAGCACATTAGTAAGAATATCATTTAATGCATTTTAAAGATAACTATGATTCTCTATTAGAATGAACAATCTACACTGTACCAATTACTACAAATCCTGCTGTGTAATTTACTGTACCTTTCAACATAACATTTCATTTTAAGATTTAAAATTTCTAGTTTTTAATTTTAAGATTACTCACAAGGAACCT G 1361 RP11- 3468070TAAGCCACACCCATTTACATCTGAGGTCACAACTACTCATCAG 755011.2ATTTTGAATAATCCTCTTTCTACTGCTTCACAACAGTTCACAAG CCACAACA 1362 RP11- 3468071TCTGTTCTTATCCGGCCACTGCCTTCCATAATAGCCTAAGAAG 755011.2 TGG 1363 RP11-3468072 CTTGACATGTCAGCTTGATTCTAGAAGTGCGTTTACCTGGAGG 755011.2ACTTACCCACAACTTTAACCTTGATGCTTGCATGTGCCTCTCCAGCTTCGTTTTTCAGATTGATGTGGTAAACACCAGAGTCATCTCT TTCAGCTATATCA 1364 TNFRSF193481420 CACTGATCAGATTACAGGCATTTCATCTCCCTGCTCGTCTGCCTTTGATCTGCATGGTTAATTTTATTTTCCTGGATTTGAAGTTTC GTCTGGGCTTGTGCTGA 1365TNFRSF19 3481421 GTAAGTACTGCAAAGAGCTCAGCATGTTGCAG 1366 TNFRSF19 3481422ACACTCAAATGAGGGAAAGTGGGAACTATAGTGTTTGTTCCCTCAGCATCTGAGGGGGACTGCTTTCAGGACACCCTCTTGGATACCAAAATCTGCAAATGCTCAAGTCCCTTACAAAAAATGGTATAA ATTTGCATATGCTCTG 1367TNFRSF19 3481423 CGTTGCCGGGCTACGGGAGAGCGCGGAGCCCTGCGCTGGGAGGTGCACGGTGTGCACGCTGGACTGGACCCCCATGCAACCCCGCGCCCTGCGCCTTAACCAGGACTGCTCCGCGCGCCC 1368 TNFRSF19 3481424GGGTTATCTTCTAGTCCACATGTCACATAATATGTACCTTTATTTACCTTTTAAACTGAAGTTTTAAAACCTGGGTTTTAAAAAGAGAACAACTACCCATCAGCAATTACAGAAGACAAAGGAACTTGTGTGTCTGAAGACTGAGTGTTATTTAGCAGCTCTTTGGTCAGCTTGGATTGGTCACATATGTGGAAACTGGGAAATAATAGGGGCTACTTACACTGGAGAAGAACACTACAAATGGTGTAAAGAGTGGTTTTGGAATGTATCCAGACTTCCTTCTAAAATAAAAATTTAAACAGCTGTGTTTGAGAGATGGGTATGCACAATTCTTGTAAGAAAGACTGTGTAGATGTTTGAGGTCCCCTTAGTCCCTGATGCTACCATTGT TCC 1369 TNFRSF19 3481425TTGTCTGTATTAGAGCACTACCTTCAAGAAATGGGGTTCTGACCTGGATTTGTGCTACCACAGTGACTTGCATT 1370 TNFRSF19 3481426AACTCTCCAACAATAAATACATTTGATAAGAAAG 1371 TNFRSF19 3481427TAAAAGTGCTACTAGAACAAGAGAA 1372 TNFRSF19 3481428GTGGAGAAGGTTTGTACAGAATTATATGCATCAAAAACAATGT CC 1373 TNFRSF19 3481429AGACTGTAGACAGCAAGAATTCAGGGATCGGTCTGGAAACTG TGTTCC 1374 TNFRSF19 3481430TAGCTCAGCAGATCCAACTCCCATGG 1375 TNFRSF19 3481431CCCAGCCTCCCGATTGGGAGACACCTCCCAGCAGGGGTCGCCAGACACCTCATACAGGAGAGCTCTGGCTGGCATCTGGTGGGTGCCCCTTTGGGACGAAGCTTCCAGAGGAAGGAACAGGCAGCAGTCTTTGCTGTTCTGCAGCCTCTGCCAATGATACCCAGGCAAACAGGGTCTGGAGTGGACCTCCAACAAACTCCAGCAGACCTG AAGCAAAGGGCCTGACTGTTTGTAGGAA1376 TNFRSF19 3481432 GTCTTCTCAAGGATTCGGGGAAGTACTGCGTACTTCCTTCAAGCTTTTAAG 1377 TNFRSF19 3481433ATGTGGCTTCGGCTATGGGGAGGATGCACAGTGTGTGACGTG CCGGCTGCACA 1378 TNFRSF193481434 GCAAGCCCTGTCTGGACTGCGCAGTGGTGAACCGCTTTCAGAAGGCAAATTGTTCAGCCACCAGTGATGCCATCTGCGGGGACT GCTTGCCAG 1379 TNFRSF193481435 TTATAGGAAGACGAAACTTGTCGGCTTTCAAGACATGGAGTGT GTGCCTTGTG 1380TNFRSF19 3481436 ACGCAACACAGGCAGAGCCAAGGGGACGCCTGGCCTTTTGA 1381 TNFRSF193481437 GTACCTGCCTGCTAAGGAACAGACCCACCTGCCTGCTGTGGTTGTATTGCCAGAAGTGTTGGATTCACATCTTGGCTGCGCTTTGTACTGATGGTGTAACCTTGGGCAAATAGTCTCCCCTCTTTGAACCTCTGTTTACTCTGGAAAATGCCCAAGTCTGCAGATTTTGGATAGAACTAAATGAACTAGTAGTCCAGCAACATGATA 1382 TNFRSF19 3481438TCGGCCATACCCTGACCCAGATGTGTTCTTTGGAGGGTCTGCTGCTTTGGAGTTGTCCTGGACGGGGAGGATCTCATGGTGCATCTGGCTCTGATGTTTGTCTTCTGGGGCTTCACCTCCCCTGGTGGGTGAGCACTGAAGGGTACCGGAAAGTGGGTTCCATGGAGTTT TGTGCCTGA 1383 TNFRSF193481439 GCAGCTCAGATGGGGGCCAGGTGCTGTGGCTCACGCCTGTAATCTTACTACTTTGGGAGGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGACACCA TATTCACAAAAAATAA 1384TNFRSF19 3481440 CCTCTGCATGATGAGCCCACAAAGCCAGTGCCTAAAGGACTAATTAAGGGCTCCATTTACTGA 1385 TNFRSF19 3481441TGGTATTTATGGTAATTAACATACAAAACAGCTGTACTTACAAT CCGGCAAGTGCCAAAGAGG 1386TNFRSF19 3481442 GTCAGGCCCCCTGGAAGATTTGGCCAGCAGGGCAGTGGTCTG CGTGCCC 1387TNFRSF19 3481443 CCGGCCCTGGAGGGAGCGGGCGACA 1388 TNFRSF19 3481444TCCCTAAGTGAAGCTGACCCACACATAACCCACACCC 1389 TNFRSF19 3481445GTGGCTTCTTGCTGGACCTAGCTTAACGACGAGCCTG 1390 TNFRSF19 3481446TCCAACTCCTACCTTGGGAGAGAATGACAGTGAACCAAACAAG TAAAGTAT 1391 TNFRSF193481447 GGAGAGCACAGCCAGGCCACAGTGGCC 1392 TNFRSF19 3481448CAGCAGATCTATTGGAGTGTGCCTGGCAGCTGGTTCTGCAGGAGCTCACCTGCCCTAATAGAATGTTCAGGCCCTTCTG 1393 TNFRSF19 3481449ATGCAGTCACCTCCACAGAATGCCCCCCGCCCCTGCCCCAGGACACCCAGACGTTGCTCAGCATGCTTACTGCCCCCACGTCTGATCACAGTGGCCCGTCATGCAGACACCAAGACCAATGGGAAG GCGGAGGACCCCGAACATCTCTGTG1394 TNFRSF19 3481450 GGTGCCTGCCAGCTTCGCCATAAACACTGCATCTGCAGTTGTTCAGAGCATGCTGACCCCATTCC 1395 TNFRSF19 3481451GTGCCAGCAAGGTCAACCTCGTGAAGATCGCGTCCACGGCCTCCAGCCCACGGGACACGGCGCTGGCTGCCGTTATCTGCAGC GCTCTGGCCA 1396 TNFRSF193481452 GTAAGAGACAGTTTATGGAGAAGAAACCCAGCT 1397 TNFRSF19 3481453GTAAGTTTTGAGCTCATTACATTTCTTAGCATTTAGGGGAAGGGCATTTATTACTATTGTCGTGCAAGTGTTCCACAAGAGACTTGGCTGAGACAAGCACCAGTGAGTTGTGAAAGAACGCA 1398 TNFRSF19 3481454AGCTTTGTAAGGAGACTTACAAGGCTGTGATGTCCCTGCGCCA CTAGGCAAAAATAAA 1399TNFRSF19 3481455 GGTCTCTGCGGTCACAGGACATTCAGTACAACGGCTCTGAGCTGTCGTGTTTTGACAGACCTCAGCTCCACGAATATGCCCACAG A 1400 TNFRSF19 3481456TGCGCTTGCTCCCATCCATGTGCTGTGAGGAGGCCTGCAGCCCCAACCCGGCGACTCTTGGTTGTGGGGTGCATTCTGCAGCCA GTCTTCAGGCAA 1401 TNFRSF193481457 GGAGATGGTGCCGACTTTCTTCGGATCCCTCACGCAGTCCAT CTGTGGCGAGTTTTCAGA1402 TNFRSF19 3481458 AGCTCAACGTCTTTGGATTCAAATAGCAGTCAAGATTTGGTTGGTGGGGCTGTTCCAGTCCAGTCTCATTCTGAAAACTTTACAGCAGCTACTGATTTATCTAGATATAACAACACACTGGTAGAATCAGCATCAACTCAGGATGCACTAACTATGAGAAGCCAGCTAGATCAGGAGAGTGGTGCTGTCATCCACCCAGCCA 1403 TNFRSF19 3481459GTAAGGCAGCGACTGGGTTCCCTGTGA 1404 TNFRSF19 3481460TGACTTACAGTAGATCAGAACTCTGTTCCCAGCATAAGATTTGGGGGAACCTGATGAGTTTTTTTTTTGCATCTTTAATAATTTCTTGTATGTTGTAGAGTATGTTTTAAAATAAATTTCAAGTATTTTTTTAAAAAACTAACACAGCTAATATATAAGAGCAAAGTGGACAGCTGCATTCTTTTATTCCTCTTTGTAAGTACAACCACTTAGCACAGC 1405 TNFRSF19 3481461ATGTCATTCTGTATCCTGGCCTGATTATATCAGAGAC 1406 TNFRSF19 3481462GAACTTTTAGGGGATTCTATAGACAAAACATTTTTTAGCTTTGGAGGGAAAAAATTGGTTTCATTCTCAAAACGGGGGAATGGAGAAGTAAGAGAAGGGAGACGAGTGAATGAAGGAAAAACAAATTAGGCAGTTAACACATACAAAGTATCTACCTCTGAGCTCTGCCTGGAGTTAGGAAAGGCTGTTCACTGATCTTGTTCTTTTGAGCCATC CA 1407 TNFRSF19 3481463GCCTCTCTTGTTAGGAGATCATCTGAAGAACTAGGGTTACGGTGCTGCCAGCTGACTAATGACTGTTTTTCAGTTTTGTCAGGAAACAGAATTACCACTCACCTTAATTTTGTAGCTTGTACCCAAGTTTGTGATGTCAATTGCCAAGACTAAGGAATGAAACGTCTTCATACGAGGTCATCCCGGAGCCAACTCATTGCCTGCTTT 1408 TNFRSF19 3481464TTGTCGTGCTCCTTCCAATTGTGTAAGATTAGTTAGCACATCATCTCCTACTTTAGCCATCCGGTGTTGGATTTAAGAGGACGGTGCTTCTTTCTATTAAAGTGCTCCATCCCCTACCATCTACACATTAGCATTGTCTCTAGAGCTAAGACAGAAATTAACCCCGTTCAGTCACAAAGCAGGGAATGGTTCATTTACTCTTAATCTTTATGCCCTGGAGAAGACCTACTTGAACAGGGCATATTTTTTAGACTTCTGAACATCAGTATGTTCGAGGGTACTATGATATTTTGGTTTGGAATTGCCCTGCCCAAGTCACTGTCTTTTAACTTTTAAACTGAATATTAAAATGTATCTGTCTTTCCTAGTATGTTTTTATCTTCTCATGTATTATCCATGGTTTTCTCTGTTTGTGACAGATTAGTAAAATTTAATGAGCCCTCTTTCTTGTGGCCGTTTCTCCATAGTTTTAGGTTTTGATATGTGTTTACTAGCTTGCCTGTGTCTGGTACATCTCATGACCTCAATTCCCTCACCTGAAATAGGAAATGAGAATGTTTCATTGTAGCCCCAAGCGGTCATGTCAACCTAGTGCCTAGTCATAATTAATTGACTTTTCCTGTATTACTTCTTTTTTTAAGTATAAACCAATGATCCTTTGGTAGTCAAGAACTCTTAGGAACATTGCCTTTTGGACATGTAAAATATTTAGGATTTGACCACACAATGGCTATGAAAATGCAAGTAGTTTCCTCGCGTGACCTCACCATGATTCACATACGTGCCACTGTTTGAAATCTGGTCTGTTTGCATTTCTGTTATGACAGAGAGATGATGTTTGCATTTCTGTTATGACAGAGAGATGATGAAAGTAGGCAGGGCTGTGTTCCTTTGTGTAGCCTGTATATATTTTCCATATGTAGAGCCCTGATTAACTTCAAGGACAAACACTGGCTGGAGAAAGCCAGACTGATGGGAATGAGACTTTGGCCAAAAATCCCAAAACATCATTTTCAATCAGTAGAGAAGTGCTTAGGGTTGAAAATTGATTTCATTTGCTACTGAATTTGGTAAATCCTGGGTAACTTTTATCAAGATGAAGACATTTTACCCTACCTACTCTAGAAATATACAACAATGTTATATTTTACACTCCTTGGAAACATTTGAGGAAAAAAATGCAATTTGCACTTCACTTTGTTGGAATATCCCATAGCACTCAATAAACTCAGCTGCTAGAGTGCCGATGTCA 1409 LPGAT1 3512095GACCTTTCTTTGTGTTATCTGCATGTTGTAACGTGTGATAAGAATGAATGTAAAGGCTGTGGCAACTGTAATTAATTTTTGTAAAGGGCTGGTCACACGTGGATCTGGTTTATGAATG 1410 DEGS1 3579471GACTTCGAGTGGGTCTACACCGACCAGCCGCA 1411 NUSAP1 3590391CAGGGATTTGAACCGCGCTGACGAAGTTTGGTGATCCATCTTC CGAGTATCGCCGGGATTTCGAATCGCG1412 NUSAP1 3590392 CTGGACTCCCTCAAGTACAGTGACCTGCAGAACTTAGCCAAGAGTCTGGGTCTC 1413 NUSAP1 3590393TTAAAAGCCTTGAAAGGCTACATTAAACATGAGGCAAGAAAAG 1414 NUSAP1 3590394TCTTGTGATGAGACTGAGATACAGATCAGCAACCAGGAAGAAGCTGAGAGACAGCCACTTGGCCATGTCACCAAAACAAGGAGAAGGTGCAAGACTGTCCGTGTGGACCCTGACTCACAG 1415 NUSAP1 3590395AACTGAAAATAAACCACCTATGCCAAAATTGGCATACTTTTATG GAGATTTCTTTT 1416 NUSAP13590396 AAATAAGTAATCCCACTGAATTCCAG 1417 NUSAP1 3590397TCAGAGCTACTGCAAAAGTTCCTTCTCCACCAGACGAGCACCA AGAAGCT 1418 NUSAP1 3590398ACAGAGATTCAAAGGTACCTTCAGAA 1419 NUSAP1 3590399 CCATTGATCAATATATTGAGAGAAA1420 NUSAP1 3590400 CAGCCCATCAATAAGGGAGGGGTCAG 1421 NUSAP1 3590401TGTGGCTTCTACTCCCATCAGCCAACGACGCTCGCAAGGCCGGTCTTGTGGCCCTGCAAGTCAGAGTACCTTGGGTCTG 1422 NUSAP1 3590402CTAAAGATAATGAGCATAAGCGTTCACTGACCAAGACTCCAGCCAGAAAGTCTGCACATGTGACCGTGTCTG 1423 NUSAP1 3590403TGCTTGGGACACACAAATTAAAGACCATCACGGGGAATTCTGC 1424 NUSAP1 3590404CCCATTCAAGTTGACAACTGAGGCAACGCAGACTCCAGTCTCCAATAAGAAACCAGTGTTTGATCTTAAAGCAAGTTTGTCTCGTC CC 1425 NUSAP1 3590405ACCATGGGGGCAATCTAAAGAAAATAATTATCTAAATCAACAT GTCAACAGAATTA 1426 NUSAP13590406 AGCAACGGAAGAAACGCGAGCAAGAACGAAAGGAGAAGAAAGCAAAGGTTTTGGGAATGCGAAGGGGCCTCATTTTGGCTGAAG AT 1427 NUSAP1 3590407CCCACTTTAGTCACGAGATCTTTTTCTGCTAACTGTTCATAGTCTGTGTAGTGTCCATGGGTTCTTCATGTGCTATGATCTCTGAAAAGACGTTATCACCTTAAAGCTCAAATTCTTTGGGATGGTTTTTACTTAAGTCCATTAACAATTCAGGTTTCTAACGAGACCCATCCTAAAATTCTGTTTCTAGATTTTTAATGTCAAGTTCCCAAGTTCCCCCTGCTGGTTCTAATATTAACAGAACTGCAGTCTTCTGCTAGCCAATAGCATTTACCTGATGGCAGCTAGTTATGCAAGCTTCAGGAGAATTTGAACAATAACAAGAATAGGGTAAGCTGGGATAGAAAGGCCACCTCTTCACTCTCTATAGAATATAGTAACCTTTATGAAACGGGGCCATATAGTTTGGTTATGACATCAATATTTTACCTAGGTGAAATTGTTTAGGCTTATGTACCTTCGTTCAAATA 1428 NUSAP1 3590408TACATAGCCCTATCGAAATGCGAGGATTAATGCTTTAATGCTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGGTCTCAAACTCCACCAAATGTACTTCTTATTCATTTTATGGAAAAGACTAGGCTTTGCTTAGTATCATGTCCATGTTTCCTTCACCTCAGTGGAGCT TCTGAGTTTTA 1429 NUSAP13590410 ATGGCCGCTTCAGACCCACAGCAAAGATTTTTGATAAGGCATGACTCCTAAACGGATGAATGAGTGCCCCATTAGAGCCAAGATTC TTTTAT 1430 NUSAP1 3590411CTTGAATCCGTGAGGCAGATGTAGTGAGCAGAG 1431 NUSAP1 3590413TAGCCAAAGTCTAAGCAGAAGCCCCTGCGACCATTCCAACACTGACAGAACATTCCTCTGCCTTGTTTTACGGATACATTGGGGAAACTTAAGGATGAGAACTTTAGAAATGGTATTTCTTGGAAACCC ACTTGCTTGTAAATCAGTGGT 1432NUSAP1 3590415 TGGTATCTGGTGTTAAGGCAGTGCCGAATGGAGGGCAGGAAACACATTTTTAAATATTTATGGATTTATGTATTTTTCTCATAAAGACAGGGTCTCCCTATGATTCCCAGGCTCTCCTTGAACGCCTAGGCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCAGATTATATTTATTTCTATTCGCTGTATTTAATTCTTAACCCCATGTTTATTTTACATAACTTCCCTATTTCTCAAAAAGAATTTAAGGCCTATTCTCAAAATAATG 1433 NUSAP1 3590417TTATGAACCATTAAGACAAATTAGACCAGGCATG 1434 NUSAP1 3590419CCCAGGGCACCTACATATCCAGATAGACATAAATTCCTCACTCCTAAGAAAACCAGGCTTACAAGGCGTCAAGGCCCTATAAAGAGGAAAAACCCAGGACGGTCCTTAGAGGCTTCCTTCAGCATGAAAACCAAGTTAAAGCCAGAGCTCATCCTGGGTTGCAGCAAGT CATGGTTGGGCCCA 1435 FBXL83665216 GCTGCTTCCCGTCCGCTGTCCTCTGC 1436 FBXL8 3665217GGGCAAAGCCCATCTGGTCCGCCGAGCAG 1437 FBXL8 3665218ACAGCTGCCAGACTTCGGTAAATCAAGGGGGCGCCCCCTGGAGACCAGAATTTTCTGGTACCCCTGGGGATCCGGCTTCAAGATCGCTGCTACCAGTGGGCACTCAAAACGGGGTGCCCATGGGTCCCAGGTACAAGCCCGGCCGAACGTATCTGAAGCCCCAGGAAACACGTGGCACAAATTCCGGGAGAAACTGTTAGCCCGGAAGATA 1438 FBXL8 3665219AGCATTTGTACACCTAAGCTCGGTCTTCCTGCAACACTTTGCG CCTTCCCGACCTCAGAGACGTCCGTCTC1439 FBXL8 3665220 AGCTATTGGGAGTGGCGGATCCTCCCACCCC 1440 FBXL8 3665221TGGCACTCATCTTCCGCCACCTGTCCCTGAGAGACCGTGCTGCCGCCGCCAGGGTCTGCAGGGCCTGGGCCGCCGCTGCTACC TGCAGCGCCGTGTGG 1441 FBXL83665222 ACTTCCCACGGGTCACTCAGCTAGGGAATGGCAGAGGCAGAATTCGAACCTAGCAGTCCGGAGGCCATGCCAAGACTCCTTAGAGACAGCTGAGAAAGCCCAGTTCCTAAAATATCATTGGCTCTCCATGTCCAGGTTTCATCCTGTGGCAGACGCCACTGAAATCTTCTAAAAGGATAGGATGCGAGTTCCCTCCTTTGGGGCAACA 1442 FBXL8 3665223AGGCCTTTTCTGCACGGCTCTAACC 1443 FBXL8 3665224AGTGCCGCGGAGAAAAACCGCTCTTCGACGCGGGCCGCGACGTCCTGGAGGCTGTGCACGCTGTATGCGGGGCGGCCAGCCAGCTACGCCACCTCGACCTGCGGCGCTTGTCCTTCACACTGGACGACGCGCTGGTGCTGCAGGCGGCGCGCAGCTGTCCCGAGCTCCACAGCCTTTTTCTGGACAACAGTACCCTAGTGGGCAGCGTGGGTCCCGGCTCAGTGCTCGAGCTACTGGAGGCCTGCCCGCGCCTGCGCGCTCTCGGCCTGCACCTAGCCAGTTTGTCGCACG CCATCCTCGAAGCA 1444 FBXL83665225 GCGCCCCGAGTGCTAGTGCCTTCTTTTGGGATTGTTGCCCCCCGGGTCTTTACCGAGTTGGGAACTGTGATGGCATCGGGACCAGTCCTGGGCGCCCTGAGACCACTCGCTGCTCT 1445 FBXL8 3665226ACACTGCCCCCCTCTCTTGCCTCCA 1446 FBXL8 3665227GTGAGTGTGAAATAAACAAATCCTGCAGTG 1447 ARL6IPIP2 3683039TGACTTCCTTACTATTGCTTCCTGGACTAA 1448 XPO6 3686340ATGGGCCTTGGTCACACTCCTTGGCTTCTCCCACCGCAAGCAACGCTGCCTGCCTCTGCCGCTCCTCCACATCTTGCCGCTGCCCAGCAGAGCTGGCTTCTGGGTCCACCTGAGCACTGGACGGTGCTCCCAGGGCGTTGGAGCAGGCGGAGGGGTGTGTGGCCAGGTACTAGGAGGCACCAGGAAATCCCGCGGGGTGGCCCATGCAGACCAGGCGCACGTGGCTCATGGGGCAGAATTGCCAAGGAC AGCTCACGACAGTGCCACCTT 1449XPO6 3686341 AATGTGCACAGGCTGGTCAACGACCTGCGCTACTACAGACTC TGCAACGACAGCCTGC1450 XPO6 3686342 TTAGTCTCAGCCATGGAGGTCCCGAGTTCCTGGCTCTGCAGCCCCTCCATTTGTCTTGGCATCTTTGTTCATACCCAGGACCCTGCCGTTCTCCCTCCTGGGTGATGAGCCCCGGTGGGGCCAGCATTGGAGTGTGCCCAGGCTTGCATTCAGGCTGAGATGGTTGGTGCTTGGGAGCTGCACTTCTGGGTCCCCAGGGTTAGAGGTGGGACCCAGGTTCCCCGGCTGTCTTGGGCTCTTTCCAGACCAGCCCCAGCTCAGCTTGGGCTGAGTTGCTGCCAGGTCCTGGGAGGAGCCCTCCTAGTACTCACCCTCTTGTCCCACTGCTGCCACCTGTGCAGGGACTGTCAGGTGGGCTGTCCCCACCCGTGCAGCACCTCGGTGGGAGCTGGGTGCTGCTGGCTCTTGGTGTCCATGAGGCCATCTTGTTGGAGCCTGACAGTGCCTGGGACCTCCTTCCCCATGGGGCTCACCTGTTCTCTTCTTCCTGTGTCAGGTGACCAGGCCTCTCTCTTGCCTGATAGGAACTTCTGGGAACTTTTCCTTGTACCGTTTTATACTTGATGAAATTAGGAAAAGAAATCGCTTTCTCCCTGGTCCTCTTGGGGTTCTTGACCTGAGTCCTCTGTGAAGCAGCTTGTCCACGGCTCCACCGTAGTGCTCAGATGCACACACTGCTCTCACTGGTGCAAACCTGGCCGCCTGCTTTCCTCATTTGCCACGTGTGGCAGGGAAGCTTTTGCTTAGACTCATCCTGTTCTCCTTTGTCTTGGGGTCTTCCTTTTCTTGGGACTTGTTCTCTCCTAAGCCTCTTCCAGTTCACTTCAGCCCCTGGATATGTTTTTTCCTTTTTCTAGAGGCCAGATCCTAATACTTAATGATCAGCTTCTAACGACATCAATATCAGTCAACTTTTTGATTTAAAGCTGTGGTTTCAAAATCTAGTTATAGGCCAGGCGCGGTGTCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACTTGAGGTTAGGGGGTTTGAGACCAGCCTGGCCAACATGGCGAAACCCTGTCTCTACTAAAAATAAAAAAAATTAGTCAGGTGTGGTGGCACACGCCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCACAAGAATCTCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCGGAGGTTGTGCCACTGCACTCCAGCCTGGGCGGCAGAGTGGGACTTTGTCTCAAAAAAAAAAATCTAGTTATATCAGAAGCACCTGGGGTACTTATTAAAAATGGAGAAACAGACTTCTGTGTTCTACCCAGGAAATTCTGGTTTGGCATTTGGGAGCCACTGATTTAAAAGACATCCCTTAGTTGGTTTTTTGAGGGTAAAATAAAAGAATCACCACCTTCCATTCAGTCACGCACTGTGTGTTTGAAGCCAGCTGCTTCTCAAGCCCCGGGCCAGGAACTGGGGCACCAGTCCCAGCCTTCACCAAGTCTTTCATGGTAGACAGGCCAATACAGCACCCTCTGTGGACCACATAGTGCCAAGCATGTGACATGTCTTGGCTCGAGTAAGCCTTCTAACAAGCCTCTGAAGTGTGGGTCCTGTTACTCCCCCATTTCACAGATGGTGGGGGCTCAGAAGGTGAGCAGTTCACAGAACTTGGAAGTGGTAGAGCTGCGAAGCAGGAGGCAGACCTGGGTGTTCTGGCCCCAGAGCCTGCACACACTCCCCAGAAGCAGATTGCTCAGGACAGAGGCGCTGAGCTGGCTGCTGGGGCCAGGAAATAGGAGGCATCTGTGCAGACTTTGGGAAGAGGCAGGCTTTGAATGGAGTTCTGGAAGAGGAATAGTGGTTGGGCAGGAAAATGAACTTGGTCCTGCTCATGGCTCTGCTGGGGCTTGCTGGGCCTGTTTGAGTCCTCACCGGGACCTACACTGAAAAAAAAAGCAGGGTCTCACCGTGTGCATGATGGCGGAGGTCAGGGCCTCACTTCTGGCCCAGGGCCTTCCATGGCCCACGCTGCGCCCAGTGGGACAGGCCTTGGGACTGTGTTTGCTGCTGCTCGGGTGGCTCTCGAGGGGCAGGGGCGGCCTGGAGCCCCGTGGGTAAAGGTTCTGCAGACATTGCTCGGTGTGCGCGTCACCTCAAGGGGCCATGGTGAAGAAGAGGGCTGTCACCACAGCCATGTCTGCGTTTGAGGGGCCGGACTCAGGAGCAAGTGTGCTGGTCTCTTCAGTGTGAGCTGGGGCCAGCTTCTTCATGGTGCAGCGCTTTGGTCTTTCTGTCCTTAGACTAGTGGTTCTGGTAGGGCTTGGTGGCAGCCTTGTGGTGAGGACTCAGTGAGTTGATGTCTGTATGTTGATTGCAGCAGTGTCTGGCACCCGAGAGGCCCTAGGGACGTATTCCTCTTG 1451 XPO6 3686343AGGTCCTGGTCCACAAGTCCCATGATCTTCTGCAGGAGGAGATTGGCATCGCCATCTACAACATGGCCTCAGTCGACTTTGATGGCTTCTTTGCCGCCTTCCTCCCAGAGTTCCTGACCAGCTGTGATGGTGTGGATGCCAACCAGAAAAGTGTGCTGGGG 1452 XPO6 3686344GTCCTTTCTCCAGCCCGACATCCACCTTTTTAAACAAAATCTCTTCTACTTGGAGACTCTCAACACCAAGCAGA 1453 XPO6 3686345ACAGGACTGAGCTTCTGTGCCTGGACTGAACTAGTAACTTTTACACCCAGGAATTCCAAAGCAGTTTAAAAATACTTTGCTTAGCC CCCAGGCAGAGGCTTAACCTCCAGG1454 XPO6 3686346 GCCGAGCTGTTTGAGCTCCTTTTCCGGACGCTCCATCACAACTGGAGGTACTTCTTCAAGTCCACCGTGCTGGCCAGTG 1455 XPO6 3686347GAGCAGTTAGCCGAGAGCATCCTCCACGAGGGCAGCACAGGCTGCCGGGTGGTGGAGAAGTTTCTGAAGATCCTGCAGGTGGTGGTCCAGGAGCCAGGCCAGGTGTTCAAGCCCTTCCTCCCCAG CATCATCGCCCTGTGCATGGAGCA 1456XPO6 3686348 ACTGATGAGATGCTGAGCTTCTTCCTCACTCTGTTTCGAGGCCTTAGAGTACAGATGGGTGTGCCTTTCACTGAGCAAATCATACA GACTTTC 1457 XPO6 3686349ACCAGACACTCAGCGTCTTAGAAGATATTGTGGAGAATATCTCGGGGGAGTCCACCAAGTCTCGACAGATTTGCTACCAGTCGCT GCAGGAATC 1458 XPO6 3686350CATTTTTGAAGCGTCCAGGCCTGTTTTCTTGTCATATGTCTCCTAGTCTTGTTTTGCCTGATTGTTTCCATAGGTTGTGGTGTAGTGGTGCATGTTCGTGTTCGCATTTCCTCTTGCATTGCTTCTGTTTGTCCCATCCTTGGTGATGCTCAGTCTGGATGCCTGTTGGGAGTAGGGCCTGCCAGTCTGTCCATTGGGAAGGTGCTTGGCAGGTGTAATTGCTCAGGACTGTAGAGAAAGTGGGCGAGGTCAAGAGTT GGACTTGGGTCTGAATGGCTCCAGCTC1459 XPO6 3686351 AGCAGTGGCCCGTGCGCTCCATCAACCACGCCAGCCTCATCTCTGCACTCTCCCGGGACTATCGCAACCTGAAGC 1460 XPO6 3686352CCAGGTGTTGGTGTGCCGAGCCCTCTCTAACATCTTGCTGCTT CCGTGGCCAAACCTTC 1461 XPO63686353 AGCTGCTGCTATCTGCGTGCCACTTACTGGTCTCACTGGCCACCACCGTGCGGCCCGTCTTTCTGATCAGCATCCCTGCAGTGCAGAAAGTATTCAACAGAATCACTGATGCCTCTGCCCTGCGACTT GTCGATAA 1462 XPO6 3686354GGGCAAAATGCTATGAAACGGCACCGCATGCTCCAGAGAAATATTTCATGAAAGGAAGTCAATCGATGCAGCAAACTTCATTGTTGTCTTATTTTAAGTAATTGCCACAGCCACCCCAACTTTGAGCAACCACCACCCTGTTCAGTCAGCAGCAGTCACTTTCAAGGAAGACCCTTCACCAGCAAAAAGATTACCGCTCTGAAGGCTCAGATGATTGTTAGCATTTTTAGCAATAAACTACTTTTTAACTAAGATATGTACATTGTTTTCTTAGACATAATGCTTATTGCACACTTTATAGACTATAGTGTAAACAAAACATATGCATTGGGAAACAAAAAAATTAGTGTGCCTTGCGTTATTGCATAATTTGCTTTATTGTGGTGGTCTGGAGCTGAACCTGCAGTATCTCTGAGGTATGCCTGTATATCCTTCCAGACTTTTTTCTCTTTTTATGTAATAAGTAATAACTAAGTTTG TAGATAGCTGGAGATA 1463 XPO63686355 GTTGTAGCCTACATGCATTCAGATACAACTTTACTTTTTTAGTTATCTGAGTTCCACATGAATACATGCTCACTG 1464 XPO6 3686356GGCTTACTCTCACTGGTTAGCACAGTATTGCAGTGAAGTTCACCGGCAGAACACGCAGCAGTTCGTGACACTCATCTCTACTACC ATGGATGCAATCACAC 1465 XPO63686357 GAGGACCTTTTGCAGATCCAGATCTTAATTTTTTTAAAAGCATGTCCTACAATCTGGATTTGTCTAATTATTTCCATTATATTAGATTCAGTTTAAACATTTTTAGCAAGGTTACTACATAGGCAATGATGTGCCTTTCCTCTTGCATCATGTCAGAAGGCTCTTAATATCAA 1466 XPO6 3686358TTTCAGCCTTGAGGAGCTCTACAGATGTGCTAGATTGACTGAAATTCTTACTCCTAAGGCTGACTTTGATGTCCTTTCTCTT 1467 XPO6 3686359TCAAAGTCACTCTGTACGGATCTCAGATAAAATTGTACAACATTGAAACTGCTGTGCCATCAGTATTGAAACC 1468 XPO6 3686360GATATATCTTATCTGTTCAGTTGGCGGGGCGCA 1469 XPO6 3686361AACATCACGGCGGAGAACGACTGCCGGCGGCTGCACTGCTCCCTGAGAGACTTGAGCTCCCTGCTGCAGGCCGTGGGCCGCCT GGCCGAGTACTTTATCGGGGA 1470XPO6 3686362 TTTGAAGAAGTTGTGTTGAAAAGTAAGGAAATTTCAGA 1471 XPO6 3686363GCCTGTGTAAATGGGCGCCAGCCGCGATTCTTGTCTACTCCTGGTGCTGTGACCGTGTATGACAATGGGATGCACATTTTGGCC AGC 1472 XPO6 3686364CTTCTTATGGGATCTGTCCCGGCTCTG 1473 XPO6 3686365TTTAAAGGCTTATGATGAAAAGCTGTGGGGGAG 1474 XPO6 3686366TGTTCTTCAGGACAATTTAGAAGTTTATTTGGGATTACAACAGT TTATAGTCACTTCAGGGTCAG 1475XPO6 3686368 TCCTGCTCACAGAGGTGTTGAATCGAATCCAGTTCAGATACAA CCAAGCCCAGCTG1476 XPO6 3686369 TTGTTTGGATATCTGGACGCTGTTTTTGGACTATCT 1477 XPO6 3686371GTGGTTAATGGAATGAAGGGTTGCCTGTCCTGTAG 1478 XPO6 3686372AGCCTTCTAGACTTGCCAGATTGAAATGACACAGTGATCTGCCCATCAACTTTTTATCATTTCCCTTCACTTTAATTGGGTCACAACACAAATGACTTAGAAAATGTGAGCGCACTAGATTATAAGAAGCCTTAGCAGACAGTGTCTGAGGATTAAAGTTGC 1479 XPO6 3686373CAGGAGCAACATGGGACATTTTATTTCCGGGCCAGTTTTGCTTTTCTGAGTAGTAGTTTTCTCTGCTTTTATTATTTCACATATCTCTGTTTTGAAAAATAGCTTTTGCAGTAATGAGCTTCAGAATTGCTTTTAGCCATTATTTCATTTTCAGCTAAGGCCTAGTATGTCTTTAC CTT 1480 XPO6 3686374AAAACCGTGATGTTTGCTCTGTATAAGAACACAATCTGATATGGTAATATGTTCTTAAAAATTATTTGGTGATAGCTTTCCATATGAATTCAAAGGCATCATTATTCACACTTTCATATTCTTTCTGTCTGTGGTTAAGAAAGGCTGTATTACCTTTTTTTTAATGATCTGTGTGTCTCATGTCTATCTCTTCATATGTTAATTTAAAAATCTAGCTGCTTGTATCAACTATCAAATATCAGTTGTTTTGACTTTAATCATAATGTAGTCACAGACAACTTTGTTGTGGCTTCCATTTGGATGGTATAGAAATGTCATTATGGATTGTCTATGTACTGATGTTGTTACGTGTAACTTTTGTGCTCTTGGTTTTACATTTTAATCCTGTGCTTCCTATTGCCCTGTGAAAGCTGAGAGGTGCCTGGGAGCAGAAAGGTGACATAAATAATGCTGTGTGCTTGCTTCCTGGCTCTGGGTCCCCTACCACTAATTCTAAACAGCTCAGTCCATTCTCAGTTGTTTAGGAGCTGCTAACCAGATCCTTGGCTTCTCTTTCCCTCTACTGCCTTTTCCCCTAACTTTCTACTGTTCATTAGCACCTGTACCAGAAGG 1481 XPO6 3686375TTGTTATTGTCCTCTCAAGTGGAGCCTACAATGACCTACTTTTTTTTTTTTTTAAAAGCACTCTAAAAGACGACTCCATCACAGTACTCTGAGGCAGGGTTTCATGATTTATGTCTCTTGCAGATGAGGTCATTTATGTATCTTACAACTGCTGCTGTATGAAAACAGGAGGGAATTTGGAAACTTATATTATGAACAATCAGATTGACGGTTTAGGG ACTTTC 1482 XPO6 3686376GAGACTGCTGCTCCTGCGTAGCCAAGAACAGG 1483 XPO6 3686377ACAGAAAGGTAGGTGTGTGCCAGTAAGTCTGAGATTAGCTGGAAGGGCTTGGGTGGTTAAGGGAAGTGACTGAGTTTGAAAAAT GCTTGTGCCTTGTGTAGGTTTGTTGTCTT1484 XPO6 3686378 TGCTGTGCTGCATGGCATCTGTAATCCTCTTT 1485 XPO6 3686379ATCAATGAACTCATGTCCAAGAACTGTGT 1486 XPO6 3686380AGCTAGCGCACCCTCTTAATTCCTACGTCTGTTTAGTCTTGAGTCTCTATGTAATTTGATGCCAGTGTGTCCTTTTGCTACAGCTTCTCCATTCCTTAATTCTTTATTTTGATTTATCTCTTTATCTGTGTGGTTTCTTTGTCTGTTATCCTCCTTGAGAA 1487 XPO6 3686381GGAGGGTTGAAGTGGGAGAATGGCTT 1488 XPO6 3686383GTCTTTTCTGTTTGATGAGAGCCTCATGACAAGGTGTAAAGGGTAAGAATAAACAGAAAGCAAACCACAACATGAGACAGGAAGGTAGGAGGAGAGGGGAGTGCCCTGGGTGACTGGGGTGGCTGCTGTGTGCTGCTGTGATACCTGTTTGCTAGGGAGACATGTATGCAATGCCTGGCCGTGAGGCCCTGAGGGTGCCGGGAGCCTGGGCTTGCTACTTGAGGGAATCTTGTAGTGAAAAGAAGTTTTTATCTCTAACTCCTTTATCCAGGCTTCTTCTTGGATGTCTAGGAACTTTCTTTATATCTCCAGTTTAGTGCTTGGCATGTGGTGGGCACTTAAAGTTGGCTGAAAGAACCATTGATTTAAAGTAAACTTGGGTTAG TGCAATGGCTC 1489 XPO63686385 TAGACCATCTCTGGATTACTTCTAATA 1490 XPO6 3686386ATGGAAATCCGTAGCTGTCTGCCCAAACTCCTTTTGGCTCACCATAAAACCTTACCTTACTTTATCCGGAACAAGCTCTGCA 1491 XPO6 3686390GCCTCTCTCAGGGCATTGGAAAGTCTGATGACAGAATTTTTTC ACGATTGTACAA 1492 XPO63686391 GAGTGATTTATCTGATTGGTACACCAGGGA 1493 XPO6 3686392TCTCAAGCTTCATCCGTGTGGTGGCGTGTGTCAGAGCTTCCTT C 1494 XPO6 3686393AGTGGAGTCATGAAGTATTTGGCCTGTTGTGACTGCCTTATTT CACA 1495 XPO6 3686394GGCCTGTCAGCCTCCGCCCGTTCAGCCTCGGGGCCGGGGCCGCCGCCACCTCTGCCCGCGGAGGCCGGGGAGCCCCTGCCTGGGCCCGCAGCCTCCCCCGCGGGGGTCGGGCCCGGGCGGGGGTCCCGAGCAGCTGCCCTCCTCGCCGGCATCCGAGCCTCATTTCCTGCTTTTTCAGTTTCCTTGGGGAGGGGCGGGTGGGTCTGGATGAATTGTCTCGGGGTCCCCCGATGAGGCGACCCGGGCGGCCCTGCCCTTTTTAGAGGGTCCCCTCGGGGCCCGGTGGGGAAGGGGTTGTCTTTGCATGGGTGGGGGACTTCCCGAGTCTGCCGGGACCATGACCTGAACTGTGCGAGCGGGACGTGTCCGAA GCCCAAGA 1496 XPO6 3686396TGCTTTGTGATAGGGAGAGTTATTTCTAAGGGAAAGGAATGTACCCTGTATTTCTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTCTTGCCCAGGCTGGAATACAGTGGGGTGATCTTGGCTCACTGCAACCTTTGCCTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTATAGGCGCCTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTGCTGACCTCAAGTGATAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCCGTACCCTGTATTTCTTGAAGTGAAGAATATAAAGTCTG TA 1497 XPO6 3686397TCACAGCTCATAGTGACCTCGATCTCCTGGTC 1498 XPO6 3686399TGCAGAGATTACCTATGTTACAGGCTTAAATTATAGATGTGAAGATGGTAAAGGGAGACACTATTTTAATCAAAAGCTTCCTGGGTACAAAGCTAATGAGAGGAAAAATTATACATTTTATCAAGCTCTTTTTCAAGTAAAGAATAGCTTTCTTTTTTCATCTGGCTTCTTGCCTGACCTTCTCCCCTTCCCCTAAATGGTGAGAGGAAGGAGAGCTTGCAGATAGATTTTCCATATCGTAGGGGATTTTTATATCTGGGAAGCACAGCATTTCATATTTATAGGAGGGTGTATATTGCCAAATGGGATATTTGGCATTACGAGTCATTTCCAGCTGAGAGAGTAAG GATGCA 1499 XPO6 3686401TCCCTGGCGTTCTGTCCAATACACTTGCCTTCAATCCAAGTTGAGGACGGTTATGGTAACCCTCTCCAAGGCTCTCTTAAGTGGGCGTCAGGGAAGCCCACTGGAGACAGGAAAGACCAAGAGGGTTGGGAGTCTAAGTGAACCTATTCCTGGGTTGGTTAGTGGTGCGTCCTGTGACAAGAAGAGAGGGACCTTGAGACGGAGAGTCACAGGCCTGATGATAGCAGGTAAGGTGGAGCCACAGTTCCACCGCTGGGATTGGTCCCTTTGATGAAGAACAGAACGTTTCCTGGCTACATTTGAAGTATAATTATTTGTAACAAAAGATGGATTTGGAAGAGAGCACTTTTAGGTGAAGGGCTTCTGGAGGTTTAAAAAGGCTAATTGTCCACTGTTCTCCACCACCTCCCGCTTTCAACCCCTTCAGTATTGACTCCTTTAACCTCATGTAGCTTTCGTGACTTTGAAA CACCATGTAGTAGAAGGAGCCAGAC1500 XPO6 3686403 TAAATTTTAGCCTTTCTGGTAGATGTGTAGCACTATCTTATTTTAAATTTGTATTTTCCTGATAACTAATGAGGCTGAACACTTATTTAT AGGCTTTTTGAATA 1501 XPO63686405 GGATGTAACTGCTAGGCCACCTTCAGTTCTTTGAAGTTAGGGACCGTCTTACTCATCATTGTATCCCAGGGGCTTAATTTAAGCAATATCAGTTACTTAGTGAGTATTGAATTCTCATTTCTCCAACAAATAGCTGAGTTGCTTAGTCACTCCAGAATTAAAGCTAGGTTTAGAATAATTGGAGCGGTGTGATGGCATGTGCCTATAGTCTCAGCTTCTCAGGAGGCTGAAGTGGGGAGGATCGCCTGAGCCCAGGGGTTTGAGGCTGCAGTGAGCTGTGATTGTTCCACTGCACTCCAGT CTGGGGTGATACAGCAACACTCTG1502 XPO6 3686407 CTCCCACATGACTATGGTACAGTTACCATCTTCGGTTAATAGAACATTGATTCAGTACTTTGATCTAACCTACTACCACCTGTATTCCAGTTTTGTCAATTGGCTCAGTCATGCCTTTCATAGCATTTTTTCCCTCCAGTCCAGGATCAATCTGTGGTCAGGTGTAGCATTTAC TT 1503 XPO6 3686409TGCAGCATGCTTTTATAGTGGTTCGTCAGTTTCATACTCATTCA TTACCTGATG 1504 XPO63686411 ATGGTGTGTGTGAAGACATGGAACTGTTATGTGGAGAGAAA 1505 RP13- 3716787ACAGTTGGTGTTACGTTAGAGCTAATAATTATACTTTAGCACGT 753N3.3TAACCTCAGAATTCTAAGGCTGAGAGTCAAACACTGCTAATTCATAGAAGGCAATAGCTTGTAATAATGAATCATAAAGCTCTTCTACTCTTTGTAGTTCAGTAGATAAAAACATCTGTCTGTAGTGAACTATTTTATCTGATGGGAAGAACACCCGAGGATCCGCCTTCAGTATAGAATCGAAGAGAAACTGCTTCACTAGCTCTTTTCCACTAGT CCGGGAGTCACCAATCATCA 1506TOP2A 3756154 TGAAATTGAATTAAGTTTAAGGCTGGGTG 1507 TOP2A 3756155GGCTGTTCCAAAACAGTAAGTTATCTCTATTGATTGT 1508 TOP2A 3756156GGAACTAAGCATGGTGGGAAATGTTCCTGCT 1509 TOP2A 3756194CTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATTAGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAA GACCTGTCTACATTGTTATATGTG1510 TOP2A 3756195 AGTGACCATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTGAACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAAAAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCATCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCTCATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTG 1511 TOP2A 3756196CAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACTCAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTAT A 1512 TOP2A 3756197CTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATTCTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAG 1513 TOP2A 3756198AGTTCCTAAAAAGAATGTGACAGTGAAGAA 1514 TOP2A 3756199GGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCC CAG 1515 TOP2A 3756200TTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAG 1516 TOP2A 3756201TGATGAAGATTTTGTCCCATCAGAT 1517 TOP2A 3756202ACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCTGGTCTGATTCAGAATCAGATAGGAGCAGTGAC GAAAGTAATTTTGATGTCCCTCCACGAGA1518 TOP2A 3756203 AAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAG 1519 TOP2A 3756204AACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAAAAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAA 1520 TOP2A 3756205GAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATT TGTGGAAAG 1521 TOP2A 3756206TGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTG ATATGCCCCTTTGGTATTTAACC1522 TOP2A 3756207 AATGAAGAGAGTGACAACGAAAAGGAAA 1523 TOP2A 3756208ATTAATTAAAGTTCTGATTCAGAGGGGATATGATTCGGATCCT GTGAAGGC 1524 TOP2A 3756209GCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTGAACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCTTTATCTTAGAGA 1525 TOP2A 3756210CCTCCTCTCATAACAGACTATAGGGAATACCATACAGATACCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACT AG 1526 TOP2A 3756211TCAAGGGTACTATTGAAGAACTGGCTCCAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCT CAGAGCTTCCCGTCAGAACATGGA1527 TOP2A 3756212 GGCTCGATTGTTATTTCCACCAAAAGATGATCACACGTTGAAGTTTTTATATGATGACAACCAGCGTGTTGAGCCTGAATGGTACATTCCTATTATTCCCATGGTGCTGATAAATGGTGCTGAAGGAATCGGTACTGGGTGGTCCTGCAAAATCCCCAACTTTGATGTGCGT GAAATTG 1528 TOP2A 3756213GACCATTATCAATTTGGCTCAGAATTTTGTGGGTAGCAATAATCTAAACCTCTTGCAGCCCATTGGTCAGTTTGGTACCAGGCTACATGGTGGCAAGGATTCTGCTAGTCCACGATA 1529 TOP2A 3756214TGTTTACTTGCTTCAAACGGAATGACAAGCGAGAAGTAAAGGT TGCCCAATTAGCTG 1530 TOP2A3756215 TCTGACATATAATGACTTCATCAACAAGGAACTTATCTTGTTCTCAAATTCTGATAACGAGAGATCTATCCCTTCTATGGTGGATG 1531 TOP2A 3756216AACAGATAGATGATCGAAAGGAATGGTTAACTAATTTCATGGAGGATAGAAGACAACGAAAGTTACTTGGGCTTCCTG 1532 TOP2A 3756217CCAGCACATCAAAGGAAGCTAAAGAATACTTTGCAGATATGAAAAGACATCGTATCCAGTTCAAATATTCTGGT 1533 TOP2A 3756218GAAGAGTGGAAGAGTTCTACTCCAAAT 1534 TOP2A 3756219TGGCCCTCTCTTCTGCGACATCGTTTTCTGGAGGAATT 1535 TOP2A 3756220AATATCATCAAGATTGTGGGTCTTCAGTACAAGAAAAACTATGAAGATGAAGATTCATTGAAGACGCTTCGTTATGGGAA 1536 TOP2A 3756221TGGGAGAGACAAATATGGGGTTTTCCCTCTTAGAGGAAAAATACTCAATGTTCGAGAAGCTTCTCATAAGCAG 1537 TOP2A 3756222CTCCACTGAGTGTACGCTTATCCTGACTGAGGGAGATTCAGCC AAAACTTTGGCT 1538 TOP2A3756223 CATTGGCTGTGGTATTGTAGAAAGCATACTAAACTGGGTGAAGTTTAAGGCCCAAGTCCAGTTAAACAAGAAGTGTTCAGCTGTAAAACATAATAGAATCAAGGGAATTCCCAAACTCGA 1539 TOP2A 3756224TGTAAATGCCTTAATTGAAAACCCAACCTTTGACTCTCAGACAAAAGAAAACATGACTTTACAACCCAAGAG 1540 TOP2A 3756225GCTGATCAGATTGTGACTAAACTTGTTGATGTTGTGAAGAAGAAGAACAAGGGTGGTGTTGCAGTAAAAGCACATCAG 1541 TOP2A 3756226AAAGGATTTCGTAGTTATGTGGACATGTATTTGAAGGACAAGTTGGATGAAACTGGTAACTCCTTGAAAGTAATACATGAACAAGTAAACCACAGGTGGGAAGTGTGTTTAACTATGAGTGAAAAAGGC TTTCAGCAAATTAGCTTTGTC 1542TOP2A 3756227 TATACATGTATCACCTTTCAGCCTGATTTGTCTAAGTTTAAAATGCAAAGCCTGGACAAAGATATTGTTGCACTAATGGTCAGAAGAGCATATGATATTGCTGGATCCACCAAAGATGTC 1543 TOP2A 3756228TGGCTATGGAGCCAAATTGTGTAACATATTCAGTACCAAATTTA C 1544 TOP2A 3756229TGAAAAGATGTATGTCCCAGCTCTCATATTTGGACAGCTCCTA ACTTCTAGTAACTATG 1545 TOP2A3756230 TAATGCTGCGGACAACAAACAAAGGGACCCAAAAATGTCTTGT ATTAGAGTCACAATTGATCC1546 TOP2A 3756231 CAAATGTGGGTTTACGATGAAGATGTTGGCATTAACTATAGGGAAGTCACTTTTGTTCCTGGTTTGTACA 1547 TOP2A 3756232GAACATATTTTGCTCCGCCCAGACACCTACATTGGTTCTGTGG AATTAGTGACCCAG 1548 TOP2A3756233 CCTGTAAATGAAAATATGCAAGTCAACAAAATAAAG 1549 TOP2A 3756234GTTCTTGAGCCCCTTCACGACCGTCACC 1550 TOP2A 3756235TTCAAGTGGAGCTCTCCTAACCGACGCGCGTCTGTGGAGAAGCGGCTTGGTCGGGGGTGGTCTCGTGGGGTCCTGCCTGTTTAG TCGCTTTCAG 1551 TOP2A 3756237TTAAATAGGAATTCATACCAGGGACAAAGCAG 1552 TOP2A 3756239GGTCACTTATACACGCATTTCTTTAAAATATCTGATTAGGTATTTATAGTTTGAAAGAGATGATGTTTCCTTGACTGAGCATCTTGAGAAATCAAGATTTAGTTGACAATTAGACATGAGGAGAATAGAGAGCTAGAAGACCTTGCATAAACTGATTGACCAAGAGAATAGATACACTAATCATGTCTACAGGAACAGAAAATAAAAGAGACAGAGAAGAGATAATAAATCTGATGGTAAAAAAAAAAAAAGGCAGGAAGATTACGAATGGCTTCTACTCTCTGGGTGTGGTGGCGCATGCCTGTAATCTCAGCACTTGAGCTGGGGAGGTCAAGGCTGCAGTGAGCCTAGGTAGTGCCACTGCACTCCAGCCTGGACACAAGAGTGAGAGAGACCCTGTCTCCAAAAAAAAATGATTTGATCATATATGATTTGACTGCCCCCTTGTGGTAATTTACATTTGTCAATGGTTTAGGGAGACTTGCCTGTATACCGGGATATACAAATTTATGCAAGCA CGAAGACAGTTTA 1553 TOP2A3756241 ATCGGCCCGTTTCCTATTATGGAAGATTTAGGTCATTTCCATGTTATAAATAATATTGAGGTGATTATTTTGGAGTATAAAACAAGAATGTTTATATTATGATCTATTACCTAACAAATAATTTTGCTCATTATATAGTAAATTGTGTTTTATCACAAGGCTATAAACAGCATGTTC 1554 TOP2A 3756243GCTCATTTGTATTCTAGATTTCTGATAGATCCCTTCTTCCCTAA TATGATCCCTAATATGAATCTTC1555 TOP2A 3756245 AAATAAAGCATGAGTACATTTTTAGTGGCTTAATATCAACTTCT ATTGCAG1556 TOP2A 3756247 CTTAAATTATTAATCATGATTTATCTTTACATATATGTGTTCTTAT TGT1557 KRT15 3757079 TTGCATGCGCTCTATTCCCCCTCTGCCTCTCCCCACCTTCTTTGGAGCAAGGAGATGCAGCTGTATTGTGTAACAAGCTCATTTGT ACAGTGT 1558 KRT15 3757080GTGTCTATTGCAGGAGAAACGTCCCTTGCCACTCCCCACTCTCATCAGGCCAAGTGGAGGACTGGCCAGAGGGCCTGCACATGCAAACTCCAGTCCCTGCCTTCAGAGAGCTGAAAAGGGTCCCTC GGT 1559 KRT15 3757081GTGGTTTCTTCCCACAAGAGAGAAATCTAA 1560 KRT15 3757082CAATTTCCACATCAATGTAGAAGAGTCAGTGGA 1561 KRT15 3757083TTGAGTAGGCTTCATTCAGGGCATGTCTCTCCCCCAGGCCCCATCTTCATACACTTCCGCTAAGATGCCCACAATTCATCCCCCTTCATGTGCAGCTTGAAAAACCCTGACATTGTTGCTCCCTGCCGGGCATACCTGCCATTGCCACTGCCCATCTCTGTGATGAGGAATTCAACACCAGATCTCTGGCAGCTCTTGAGGGATTGGCCAGTGG CCATTCTCAGGGGTGCTGTCTAGTTTTCC1562 KRT15 3757084 GATGGCTGGCATTGCCATCAGGGAAG 1563 KRT15 3757085AGGATCTGGACTCCTCACTCTGGTCCTTGGCTGTTACCTGGGACAGGTCACTTCCTCTCTCTGGATCCGTGTTTCTTCTGTAAATGATAGAGGCTGGGCTAGTGGTAGTTAAGATCTAGTGCTCATTCCATTCTCTGCATGAGATAGATGGGTATTCTTGTAGTTCAGAATCTTGACCAGCTCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGTCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCATGGCCAATATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCACAAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGGGCTGAGATCGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGATTCCGTCTCAAAAAACAAAACAAAACAAAACAAAATCTGTCTACTTGGGGATAGCAGGCCTGGATGGGCTAGCAGGATGTCCCACCCCTAGAGGAGTCAGATGTGTGGGTGGTGGTGGTGTAGGGTCTGAAGAACACTGCATAGCTATCTACATGAGCTTCCCTTACGGACACTTGAGCTTGTGCCCTTTGCT TAAATC 1564 KRT15 3757086AGAGTGCCGCTATGCCACGCAGCTGCAGCAGATCCAGGGGCTCATTGGTGGCCTGGAGGCCCAGCTGAGTGAGCTCCGATGCGAGATGGAGGCTCAGAACCAGGAGTACAAGATGCTGCTTGACA TAAAGACACGGCTGG 1565 KRT153757087 CCTGATGTGTCTATGCATCTGTCACTCCCCCA 1566 KRT15 3757088AGAGGTGGCCTCCAACACAGAAATGATCCAGACCAGCAAGACGGAGATCACAGACCTGAGACGCACGATGCAGGAGCTG 1567 KRT15 3757089CTGGCCGGCCAGGTCAATGTGGAGATGGACGCAGCACCGGGTGTGGACCTGACCCGTGTGCTGGCAGAGATGAGGGAGCAGTACGAGGCCATGGCGGAGAAGAACCGCCGGGATGTCGAGGCCT 1568 KRT15 3757090GTGAGAGCTGGCCCCCATCACCCCTGA 1569 KRT15 3757091TGACATCAACGGCTTGCGCCGAGTCCTGGATGAGC 1570 KRT15 3757092CTCCTCTTCCTGCATTGCCCACTTTACTTGGCCTTCTCCTGGCTCTGACTCAGGCAGCCAAGACCCCTCCCACTTCC 1571 KRT15 3757093ACCATCGACAACTCCCGGGTCATCCTGGAGATCG 1572 KRT15 3757094GTTCTGTAGATCCATGGCTGTGTCCAAGGTGTGCAGGAGGCAGTGACCATGAGTTGTCCACAGTGGGGCTGGTGGAGTGTCTCTGAGAGAGCTATTGTCAGAGCTGGCTGCACCCCACTGCCCCACTCTCCTGGGCAACCAATTCCCACAGGCAATACTGCCTCCTTGG TCTTTCGTGCCCTGGAGA 1573KRT15 3757095 GTGAGTCCTCGGATGTCAAAGAGAGG 1574 KRT15 3757096CAACCAGCCCAGAATGCGACTACAGCCAATACT 1575 KRT15 3757098CTCTGGCAATGAGAAAATTACCATGC 1576 KRT15 3757099GTTTGTCTCTTCAGGGTCAGGAGGAGGATATGGGGGTGGCATGAGGGTCTGTGGCTTTGGTGGAGGGGCTGGTAGTGTTTTC 1577 KRT15 3757100GGTGGAAGCCGAAGTATCTCAGCTTCTTCTGC 1578 KRT15 3757101GAGGTCCCACAACACCCTCTGAAGGGTATATAAGGAGCCCCAGCGTGCAGCCTGGCCTGGTACCTCCTGCCAGCATCTCTTGGGTTTGCTGAGAACTCACGGGCTCCAGCTACCTG 1579 KRT15 3757102GATCGGCCAGTGGACTCCCAAACTAAGAACACGGAGCTGTCCTCTTGGGGAGAGGCTCAGGGCTCGGGGAAGTGAAGTCCAGCTGAGGGCACAGTTGGCCTGAGCTGCTCTCAGTACAGGCAGAGGCCTTGGTAGCTGTGCTGTGATGAGAGTTCGCTCCCTGCTGCTCTCTTCTGGCATGGAGAGATGAACCTGTAATCCAAGTGTTAA AACCGTGCCCTG 1580 KRT153757103 CCCAGCCTTATCAGCGGAGGTTTGCCCCAACACATCCCAGAAACGAGCAAAGGTTCAGCGCCGTGCAGTTGGCAGGTGTCGGGATCATCAGTCATCCCCTTGTCAGTCCCAAGCCTGCTGGGCTTTTGTGAGGGTGCCAGGAACACAGGCTGGAGGATGGCAGGAGGGGAGTAGAGGTGGGAGGAGGGGAGTCCATCTGCAGCACCAGGTAAGGGGATGGATGCTGGCTCCTCTGGTCACCTCAGCTGGA ACACTACTCAAGGTC 1581 KRT153757104 GACAGAGCTTTATCTTCGCAAGGCCATCCCACCTGGTGCTAATGAGGAGGCTCCGGGCCCCACCCAGATCTGGAGCTCACAGTAGCGGTTTGGACTGAAACCAGGGATTTGTGCGTGGGGCAGTGAGGGGGGCAGCTGCCGCCCCTGGCCTGGGCCTGAGAGTATAGAGAAAGCCACCTCGAGGGGCTGCTGGAGGAGAGTCAGGTGCAGAAGGGGATCTGGCTGGGGTCCAGCCCTTCCTCACCCTGGGGTGAAAGGCGAGTAATTGTTCTTGAGTTAATTGCTGGGGCCACAATGTCTGCAGAGGCTTTTAATGAGCTCTGGATGATCTGAGTTTGATTATTTTTCTTTCGGAGGAAAAGACAATACCCTCCCACCCATGAGACAATACCACACTGTCTGTGCCCAGCATTGGAGGCCAGGCTCACTGCGAAGATGGATGAGAAGGAACCCACCCCCAGCCTTGCTGGCTGGCAGTTCCCCTTGCCAGCCCAGCTCAGATGCAGGAATTTGGGGTCTGCAGGAAGGACTCTTTCCCTGTGCCCTGTTTGGTTGAGGGTGTGAGGACCTGTTTGAGTCCTGGCTTTGCCCCTTACCAGTGGTGCCACCTGGCACAAGTTGCTTCACCTCTCCAAGTTTCAATTTCATTCTTTCTGAATCTTGGGTGGGGGTCACCCTCTGTTGTGAGGATGAGAGGAGGTGATGGATGCAAAAGTGCTTTGTAAATCACAAAGTGCAGGGTAGAAGTAAAGGATTATGCTATTATAGCAAAATAAGAACCTAAGAACAACCTGCGTTGCCCCATAGGAGCTGGCTATGGAAGGTCGATGCCGTTGAGCCTAAGAACATGCTCAGGCTCACAGGGCATGTTCTGATGCCCAACGACAAAGCCCCTCCTGGTGAGGGCACTCAGGCGCAGGTGCCGGTCATGCACCCTGGCCCCTGCATGTCTGGCACCTGGGTGGGGATCCAGGAGGGGGCAGGATGGGGGCTCTTGGGCCACAGGGCTTCCCTGGAAGTGAGAGTTGAGAGCGCCCCTTGCCACAGGGAAACAGAGACTTAAAAAGGTAAATGTCCACAGTCTTACCATGGTAATTGGTAGGGTCAGGATTTGAACCCAGGCCTCACAGTCTTACCATGATAATTGATAAAGCCAGGATTCAAACCCGGGCCTGAGGGACTCCAGAGCCCTGTCCACTTCACCATGCTGCAACCTGGGCTAGGAATCCTCCTCCTGAGTTTCTGTAAGCCCTGGGGCCAGGTCCAGAGGGCTGAGCCACACCTCCAAGTGGCACTGCCCACAGGTATCAGGTGTCCCTGGAAAGGTGTCCCTGAGCTGGTGGCAGAGAAAA GGGCTCTCCTGAGTGTTCAACTC 1582KRT15 3757105 GCAGGCCCAACCCTATGAGTGATGGGGGCAAGTGAGGGACACTAGTTCCACGCCCGCATGCTGCCAAATGTACTCAGCACCCTGCTAAGGAGGCTGGAGACCCCATCACGGCCATGGCAATCCCGAAGGAGGAGCTGTTTCAAGGTTGGTTATGAACATGTAACCCCAGAGCCCCGCTGCTGTAGCCTGGACTGGGACCCCCTTCTGCCCCCTCCCTAGCTGTCCTGTTCTGGCCTCCAGCACCCACAAACCACCACCCCCAACTTAACTTCTCAGGAAGCCTTGGAGCTGGAGGGAGAGGCCTGGCTGCACCCCCAGCTGGGACTGCCCAGAGGCGCTTGTCCCTGCCCATGAAAGCCTCCCTTGTCACAGCTGAAACCTTCCCTCTGCCTCAGGGGCCCCTGGAATGTGGCTGCGGGGCGGGGTCTGGGCCCACACAGGTGGGGCAGGTGACTGTCAGGTCTCAGGCCTGAGTGTCAGGAATGAAGCCTGCCTTTGTGTGTGCACAGTGCAGGGTGGGGCTGGACTGGGGACACTTTTCTGTCTCAGCCTGGAGACCTGGGATAGGAGGGAGAGGGGAGTGGGGAAGTTGAGGGGAGTGCCTTTACATCCTGCTGGTCATCGTGGCCACTTCAGTCTGTTGAGCATTTCCTGTGAGTCATCTTGCTCCAACTGAGAGTCAGGCTGAGCTGGAGTTATTTCCATTTTCCTG ATTGGTAGACTAAGGCTCA 1583TMEM100 3763391 CGTCTTTGGTCAGGAACTTTATAATGTGCTAT 1584 TMEM100 3763392TTGCAGTTCCAAATTGCCATCTTCCCTTGTCTCATTTGCAAGTTCTCAATTGTATTTCTCTCAAATGGACAGGTTCCTTCTTTACTGGAGGATTTTTGTTTTTATCATATTGGTTTTTCATTACTTCTGAATAGTCTTAATTACGTTTACTAAATTCTAAAGGATTTCTGTGCTATTA TAATTAGG 1585 TMEM1003763393 ACCCTAAGGGCTACTTCTGAGACTGAAAAATCAGCTTTCTATTTACATGAAACACTTTGGGGGTCATGGGAGTGCACAGCATTAGACAGTATTTGGTTCACCCTGTAAAGTAGCCAAGAAAAGATGAGAAAAATCAAGATAGGCCTGGCACACTAGACATTTGCCTCCAAAAGAAATAACCTACAGTCTTAAGATGTATCATAAAAATGTTCTGCCAAGGATCTAAATTACCTTGGGTTTCGCATATGTCTATGA 1586 TMEM100 3763394GTTGTGATCACCACAGTCCCTCTGGTCAGTGAGATTCAGTTGATGGCTGCTACAGGGGGTACCGAGCTCTCCTGCTACCGCTGCATCATCCCCTTTGCTGTGGTTGTCTTCATCGCCGGCATCGTGGTCACCGCGGTGGCTTACAGCTTCAATTCCCATGGGTC 1587 TMEM100 3763395TGGTGAGACTGTCCAGATCTAGTCTGTAAACCCAGCTTAGAAG CACT 1588 TMEM100 3763396TTGGAAGATATTGTTACACTTCAGACCACAAATCCCCACCTCA TT 1589 TMEM100 3763397AATTTGGGGACAGATCTTGATTTTCAGGTTAGCTCAATCTCAG CTTTGG 1590 TMEM100 3763398AGAAGTTGGACGAAGAGGCTCAGGCGTTGCTGTTTCTTGTCTT CCAAGTCAAGTGGTTACTCTGGTAATG1591 TMEM100 3763399 ATCCCAAACCAGAGCAGACCCTATAGTAAAGTATTTTTACATCTTTTCCTTTCCCCAGAAGAGATCCCTAACCTATTGTTTTAT 1592 TMEM100 3763400GTTTGCACCTTTAGCTTTGGTAACAGGAAAGCATGCTTTTCAACAGAATAAGGTGATATTCAGAGCTTCAGTGCAGTTATTGGGCTATCTTGCAGGCAAAGTGGTACTAGAAAATAGAGGGGAATTGC CCTCAAGGGCC 1593 TMEM1003763401 ATGCTCCTCTTACCAAGCCTGCAACTTAAAACCTATGGTTTAAACTGTGCTTTCAATTATCTGGAGGAGGCCAGCACTGATGAGCCCATCCTGAGCCAGTCATTTTAAGGCCAGTGCTACCTAACTGAG ACAAGGCTAATCTGGTC 1594TMEM100 3763402 CAGTTTATTATGGTATTGGACACCCCATGCTCCTTACTGCATTGGCTTTGGGTAAGAAGGAGTGAAAATTAGTGTGCGAACCTGAAA ACCTAGAATTTCTGATTGGGACTGA1595 RPL31P57 3766793 AAAATCTACAGTCGGTGTGAATGTGAACTAA 1596 RPL31P573766795 AAAGAGCTCCGGAAACTTGCCCTGAAGGAGATGGGAACTCCAGATGCACACTTTGATACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAATAAGCAACGTCTCATACTGTATCCATGTTCGGTTGT CCAG 1597 HIF3A 3836706ATGGCGCTGGGGCTGCAGCGCGCAAG 1598 HIF3A 3836707GGGGTTTTATCTGGCCATGTTCCCATGGGACCCTGGAAAATGT TCTAGGTCCTCAGCTTTCC 1599HIF3A 3836708 ATCTCACCGCCGTGCGCACCCACTCGTAACTCGCACCCGGGTCCTGGCTGCACCGCATCCCCTCCTGCACCCCCTGGATGGCCC TTCAGCCAACGGGGGCCTG 1600HIF3A 3836709 CAAGGATGCTCTTGGGAAGTCCCTGGTGG 1601 HIF3A 3836710GTACGGCTTGCAGCCCAGAGTGCCCAGTGAG 1602 HIF3A 3836711TCAAGATGAGGAGCCAGTAGTGAGG 1603 HIF3A 3836712CGCCACAGAGAGGAGCGAGGCGCCAGAGGCACC 1604 HIF3A 3836713GTCGACCACGGAGCTGCGCAAGGAAAAGTCCC 1605 HIF3A 3836714TGCTGTACCAGCTGGCTCACACGCTGCCCTTCGCCCGCGGCG TCAGCGCCCACCTGGACAAGGC 1606HIF3A 3836715 ATGCGCCTCACCATCAGCTACCTGCGCATGCACCGCCTCTGC GCCG 1607 HIF3A3836716 GGAATCCAGGCCACTAGGATGTACCCCCACTTCCTTGG 1608 HIF3A 3836717ACCACTGGATGCCTGCTACCTGAAGGCCCTGGAGGGCTTCGTCATGGTGCTCACCGCCGAGGGAGACATGGCTTACCTGTCGGA GAATGTCAGCAA 1609 HIF3A3836718 TTGGTATCTGTTCCTTTTCTCTGCCTCGTTACCCCACTCCTGGT A 1610 HIF3A3836719 CTGGAGCTCATTGGACACAGCATCTTTGATTTCATCCACCCCT GTGAC 1611 HIF3A3836720 GAGCTTCAGGACGCCCTGACCCCCCAGC 1612 HIF3A 3836721GAGGCCCCCACGGAGCGGTGCTTCTCCTTGCGC 1613 HIF3A 3836722ATGAAGAGTACACTCACCAGCCGCGGGCGCACCCTCAACCTC AAGGCGGCCACCTGG 1614 HIF3A3836723 TGCTGAACTGCTCTGGACATATGAGGGCCTACAAGCCACCTGCGCAGACTTCTCCAGCTGGGAGCCCTGACTCAGAGCCCCCGCTGCAGTGCCTGGTGCTCATCTGCGAAGCCATCCCCCACCCAGGCAGCCTGGAGCCCCCACTGGGCCGAGGGGCCTTCCTCA 1615 HIF3A 3836724CGCCACAGCCTGGACATGAAGTTCACCTACTGTGACGACAG 1616 HIF3A 3836725AAGTGGCTGGCTATAGTCCCGATGACCTGATCGGCTGTTCCGCCTACGAGTACATCCACGCGCTGGACTCCGATG 1617 HIF3A 3836726GTGCGAAGCCAGCTGCCACATGGCCCCCAGCTGACACCAGG ACCCCCCAG 1618 HIF3A 3836727CCCAGGATGCACTGCCTCCCCACCTCAACACCAGCTCCCTGCTCCCCAAGCCCCAAGGAACTGTCTCCTTCCTTGCCCCCTCATA CCCAGTCCCCAGATATTTCTCTCCC1619 HIF3A 3836728 CAGTAACAGGGCAGTATCGCTTCCTGGCCCGGAGTGGTGGCTACCTGTGGACCCAGACCCAGGCCACAGTGGTGTCAGGGGGACGGGGCCCCCAGTCGGAGAGTATCGTCTGTGTCCATTTTTTA 1620 HIF3A 3836729TGGGCCTGATCTGCATGTGTGGACAGGTGTGTGTGTGTGTGTGTGTGTGTGCGTATGAGCATGCATGTGTATCATGCATAAGTGTATGTGAGGGAGTGTGCACGTGTACACATATGAGGAATGTGTGTCACCATGTAAATGCCGGTGTGTGTGTCTGCATGGACACAGGTATGTGTATGGGTGTGTAGACTGTTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCGTGAACCTCTGCTTAAGTG 1621 HIF3A 3836730GCAAAGTGGTTAGGACCCATTCTCAAAAAAAAAAAAAAAAAAAAACCTGAAAACAGACCAAAAAAAAAAACCACACACACGCAAAGATAGATGGTTTGCATATGGTAAATTCTCTTTATGGTACACAGTTCTGTGAATTTTTGACACACGCATGCAGTTG 1622 HIF3A 3836731TGCACCCGGCCCATGTTGTGGTTTATATCAGTAGTTCCTTTGTAAATAGTGAACAGTATTCCATGGTATGAATAGAGCACAGGTTTTTTTTTTATCCATTCACCAGTTAGAAGACATTGGGCTGTTTCCAAGTTTGGGTGATTACAAAAAAACAGCTACTGTAAACATTCTCATACAAGATTTTATGAGATCACATGTTTTCATTTCTCTTGGGTAAACAGCTAGGATTGGAATGGATGGGTTATATAGTAAGTGTATATTTAATCTAAGAAACTGCCATGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAAGCCAAGGAAGGAGGATGACTAGAGCCTCTGAGGTGAAGACCAGCCTGGGCAAAGTGGTTAAG ACTCAACCGC 1623 HIF3A 3836732GACAGAGTTTTGCCCTTGTCACTCAG 1624 HIF3A 3836733TGAAACCCTTATAGGAGACAAATAAATGTGGGCAATTATTTTCTGCAAAATGCCCTCCAAGCCCCTGGGCGCCATTGCCTTCTGTA ATAGGACATCACC 1625 HIF3A3836734 AAGAGACCGGAGTGGTGCTGTCCCTGGAGCAAACGGAGCAACACTCTCGCAGACCCATTCAGCGGGGCGCCCCCTCTCAGAAG GACA 1626 HIF3A 3836735CCCGGATCCTTGCCTTCCTGCACCCGCCTTCCCTGAGCGAGGCTGCCCTGGCCGCTGACCCCCGCCGTTTCTGCAGCCCTGACCTCCGTCGCCTCCTGGGACCCATCCTGGATGGGGCTTCAGTAG CAGCC 1627 HIF3A 3836736TGCTCTCCTAATAATGCAACAATCGTCAACACAGAAGAAGACTTCTGTGACCAAATGTGGGCAGTTTTTCCCACACACCAAGCAGCGGACACCAGCTGGGTGTCCTCCAATTCAATTCCGGCATCATCT A 1628 HIF3A 3836737CCAGATGAACTACCTGTGGGCACCGAGAATGTGCACAGACTC TTCACCTCCGGGAAAGACACTGAGG1629 HIF3A 3836738 CAAACTCTCAGTCAGGGCTACAGTCATCTGGGGTTAGAGGGTTTTCTTCCAAGCTCACACACATGAGGTTGTTGGCAGGCCTCAATCCCTCACTTTGCTTTGGCTGGAGGCCTCAGTTCCTCATCACGTGAACCTCTACATAGACTCCCTAAGTGTCCTCACAACATGGCA GTTGGCTTCCCTAAGGCAAA 1630HIF3A 3836739 CCAGCTCAACGCCAGCGAGCAGCTACCCAGGGCCTACCACAGACCTCTGGGGGCTGTCCCCCGGCCCCGTGCTCGGAGCTTC CATG 1631 HIF3A 3836740CCAGAGCTCAGAGGACGAGGACGAGGGAGTGGAGCTGCTGG GA 1632 HIF3A 3836741CAGCCCAGAACACGAAAACTTTCTGCTC 1633 HIF3A 3836742GGGATTCTCTGGCCCTCATTACCTAGCTGGCTTAAACCTACTG TTTTATA 1634 HIF3A 3836743CTGGTTGAGGGTCATACAGAAAGTCAGTGGGCCAGCTGAGAC TAAAGCCTGATCT 1635 HIF3A3836744 GTCCTCGGGCGAAGGAAGAAGGAGAAGGGGGATGAGGCCCT GGAGGAACACAA 1636HIF3A 3836745 AGTTTCCTTCTGACAGGAGGACCAGCCCCAGG 1637 HIF3A 3836746AGCACCCCACTCCTGAACCTGAATGAGCCCCTGG 1638 HIF3A 3836747AAGTGTAACGGGGAAATAATGCATGCAAGGAAAAAGGTTTGGAGTAGGGGGATTTCAGTTTTAAACAGTATGATCAGGGTGGTTT CATTGAGAAGGT 1639 HIF3A3836748 AGTGCGCTTCATTACGTCTGGCTAATTTTTTAATTTCTGTAGAGAAAGAGGTCTTGCTATGTTGCTCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTTCCAAAGTGCTGAGATTGTGCCTGGCTGTCTCTGTCTTCTTTGGGGAAAAGCAAGGCCAATGTAGCTGAAGCAGAGAGGAGAGAAAGGTGAGGGCTGACTGCATGGAGCCTCTGTGGGGCATTGTGATGGCTTTGAAGTCACCTTGCTTGAGGAGGCTGCCTCAGGGCCTTTGCATATCCTGATCCTTCTGCCTGGCATACTTTTCCCTCTGTTCTTTGCCATGTTACCACATCCTTTAGATCTCAAACCAAATATTACTCCTTACACAAAGCCCTGCCTAACTTCATACGCTCATGGTTTATAACACTCCATAATTACACAGGCCTTTGTGTCATAATTTGATGACTGTCTGTCTTCTCCTTTGGGTATGAGACCTTCAAGGGCAGGGGCCAGGGCTGTCTGGGTCCCTGCTGTTCTCTTCTTTGTGCACATGGGTGGGCGGTGGCTAAGCACAGAGGAAGTTCTCAGCACATATTTGTGAATGAGGAGCTAAGATTCACGCACTCGCACTGTGCCTAGCTTTGTGCTAAATCCTCTATGCACCTGATCCAATTGGCGCTTCTCACTGGAGT GTCGGTCCCATA 1640 HIF3A3836749 GTTTTCACTTTGTCACCCAGTCTGG 1641 HIF3A 3836750ACCACCACGCCCGACAGTAAATATGTTTTGAA 1642 HIF3A 3836751CACAGCAAGTAAATAGCAATGCCTGGATTCAAACTAGGGCAGCATCTGACTCTGGACTCGGGTTCTTCACCGCAGCCCTGAACACCCCAGAGAGGTTCAGAGAGCAGAACGTGCCCAAGACGTCACTGCCGTTTGAATCCAGACAGGCTTGCCTCACCACCCAGG 1643 HIF3A 3836752CTCACTGCTCTCTCCGTACTCAGACGAGGAC 1644 HIF3A 3836753TGGTCTCAGCTCAGTGACCTCTGGGAGGTGGTCCCTGGCCCCCTCCTCCTTCTCTCAGGATTTCTCTTGGGGTTCTCAATACTTGGTTACCTCATTATCCCTTTCTCTGCCTCTCTTGGCTTTATTTTGGGGAATCAGGGGTGAGGAGGGTTGGGGGGGTCATATCTGTGTTTCCAGGTTCTGGGGAGAACAATGATCCACGGGTCAACGTGAT CACATTTC 1645 HIF3A 3836754CCAGTGACTTCCGATTGAGGCCAAAGACCCCAAGCTGCCCGCCAGCTCTGACTGCCCCTTGCGCTCTGGGCTTCCTGCCGCCCC CAGCTTTGCCTGGACACTGA 1646HIF3A 3836755 TGACCTGCACTGGTTCTAGACCACACAACCTCCAATGTGGTCTGCTTTAGATCACCTTCTTCTTCTTCCTTCTTCCTCTTCCTCTTCCTCCTGCTCCTCTTCCTCTTCTTCTTCTTTTTTTTTTTTGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATTTCAGCTTACTGCAGCCTCCGCGCCCTGGGTTCAAGTGATTCTCCTGCCTCAACTTCCCAAATAGCCGGGACTACGGGCATGTGCCACATTGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCACGTTGTCCAGTCTGGTCTCGAACTCCTGACCTCAAGTGCTCCACCTGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCTAGAACTCACTTTCTCCAAATCCCTCTGCTTCGAATTTCACCGTCTTCAGCTCTTTCTAGTTCTGGGCCTCACCAGCCTCTCATTCTGCCTGTTTTCAAACCTTACGATCC CCAAAAATTGTCTGGTTCTGGGCCTCTA1647 HIF3A 3836756 CCGGTTCCAGATCTTATATTCAGTGATTTCCTCTGGTTCTGGACCCCACAACTCCAAGCTTCCTATTGGTTCCAGTTCTCCTGATCGGTAATACATTTGGTTCCAAATCCAGACCTCTTAATCTCTCTCTTTTTTTTTTTTTTTTTTTGAGACAGAGTCCCACTCTGTCACCCAGGCTGGAGTACAGTGGCTCAATCTCGGCTCACTGCAGCCTCCACCTCCTGGGTTCAAGCAATTCTTGGGCCTCAGCCTCCCAAATAGCTGGGATTACAGGCATGTGCCACCACGCCCAGCTAAGTTTTATATTTTTAGTAGAGACAGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCCGACCTCAACTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGAAATTACAGGAGTGAGCCTGGCCAGACTTCTTAATTTCTAAATCACTTTTGTTTTAGACCTTATGAGGCTCAGCTTATTCTTCTGCAGTTCTCTATAACCAAGACTCATTTTCTCTCATCAAAAACAAGTACAGAGAGTTTGATGTGTTTATCTCTTTTTTCTTCCTCTTCTTTTTTTTTTTTTTCTTTTTTGAGATGGAGTCTCTCTCTGTTGCCCAGGCTGGAGTATAATGGTGCCATCTAGGCTCACTGCAACCTCCGCCTCCTGATTCAAGTGATTCTCCTGCCTCAGCCTCCTAAATTGGTGGGATTACAGGAGCCCACCACCACATCCGGCTACCTTTGTGTATTTTTTAGTAGAGACGGGGTTTTGCCAAGTTGGAGGGGCTGGTCTTGAACTCTTGACCTCAGATGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATAAGCCACCGTGCCCGACCCTGTCCTTATCTTATAATAACCAGTTCTTCTAGAACCAGACGATGCTCTAGTTCTCCTAGATTCTGAACCTCATGACCTGTACCACTCACTAGTTCCAGACTACACAACTTCTAGAAGGTGCCACCTCCAGGGTCCTGATTCAAGATCTGGTGATCTGCTGTTTCTCTGGTTCTAGAACTGACTTACAAGTGCCTTCTGATTCTAGACCTCATTCCGTAAGTTCCCTTG 1648 HIF3A 3836757CCCAGCCTCCTAAATCTATTCTGGGCTTCCC 1649 HIF3A 3836758CACTGAACTTACCCAATTCCTTCTTTCAGTCTTAAGTTTTCCCATTCTAAACCCCTACCCTCTAGGCTGTGCTGCTCCTGGACTTCATGCCTCTCCATTCTCATTGCCTACAATCTCTGTGCCCCAGAACCCCCTCCACTTCCCACCCCAGCCCTCCAGACATGCACTTACCTTGACTTTACCCCACATGTTTGGGGCACCTGGGGC 1650 HIF3A 3836759AGCTGTCTGCCACCATCTATGTGCCTCCCTTACCCCCCAGCTTTCTTTCTACAGATGGTGCTACTCTTGGTCTCCCACAGGAAAAGGCCTCCCCCCTTCTTAGCCCCATTTACCCCGTTTGTGGAAGGCACTGCTCGCTCTGTTTTGTCAGAGAGTGGCCTATCCAGATTGG TGCTA 1651 TPX2 3881448TCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGCGCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCTCTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGA GGCTGTCGGCTAATAAC 1652 TPX23881449 ATGCCCTCAGGAAGTGTGGCGTTTGATGGAGGAAAACAGA 1653 TPX2 3881450TGAGGGAGTTCAAGAGCCAGTTTGTGTTTCTGTGCTTCACAAA GCCACCCTTGTCTAATTCTTGA 1654TPX2 3881451 TGATACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAG ACTGATTAAACC 1655 TPX23881452 GAGTGTGCACTTCAGTGGCGTGATC 1656 TPX2 3881453CATTTGGGTAAGTTAATAGTCAATTTATAGGCCACGTAAATGGGAAGGATTATTTCCTTAAATCAAGAGATTAGACAATCATTGCTTGTCATGAATATTTAATAAAAATTTGAGAAAGCTCAGTTTCTTTTGGGCTGCAAACATAGATCTAGGGAAATAAATACTGCTTAACTA TTTTGTTG 1657 TPX2 3881454AAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAA CCTGCTCTTCTGC 1658 TPX23881455 CACAAGTTAAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACAT AGATT 1659 TPX2 3881456TACTGGTAGGGAGCTTTAGTTTGCATTTTAAATGCGTGATAGTGATTTGTTTTGCTTCCTTGCTGATCAGACAATGATGATCTTCCC TTTTCACAG 1660 TPX2 3881457GGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCTAATCTTCAGCAAGCTATTGTCACACCTTTGAAAC 1661 TPX2 3881458GACAACACTTACTACAAAGAGGCAGAAAAAGAAAATCTTGTGGAACAATCCATTCCGTCAAATGCTTGTTCTTCCCTGGAAGTTGA GGCAGCCATATCAAGAAAA 1662TPX2 3881459 CAAGAGATGTGCCACTCCTGTAATCATCGATGAAAT 1663 TPX2 3881460CCTTGTATACCACTTGTAAGTTTCTTTTCTGAATTTACACTTTAGATTGAATAGATTAAAATTAAAAATGGTACATCTGTAATATGTTT GGTGTACCTCAA 1664 TPX23881461 TCCATATGCAGTAGATTTGGGGAGGAGGGTACAGGCTATGCT TCAGGGAATTGAAAAC 1665TPX2 3881462 AGAAGGCAGTGCTCATCAAGATACTGCTGAAAAGAATGCATCTTCCCCAGAGAAAGCCAAGGGTAGACATACTGTGCCTTGTATG CCACCTG 1666 TPX2 3881463GAGAAGAGTATGAAAATGCAGCAAGAGGTGG 1667 TPX2 3881464ATCAGTGAGCCAGGTCACCAAATCAGTTGACTTCCACTTCCGCACAGATGAGCGAATCAAACAACATCCTAAGAACCAGGAGGAATATAAGGAAGTGAACTTTACATCTGAACTACGAAAGCATCCTTC 1668 TPX2 3881465GGTTGGGGCAGACCAGTCAAATCTCATGCAGTTTTGTTACCAGAGCACCAACAAAATCAGTAATAATCGTTAAGTAAAAATGCTAGTACTAATAATCTCCACTTGCATTTGTAGTCAGTATCATCATTTTTTGAAATTAGTTATTTGCATTCTTAAACCCTGAGGTTATGCTTCTTTCTTTGAGATACAGGTCCTTGAAGGGTTTTGCTTCCAATTAGAGACCAGTTTTATCAAAATTACTGGTCCAAGGAATAGGAATAGG CTTCTTCATCAGTCTC 1669 TPX23881466 CTCTGTGCCGAATATGTGGCTTATGGTAGATGTGAGCTCTTCC GTGACATTTCATT 1670TPX2 3881467 GCCCGAGTGACTAAGGGATGTACCATTGTTAAGCCTTTCAACCTGTCCCAAGGAAAGAAAAGAACATTTGATGAAACAGTTTCTACATATGTGCCCCTTGCACAGCAAGTTGAAGACTTCC 1671 TPX2 3881468ATGGCTCACTTCAGTGTCCAACTCCTGGGCT 1672 TPX2 3881469TGAATCACCACTTACAAGTAAACTGGGTCTTGCGGATCTAGAT GAACATCTGTC 1673 TPX23881470 CTGTTACCCTCCAAATCTTCTGTGACCAAGATTTGCAGAGACCCACAGACTCCTGTACTGCAAACCAAACACCGTGCACGGGCTGTGACCTGCAAAAGTACAGCAGAGCTGGAGGCTGAGGAGCTCG AGAAATTGCAACA 1674 TPX23881471 GTAAGTCCCACTGGCAGTATCTGAG 1675 TPX2 3881472CTTGATCCCAGAATACTTGAAGGTGGGCCCATCTTGCCCAAGAAACCACCTGTGAAACCACCCACCGAGCCTATTGGCTTTGATTTGGAAATTGAGAAAAGAATCCAGGAGCGAGAATCAAAGAAGAAAACAGAGGATGAACACTTTGAATTTCATTCCAGACCTTGCCCT ACTAAGATTTTG 1676 TPX23881473 CACCTGTTTCAGATGAGGTAACCGAGGCACACAGAGGTTATGTAGTATTCCTAGAGCACTCAGCTAGTACATGGTGGAGCAAGTAAGAGTTCAGACACTCTAGCTACAGAGTCTGTGATCCTAATACCTCATTATATGCCTCTCCATTACATGATAGAATTTTGACTTGCAGAAATGCAAATGGACTGGATTGGCAGAACATTCCAGGCAGTAGGAATTACATGATAAAAAGCCTGACGGTGGGAAACAAGAAGCTTCTACTGGGAGCTGTTAGTGGGTCAGTTAAGCTGGAGAAAAGTTTATCAAGAGCCACTGGAAACTGTTTCAGAGAAGTGAGTTGTAGTTTGATAATAGGCTCACAACCACAAGTTTAGAGAAAATGTGCAATCAGGAAGCAAGGCTACAGTCAGAGAATAAGCAATGGAGTTAAGCACCTGCATAAATGCGAAAGCGGCTTTTAGTTACATTTC AGTG 1677 TPX2 3881474ACAGGGACCGTGTGTATCTATATTATTCACTCTGTATCCCTAGCCCCTAGCATAGTGACCACCACAGCACAAGCACTCTGATATCGGATAACTGAGTGAGTAATAGTAGAAGCTGACATGCACCTAGACACTAGGAATTCAAAGATGGTATAAGACACGGCCCTTGTCCTCAAAGCTTTCATAGTCTGGTAGAGCATATAGATGTGTAAATGAGTAAATATGGTAATATTAACCAACATATGTTCATTGAACAGTTAC TACGGGGTCTTCTA 1678 TPX23881475 AGTGGAGATCATTTTGTGATATCTAATTGAGTTGCTTACTCCTT TCAG 1679 TPX23881476 TGTTCCTGAAAAGAAGGTACTTCCAATCACC 1680 TPX2 3881477CATTGAAGAACAGAATTCGAATGCCCACCAAAGA 1681 TPX2 3881478GACGAACCGGTAGTGATAAAAGCTCAACCTGTGCCACATTATGGGGTGCCTTTTAAGCCCCAAATCCCAGAGGCAAGAACTGTGGAAATATGCCCTTTCTCGTTTGATTCTCGAGACAAAGAACGTCA GTTA 1682 TPX2 3881479GTGCCCAAGTTCAAGGCACTTCCCTTGCCTCATTTTGACACCATTAACCTGCCAGAGAAGAAGGTAAAGAATGTGACCCAGATTGA ACCTTTCTGCTTGGAGACTGACAG1683 TPX2 3881480 GTAGGGGATGGGGAGAGCAGCCAAAATGTTAATTGCTTG 1684 TPX23881481 TTGGAGGTGGGAAGAATACTTTATAGGTGATACTGTATAGTTCCTAATGAATCATGTGTGAAGGCAGAAAATGTCTAGTTGTTTATTTTTATGATATAAAGATAGGTCTTAAAAGTACCTTTAAAATTTTTTGTTTTTTTTAATTGACAAATAATAGTTGTACATATTCTTGGGGTACATAGTGATGTTTCAATATGTATAATGTGTAATGATCTGATCAGGGTAATTAGCATATCCATAATCTCAAACATTTATCATTTCTTTGTGTTTGGAATCTTTTTTTTTTTAATTTAAAAGTAAACTTTAGCACA CCAACATG 1685 TPX2 3881482CTTGTTTCAAGGCTCGTCCAAACACCGTCATCTCTCAGGAG 1686 TPX2 3881483TTCAGGAACCTTTTCAGCTGGCTACTGAGAAGAGAGCCAAAGAGCGGCAGGAGCTGGAGAAGAGAATGGCTGAGGTAGAAGCCCAGAAAGCCCAGCAGTTGGAGGAGGCCAGACTACAGGAGGAA GAG 1687 TPX2 3881484TGGGAGCATGAGCACTGACGAACACAAACATGCCTCTG 1688 TPX2 3881485AACCATGATGCCTTTCCTAGGACTGTTTTTTATTTATTTGTTTATTTTATTTATGTAACTTATTATTTCCTCTGGGGTTAAGAAGCACCACTGAGTTTTGTAATTAGACAAGAATACATAGCGAAGGACATGGGAATTAAATGGCAACTGTATTTTTGTTTTAATACTGAGCCCAAACTCCTTGGAGTTACAGTGTTCGTCGCTCCAGGTAATCCTCTACTAACATAATTATTTAGATGTTGGTTATCCAAAAAGAAACCTGAACTCCACATTAAGGACCAATCTGCTAGGAGGGC 1689 TPX2 3881486TGTACTCTGGGAAATTCTTAGCTTGTAACTTCTCTGCTATACTTGAGTACAGCCCTATTATACCCTAGTAAATCACACAGGACATAGGTTTGGCATTCTTTAGTGAAAGCTGAGGGACTTGAGGAGACTGTGGCCTAAAGGAAAGCTGGGGGACCCAATAGAGACCTGAATAGAAACCCTTTTGGGCTCCAAAGCACATACACTTTTCCATCATACCGTGTTGCCCCCCAGGCCCCACTCCCCACACCTGAAACTAG TGACTGGGACCTGTA 1690 TPX23881487 GTGCATAAGGCAAATCCAATACGCAAGTACCAGGGTCTGGAGATAAAGTCAAGTGACCAGCCTCTGACTGTG 1691 TPX2 3881488CCAAATTCTCCACTCGATTCCACTGCTAA 1692 TPX2 3881489TCAGCTGTGAGCTGCGGATACCGCCCGGCAATGGGACCTGCTCTTAACCTCAAACCTAGGACCGTCTTGCTTTGTCATTGGGCATGGAGAGAACCCATTTCTCCAGACTTTTACCTACCCGTGCCTGA GA 1693 TPX2 3881490CAGAAAATAAAGATAGTTAAATCCT 1694 TPX2 3881491GTCCTCTTCTCTGCATACCGTGAATTTATAGTTAAGGATCCCTTTGCTGTGAGGGTAGAAAACCTCACCAACTGCACCAGTGAGGAAGAAGACTGCGTGGATTCATGGGGAGCCTCACAGCAGCCACGCAGCAGGCTCTGGGTGGGGCTGCCGTTAAGGCACGTTCTTTC 1695 TPX2 3881492GGAACCGTGCAGTGTGCATTTTAAGACC 1696 TPX2 3881493 TGGCCTGGAATAAATACGTTTTGTC1697 TPX2 3881499 ATGGAGTTTCACCATTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTACCTGCCTCGGCCTCTGAAA 1698 TPX2 3881500GTGCTCTGAAACCTACTTTGCCTGATATTAATATAGCCACTCTAGTTTTCTTTTGATTGGTTTTAGCATGGTATGTCTATATTTAAAGTGCATTTTTTTGTAGACAGCATATAATTGGGTCTTGCTTTATTATTTAATATTATTGTTGCTGCATTTTAATTGGAATAAATGCATCTATTTTAGCCTTGACATGCTATGCTATTATTTTGTGTGTGCGTGTGAGTCTCTCTGCCCCAAAAATATTTCTTTAGGAGATGAACCAAATGATTGTTCTCTGAAATGAATAATGCCTAAACTATGTTTTCATGGCCTATCTTTTCTTCCCTGTCATCTTGTTGCAGTTTAATTCCTTTATCAGGAGTCAGTTCATATGCTATGTGATTAAGTGCTGTTTCTTCCA TG 1699 WFDC2 3886939TAAATCCCCGCACCTGAGCATCGGCTCACA 1700 WFDC2 3886940ATGCCTGCTTGTCGCCTAGGCCCGCTAGCCGCCGCCCTCC 1701 WFDC2 3886941CTGCTGCTGTTCGGCTTCACCCTAGTCTCAG 1702 WFDC2 3886942CCAGGCTGACCAGAACTGCACGCAAGAGTGCGTCTCGGACAGCGAATGCGCCGACAACCTCAAGTGCTGCAGCGCGGGCTGTG CCACCTTCT 1703 WFDC2 3886943GGCGGGGCCGCGCTGGGCTGGGAGGAG 1704 WFDC2 3886944GCAGTTTCCTTCTCGAACCGGCCGAAGCCTGCCCTGCGGGAAAGCCCGGAGCCTGGGGCGCTCACCTCTCCTCTTGGAGTCCCTCCCTGGGGGCCTCCCCCAGCCCTGGGGAAAGACTGGGAGAGCCTGGCCTGGCAAGATTTTCCCCAATTCCTCTGTCCAGGCGGAAAGGAACTTTACAGATTTAGGAAAATGCCCCGCTCATCTTAAAGATGTGTAAGGGAGCATCGGTGAGAAAAAAATGTTCTTGCCCAAGGTCACACCGCCATCCCATGGCTGCTGGAGTCATAGTGAG GGTTCA 1705 WFDC2 3886945CTGGACACTGTATCGCCCTTCGTCGTCTTTCAGTCAATCTCTTCCACTCTAAGGATTGAGTGAGCGCGAGCTGGGGACTCTCTCA AAG 1706 WFDC2 3886946GCAGTCTCCACCAGGCTATCAGAACAGGGGGTGGCTTAAAC 1707 WFDC2 3886947CTTTATCCAGAATACAGCCCCTGTGACTTTT 1708 WFDC2 3886948TACGGTGACCCAAGACACCGATCAGCAGGGAGGTG 1709 WFDC2 3886949AGATTTGGAGAGAAAGCAGGCAGCAGCCAGATGAGAGAGGTGGAGGAGCAAAGGAGGGAGTCTTTGCTGTTTGATGGATGA 1710 WFDC2 3886950ATCAGGTGGCTGTAGATGTGTAGTGT 1711 WFDC2 3886951GTATCTGCTCCAGAGTGCACTATTCCTCACGGCACAGTCCCTCATGGCTTCCCTTGGCTAGGGGAGGGAGTTCCCTGACCTCTTGTGCTTCCCAGGTGAGATGATGCCCTACCCTACTTCTGCTCGCC 1712 WFDC2 3886952AACCATGATGTACCTCAGTTGATGAATGGATTTGGCTGGGCCTGGCTCCCCTCTATCTAACCTGGGAAGTGGAGTGTGATTGTGTGTGTGTTTGTTAGTGGAAGGACGTGTGGTTTCTCTCTGCATGGATGAATGAGTGTATTTGGAGGGTCATGGTGCTGAGAGACTGCAACTGGGATTCGGTCTGTGGGTATGAGTGAAGATTATAAGTGTGTAACCCCTCACATGTGTACTGTACTTTACACTTTAAGTGGCAGCATAGTGCTTAACCATGGCAGCAGCAGTTAACACATAGACTC TGCAGCTAGATTTCTTGGGGTTC 1713WFDC2 3886953 TTAGGGGCTTGATACCTGGCATGTAATAAGAGCTAATTAAGTGTTCACTGTTATAATTTCTCATAACTACAGAGTAGT 1714 WFDC2 3886954TGGCACCTAAAGACACGGAGGCTCTGGGAGATTTCTGGCCCTAGGCCACGAAGGCCCACTTGGGACTCAAGCT 1715 WFDC2 3886955GGTCCTGTGATTCCATTTGGGAGCAGGAGGAGGGATTTGCAG 1716 WFDC2 3886956CTCAGGTGCCCAAGATGGACTCAGGCAGGCAGCTCTGCTGTA TGTGAAGCCCAGTGAGG 1717 WFDC23886957 ATGCTGCAGGTACAAGTTAATCTCCCTGTATCGCCTCTGCCCA CTTACCCT 1718 WFDC23886958 GTGAACATTAACTTTCCCCAGCTCGGCCTCTGTCGGGACCAGTGCCAGGTGGACAGCCAGTGTCCTGGCCAGATGAAATGCTGCC GCAATGGCTGTGGGAAGGTGT 1719WFDC2 3886959 GCCTAGTCTAATGGATATTGTTGTTGATGGTATTGTTATAATTT TCT 1720WFDC2 3886960 CCACCACCAGGCTGAGCAGTGAGGAGAGAAAGTTTCTGCCTGGCCCTGCATCTGGTTCCAGCCCACCTGC 1721 WFDC2 3886961CCCTCTTGGGCTGACCACAGCTTCTCCC 1722 FMO5 3928073GTGGGAAGAAAGACTGGGATGATGACCAAAA 1723 FMO5 3928077GAAAACTCTGGAGTTAAGGCCAATGAAGTAATCTCTAAACTTT ATGCAGTAC 1724 FMO5 3928078AATTGAATTAGCCAAACAGATCACATCA 1725 FMO5 3928079GGCTCTACAGACAATCTGATGGATGA 1726 FMO5 3928081 GAGATACTCAGGTGGTGGTTTTTAA1727 FMO5 3928085 CTATTGCTGATACTGGTGCAAATGTCGTAGTAACAGGTGGCAAAGTGGCAGACATGGCTCTTCATTA 1728 FMO5 3928087AAATAGCAGTGTACTCTTGTCCTTTTGATGGCATGATAACAGA AACTAAG 1729 FMO5 3928089GTTGATAACATCAGAGTTTGTAAAATTCT 1730 FMO5 3928093CCTGGAATTAGCTGAAGAACTTCTGA 1731 FMO5 3928097AGAAGAGGCTGTGTATAGAAACATACAAGCTTGCAAGGAGCTT GCCCAAACCACTCGTACAGCATATGGAC1732 PCAT14 3939348 GGTGAAGGGACTCTCGAGTGTGGTCATTGA 1733 PCAT14 3939349AAGGCCTCCGTCTCCTGCATGTCCTT 1734 PCAT14 3939350GGTACTCTACAGTGTGGTCATTGAGGACAAGTTGACGAGAGA GTCCCAAGTACGTCCACGGTCAGC 1735PCAT14 3939351 CAGCAAGGAACGGAAAGTTCACATTGTAAATATGTAGCAGAGTCTGTAATGGCTCAGTCAACGCAAAATGTTGACTACAGTCAATTACAGGAGATAATATACCCTGAATCATCAAAATTGGGGGAAGGAGGTCCAGAATCATTGGGGCCATCAGAGCCTAAACCACGATC 1736 PCAT14 3939352CTACAATGAACTCACTGGAGATGCAAAGAAAAGTGTGGAGATG GAGACACCCCAATCGACTCGCCAG1737 PCAT14 3939353 CAGGAACGGAGACAATCGTGAAAGCTGCTGATAGCCTCACAAATCTTAAGCCAGTCACTTGGGTTAAAAGCATCAGAAGTTTCAC TATTGTAAATTTCATA 1738 PCAT143939354 ATGGGCCATAGTGACGATGGTGGTTTTGTCAAAAAGAAAAGGGGGGGATATGTAAGGAAAAGAGAGATCAGACTTTCACTGTGTCTATGTAGAAAAGGAAGACATAAGAAACTCCATTTTGATCTGTACTAAGAAAAATTGTTTTGCCTTGAGATGCTGTTAATCTGTAACTTTAGCCCCAACCCTGTGCTCACGGAAACATGTGCTGTAAGGTT TAAGGGATC 1739 PCAT143939356 ATTTTAGGCGCTGGACTTGGGTTCGGGGCACCTGGCCTTTCCTTGTGTATTTCTCCTACTGTCTGCCTAACTATTTAATACAATAAAAGAAAACCAGCCCCTGGTTCTTGTGGTGTTTCCACCCTCCCGGGTCCCCGCTGGCTGCCTGGCTTCCTCCCGCAGCTCCTGCTGTGTGTGTATGTGTGTGTGTGTGCACATCTGTGGGGCGTATGTGTGTTCGTCTTTGTAATTGAGGCTGCAGAGTGGAGAGAGCAGGGGTTTTCTCTGGGGACCCAGAGAGAAGGAGGCGTTTTCACCA CAGC 1740 PCAT14 3939358CCTTTGAGGGAGATCAAGTCTAAATTTGAAGGGAGTCCAAATTCATACTGGGGTAATTTATTCAGATTATAAAGGGGGAATTCAGTTAGTGATCAGCTCCACTGTTCCCCGGAGTGCCAATCCAGGTGATAGAATTGCTCAATTACTGCTTTTGCCTTATGTTAAAATTGGGGAAAACAAAAAGGAAAGAACAGGAGGGTTTGGAAGTACCAACCCTGCAGGAAAAGCTGCTTATTGGGCTAATCAGGTCTCAGAGGATAGACCCGTGTGTACAGTCACTATTCAGGGAAAGAGTTTGAAGGATTAGTGGATACCCAGGCTGATGTTTCTGTCATCGGCATA GGTACTGCCTCAG 1741 PCAT143939360 CAGATGGCGTATAATGCCGTAATTCAACCCATGGGGGCTCTCCCACCCCGGTTGCCCTCTCCAGCCATGGTCCCCTTTAATTATAATTGATCTGAAGGATTGCTTTTTTACCATTCCTCTGGCAAAACAGGATTTTGAAAAATTTGCTTTTACCACACCAGCCTAAATAATAAAGAACCAGCCACCAGGTTTCAGTGGAAAGTATTGCCTCAGGGAATGCTTAATAGTTCAACTATTTGTCAGCTCAAGCTCTGCAACCAGTTAGAGACAAGTTTTCAGACTGTTACATCGTTCACTATGTTGATATTTTGTGTGCTGCAGAAACGAGAGACAAATTAATTGACCGTTACACATTTCTGCAGACAGAGGTTGCCAACGCGGGACTGAC AATAACA 1742 PCAT14 3939362GGTTGCCGTCATTACAGTGTTAACAAGATTTTAATCAGTCTATTAACATTGTATCAGATTCTGCATATGTAGTACAGGCTACAAAGGATATTGAGAGAGCCCTAATCAAATACATTATGGATGATCAGTTAAACCCGCTGTTTAATTTGTTACAACAAAATGTAAGAAAAAGAAATTTCCCATTTTATATTACTCATATTCGAGCACACACTAATTTACCAGGGCCTTTAACTAAAGCAAATGAACAAGCTGACTTGCTAGTATCATCTGCATTCATGGAAGCACAAGAACTTCATGCCTTGACTCATGTAAATGCAATAGGATTAAAAAATAAATTTGATATCACATGGAAACAGACAAAAAATATTGTACAACATTGCACCCAGTGTCAGA TTCTACACCTGGCCACTC 1743PCAT14 3939364 AGGTCAGGCCGGTTCTTTGCTCTGAACCCTGTTTTCTGTTAAGATGTTTATCAAGACAATACATGCACCGCTGAACATAGACCCTTATCAGGAGTTTCTGATTTTGCTCTGGTCCTGTTTCTTCAGAAGC 1744 PICK1 3945181ATGCTGCCGGATGAGGTGGATGCCTGGCTGTGGCTCTGGGAGAGCCAACCTCCCCCAGGGAACCCACTTTACACAATAGCAGTGGCAGCAGAGGCTGGCGAGGAGACAAGATTCGGACTCTGGG GAGCACTGATAGCATTTCCCGAGCCTCA1745 PICK1 3945182 ACGCTGTCAGCCTGTCCAGACCGTTCCTCTGTTTTCGCTTGTTCCTACTAACAGCGAGCTTCCGCCAATACTTGTTCTCGTTCTTGGTTCCGAGCGTCCCGGGAGCCGGGAAGGGAAGGATTGTCTGCAGGGATTGGAGCAAATATCCAGTGGGGGGAAAGCCGGGACTTCCGCGTCTTGCCGGAAGTGACGTGACAATCGCGGCCA 1746 PICK1 3945183TGGCCGGGACCCGGCTGTGGGACCAACGCTTCCG 1747 PICK1 3945184ACTCTGGGATCTGAGCCTATCGCCCTGGCCTGGAGC 1748 PICK1 3945185TTGGGTTCCTTAAATCCTATGCTCCTTTCT 1749 PICK1 3945186CCCTACCGAGCTGGGCAGTTAGCCAGCCCACTCCAACT 1750 PICK1 3945187CAGACTTGGATTATGACATCGAAGAGGATAAACT 1751 PICK1 3945188AAGGATGCTCAGAACCTGATCGGGATCAGCATTGGAGGAGGG GCCCAGTACTGTCCCTGCCTCTATATCGT1752 PICK1 3945189 AGCAGCCTTGGACGGCACAGTGGCAGCTGGCGATGAGATCACCGGTGTCAATGGCAGGTCAATCAAAGGGAAAACTAAGGTGG AGGTGGCGAAGATGATTCAGGA 1753PICK1 3945190 CAGAGCAGGTGTCCAGAGGCAGCAACACATGTTTCTGAGA 1754 PICK13945191 GAGGTGACCATCCACTACAACAAGCTGCAGGCGGACCCCAAG CAGGGCATGTCCCTGGACATT1755 PICK1 3945192 GCCCAAAGGAGAAGTGCCACAGCCAGCCCTGCCCTCCCCTTTATGACAGGAGAATCCAGAGTTACATGGCTGTGGGCTCTGACCTCTGACCAAGCAAATCTGAAAGGCCTGGGAGGCCTCCCGGTGCTCTCCCTGCATCTGTTCTTGTACTCTGTC 1756 PICK1 3945193TGTTGAAGAAAGTCAAGCACCGGCTGGTGGAGAACATGAGTTCAGGGACCGCAGATGCTCTGGGCCTGAGCCGGGCCATCCTG TGCAA 1757 PICK1 3945194CTCTGCCCGTGGAACTGAGAAGTCACCATCTCTGTACCCCCAGAGGCCTCTCCAGCTCCCGGAGGGTCCACAGCTGTCAGCTGGGCTGTCTTAGCCAGTGCCCCTCAGGTCACAGATGGGAAAATAGACTTAGTGTGGGGAGGTGCCTCTGCCCCTGCCCTCAGCCCCTTACCCCTCACCCCAGCACTCTCGCGGCCCACCTCCTGCCTCCTTTGTCCAGGAGGTGGTGCTGCTGCCCTTGCCTCTGCAGGTCCTCCCTTCGTGGTGGCTGCGCAGGCGAGGGGGGAGGCGTGTACATGCACATTTACACACGCATGCACACATGCGCACACACTTTCCCTCCCTGGGGTGGCCAGCGAAACACTCAGTCCCCCTCCTACCGTCGCCAGTCCGAGTTTAAAAATAGCAGCAGCTCTGCAGTGTGCCTGTGGGGTAGATATAAATACTTCTAGAAATTGTAGGCTCAGCTGGGCACACTGGGCTTTATTGGCTAA 1758 PICK1 3945195CTTGTCAAGAGGCTAGAGGAGCTGGAGCGGACCGCTGAGCTA TACAAAG 1759 PICK1 3945196TACGGGCCTTTTATGAGCTGTCGCAGACTCACCGGG 1760 PICK1 3945197CCTGCGGGGAACATCTAGATCAGCTGGTCTCTTAAGGGCCGCAACGATGAACAGGCCCCACCCTGTCTCCTCACACTGCCACTGGCAGTACACAAGGCCCTTGCTTATTTATATTTCTGACAACCTGTAACTCTGGGCAGGCCGACTGCAGCTGACCCCAGCTACTGCAGAAAATGAAGCCCAGACAAAGGAGAGGGCCACACTGCTCCCAAGTGGTGGAGCTGTTGTTCCAATCCAGGTGTCTAGACTCGGAC CAGTGTTCTGCCTCA 1761 PICK13945198 CAATCCAGTTTCCTCCAGGTGTAGACTCAGCTCCTTCAGGGGGTTTAGACCAGCTCTCTTGGAGGTGTAGCCCCTGTGCAGACATTGGCTTCCAGCCTGCCAGGCCCCCTGCCCTGCTTCTCCCCAACAAACCCCTGGCTTCTCTTAGGGGGCCAAGTAGGGGCAGCCT TCAAGGCAAACTTGTCCTGCA 1762PICK1 3945199 TTTGGGGACGTGTTCTCCGTGATCGGGGTGCGGGAGCCCCAGCCAGCTGCGAGCGAGGCTTTTGTGAAGTTCGCCGATGCCCACCGCAGCATCGAGAAGTTCGGCATTCGGCTTCTGAAAACCA 1763 PICK1 3945200ACTGAGTCACAGCTTGCCCTAGGCCTGGCACTAGTCTTCTCATCCTTGAGAGGGACAAGGCATCAGGGAGCACCATCTGGCTCTGATAGTCGAGTCCACCAACAAGGGTGACGCATCAGTGCCATTC ATTG 1764 PICK1 3945201GACGGATCTGAACACGTACCTCAACAAAGCCATCCCGGACACTCGCCTCACCATCAAGAAGTACCTGGACGTGAAGTTTGAGTAC CTG 1765 PICK1 3945202CTGCTGCGCCTGCACAAAGAAGCATCTG 1766 PICK1 3945203GGACTCCCTGAACACCTGCGCCAGCCTCTCCTGCTGCGTGTGGGTGATGGGGGTGGAGCTGGGGACCTGGGGTGGGGGTAGTA CCACTCTGACAGCCT 1767 PICK13945204 GATGGATGACGAGGAATACAGCTGCATT 1768 PICK1 3945205CTGGACTCTCGTTCCTGGAGATTTAGGGCCATCTTCCCAGTCCCGCTCGCTGGGCCTCGGGGTGCTGGGCACCCGGCCGGGAACCACTCCCTCAGTCTGGGGGACTCTTGGAGGGAAATCGGATTTTCTTCACTCCTATGAGGCGCTTTTAAGTGTTTGATTTTTCTGCTGTCGGGATCCATTTCGTGGCCAGTGTTCATTGAATGTGGCAGAGGTTTGGGTTTGGTTTTTTCCTCTCTTCAAAGCTATCACTGAGTGCTTCTGAGAAACACTGAAGTCTCAGAAATGAGGTCTCAGGAATGAAGAACAGCCGTGGCTTTGAAAGCACA 1769 PICK1 3945206GGCGAGCCCCTTTACCGGGTGAGCACCGGCAACTATGAGTACCGCCTGATCCTGCGCTGCCGCCAGGAGGCGCGCGCCCGCTT CTCCCAGATGCGCAAGGATG 1770PICK1 3945207 GCCTCGTGTCCACCATGTCCAAGTACTACAACGACTGCTACGCAGTGCTGCGGGATGCCGACGTCTTCCCCATCGA 1771 PICK1 3945208GTAGACCTGGCGCACACCACATTGGCCTATGGCCTCAACCAG G 1772 PICK1 3945209GTTCACAGATGGGGAGGAGGAGGAGGA 1773 PICK1 3945210TGGGGAGCCGTCCAGGGATACACGAGGGGCTGCTGGGC 1774 PICK1 3945211GTGCCCCGCGGCTGTGGTGCCGGGGGCAGG 1775 PICK1 3945212GCGACGCATAAAGGCCTGCTGGCTTGGGGCGCCTGCCTCCCTGCTCCTCTGTCCTCGCACAGCGAACCTGGGCTCCTGCCCAGGACAGGCACCAGGGTCATGGCCTGGGACCTGGACACTGGCCCCTCCACCCTCCCTCCCCTCCCGGCTCCCCGGCCAGAGGGAGAGCTTGGTCTCTGGACCTGCCTTAGGAAGGAGAGGGAGGGCAGGAAGGAAAAGAAAGGACTTGGAGGTGGCAGGAGTCCGAGCCCTGCTCCTTGTGGGCGCTCACACTGCCCCCGGAGCCTGCTGGGAGTGGGGCCAGCCGTGGACAGCTGAGGTTGGGGTCAATGCCTCCTGGGCACCCTTGCCTCGCCCCAGACCGGCCCGTCCAGTCCCCATCACACCTCGGCGGCCTTTATTTA 1776 PICK1 3945213TGGGTTCTGGGCCTGTATCGAATAAACACAAACCTG 1777 FTH1P8 3994182CTCAGAGGCGGCCATCAACCGCCAGATCAA 1778 FTH1P8 3994183GTCTTACTACTTTGACCACGATGATGTGGCTTTGAAGAACTTTGCCAAATACTTTCTTCACCAATCTCATGAGGAGAGGGAACATG CTGAGGAACTGATGAAG 1779FTH1P8 3994184 CTGGGAGCGGGCTGAATGAGATGGAG 1780 VBP1 3996816CGCAGCCAATCAGCACCTAGAGGTTGGGCTACTTTCGGCCAAAGGAGAACGGGGACTTGTGGGGGACGCTCCCTGCGCACCAATGAATGTGCATGGAGATGGAGAGGCGGGCCTGCAAGTGCGA ACAAGCCAATC 1781 VBP1 3996817CGGCCGTTAAGGACAGTTGTGGCAAAGGAGAAATGGCCACAGGGAATGGGCGGCGGCTCCACCTGGGGATTCCTGAGGCCGTG TTT 1782 VBP1 3996818TGGCCTCTAAATAGACCAGGGTCTGAATCCTGGCTCTGCTTCCCAGTTGCTGCTTAACCTTAAGCATATTATTTTACCACTTTGAGCTTGAGTTTCTTTAACTGAAATAGGGATGACAATACTTAGAGAGTTGTTATGGGAAACAGAGAACATGCTTGCAGTATTGCAGTGTAGTAGGTGTCGAATAGGTATTAATATTCATGATGATAGGAAGCAATATACCATAGTGGTTAGAAGTCAGACCCAGTCCATTCCCCAAC CCCGCTGAGGCAGTAATTTGTTTTC1783 VBP1 3996819 CAGTATTAAAGAAGCTGGATGAACAGTACCAGAAGTATAAGTTTATGGAACTCAACCTTGCTCAAAAGAAA 1784 VBP1 3996820GCTAAAAGGTCAGATTCCTGAAATTAAACAGACTTTGGAAATT CTAAAATACATGCAGAAGAAAA 1785VBP1 3996821 GAGTCCACCAACTCAATGGAGACCAGATTCTTGCTGGCAGATAACCTGTATTGCAAAGCTTCAGTTCCTCCTACCGATAAAATGTGT CTG 1786 VBP1 3996822TGCATATGTTCTTCCTGTCCTTACACATTCTTTATAAGGTTGTTCCCACATTGTTGGAGCACAGAGCCATTATATACTGTTTGCTCTCTCTCTTTCTCTCTCTCATCTTTCATTTATCCTAGTTCTTCGTGT AAATATTG 1787 VBP1 3996823TTGATGAAGCTCAGGCATTGTTGGAAAAGAATTTATCGACTGCCACAAAGAATCTTGATTCCCTGGAGGAAGACCTTGACTTTCTT CGAGATCAATTTACTACCACAGA 1788VBP1 3996824 TCATCTGACGGGTAGTGTGGAAACTTCATCCAGCTATGAGATGACGAGGGCCTAGGACGGGTGGCTTGTGGAAAGGAAAAGATATTAAACGTGTGAGAAAAAAACAGGATCCAGTGACTTAGATGGGTACAGGAGCCAAAAGTGAGGAAATCCTCTAAGATGAGTCCTACAAGCTTAGTTAAATGCCATTTGTTATTGCTAGTACTGC 1789 VBP1 3996825ATATGGCCAGGGTTTATAATTGGGATGTAAAAAGAAGAAACAA GGATGACTCTACCAAGAACAAA 1790VBP1 3996826 TATGGAAGCTGAATGCCGGACGCTAGCACAGTTTACTTTTTCCCTTTCTAATCGGCTGATGTTACTCTCACTTGATGTGGTTAAACCATTTTAGAGGTAGAGAAGACAGACAGTTTGAATATTTGTAAACTTGTTTTTCTTTGGTATATTTAGGACTTAGTGGTCCTCTGTTGCTATTGTCTTCTATAAGTGGAGTTTCATGACTTACTGCTTAACGAATAACTAACTACTATGATATTCTGGACATTTTAGGAAATGGTAAT TTGCCTTGCTACACATTAAGAGGG1791 VBP1 3996827 GCCTAAGGTGATTTTGTAGTTCTTAACAGTTCTCCAGAGCATCTTGAACAGGAATATTAAGATAAATGTGAATCTGCAATGGCTGAAAAGAGTTGTGAGCTTTTTTATTCATGATAAAACCTTATAGGAATAGTATAAAAAATCCCTGTGGAAAGCTACTAGTACATTGACCAG CGCTGGGTGATACAGATTCT 1792KIAA1210 4019318 GCTCTAAGCTTTGCAAGGGATCCTAAAAGAGGCGGTGGAAGTGAAAATTCTGGGTCTCCAAGAAAATTTCTGCACAGCCAGTTCTCCAATCAGCCTATCACCCCTTGAAACATCTTCCCTGTGTCCCTGGGGGCCCCTGATGCTTTCTCCTTGGGTGATAGTAACATGCAGAGCACTTACACAAAGCTCCCTCTTTGGACATACCCCACGTCGACCTGTCACAGGCCTGGCTGTAGCGAGCACCTCCCTATGACGCAGAATGCTTCTTGGGAATTATCTTACTCCTCTGGAGGGTTAGTCCATCAATGTTTTGCTTCTTGTCCCAATACTACTGTGACCCTCTCTGATCGCACAGAAATCACTGCCTATCACATATATCCTGTTAAGCACTGAAGACCCTATTGAAATTAGAGTTCTACAGATGCCAAAAGCTGTACTTTCCATCAGGCAGATGGCAAGCTTACTGCCTTGATGCACATCTGGAGCCACTGGAGCTCCTTCCTCTCTGGTTCCAGCATTAAGGTGGAGAACTCCATGTAGCTTCTTGTCCTTTCCCCTCAGCTGTCTTTGCTTCACAAGGTTTTAGCCCAAAGCAAGAGTGCAATCCCAAAGCCACAGAGAAATGAACTTTCCGCTACCTGGAAGCTTTAAGTGAGTAAATCAGCTTTTCCCCTCTCATTCCTAGAGGCACACACCTCAAAAGTTACTAGGCTGGAGAGACCCTACCTTCCAGTGACCCACTCATCCCCCAGCCACGGAGAAGAGGGAAGACCAAAAAGGGAGAGTGAGAAAGAGGATGAGAGGGATGGTCAGCTGTGAGGGGAGGGGGCAAGTGGCCCAGCAAATGTTGATGCCTCCCTTCCCATCTTGCCACACGGTCTTTTTCTTTTGTAGCACAGCCTCCATTAATAACTCCTCGGCTGAGGATGAAGATGTAGGCACCTTTACCCCCAGAGCCAGTTCCTTAATTGGCTGGCTTTCTGAGATGCAGACCACCCTAGAATCTCATCTAGGTTCACTAGAAGTTAGTTAAATCTTCCTTTCTCTGTCTTTCTCTTCATTCCATCCCCCAAACCCACCAAACACTAAGGGAGAGCTCCCTTTGGATGTCTG GGCAGTAAACCTAGCTCATT 1793KIAA1210 4019319 AGAAACCAAACGATCTTCAACTCTCCCAGCCAAGTTCCAGAACCCAGTTGAGCCAATTGAGCCTGTCTGGTTCTCACTGGCCAGGAAGAAAGCCAAAGCATGGAGCCACATGGCA 1794 KIAA1210 4019320GATCAGAGGAAACCTGAAAGGAGGAAACATTATATGGCATTCCATAAACAACATACCCCAATATCGCTGGGGTTCCTTATTGCTTGT GTGTTATTTGCTGTGGTTCC 1795KIAA1210 4019321 CCAGTGTCCATAAACAGGAGAAGACAGCACAGATGAAGCCACCTAAGCCTACAAAATCAG 1796 KIAA1210 4019322CCTGCTGGTCAACAGTCAGATTATGCTGTCTCAGAGCCGGTTTGGATAACTATGGCAAAGCAGAAGCAGAAGAGTTTCAAGGCCCACATTTCTGTGAAAGAGCTGAAAACTAAGAGCAATGCTGGAGC CGATGCTGAGACTAAGGAGCCTA 1797KIAA1210 4019323 TCCAGATGGCAAGCAGATATCAAGTGGA 1798 KIAA1210 4019324TTTGGAGTTCGACTGAAAAGAGCCCCTCCCTCGCAGAAGTATAAGAGTGAGAAACAAGATAACTTCACCCAGCTTGCTTCAGTGCCCTCGGGCCCAATTTCATCCTCTGTAGGCAGGGGACATAAAATC AGAAGCACTTC 1799 KIAA12104019325 TCCTCAAATTTCGAGCGGGCTGCTATTGAGGCAGACATTTCTGGGAGTCCATTGCCTCCCCAATATGCTACCCAGTTCTTAAAGAGGTCTAAAGTTCAGGAAATGACCTCACGACTAGAGAAAATGGCTGTTGAAGGCACTTCTAACAAATCACCGATTCCCAGGCGTCCGACCCAGTCATTCGTGAAATTTATGGCACAGCAAATCTTTTCAGAGAGCTCTGCTCTTAAGAGGGGCAGTGATGTGGCACCTCTGCCTCCCAATCTTCCTTCCAAATCTTTATCAAAGCCTGAAGTCAAGCACCAAGTTTTCTCAGATTCAGGGAGTGCTAATCCTAAGGGAGGCATTTCTTCAAAGATGCTACCTATGAAGCACCCTTTACAGTCCTTGGGGAGGCCTGAAGACCCACAGAAAGTTTTCTCTTATTCAGAGAGAGCTCCTGGGAAGTGCAGCAGTTTTAAAGAGCAGCTGTCTCCCAGGCAGCTTTCCCAGGCCTTGAGGAAACCTGAGTATGAGCAAAAAGTCTCCCCTGTTTCTGCCAGTTCTCCTAAAGAGTGGAGGAATTCTAAAAAGCAGCTGCCTCCCAAACATTCTTCCCAAGCCTCAGATAGGTCTAAATTCCAGCCACAGATGTCATCAAAGGGCCCAGTGAATGTACCTGTAAAGCAGAGCAGCGGTGAGAAGCACCTGCCTTCAAGTAGTCCTTTCCAGCAACAGGTTCATTCAAGTTCTGTGAATGCTGCTGCTAGGCGATCTGTTTTTGA 1800 KIAA1210 4019326GGCTATCCAATGTCAGCAGCATATGGAAGAAGATGGAGAAGAAAAGGAGCAAGTGTTTCAGGATTGAGTGGGTGTGAATTCAAAGGAAGAAGCCTTAAACAATCCAGTGAAGGGTATGGCCTGGGCGATAGAGCTGGGTCTTCACCTACCAATAAGACTGCCAGGAATGT CCCTTTCTCGCACTTGTCCTTAG 1801KIAA1210 4019327 TGGAGCATAGTCAGCTATTATCAGCGCTGTATGCTGGATATGAAACTACTGGATGGAGCTAAGGATGCAGCAGATAGTGAGGGAA GAAAGGCACAAGGGGCCCTTCCAT 1802KIAA1210 4019328 TGTTGGCTCCAGTTGATGGCAAGCTGATTTCTAGCAGTATTTGATAAAAAAATTCCAGTTCCTCAAATTAAGTTGAATAGTTATGTTACGTTTTTGCCACAAAGGATTTCACATGTGGGTCCAAAGACAG GACATTCCTAAACACGTTT 1803KIAA1210 4019329 AACCTTCCATTGGTTTCTGAAGAAGAAAAGAGCATAACCAAACCAAAAGAAATCAACGAAAAGAAGCTGGGA 1804 KIAA1210 4019330CCTTCCAGTGTGGTTCAGTCATTTCCAGGGTATTTTAGAGGGATCCCTGCAGTGTGTCACTCAGACATTAGAA 1805 KIAA1210 4019331CACAGTCCTTGACTGCATTTGCCACACTTGCCTCTACCAGTAGCACCCAGCTGCCCATTGGTTTCAGCACCCCAGCCACCACCCAGGGCTGTTTGGATTCTTCAGCTGCTCGCCACAAAATGACTT 1806 KIAA1210 4019332GGTTACAGGCTCCATCACTATCCCACTGGAG 1807 KIAA1210 4019333ATCCCACCTGTTATCCAACCTGAAATAATTTCTAAGAACTTGGTAGAAATCTCTCTCGATGATGAGTCACCTAAGAATCCACAAAAGAAGGCTTTACCACATAAGAGTTTGACAGCG 1808 KIAA1210 4019334TTCTAATGGATTAAGTGACATTCAGAACAACGAGGAGATTGTT AAAGAAGAA 1809 KIAA12104019335 CTCTGCCTAAACCTAGGAGTAAGGTTCCTGGAGTTGTGTCTGGAGCCATGTCAGGAGCTGTGCTTCAAAATGTGCCTACAAGTGCA GTCTGGGTT 1810 KIAA12104019336 TTCCTTCTATGGATCCCCAGAGAGG 1811 KIAA1210 4019337GCAGCATGGGGAGCAAAGCCCTATCCCATGATAGCATCTTCA TGTTGGGTCCTGAGCCTGAAAGATCA1812 KIAA1210 4019338 AAAGAAGCCGAAGATACCCAGGAAGAAGAA 1813 KIAA12104019339 CCTACAATGGCTGAATCACTAAGTGAAATTTCTGACAGTCTGG ATGT 1814 KIAA12104019340 ATGCCCTGTACCCAAGGTGATTTACAGCAGGGTTTCCTTAAAGCTAGGTATTTGGAGCCCTCACCTCCCAGGAGTCACCTGGAAG GTTCTGGACTTGCAGGTCCCT 1815KIAA1210 4019341 TGATTGCTGGTAATCTTGGGGATCTGGCCAGGATAGTGGGCCCCTCACATCATGCTAGTCAGCTTCTCCTACTCCAAG

Example 2: Validation of a Genomic Classifier to Predict AggressiveProstate Cancer in Humans

The genomic classifiers described in Example 1 above were furthervalidated as follows. Expression profiles from assays of biopsy andradical prostatectomy (RP) tumor tissue specimens from multiple patientcohorts were analyzed. This included genome-wide expression, treatmentand outcomes data from prostate cancer patients treated with RPretrospective institutional cohorts and pathological data from clinicaluse of the Decipher RP test.

Prediction of Future Metastasis

RP clinical validation of the genomic classifiers (DV1 and DV2) abilityto prognosticate the development of postoperative metastasis at 5 yearsand 10 years was determined. As shown in Table 8 below, genomicclassifiers DV1 and DV2 were prognostic for 5-year metastasis and10-year metastasis. Similar results were observed for prostate-cancerspecific mortality end-point (See Table 9). Multivariable analysisfurther demonstrated that the prognostic information in the GC models isindependent of clinical risk factors.

TABLE 8 Metastasis Endpoint for Genomic Classifiers Cumulative Incidenceof Cumulative Incidence of 5 year Metastasis @ 5 year - Metastasis @ 10year - MVA HR AUC Risk Group Risk Group Dataset Classifier (95% CI) (95%CI) Low Int High Low Int High Decipher Dv1 1.20 0.72 2.4 5.8 15.2  5.515.0 26.7 Meta RP (1.09-1.33) (0.66-0.78) (n = 855) Dv2 1.33 0.79 1.56.8 15.2  3.9 12.0 31.4 (Spratt JCO (1.18-1.49) (0.73-0.84) 2017) Dv1 +CC — 0.78 — — — — — — (0.72-0.85) Dv2 + CC — 0.82 — — — — — —(0.77-0.86) CCF RP Dv1 1.28 0.78 5.1 4.8 17.5 15.4 38.0 60.1 (n = 179)(1.12-1.47) (0.67-0.88) (Klein EU Dv2 1.27 0.75 4.2 4.5 20.6 11.2 42.567.5 2015) (1.09-1.48) (0.62-0.87) Dv1 + CC — 0.76 — — — — — —(0.62-0.91) Dv2 + CC — 0.74 — — — — — — (0.61-0.87) Leuven RP Dv1 1.260.71 13.3  7.1 34.5 41.5 22.1 56.1 (n = 61) (1.07-1.49) (0.50-0.87) Dv21.20 0.74 14.3  18.8  29.2 29.4 45.5 51.3 (1.03-1.41) (0.53-0.89) Dv1 +CC — 0.78 — — — — — — (0.64-0.95) Dv2 + CC — 0.76 — — — — — —(0.61-0.97)

TABLE 9 PCSM Endpoint for Genomic Classifiers Dataset Classifier OR (95%CI) AUC (95% CI) Decipher PCSM Dv1 1.48 (1.33-1.64) 0.73 (0.67-0.78)[All patients] Dv2 1.47 (1.36-1.58) 0.79 (0.74-0.84) (n = 561) Dv1 + CC1.31 (1.17-1.46) 0.80 (0.75-0.83) (Karnes EU 2017) Dv2 + CC 1.33(1.23-1.45) 0.82 (0.79-0.86) Decipher PCSM Dv1 1.37 (1.21-1.54) 0.69(0.62-0.76) [High Risk: Dv2 1.35 (1.24-1.48) 0.73 (0.67-0.79) PSA > 20or RP Dv1 + CC 1.29 (1.14-1.46) 0.72 (0.68-0.77) Gleason > 8 or RP Dv2 +CC 1.30 (1.18-1.43) 0.75 (0.71-0.79) Stage pT3b/N1] (n = 323) DecipherPCSM Dv1 1.35 (1.18-1.53) 0.69 (0.62-0.77) [BCR patients] Dv2 1.34(1.22-1.49) 0.74 (0.67-0.81) (n = 212) Dv1 + CC 1.25 (1.09-1.43) 0.75(0.70-0.80) Dv2 + CC 1.26 (1.14-1.41) 0.77 (0.72-0.82)

Treatment Guidance

Treatment guidance, including adjuvant radiotherapy and salvageradiotherapy from Decipher RP testing was determined. Table 10 showstreatment guidance data for the metastasis endpoint for genomicclassifiers.

TABLE 10 Treatment Guidance - Metastasis Endpoint for GenomicClassifiers Cumulative Incidence of Cumulative Incidence of 5 yearMetastasis @ 5 year Metastasis @ 10 year MVA HR AUC Adjuvant SalvageAdjuvant Salvage Dataset Classifier (95% CI) (95% CI) RT RT RT RT ART vsSRT Dv1 Low — — 0 6.0 9.4 10.7 guidance Dv1 High — — 7.5 23.3 7.5 31.3(n = 188) Dv2 Low — — 0 3.6 0 7.7 (Den JCO Dv2 High — — 6.6 25.1 17.234.4 2015) SRT Dv1 1.3 0.81 — — — — intensification (1.09-1.6) (0.7-0.9)(n = 170) Dv2 1.68 0.86 — — — — (Freedland (1.32-2.3) (0.73-0.95) EU2016) Dv1 + CC — 0.8 — — — — (0.7-0.9) Dv2 + CC — 0.88 — — — —(0.81-0.94)

These results showed that genomic classifiers of the present inventionare useful for predicting presence of higher-grade disease in prostatecancer subjects. These results further showed that genomic classifiersof the present invention are useful for predicting metastasis inprostate cancer subjects. These results suggested that the methods andmarkers of the present invention would be useful for diagnosing,prognosing, determining the progression of cancer, or predicting benefitfrom therapy in a subject having prostate cancer. The results showedthat the subtyping methods of the present invention may be used todetermine a treatment for a subject with prostate cancer.

Although the disclosure has been described with reference to the aboveexamples, it will be understood that modifications and variations areencompassed within the spirit and scope of the disclosure. Accordingly,the disclosure is limited only by the following claims.

1. A method comprising: a) obtaining a biological sample from a subject;and b) detecting the presence or assaying an expression level in thesample from the subject for a plurality of target sequences, wherein theplurality of target sequences is selected from Table 1 or SEQ ID NOs:1-1815.
 2. The method of claim 1, wherein the plurality of targetsequences comprises a coding and/or non-coding target.
 3. The method ofclaim 1, wherein the plurality of target sequences comprises a nucleicacid sequence.
 4. The method of claim 3, wherein the nucleic acidsequence is a DNA sequence or an RNA sequence.
 5. The method of claim 1,wherein the plurality of target sequences comprises at least 5, 10, 15,20, 25, 30, 35, 40, 45, 50, 55 or 60 target sequences selected fromTable 1 or SEQ ID NOs: 1-1815.
 6. The method of claim 1, wherein thesubject has cancer.
 7. The method of claim 6, wherein the cancer isselected from the group consisting of skin cancer, lung cancer, coloncancer, pancreatic cancer, prostate cancer, liver cancer, thyroidcancer, ovarian cancer, uterine cancer, breast cancer, cervical cancer,kidney cancer, epithelial carcinoma, squamous carcinoma, basal cellcarcinoma, melanoma, papilloma, and adenomas.
 8. The method of claim 1,further comprising administering a treatment to the subject.
 9. Themethod of claim 8, wherein the treatment is selected from the groupconsisting of surgery, chemotherapy, radiation therapy,immunotherapy/biological therapy, and photodynamic therapy.
 10. Themethod of claim 1, wherein the biological sample is a urine sample, ablood sample or a prostate tumor sample. 11-19. (canceled)
 20. A kit forpredicting cancer aggressiveness or risk of metastasis, the kitcomprising agents for assaying an expression level of a plurality ofgenes, wherein said plurality of genes comprises one or more genesselected from Table 1 or SEQ ID NOs: 1-1815.
 21. A system for analyzinga cancer, comprising: a probe set comprising a plurality of targetsequences, wherein the plurality of target sequences hybridizes to oneor more targets selected from Table 1 or SEQ ID NOs: 1-1815; or theplurality of target sequences comprises one or more targets selectedfrom Table 1 or SEQ ID NOs: 1-1815; and a computer model or algorithmfor analyzing an expression level and/or expression profile of thetarget hybridized to the probe in a sample from a subject suffering fromprostate cancer.
 22. A probe set for prognosing or diagnosing cancer ina subject, the probe set comprising a plurality of probes for detectinga plurality of target nucleic acids, wherein the plurality of targetnucleic acids comprises one or more gene sequences, or complementsthereof, of genes selected from Table 1.